CCAPD: Alignment of Glutathione-S-Transferase (GS) Class Sigma or Glutathione-requiring prostaglandin D synthase

10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPNYKLxYFNMRGR =================================================================================================== * RAT ----------------------------------------------------PNYKLlYFNMRGR * HUMAN ----------------------------------------------------PNYKLtYFNMRGR * Bovine ----------------------------------------------------PNYKLiYFNMRGR * Canis_lupus ----------------------------------------------------PkYKLiYFNMRGR * Chicken ----------------------------------------------------PNYKLtYFNLRGR * Mouse ----------------------------------------------------PNYKLlYFNMRGR * Human-PTGD2 ----------------------------------------------------PNYKLtYFNMRGR =================================================================================================== * D_MELANOGASTER adeaqappaeg------appaegeapppaegaegaveggeaappaepaepikhSYtLfYFNVKal * D_pseudoobscura adeaqappaegappaeaappaegeappaaegdapppaegeaa-paepaepikhSYtLfYFNVKal =================================================================================================== * 1TW9F.HELIGMOSOMOIDES_POLYGYRUS -----------------------------------------------------HYKLtYFNgRGa =================================================================================================== * C_ELEGANS ----------------------------------------------------PSYKLtYFffRGl =================================================================================================== * OMMASTREPHES_SLOANI ----------------------------------------------------PkYtLhYFpLmGR * Ommastrephes ----------------------------------------------------PkYtLhYFpLmGR =================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPNYKLxYFNMRGR 70 80 90 100 110 120 130 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus AEIIRFIFAYxNIQYEDxRIExqxdwpeIKxTLPFGKIPILDVDGxxLHQSLAIARYLxKxxxLA =================================================================================================== * RAT AEIIRYIFAYlDIKYEDhRIE-QaDWPKIKpTLPFGKIPVLEVEGltLHQSLAIARYLtKntdLA * HUMAN AEIIRYIFAYlDIQYEDhRIE-QaDWPEIKsTLPFGKIPILEVDGltLHQSLAIARYLtKntdLA * Bovine AEIIRYIFAYlDIKYEDhRIE-QaDWPEIKsTLPFGKIPILEVDGlnLHQSLAIARYLtRntdLA * Canis_lupus AEIIRYIFAYlDIKYEDhRIE-QtDWPEVKsTLPFGKIPILEVDGlnLHQSLAIARYMtKntdLA * Chicken AEIcRYLFAYagIKYEDhRLE-gaDWPKIKpTIPFGKVPILEVDGviIHQSLAIARYLaResgLA * Mouse AEIIRYIFAYlDIKYEDhRIE-QaDWPKIKpTLPFGKIPVLEVEGltIHQSLAIARYLtKntdLA * Human-PTGD2 AEIIRYIFAYlDIQYEDhRIE-QaDWPEIKsTLPFGKIPILEVDGltLHQSLAIARYLtKntdLA =================================================================================================== * D_MELANOGASTER AEpLRYLFAYgNqEYEDvRVt-RdEWPaLKpTMPmGQMPVLEVDGkrVHQSIsMARFLaKtvgLc * D_pseudoobscura AEpLRYLFAYgaMEYEDvRVt-RdEWPaLKpTMPmGQMPVLEVDGkrVHQSIsMARFLaKtvgLc =================================================================================================== * 1TW9F.HELIGMOSOMOIDES_POLYGYRUS gEcaRqVFAlaDqKYEDvRLt-QetFvpLKaTfPFGQVPVLEVDGqqLaQSqAIcRYLaKtfgfA =================================================================================================== * C_ELEGANS gEpIRlLFhlagVQFEEvRMnpdqtWlDIKdStPmkQLPVLNIDGfeLpQSgAIlRYLaRkfgfA =================================================================================================== * OMMASTREPHES_SLOANI AELcRFVlAahgeEFtDrvVE-maDWPnLKaTMysnaMPVLDIDGtkMsQSMcIARhLaRefgLd * Ommastrephes AELcRFVlAahgeEFtDrvVE-maDWPnLKaTMysnaMPVLDIDGtkMsQSMcIARhLaRefgLd =================================================================================================== Consensus AEIIRFIFAYxNIQYEDxRIExqxdwpeIKxTLPFGKIPILDVDGxxLHQSLAIARYLxKxxxLA 140 150 160 170 180 190 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus GKTxMEExRVDAIVDTLNDFMxxxxxxwxexkxeevkdqmxxelxxxxxxxxPxLMQxLDxFLxx =================================================================================================== * RAT GKTeLEQcQVDAVVDTLDDFMsl-fp-WaE-EnQDLKERtfnDLlt---rqaPhLLKdLDtYLg- * HUMAN