CCAPD: Alignment of Poly(A) Polymerase

10 20 30 40 50 60 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- ================================================================================================= * BOVINE ----------------------------------------------------------------- * Apis_mellifera -wssq------------------------------------------------------------ * Canis_lupus sgrkaqaeageehrg-----yptldntvaemrvvaeemekg-vtsdgfwrcnsqela-mgwlqlv * Danio_rerio ----------------------------------------------------------------- * D_melanogaster ----wn----------------------------------------------------------- * Chicken agfsqntgsggikrercaclypaakreas-----lsfrnagevsptaperaifpryagvgdsggv * Human ----------------------------------------------------------------- * Macaca_mulatta -------------------m--------------------------------------------- * Mouse ----------------------------------------------------------------- * Rat ----------------------------------------------------------------- * Strongylocentrotus_purpuratus ----------------------------------------------------------------- * Tribolium_castaneum -wssq------------------------------------------------------------ * X_laevis ----------------------------------------------------------------- * X_tropicalis ----------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 70 80 90 100 110 120 130 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxpxstqxxxxxxsxqsxxxxxkxxxxxxFGITspVSiaxPkesExll ================================================================================================= * S_CEREVISIAE -----------------------------------------ssqkvFGITgPVStvgataaEnkL * Candida_glabrata -----------------------------------------nyqkvYGITgPVSIAgPtaaEnkL * Eremothecium_gossypii -----------------------------------------sqqkvYGVTgPISkegPtaaEnkL * Kluyveromyces_lactis -----------------------------------------sqkkiFGVTgPIStegPtaaEnaL ================================================================================================= * BOVINE -----------------pfPvTTQ-----gSqQT-qppqKh-----YGITSPISLAaPKETDcLL * Apis_mellifera -----------------gnnsNSn-----nSsKe-eknlRt-----lGMTSaISVAePKpSDftr * Canis_lupus sdcr-n-plavilsnfvcsPvTTQ-----gSqQT-qppqKh-----YGITSPISLAaPKETDcLL * Danio_rerio -----------------pfPiTSQ------vqta-qptpKh-----YGITSPISLApPKEaDlVL * D_melanogaster -----------------sePthrQhhqhngNstSggppaKq-----lGMTSaISLAePRpeDlqr * Chicken spavpaqplslrnspg-plPvTTQ-----gS-QT-qqlqKh-----YGITSPISLAaPKEfDcML * Human -----------------pfPvTTQ-----gSqQT-qppqKh-----YGITSPISLAaPKETDcVL * Macaca_mulatta -----------------pfPvTTQ-----gppQq-aplpKc-----YGISSPISLAvPKETDcLL * Mouse -----------------pfPvTTQ-----gSqQT-qppqRh-----YGITSPISLAaPKETDcLL * Rat -----------------pfPvTTQ-----gSqQT-qppqRh-----YGITSPISLAaPKETDcLL * Strongylocentrotus_purpuratus ---------------------STa-----sSesS---tkKt-----YGITSaISLvgPRpeDnrq * Tribolium_castaneum -----------------pvnngTQ-----nNkEN-vtqkndtkiptlGMTSaIStApPKpSDlLk * X_laevis -----------------pfPlaSQ-----gSqQS----qKt-----YGITSPISLAtPKDTDctL * X_tropicalis -------------------reTlg-----sSvla-gqppKh-----YGITSPISLAgPKDTDhIy ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxpxstqxxxxxxsxqsxxxxxkxxxxxxFGITspVSiaxPkesExll 140 150 160 170 180 190 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus tqKLiQsLKpyGvFEdEEElxrRVlVLgELnsLvQEFVrEVSKxKNMpesMienvGGKIFTYGSY ================================================================================================= * S_CEREVISIAE