CCAPD: Alignment of Alcohol Dehydrogenase 1 (ADH1), Gamma Isozyme for primates

10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus sTAGKVIKCKAAVlWExkKPfSIEEVEVAPPQANEVRIKMVASGICRSDDHvVsGxLxxx ==================================================================================================== * GADUS_MORHUA aTvGKVIKCKAAVaWEanKPlvIEEIEVdvPhANEIRIKIIATGVChTDlyhLfegkhkd * Danio_rerio aTAGKVIKCRAAVaWEpKaPlmMEEIEVAPPQegEIRIKVIATGLChTDlyhLvdg-dkr * Oryzias_latipes aTAGKVIKCKAAVaWEpnKPlvIEDIEVAPPQANEVRIKIVATGVChTDlyhLfegMhkd ==================================================================================================== * HUMAN STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVAaGICRSDEHVVSGnLv-t * HORSE STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1A71A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1AXEA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1AXGA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1JU9A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1MGOA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1N8KA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1QLHA_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGtLv-t * 1QV6A_Horse STAGKVIKCKAAVLWEeKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDqVVSGtLv-t * Apteryx_australis STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRIKILATGICRSDDHVITGaLv-r * Canis_lupus STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVASGICRSDDHVVTGaLv-v * Coturnix_coturnix STAGKVIKCKAAVLWEanKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGaLa-m * Chicken STvGKVIKCKAAVLWEanKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGaLa-m * Mouse STAGKVIKCKAAVLWElhKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGtLv-t * Rabbit STAGKVIKCKAAVLWQlnKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHaVTGsIa-v * Papio_hamadryas STAGKVIKCKAAVLWEvKKPFSIEEVEVAPPKAHEVRIKMVAvGICRSDDHVVSGtLv-t * X_laevis aTAGKVIKCKAAIaWgpKQPlTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGaIsdm * X_tropicalis aTAGKVIKCKAAVaWgpKQPlTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGaIsdm * Rat-ADH1 STAGKVIKCKAAVLWEphKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHaVSGsLf-t * Rat-Q8K571 STAGKVIKCKAAVLWEphKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHaVSGsLf-t * Struthio_camelus-ADH1 STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGvLv-m * Struthio_camelus-ADH1_VAR STAGKVIKCKAAVLWEpKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGvLv-m * Alligator_mississippiensis-ADH1 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Alligator_mississippiensis-ADH1_VAR_1 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Alligator_mississippiensis-ADH1_VAR_2 STAGKVIKCKAAItWEiKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVtaGlLt-m * Human-ADH1G STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVAaGICRSDEHVVSGnLv-t * Human-ADH1G_VAR_1 STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVAaGIChSDEHVVSGnLv-t * Human-ADH1G_VAR_3 STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVAaGICRSDEHVVSGnLv-t * Human-ADH1G_VAR_4 STAGKVIKCKAAVLWElKKPFSIEEVEVAPPKAHEVRIKMVAaGICRSDEHVVSGnLv-t ==================================================================================================== Consensus sTAGKVIKCKAAVlWExkKPfSIEEVEVAPPQANEVRIKMVASGICRSDDHvVsGxLxxx 70 80 90 100 110 120 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus pxPvILGHEaAGIVESIGEGVSslRPGDKVIPLWvPQCGKCkxCkNpKsNlCxKxNDLxx ==================================================================================================== * GADUS_MORHUA gfPVVLGHEgAGIVESVGpGVTefQPGEKVIPLFIsQCGECRfCQSPKTNqCvK-gwa-n * Danio_rerio gfPVVLGHEsAGVVESVGpGVTdyKPGDKVIPLFLsQCGKCKfCKcPKTNLCes-Swa-t * Oryzias_latipes gfPaVLGHEgAGIVESVGpGVSefQPGDRVIPLFIsQCrECRfCKSPKTNqCeK-gwa-a ==================================================================================================== * HUMAN PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRiCKNPESNyClK-NDL-g * HORSE PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * 1A71A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLWtPQCGKCRvCKHPEgNfClK-NDL-s * 1AXEA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLWtPQCGKCRvCKHPEgNfClK-NDL-s * 1AXGA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * 1JU9A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * 1MGOA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLatPQCGKCRvCKHPEgNfClK-NDL-s * 1N8KA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * 1QLHA_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * 1QV6A_Horse PlPVIaGHEAAGIVESIGEGVTTVRPGDKVIPLFtPQCGKCRvCKHPEgNfClK-NDL-s * Apteryx_australis PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECsaClStKgNLCsK-NDI-g * Canis_lupus PlPIILGHEAAGIVESIGEGVTTVKPGDKVIPLFtPQCGKCnvCKHPQgNLCvK-NDL-s * Coturnix_coturnix PfPVILGHEAAGVVESVGEkVTlLKPGDaVIPLFVPQCGECRsClStKgNLCiK-NDLss * Chicken PfPIILGHEAAGVIESVGEkVTSLKPGDaVIPLFVPQCGECRsClStKgNLCiK-NDLss * Mouse PlPaVLGHEgAGIVESVGEGVTcVKPGDKVIPLFsPQCGECRiCKHPESNfCsR-SDL-l * Rabbit PlPVILGHEAAGIVESIGEGVTTVKPGDKVIPLFtPQCGKCRiCKHPESNfCli-NDL-g * Papio_hamadryas PlPaILGHEAAGIVEgVGEGVTTVKPGDKVIPLFtPQCGKCRvCKNPESNyCfK-NDL-s * X_laevis kfPaILGHEgAGIVESVGEGVkNIKPGDKVIPLFVPQCGECRsCtNsRSNLCdK-HDI-g * X_tropicalis kfPaILGHEgAGIVESVGEGVkNIKPGDKVIPLFVPQCGECRcCtNvRSNLCdK-HDI-g * Rat-ADH1 PlPaVLGHEgAGIVESIGEGVTcVKPGDKVIPLFsPQCGKCRiCKHPESNLCcQtkNL-t * Rat-Q8K571 PlPaVLGHEgAGIVESIGEGVTcVKPGDKVIPLFsPQCGKCRiCKHPESNLCcQtkNL-t * Struthio_camelus-ADH1 PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECsvClStKgNLCrK-NDI-g * Struthio_camelus-ADH1_VAR PfPIILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECsvClStKgNLCcK-NDI-g * Alligator_mississippiensis-ADH1 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFVPQCGECmpClksngNLCiR-NDL-g * Alligator_mississippiensis-ADH1_VAR_1 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFVPQCGECmpClksngNLCiR-NDL-g * Alligator_mississippiensis-ADH1_VAR_2 PlPMILGHEAAGVVEStGEGVTSLKPGDKVIPLFVPQCGECmpClksngNLCiR-NDL-g * Human-ADH1G PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRiCKNPESNyClK-NDL-g * Human-ADH1G_VAR_1 PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRiCKNPESNyClK-NDL-g * Human-ADH1G_VAR_3 PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRiCKNPESNyClK-NDL-g * Human-ADH1G_VAR_4 PlPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFtPQCGKCRiCKNPESNyClK-NDL-g ==================================================================================================== Consensus pxPvILGHEaAGIVESIGEGVSslRPGDKVIPLWvPQCGKCkxCkNpKsNlCxKxNDLxx 130 140 150 160 170 180 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxpxxxgxmxdgTsRFTCKGKxIhnFLgtSTFSQYTVVNExaVAKIDaaaPLEKVCLIGC ==================================================================================================== * GADUS_MORHUA esPdvmsp---keTRFTCKGRkVlqFLGTSTFSQYTVVNQiAVAKIDpsAPLDtVCLLGC * Danio_rerio kyhdimae---pTSRFTCRGQtIlqFMGTSTFSEYTVINQnAVAKIDenAPLDRVfLLGC * Oryzias_latipes dhydvmal---adSRFTCKGKkVlqFMGaSTFSEYTVMNQiAVAKIDpAAPLDKVCLLGC ==================================================================================================== * HUMAN -nP-r-GtLqDGTrRFTCsGKpIHHFVGvSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * HORSE -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1A71A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1AXEA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1AXGA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1JU9A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1MGOA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1N8KA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1QLHA_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * 1QV6A_Horse -mP-r-GtMqDGTSRFTCRGKpIHHFLGTSTFSQYTVVDEisVAKIDAAsPLEKVCLIGC * Apteryx_australis -sa-s-GlMpDGTTRFTCKGKaIHHFIGTSTFTEYTVVHEtAVAKIaAAAPLEKVCLIGC * Canis_lupus -kP-r-GtLqDGTiRFTCRGKpIyHFLGiSTFSQYTVVDEfsVAKIDAAsPLEKVCLIGC * Coturnix_coturnix -sP-t-GlMaDGTTRFTCKGKaIHHFIGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGC * Chicken -sP-t-GlMaDGTTRFTCKGKaIHHFVGTSTFTEYTVVHEtAaAKIDsAAPLEKVCLIGC * Mouse -mP-r-GtLrEGTSRFSCKGKqIHNFIsTSTFSQYTVVDDiAVAKIDgAsPLDKVCLIGC * Rabbit -kP-k-GmLlDGTSRFTCKGKpIHHFIGTSTFSQYTVVDEiAVAKIDAAAPLEKVCLIGC * Papio_hamadryas -nP-r-GtMqDGTrRFTCgGKpIHHFLGiSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * X_laevis -py-i-GlLlDkTSRiTCKGKpVyNFLsTSTFTEYTVLDEicVAKIDdnAPLDKVCLIGC * X_tropicalis -py-r-GlMlDnTNRFTCKGnpVytFLsTSTFTEYTVLDEicVAKIDdnAPLDKVCLIGC * Rat-ADH1 -qP-k-GaLlDGTSRFSCRGKpIHHFIsTSTFSQYTVVDDiAVAKIDAAAPLDKVCLIGC * Rat-Q8K571 -qP-k-GaLlDGTSRFSCRGKpIHHFIsTSTFSQYTVVDDiAVAKIDAAAPLDKVCLIGC * Struthio_camelus-ADH1 -pa-s-alMpDGTSRFTCKGKaIHHFaGTSTFTEYTVLHEtAVAKIDAAAPLEKVCLIGC * Struthio_camelus-ADH1_VAR -pa-s-alMpDGTSRFTCKGKaIHHFaGTSTFTEYTVLHEtAVAKIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1_VAR_1 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Alligator_mississippiensis-ADH1_VAR_2 -sP-s-GlMaDGTSRFTCKGKdIHHFIGTSTFTEYTVVHEtAVARIDAAAPLEKVCLIGC * Human-ADH1G -nP-r-GtLqDGTrRFTCsGKpIHHFVGvSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * Human-ADH1G_VAR_1 -nP-r-GtLqDGTrRFTCsGKpIHHFVGvSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * Human-ADH1G_VAR_3 -nP-r-GtLqDGTrRFTCsGKpIHHFVGvSTFSQYTVVDEnAVAKIDAAsPLEKVCLIGC * Human-ADH1G_VAR_4 -nP-r-GtLqDGTrRFTCsGKpIHHFVGvSTFSQYTVVDEnAVAKIDAAssLEKVCLIGC ==================================================================================================== Consensus xxpxxxgxmxdgTsRFTCKGKxIhnFLgtSTFSQYTVVNExaVAKIDaaaPLEKVCLIGC 190 200 210 220 230 240 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus GFSTGYGxAVkxAKVxpGSTCAVFGLGGVGLSvIMGCKaAGAxRIIaVDiNkEKFaKAKE ==================================================================================================== * GADUS_MORHUA GvSTGFGaAVntAKVePGSTCAVFGLGaVGLaaVMGChsAGAkRIIAVDLNpDKFeKAKv * Danio_rerio GiTTGYGaAVntAgVtPGSvCAVFGLGaVGLaaVMGCKnAGAsRIfAVDINEKKFeKAKv * Oryzias_latipes GvcTGFGaAVntAKVePGSTCAVFGLGaVGLaaVMGCKfAGAkRIfAVDtNpEKaeKARv ==================================================================================================== * HUMAN GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVVMGCKAAGAaRIIAVDINKDKFAKAKE * HORSE GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1A71A_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGaGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1AXEA_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1AXGA_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGaGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1JU9A_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1MGOA_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1N8KA_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1QLHA_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * 1QV6A_Horse GFSTGYGsAVKvAKVtqGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDRFAKAKE * Apteryx_australis GFSTGYGaAVQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAIDINKDKFAKAKE * Canis_lupus GFSTGYGsAVnvAKVtPGSTCAVFGLGGVGLSVIMGCKAAGAaRIIgVDINKDKFAKAKE * Coturnix_coturnix GFSTGYGavLQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAIDINKDKFAKAKE * Chicken GFSTGYGavLQtAKVeaGSTCAVFGLGGVGLSVVMGCKAAGAsRIIAVDINKDKFAKAKE * Mouse GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVIIGCKAAGAaRIIAVDINKDKFAKAKE * Rabbit GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVIMGCKAAGAsRIIAVDINKDKFpKAKE * Papio_hamadryas GFSTGYGpAVKvAKVtPGSTCAVFGLGGVGLSaVMGCKAAGAaRIIAVDINKDKFAKAKE * X_laevis GFSTGYGsAVKtAKVePGSSCAVFGLGGVGLSVLIGCKvAGAaKIIgVDtNpDKFAKAKE * X_tropicalis GFSTGYGsAVKiAKVeqGSSCAVFGLGGVGLSVLIGCKvAGAsKIIgVDtNsDKFAKAKE * Rat-ADH1 GFSTGYGsAVQvAKVtPGSTCAVFGLGGVGLSVVIGCKtAGAaKIIAVDINKDKFAKAKE * Rat-Q8K571 GFSTGYGsAVQvAKVtPGSTCAVFGLeGVGLSVVIGCKtAGAaKIIAVDINKDKFAKAKE * Struthio_camelus-ADH1 GFSTGYGaALQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIgVDINKDKFAKAKE * Struthio_camelus-ADH1_VAR GFSTGYGaALQtAKVePGSTCAVFGLGGVGLSVVMGCKAAGAsRIIgVDINKDKFAKAKE * Alligator_mississippiensis-ADH1 GFSTGYGaAVKdAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Alligator_mississippiensis-ADH1_VAR_1 GFSTGYGaAVKdAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Alligator_mississippiensis-ADH1_VAR_2 GFSTGYGaAVKtAKVePGSTCAVFGLGGVGLStIMGCKAAGAsRIIgIDINKDKFAKAKE * Human-ADH1G GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVVMGCKAAGAaRIIAVDINKDKFAKAKE * Human-ADH1G_VAR_1 GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVVMGCKAAGAaRIIAVDINKDKFAKAKE * Human-ADH1G_VAR_3 GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVVMGCKAAGAaRIIAVDINKDKFAKAKE * Human-ADH1G_VAR_4 GFSTGYGsAVKvAKVtPGSTCAVFGLGGVGLSVVMGCKAAGAaRIIAVDINKDKFAKAKE ==================================================================================================== Consensus GFSTGYGxAVkxAKVxpGSTCAVFGLGGVGLSvIMGCKaAGAxRIIaVDiNkEKFaKAKE 250 260 270 280 290 300 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus LGATECVNPqDYxKPIxEVLxEMSnxgGVDFSFEvIGrlEtMxxALxsChxxyGvSVIVG ==================================================================================================== * GADUS_MORHUA fGATDfVNPnDhsEPIsQVLsKMTN-GGVDFSlEcVGnVgvMrnALeSClkgWGVSVLVG * Danio_rerio fGATDfLNPKaFnKPIsEVLiEMTNgGGVDFSiEctGntEvMrsALeSCakgWGVSVVVG * Oryzias_latipes fGATDfVNPKDYnKPIsKVLaEMTN-GGVDYSlEcVGnVDvMrsALeSCmkgWGVSVVVG ==================================================================================================== * HUMAN LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGQLDTMmasLlcCHeacGtSVIVG * HORSE VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1A71A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1AXEA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1AXGA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1JU9A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIsG * 1MGOA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * 1N8KA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVItG * 1QLHA_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVa * 1QV6A_Horse VGATECVNPQDYkKPIqEVLtEMSN-GGVDFSFEVIGRLDTMvtALscCqeaYGVSVIVG * Apteryx_australis LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVILG * Canis_lupus VGATECISPQDYkEPIqEVLkEISg-GsVDFSFEVIGRLDTMvaALscCqesYGVSVIVG * Coturnix_coturnix LGATECVNPKDFkKPIhEVLtEMTg-kGVDYSFEVIGRIETMteALaSCHynYGVSVIVG * Chicken LGATECINPKDFkKPIhEVLtEMTg-qGVDYSFEVIGRIETMtaALaSCHnnYGVSVIVG * Mouse LGATECINPQDYsKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHaacGVSVVVG * Rabbit VGATECINPQDYkKPIqEVIqEISD-GGVDFSFEVIGRLDTVvaALlSCHgacGtSVIVG * Papio_hamadryas LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTImasLlcCHeacGtSVIVG * X_laevis LGATECINPnDYkEPIhEVLaKMSN-GGLDYTFEcIGntKvMesALlatHfgcGtSVIVG * X_tropicalis LGATECINPnDYnEPIhEVLaKISD-GGLDYTFEcIGntKvMesALkatHfgcGtSVIVG * Rat-ADH1 LGATDCINPQDYtKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHsacGVSVIVG * Rat-Q8K571 LGATDCINPQDYtKPIqEVLqEMTD-GGVDFSFEVIGRLDTMtsALlSCHsacGVSVIVG * Struthio_camelus-ADH1 LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVIVG * Struthio_camelus-ADH1_VAR LGATDCVNPKDFtKPIhEVLmEMTg-lGVDYSFEVIGhtETMaaALaSCHfnYGVSVIVG * Alligator_mississippiensis-ADH1 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Alligator_mississippiensis-ADH1_VAR_1 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Alligator_mississippiensis-ADH1_VAR_2 LGATECINPlDckKPIqEVLsEMTg-GGVDYSFEVIGRIDTMtaALacCqdnYGtSVIVG * Human-ADH1G LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * Human-ADH1G_VAR_1 LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * Human-ADH1G_VAR_3 LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG * Human-ADH1G_VAR_4 LGATECINPQDYkKPIqEVLkEMTD-GGVDFSFEVIGRLDTMmasLlcCHeacGtSVIVG ==================================================================================================== Consensus LGATECVNPqDYxKPIxEVLxEMSnxgGVDFSFEvIGrlEtMxxALxsChxxyGvSVIVG 310 320 330 340 350 360 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus VppxxqnLSmNPMlLlsGRTWKGxIFGGFKSKDxVPKLVaDFMaKKfxLDxLITHxLpfe ==================================================================================================== * GADUS_MORHUA wt-dlhDVatrPIqLIaGRTWKGsMFGGFKgKDgVPKMVkaYLdKKvkLDefITHrMPlE * Danio_rerio wt-nvQDfSakPIqLIyGKTWKGsLFGGFKcKDsVPKLVrDYMsgKimLDefITHkMnlE * Oryzias_latipes wt-dkhDfSarPIqLIaGRTWKGtLFGGFKSKDgVPQMVkaYMeRKvkLDefITHnMtlt ==================================================================================================== * HUMAN VPPdsQNLSINPMLLLTGRTWKGaIFGGFKSKEsVPKLVADFMAKKFsLDaLITNvLPFE * HORSE VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1A71A_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1AXEA_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1AXGA_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1JU9A_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1MGOA_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1N8KA_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1QLHA_Horse VtPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * 1QV6A_Horse VPPdsQNLSMNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFaLDpLITHvLPFE * Apteryx_australis VPPaaEkISfDPMLLfSGRTWKGsVFGGWKSKDaVPKLVADYMeKKFvLEpLITHtLPFi * Canis_lupus VPPnsQSLSMNPMLLLTGRSWKGaIFGGFKSKDsVPKLVADFMAKKFpLEsLITHvLPFE * Coturnix_coturnix VPPaaQkISfDPMLIfSGRTWKGsVFGGWKSKDaVPKLVADYMkKKFvLDpLITHtLPFt * Chicken VPPaaQkISfDPMLIfSGRTWKGsVFGGWKSKDaVPKLVADYMkKKFvLDpLITHtLPFt * Mouse VPPnaQNLSMNPMLLLlGRTWKGaIFGGFKSKDsVPKLVADFMAKKFpLDpLITHvLPFE * Rabbit VPPdsQSLTVNPMLLLSGRTWKGaIFGGFKSKDsVPKLVADFMAKKFsLDpLITNvLPFE * Papio_hamadryas VPPdsQNLSINPVLLLTGRTWKGaIFGGFKSKEsVPKLVsDFMAKKFsLDaLITNvLPFE * X_laevis LaPasarVlVDPMeMLTGRTlKGaLFGGWKSRDdVPKLVADFMAKKFeLDgLITHrstlD * X_tropicalis LaPasarVSVDPMeMLTGRTlKGaLFGGWKSRDeVPQLVADFLAKKFeLDgLITHrstlD * Rat-ADH1 VPPsaQSLSVNPMsLLlGRTWKGaIFGGFKSKDaVPKLVADFMAKKFpLEpLITHvLPFE * Rat-Q8K571 VPPsaQSLSVNPMsLLlGRTWKGaIFGGFKSKDaVPKLVADFMAKKFpLEpLITHvLPFE * Struthio_camelus-ADH1 VPPaaEkLSfDPMLLfSGRTWKGsVFGGWKSKDsVPKLVADYMeKKFvLDpLITHtLPFh * Struthio_camelus-ADH1_VAR VPPaaEkLSfDPMLLfSGRTWKGsVFGGWKSKDsVPKLVADYMeKKFvLDpLITHtLPFh * Alligator_mississippiensis-ADH1 VPPasEkITfNPMMLfTGRTWKGsVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Alligator_mississippiensis-ADH1_VAR_1 VPPasEkITfNPMMLfTGRTWKGtVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Alligator_mississippiensis-ADH1_VAR_2 VPPasEkITfNPMMLfTGRTWKGsVFGGWKSKEsVPKLVADYMeKKinLDgLITHtLPFD * Human-ADH1G VPPdsQNLSINPMLLLTGRTWKGaIFGGFKSKEsVPKLVADFMAKKFsLDaLITNiLPFE * Human-ADH1G_VAR_1 VPPdsQNLSINPMLLLTGRTWKGaIFGGFKSKEsVPKLVADFMAKKFsLDaLITNiLPFE * Human-ADH1G_VAR_3 VPPdsQNLSINPMLLLTGRTWKGaIFGGFKSKEsVPKLVADFMAKKFsLDaLITNiLtFE * Human-ADH1G_VAR_4 VPPdsQNLSINPMLLLTGRTWKGaIFGGFKSKEsVPKLVADFMAKKFsLDaLITNiLPFE ==================================================================================================== Consensus VppxxqnLSmNPMlLlsGRTWKGxIFGGFKSKDxVPKLVaDFMaKKfxLDxLITHxLpfe 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----| Consensus KINEgFDLLRsGESIRTILsfx ============================================================== * GADUS_MORHUA sVNDaiDLMKhGKcIRTVLSle * Danio_rerio QVNDaiNLMKTGQgIRTIMTvs * Oryzias_latipes QVNEaiELMKrGgcIRTVLSvs ============================================================== * HUMAN KINEGFDLLRSGKSIRTVLTF- * HORSE KINEGFDLLRSGESIRTILTF- * 1A71A_Horse KINEGFDLLRSGESIRTILTF- * 1AXEA_Horse KINEGFDLLRSGESIRTILTF- * 1AXGA_Horse KINEGFDLLRSGESIRTILTF- * 1JU9A_Horse KINEGFDLLRSGESIRTILTF- * 1MGOA_Horse KINEGFDLLRSGESIRTILTF- * 1N8KA_Horse KINEGFDLLRSGESIRTILTF- * 1QLHA_Horse KINEGFDLLRSGESIRTILTF- * 1QV6A_Horse KINEGFDLLRSGESIRTILTF- * Apteryx_australis KINEGFDLLRkGKSIRSVLvF- * Canis_lupus KINEGFDLLRSGKSIRTVLTF- * Coturnix_coturnix KINEGFDLLRTGKSIRTVLvl- * Chicken KINEGFDLLRTGKSIRSVLvl- * Mouse KINEaFDLLRSGKSIRTVLTF- * Rabbit KINEGFDLLRSGKSIRTILTF- * Papio_hamadryas KINEGFDLLRSGKSIRTILmF- * X_laevis KINEGFDLLRkGDSIRTILqis * X_tropicalis KINEGFDLLRkGDSIRTILqis * Rat-ADH1 KINEaFDLLRaGKSIRTVLTF- * Rat-Q8K571 KINEaFDLLRaGKSIRTVLTF- * Struthio_camelus-ADH1 KINEGFDLLRTGKSIRSVLlF- * Struthio_camelus-ADH1_VAR KINEGFDLLRTGKSIRSVLlF- * Alligator_mississippiensis-ADH1 KINEGFELLRTGKSIRSVLTF- * Alligator_mississippiensis-ADH1_VAR_1 KINEGFELLRTGKSIRSVLTF- * Alligator_mississippiensis-ADH1_VAR_2 KINEGFELLRTGKSIRSVLTF- * Human-ADH1G KINEGFDLLRSGKSIRTVLTF- * Human-ADH1G_VAR_1 KINEGFDLLRSGKSIRTVLTF- * Human-ADH1G_VAR_3 KINEGFDLLRSGKSIRTVLTF- * Human-ADH1G_VAR_4 KINEGFDLLRSGKSIRTVLTF- ============================================================== Consensus KINEgFDLLRsGESIRTILsfx

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