GnTeMEQchVDAIVDTLDDFMsc-fp-WaE-KkQDVKEQMfnELlt---ynaPhLMQdLDtYLg- * Bovine GKTeLEQcQVDAIVDTLDDFMsr-fp-WtE-KrQDIKNQIfkELlt---cdaPpLLQnLDtYLg- * Canis_lupus GKTeLEQcQVDAIVDTLDDFMsr-fp-WaE-KnQDIKDQMfnELlt---ydgPhLLQdLDtYLg- * Chicken GQTpVEQalaDAIVDTIDDFMml-fp-WaE-KnQDVKEKafnDIlt---nkaPeLLKdLDtFLg- * Mouse GKTaLEQcQaDAVVDTLDDFMsl-fp-WaE-KdQDLKERMfnELlt---hqaPrLLKdLDtYLg- * Human-PTGD2 GnTeMEQchVDAIVDTLDDFMsc-fp-WaE-KkQDVKEQMfnELlt---ynaPhLMQdLDtYLg- =================================================================================================== * D_MELANOGASTER GaTpwEDlQIDiVVDTINDFrlkiavvsyE-peDEIKEKklvtLna---eviPfyLEkLEqtVkd * D_pseudoobscura GaTpwEDlQIDiVVDTINDFrlkiavvsyE-peDEIKEKklvtLna---eviPfyLEkLEqtVkd =================================================================================================== * 1TW9F.HELIGMOSOMOIDES_POLYGYRUS GaTpfEsalIDsLaDaytDYraemktyYytalgfmtgDvdkpKtdvll-partkfLgfItkFLkk =================================================================================================== * C_ELEGANS GKTpeEEawVDAVhDlfkDFLaefkkfaaErRsgKsaEEVekfrsefflparntyfniLNglLek =================================================================================================== * OMMASTREPHES_SLOANI GKTsLEKyRVDeItETLqDifndvvk-ikf-apEaaKEaVqqnye----ksckrLapfLEglLvs * Ommastrephes GKTsLEKyRVDeItETLqDifndvvk-ikf-apEaaKEaVqqnye----ksykrLapfLEglLvs =================================================================================================== Consensus GKTxMEExRVDAIVDTLNDFMxxxxxxwxexkxeevkdqmxxelxxxxxxxxPxLMQxLDxFLxx 200 210 220 230 240 250 260 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus nxxxxxWLIGNxVTFADxYWeIxSxTLLxxxxexLLExYPKLVxLREKVQAIPxVxxWIKRRPqt =================================================================================================== * RAT Dk---eWfIGNyVTWADfYWDIcStTLLvlkpD-LLgiYPRLVsLRnKVQAIPaIsaWIlKRPQT * HUMAN gr---eWLIGmsVTWADfYWEIcStTLLvfkpD-LLDnhPRLVtLRKKVQAIPaVanWIKRRPQT * Bovine en---eWLIGDsVTWADfYWEIcStTLLvfksD-LLDihPRLVtLRKKVQsIPaIadWIlRRPQT * Canis_lupus ek---eWLIGDsVTWADfYWEIcStTLLvfkpD-LLDihPRLVtLRKKVQAIPaIadWIQQRPQT * Chicken Dk---kWfVGksVTWADfYWDVcStTLLsykaD-LaDkYPRLLaLRDRVEALPaIaaWIQKRPKT * Mouse Dk---eWfIGNyVTWADfYWDIcStTLLvlkpg-LLDiYPKLVsLRnKVQAIPaIsaWIlKRPQT * Human-PTGD2 gr---eWLIGNsVTWADfYWEIcStTLLvfkpD-LLDnhPRLVtLRKKVQAIPaVanWIKRRPQT =================================================================================================== * D_MELANOGASTER Nd---ghLalgkLTWADvYFagiTdyMnymvkrdLLEpYPaLrgVvDaVnALepIkaWIEKRPvT * D_pseudoobscura Nd---ghLalakLTWADvYFagiTdyMnymvkrdLLEpYPaLrgVvDaInALepIkaWIEKRPvT =================================================================================================== * 1TW9F.HELIGMOSOMOIDES_POLYGYRUS Ns--sgFLVGDkISWvDllvaehvadMtnrvpE-yIEgFPEVkahmERIQqtPrIkkWIEtRPET =================================================================================================== * C_ELEGANS Sn--sgFLIGSdITFADlvvvdnllTLknyglf-deseFtKLaaLREKVnsyPgIkeYIaKRPvT =================================================================================================== * OMMASTREPHES_SLOANI NgggdgFfVGNsMTlADlhcyValevpLkhtpE-LLKdcPKIVaLRKRVaecPkIaaYLKKRPvr * Ommastrephes NgggdgFfVGNsMTlADlhcyValevpLkhtpE-LLKdcPKIVaLRKRVaecPkIaaYLKKRPvr =================================================================================================== Consensus nxxxxxWLIGNxVTFADxYWeIxSxTLLxxxxexLLExYPKLVxLREKVQAIPxVxxWIKRRPqt 270 280 290 300 310 320 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus el ==================================== * RAT KL * HUMAN KL * Bovine KL * Canis_lupus KL * Chicken aI * Mouse KL * Human-PTGD2 KL ==================================== * D_MELANOGASTER EV * D_pseudoobscura EV ==================================== * 1TW9F.HELIGMOSOMOIDES_POLYGYRUS pf ==================================== * C_ELEGANS Ey ==================================== * OMMASTREPHES_SLOANI Df * Ommastrephes Df ==================================== Consensus el

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