ndsLIQeLKkeGsFEtEQEtanRVqVLkiLqeLaQrFVyEVSKkKNMsDgMarDaGGKIFTYGSY * Candida_glabrata ndELIQeLKkensFEsEQEtanRVkVLktLqeLtEKFVyEVSKkKNMsDgMarDaGGKIFTYGSY * Eremothecium_gossypii ndELIQeLKkeGtFEsEEEtaKRIkVLeELqaLaQEFVfKVSRkRNMsEgMarDaGGKIFTFGSY * Kluyveromyces_lactis ndsLIQqLKkeGsFEtEEEtgKRVaVLeifqkLtQEFVyQVSKkKNMsDgMarDaGGKVFTFGSY ================================================================================================= * BOVINE TQKLVETLKPFGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Apis_mellifera TnELkEaLKPYnVFEsEEELnhRMeILsKLNaLVKQWIRDtSvaRNMPpNVaEqVGGKIYTFGSY * Canis_lupus TQKLIETLKPFGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Danio_rerio TRKLtETLRPFGVFEEElELqRRILVLGKLNTLVKfWIREVSEaKNIPaSVIDSVGGKIFTFGSY * D_melanogaster TdELrgSLEPYnVFEsQDELnhRMeILaKLNTLVKQWVKEISvsKNMPESaaEkLGGKIYTFGSY * Chicken TQKLIETLKPYGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Human TQKLIETLKPFGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Macaca_mulatta TQRLIETLRPFGVFEEEEELqRRILVLeKLNNLVKEWIREISEsKSLPQSVIENVGGKIFTFGSY * Mouse TQKLIETLKPFGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Rat TQKLIETLKPFGVFEEEEELqRRILILGKLNNLVKEWIREISEsKNLPQSVIENVGGKIFTFGSY * Strongylocentrotus_purpuratus TKELVEaLKPhGVFENEEELnhRLVVLGKLDqIVKDWIRlVaEeKNIPpNIaDtVGGKIYTFGSY * Tribolium_castaneum TQELeEaLKPFGVFEsEQELnhRMVILGKLySLVKQWIKDVSisKNMPESVaENVGGKIYTFGSY * X_laevis TQKLIETLKPYGVFEEEDELqhRILILGKLNNLVKEWIREISElKNLPQSVIENVGGKIFTFGSY * X_tropicalis TQKLtEaMRPFGVFEDDaELshRMVVLGKLNNLVKEWIgELgEqKSLPpSIIsaVGGKIFTFGSY ================================================================================================= Consensus tqKLiQsLKpyGvFEdEEElxrRVlVLgELnsLvQEFVrEVSKxKNMpesMienvGGKIFTYGSY 200 210 220 230 240 250 260 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus RLGVHtkGaDIDaLcVaPKHVdRsDFFssFyekLRxReELEDIraVeDAFVPIIKIxFNGIeIDL ================================================================================================= * S_CEREVISIAE RLGVHgpGsDIDtLvVvPKHVtReDFFTvFdslLReRKELDEIapVpDAFVPIIKIkFSGIsIDL * Candida_glabrata RLGVHgpGsDIDtLvVvPKHVtReDFFTvFdalLReREELDEIapVpDAFVPIIKLkFSGIsIDL * Eremothecium_gossypii RLGVHgpGsDIDtLvVvPKHVtRdDFFTvFdElLRaRpELDEIapVpEAFVPIIKIkYSGIsIDL * Kluyveromyces_lactis RLGVHgpGsDIDtLiVvPKHVsReDFFTvFdalLReRpELEEIasVpDAFVPIIKIkFNGIsIDL ================================================================================================= * BOVINE RLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Apis_mellifera RLGVHhKGADIDALCVvPRHIyRSDYFTSFFElLKmQEEVtDLRAVEEAFVPVIKMnFDGIEIDM * Canis_lupus RLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Danio_rerio RLGVHTKGADIDALCVAPRHVERTDFFSSFYEKLKeQEEVKDLRAVEEAFVPVIKLaFDGIEIDI * D_melanogaster RLGVHhKGADIDALCVAPRNIERTDYFqSFFEvLKkQpEVtEcRsVEEAFVPVIKMnFDGIEIDL * Chicken RLGVHTKGADIDALCVAPRHVERSDFFTSFYEKLKqQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Human RLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Macaca_mulatta RLGVHTKGADIDALCVAPRHVDRSDFFTSFYvKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Mouse RLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Rat RLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDI * Strongylocentrotus_purpuratus RLGVHTKGADIDtLCVAPlHVERSDFFkSFYDiVKalpEtKDcRAVEEAFVPVIKLvFDGIEMDI * Tribolium_castaneum RLGVHnRGADIDALCVAPRHIsRNDFFgSFYElLKkQpEVtDLRAVEEAFVPVIKMnFDGIEIDM * X_laevis RLGVHTKGADIDALCVAPRHVDRSDFFSSFYEKLKqQEEVKDLRsVEEAFVPVIKLcFDGIEIDI * X_tropicalis RLGVHTKGADIDsLCVAPRHVERSDFFqSFsEKLKqQDgIKNLRAVEDAFVPVIKfeFmntEIDL ================================================================================================= Consensus RLGVHtkGaDIDaLcVaPKHVdRsDFFssFyekLRxReELEDIraVeDAFVPIIKIxFNGIeIDL 270 280 290 300 310 320 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus IFARLaIqxVPeNLdLrDdsLLRNLDiKcLRsLNGcRVTDEILhLVPNiDSFRItLRAIKLWAQR ================================================================================================= * S_CEREVISIAE IcARLdqpqVPlSLtLsDkNLLRNLDeKdLRaLNGtRVTDEILeLVPkpNvFRIaLRAIKLWAQR * Candida_glabrata IcAKLdIaqVkpSLtLdDkaLLRNLDeKdLRaLNGtRVTDEILeLVPkpsvFRIaLRAIKIWAQR * Eremothecium_gossypii IcARLdIpqVPlNLtLsDkNLLRNLDeKdLRaLNGtRVTDEILeLVPkptaFKIaLRAIKLWAQR * Kluyveromyces_lactis IFAKLdLpqVPiSLtLsDkNLLRNVDeKdLRaLNGtRVTDEILeLVPNktSFKIaLRAIKIWAKR ================================================================================================= * BOVINE LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Apis_mellifera LFAKLALKeIPDSMDLRDDmLLKNLDqKCVRSLNGCRVTDEILrLVPNIENFRLaLRAIKLWAKR * Canis_lupus LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Danio_rerio LFARLALQtIPENLDLRDDgLLKNLDIRCIRSLNGCRVTDEILHLVPNIENFRLTLRAIKLWAKR * D_melanogaster LFARLsLKeIPDDfDLRDDNLLRNLDhRsVRSLNGCRVTDEILaLVPNIENFRLaLRtIKLWAKK * Chicken LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Human LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Macaca_mulatta LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKc * Mouse LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Rat LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKR * Strongylocentrotus_purpuratus LFARLALRvVPENLDLtDDSLLKNLDpKCVRSLNGCRVTDEILNVVPSkENFRLTLRtIKLWAKK * Tribolium_castaneum LFARLlLKeIPDSMDLRDDlLLKNLDqKCVRSLNGCRVTDEILrLVPNVDNFRLaLRAIKLWAKR * X_laevis LFARLALQtIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKR * X_tropicalis VFARLpLQcIPDNLDLRDDSrLRNLDIRCIRSLNGCRVTDEILHLVPNkENFRLTLRAIKLWAKR ================================================================================================= Consensus IFARLaIqxVPeNLdLrDdsLLRNLDiKcLRsLNGcRVTDEILhLVPNiDSFRItLRAIKLWAQR 330 340 350 360 370 380 390 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus hxVYsNIlGFlGGVsWAMLVARtCQLYPNAiastILNRFFIIfSKWKWPnPVILKqpDDxxnLnl ================================================================================================= * S_CEREVISIAE raVYaNIfGFpGGVaWAMLVARiCQLYPNAcsavILNRFFIIlSEWnWPqPVILKpiEDg-pLqV * Candida_glabrata raIYaNVfGFpGGVaWAMLVARiCQLYPNAcsavILNRFFkIlSEWKWPqPVILKpiEDg-pLqV * Eremothecium_gossypii raVYaNVfGFpGGVaWAMLVARiCQLYPNAcsavIVaRFFhIlTRWsWPqPVLLKpiEDg-pLqV * Kluyveromyces_lactis raVYaNVfGFpGGVaWAMfVvRiCQLYPNAcsavIISKFFqIlSRWKWPqPVLLKpiEDg-pLqV ================================================================================================= * BOVINE HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Apis_mellifera HgIYSNVLGYLGGVSWAMLVARTCQLYPNAVAaTLIeKFFLVFSQWKWPqPVLLKQPDNv-NLgf * Canis_lupus HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Danio_rerio HnIYSNILGFLGGVSWAMLVARTCQLYPNAVAaTLVHKFFLVFSKWEWPNPVLLKQPEDc-NLNL * D_melanogaster HgIYSNsLGYfGGVTWAMLVARTCQLYPNAaAaTLVHKFFLVFSRWKWPNPVLLKhPDNv-NLrf * Chicken HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Human HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Macaca_mulatta HnIYSNILGFLGGVSWAMLVARTCQLYPNAVASTLVrKFFLVFSEWEWPNPVLLKEPEEr-NLNL * Mouse HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Rat HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * Strongylocentrotus_purpuratus kgVYSNaLGFLGGVSWAMLVARTCQLYPNAaASTLVNKFFLVFTKWaWPqPVLLKpPNtsteLgf * Tribolium_castaneum HgIYSNaLGYLGGVSWAMLVARTCQLYPNAapaTLVHKFFLVFSQWKWPqPVLLKQPsNv-NLgf * X_laevis HnIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNL * X_tropicalis rgIYSNMLGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEDs-NLNL ================================================================================================= Consensus hxVYsNIlGFlGGVsWAMLVARtCQLYPNAiastILNRFFIIfSKWKWPnPVILKqpDDxxnLnl 400 410 420 430 440 450 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus pVWNPKInpsDRfHlMPVITPAYPqqnSTyNITvSTKxvmVxxQEfQRGVaITnEIllnKaxWsk ================================================================================================= * S_CEREVISIAE rVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeSTK-k-VilQEFvRGVqITNDIfsNKksWan * Candida_glabrata rVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeSTK-a-VilKElnRGIqVTNDIfayKktWad * Eremothecium_gossypii rVWNPKIyaNDRlHkMPVITPAYPsmcSThNIceSTK-k-VilnElQRGVeVTtDIftNKktWgd * Kluyveromyces_lactis rVWNPKIyaqDRsHkMPVITPAYPsmcaThNISeSTK-k-VilsElQRGVeVTqKIfsNElsWed ================================================================================================= * BOVINE PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Apis_mellifera PVWDPRVNiSDRYHLMPIITPAYPQQNSTFNVSVSTRtIMq--EaFEnGLsITeEIIMgKAtWdK * Canis_lupus PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Danio_rerio PVWDPRVtPSDRYHLMPIITPAYPQQNSTYNVSaSTRaIMV--EEFKRGLAITDEILqNKAdWSK * D_melanogaster qVWDPRVNaSDRYHLMPIITPAYPQQNSTFNVSeSTKkVIL--tEFnRGMnITDEIMLgRipWeR * Chicken PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Human PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Macaca_mulatta PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMI--EEFKQGLAITHEILLSKAeWSK * Mouse PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Rat PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRmVMV--EEFKQGLAITDEILLSKAeWSK * Strongylocentrotus_purpuratus aeWDPRVNvSDRFHLMPIITPAYPQQNSTYNVSqSTKtVIe--QElQgGLAITqEIMqgKAtWeK * Tribolium_castaneum aVWDPRVNiqDRYHLMPIITPAYPQQNSTFNVSgSTRqIIM--EEFKlGLqLTDDIMLSKqtWdK * X_laevis PVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRaVMV--EEFKQGLAITDEILLlKAeWSK * X_tropicalis PVWDPRVNPaDRcHLMPIITPAYPQQNSTYNVSISTRsVMV--EEFKQGLsVTDEILLgRcdWSK ================================================================================================= Consensus pVWNPKInpsDRfHlMPVITPAYPqqnSTyNITvSTKxvmVxxQEfQRGVaITnEIllnKaxWsk 460 470 480 490 500 510 520 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus LFEapNFFxRYKhYLvIMASaxxSDEEhLKWvGLVESKLRLLVgsLEknefItIAHvnpKsFxpx ================================================================================================= * S_CEREVISIAE LFEknDFFfRYKfYLeItAytrgSDEQHLKWsGLVESKVRLLVmkLEvlagIkIAHpftKpF-e- * Candida_glabrata LFtkhDFFfQYKyYLtItAatrgdDEEHLKWsGLVESKLRLLtlkLEtipgIkLAHpffKpF-e- * Eremothecium_gossypii LFQkhDFFyKYKfYLtVMAStkgSDEQHLKWsGLVESKLRLLVlkLEvlsgInLAHpytKpF-e- * Kluyveromyces_lactis LFKkhDFFfKYKfYLtVMvStkgSDEQHLKWsGfVESKLRLLVqkLEvlpgInLAHpfiEpY-e- ================================================================================================= * BOVINE LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Apis_mellifera LFEpPNFFgKYKHYIVLLArsl-TaEDqLEWcGLVESKIRhLIGTLERNphITLAHVNPEaF-P- * Canis_lupus LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Danio_rerio LFEAPNFFqKYKHYIVLLASAq-TEKQHLEWVGLVESKIRILVGNLEKNEFITLAHVNPQSF-P- * D_melanogaster LFEAPSFFyRYRHFIVLLvNsq-TaDDHLEWcGLVESKVRLLIGNLERNphIaLAHVNPKcF-ef * Chicken LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGNLEKNEFITLAHVNPQSF-P- * Human LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Macaca_mulatta LFEAPSFFqKYKHYIVLLASAp-TEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Mouse LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Rat LFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * Strongylocentrotus_purpuratus LFEssNFFgKYKHYIVLIASAg-NEDDHLKWVGLVESKIRVLVGNLERNphIkLAHVyPKSisP- * Tribolium_castaneum LFEpPlFFmKYKHFIVLLvSAe-SpEDHLEWcGLVESKfRLLIGTLERNQhITLAHINPESF-s- * X_laevis LFDAPNFFqKYKHYILLLASAp-TEKQrLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSF-P- * X_tropicalis LFEpPNFFhKYKHYIVLtASAs-TEEhHLEWVGLVESKIRVLVGNLERNsFITLAHVNPQSF-P- ================================================================================================= Consensus LFEapNFFxRYKhYLvIMASaxxSDEEhLKWvGLVESKLRLLVgsLEknefItIAHvnpKsFxpx 530 540 550 560 570 580 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxpkdnxexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxexx ================================================================================================= * S_CEREVISIAE -------s-------syccpteddyemiqdkygshktetalnalklvtdenkeeesikdapka-- * Candida_glabrata -------a-------aycytddqdaktilnnhgshitekalekftkvtdenkddedvkskkkv-- * Eremothecium_gossypii -------s-------tyaykteeqykeifdnygthktedvlkkytevtnenkddeslkgmekv-- * Kluyveromyces_lactis -------s-------syiynnedeykeimnnygthktegvlkkftkitdankddeasknsnqv-- ================================================================================================= * BOVINE -------a-PKENpDk----------------------------------------------E-- * Apis_mellifera ---------PlE-pEp----------------------------------------------E-- * Canis_lupus -------a-PKENpDk----------------------------------------------E-- * Danio_rerio -------g-PKEgnDk----------------------------------------------E-- * D_melanogaster kkgqsann-sQNNsgn----------------------------------------------E-- * Chicken -------a-PKENpDk----------------------------------------------E-- * Human -------a-PKENpDk----------------------------------------------E-- * Macaca_mulatta -------a-PKENpDm----------------------------------------------E-- * Mouse -------a-PKESpDr----------------------------------------------E-- * Rat -------a-PKESpDr----------------------------------------------E-- * Strongylocentrotus_purpuratus -------stPlDgsEe----------------------------------------------Ekt * Tribolium_castaneum -------l-lEsqrEs----------------------------------------------n-- * X_laevis -------a-PsENsEk----------------------------------------------E-- * X_tropicalis -------g-nRDHcKd----------------------------------------------n-- ================================================================================================= Consensus xxxxxxxxxpkdnxexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxexx 590 600 610 620 630 640 650 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xexxxxxxxxxxxxxxxxfxTmwxIGLvfkkxensenvsvDItfdiQsFtDtvyrqaisxqmxex ================================================================================================= * S_CEREVISIAE -y----------------lsT-myIGLdFnienkkEkV--DIhipcteFvNlcrsfnedyg-dhk * Candida_glabrata -h----------------itT-myVGLgvsvenkkEkI--DMhipcgeFfNlcrnfheSyQ-npe * Eremothecium_gossypii -h----------------itT-myIGLniavdEkk-kI--DIhvpcQeFfNlcrsfq-eyE-dte * Kluyveromyces_lactis -h----------------iaT-mfIGLdinteESk-kI--DIhipcQeFfNlcrsl-pdyE-dpe ================================================================================================= * BOVINE -E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Apis_mellifera -r----------------hcSMWfIGLLFaK---SENLNVDLTYDIKSFvDSIlRQAeqlsMlK- * Canis_lupus -E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Danio_rerio -E----------------FsTMWvIGIVFKKmEgSENLNVDLTFDIQSFTDTVYRQAITsKMfE- * D_melanogaster -DdlkqsqgnqsavtsapFcSMWfIGLeF---ErSENLNVDLTesIQNFTEhVmmhgVNiKMlK- * Chicken -E----------------YrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Human -E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Macaca_mulatta -E----------------FrTMWvIGLVlKKpENSEiLSIDLTYDIQSFTDTVYRQAMNsKMfE- * Mouse -E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Rat -E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * Strongylocentrotus_purpuratus dE----------------hsTLWfIGLeFQplgpatN--VNLTlDIQfFvNTVhRhsVTiKLlQ- * Tribolium_castaneum -t----------------hcSMWfIGLeFa---kSENLNVNLTFDIQqFTETVqnhALNisMlK- * X_laevis -E----------------FrTMWvIGLVFKKmENSENLSVDLTYDIQSFTDTVYRQAINsKMfE- * X_tropicalis -E----------------YvSMWfLGIIFKKvENaESVNIDLThDIQSFTDTVYRQAnNinMlK- ================================================================================================= Consensus xexxxxxxxxxxxxxxxxfxTmwxIGLvfkkxensenvsvDItfdiQsFtDtvyrqaisxqmxex 660 670 680 690 700 710 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxmkLxaxhVKkrELhExVpnxllqrxkkknsxkxlxxxxxxxxxkxsxlnnsslnlsxnsessx ================================================================================================= * S_CEREVISIAE vf-nLalrfVKgyDLpDeVfDeneKRpsKKSkrKnLdarh--etvKrSksD------aaSgD--- * Candida_glabrata vy-sLviryLKsyELpDdVfgedeQRptKKlSkKrkeakydeeaaKrSkae------TiSks--- * Eremothecium_gossypii tf-sLvikyVKlyDLpDhVyDegeQRpvKaSkkRknekag--kkaKrpksSSvlaadaeDSt--- * Kluyveromyces_lactis ty-sLiikyVKvhDLpDeVyqegetRpvKsSkkRkpeksg--eksKrpksD------psNgKSTt ================================================================================================= * BOVINE vdMKIaAmHVKRKQLHQlLPShVLQK-KKKHStEgV---------KlTpLNDSSLDLSmDSDNSm * Apis_mellifera egMwIevkHVKKRDLHtyVspsLLKR-ERK--vsg-------------tVHkNg-NIa-gNgNSg * Canis_lupus vdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEgV---------RlTpLNDSSLDLSmDSDNSm * Danio_rerio qdMKItAmHVKRKQLHQlLPevaIhRsKRKHSsdgV---------R--aMNDSNLDLSlDSDNSm * D_melanogaster egMtIdArHVKRKQLslyLdSdfLKR-ERK-SmEsh---------n--nfNN-TL-LanrkrlSt * Chicken mdMKIaArHVKRKQLHQlLPNhVLQK-KKKHStEgV---------RlTaLNDSSLDLSmDSDNSt * Human vdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEgV---------KlTaLNDSSLDLSmDSDNSm * Macaca_mulatta mgMKItAmHLRRKELHQlLPHhVLQd-KKaqatEsr---------RlTdLNDNSfDLSagcENSm * Mouse ldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEgV---------KlTaLNDSSLDLSmDSDNSm * Rat ldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEgV---------KlaaLNDSSLDLSmDSDNSm * Strongylocentrotus_purpuratus egMKIeAkHVKR--yeEqaPt--------gNaaE-------------ip----TIkVTapdEdT- * Tribolium_castaneum egMKLeArHVKRKQLyQyLspsLLKR-ERKtSitvk---------sqSngtDSkkrLS-DpgNSd * X_laevis teMKIaAmHVKRKQLHQlLPShVLpK-KKKHSvEgV---------KlvsLNDSSIDLSvDSDNSm * X_tropicalis kgMRIeAtHVKRKQLHhyLhaeVLQK-RKKqSvpdInrsasallsKrTsLDgNcLDsSrDTDTgt ================================================================================================= Consensus xxmkLxaxhVKkrELhExVpnxllqrxkkknsxkxlxxxxxxxxxkxsxlnnsslnlsxnsessx 720 730 740 750 760 770 780 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus svxspsnxxkxxxxxssplxnsxxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxsxxx ================================================================================================= * S_CEREVISIAE ----niNgttaavdvN------------------------------------------------- * Candida_glabrata ----avSeattvssa-------------------------------------------------- * Eremothecium_gossypii ----maDgstvseepqpPLsNTtapStntgaelsvaaggASt----------------------- * Kluyveromyces_lactis TtsgnTNssspvndaN-stpSSnvpansnTNaitedpmtATt----------------------- ================================================================================================= * BOVINE SVpSPTSamK-----TSPLnSSg-sSQGRNSpapavTa-ASVtniQatE-V-sLPqiNsSeSsgg * Apis_mellifera SV-SP----------rNP----g-nTtnRkrlsdqnqd-ASIkkrKvnD-g-eqPsvthhgedgs * Canis_lupus SVpSPTSamK-----TSPLnSSg-sSQGRNSpapavTa-ASVtnpQatE-V-sVPqvNsTeSsgg * Danio_rerio SVpSPTgp-s-----aakIarap-spQGsTgtatntSelqgkteatgeN-t-hLasvDgTsSsna * D_melanogaster eLaqsqDplp-----pgqqpSSg--NRGRdS------g-AkIqrlsd-----sLteeNsNaSs-- * Chicken SVpSPTSamK-----TSPLnSSg-sSQGRSSpapavTa-ASVtniQasE-V-tVPqtNsSeSsgg * Human SVpSPTSatK-----TSPLnSSg-sSQGRNSpapavTa-ASVtniQatE-V-sVPqvNsSeSsgg * Macaca_mulatta SVpSsTStmK-----TgPLiS---sSQGRNSpalavmt-ASManvQatE-I-sLqqmNtSeSsgv * Mouse SVpSPTSamK-----TSPLnSSg-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeSpgg * Rat SVpSPTSamK-----TSPLnSSg-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeSpgg * Strongylocentrotus_purpuratus --qePS--iK-------PsgDda-qTfkRpSspppvSe-spskkvRtdNgV-tIP-----dTkqg * Tribolium_castaneum -sdNPNkkiR-----lSeemHSt-plfGvSNssp------------------------------- * X_laevis SVpSPTNatR-----TSPLnSSg-lSQG-NSpatpvS--lSVtntQatD-V-mVPqnNsTeNsgg * X_tropicalis pcdSPTSchK-----SSrsdSpslpdaqRqSllektSt-gcsqkmadvh-VhaePaqglSipvig ================================================================================================= Consensus svxspsnxxkxxxxxssplxnsxxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxsxxx 790 800 810 820 830 840 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxixxxxxexxxsxxxxpxxxxxxxxxrlxsxxxxxxxxxxxxxxxxxxxxxxixxxixxxk ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- ================================================================================================= * BOVINE tssesIpqtatQpaiSsppkPtvsrvvsstRLvNppprp------sgnaa----akIpnpIvgvK * Apis_mellifera l----VvqscgEdsnSgfsldeykqtlsaaK----degp------tgast----vaqegyVct-- * Canis_lupus tssesIpqtatQpaiSpppkPtvsrvvsstRLvNppprp------sgnaa----tkIpnpIvgvK * Danio_rerio sgkgaappqstsp-iqsekkPse-----q----Nplpsp------clsae----paVkrpasalE * D_melanogaster -----------DmgagtpttPt------taQLsapsfks------sgkng----seI--dVve-Q * Chicken ssnesIpqtatQpaiSpppkPtisriassthLlNpspri------sgnva----tktpspVtavK * Human tssesIpqtatQpaiSpppkPtvsrvvsstRLvNppprssgnaatsgnaa----tkIptpIvgvK * Macaca_mulatta alnesIphavsQpaiSpspkamaarvvsstcLiShpdlq------etqqq----tyL---Il--- * Mouse pssesIpqtatQpaiSpppkPtvsrvvsstRLvNpsprp------sgnta----tkVpnpIvgvK * Rat pssesIpqtatQpaiSpppkPtvsrvvsstRLvNpsprp------sgnaa----tkVpnpIvgvK * Strongylocentrotus_purpuratus eddseVketeeEe--------------detQtfk---rp------ss----------pipVl--- * Tribolium_castaneum ----------------------------------------------------------------- * X_laevis slnesIpetathpafSstprPlvtrvvssmRLvNqvqkp------vtntv----tkMpspVagvK * X_tropicalis skpesaivvkgllppSgctiPtvvglnvipRLpSppnfs------qgnttqnglinLspksaaaK ================================================================================================= Consensus xxxxxixxxxxexxxsxxxxpxxxxxxxxxrlxsxxxxxxxxxxxxxxxxxxxxxxixxxixxxk 850 860 870 880 890 900 910 ----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxpxxxesxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxq ================================================================================================= * S_CEREVISIAE ----------------------------------------------------------------- * Candida_glabrata ----------------------------------------------------------------- * Eremothecium_gossypii ----------------------------------------------------------------- * Kluyveromyces_lactis ----------------------------------------------------------------- ================================================================================================= * BOVINE rtssPhkeESpkktktee-detsedanclalsghdktetkeqldtetsttqsetiqtatsllasQ * Apis_mellifera ----------------------------------------------------------------- * Canis_lupus rtssPhkeESpkktktee-detsedanclalsghdktetkeqldtetsttqsetihtaasllasQ * Danio_rerio nemt-kkaKvedlsapea-kssgetdghvapaivevipsdgelktetelmvedtaekvp--l-aQ * D_melanogaster eptqPhnngN-----ass-nttttevacs------------------------------------ * Chicken rtssPhkeDSpkkmkieeqdeisettscidvnehermetkelletevn-vnsqmehlqttlqapQ * Human rtssPhkeESpkktktee-detsedanclalsghdkteakeqldtetsttqsetiqtaasllasQ * Macaca_mulatta ----------------------------------------------------------------- * Mouse rtssPnkeESpkktktee-detsedanclalsghdktetkeqvdletsavqsetvpasasllasQ * Rat rtssPhkeESpkktktee-detsedanclalsghdktetkeqvgmetsaapseaapasaslvasQ * Strongylocentrotus_purpuratus -espPkkmKTdngikagg-epvsltsdc-----nengesee----dtsp------qplprlvirQ * Tribolium_castaneum ----------------------------------------------------------------- * X_laevis rtssPtneESpkktktee-de-ndssnstevdeqnkleteelkevhseekssspvpga--lpssQ * X_tropicalis rahpPcleDSpkrirdte-mllglpeptfiepsvpheeerqqsgeniipagampiptidr-srsQ ================================================================================================= Consensus xxxxpxxxesxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxq 920 930 940 950 960 970 ----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus kxxsxdlxdxxxxlpxxxxxxvxknsiklxln ================================================================ * S_CEREVISIAE -------------------------------- * Candida_glabrata -------------------------------- * Eremothecium_gossypii -------------------------------- * Kluyveromyces_lactis -------------------------------- ================================================================ * BOVINE KtsStDLsDipa-LPanp-ipViKNSIKLrLN * Apis_mellifera -------------------------------- * Canis_lupus KtsStDLsDipa-LPanp-ipViKNSIKLrLN * Danio_rerio KtsNaDLsDvpv-LPsnp-ipVvKNSIKLrLS * D_melanogaster -------------------------------- * Chicken KtpStDLsDipa-LPanp-ipViKNSIKLrLN * Human KtsStDLsDipa-LPanp-ipViKNSIKLrLN * Macaca_mulatta -------------------------------- * Mouse KtsStDLsDipa-LPanp-ipViKNSIKLrLN * Rat KtsStDLsDipa-LPanp-ipViKNSIKLrLN * Strongylocentrotus_purpuratus RvpSgELpDmaspLPvapkapIaKNTIRLnLN * Tribolium_castaneum -------------------------------- * X_laevis RssStDLsDisv-LPatp-ipViKNSIKLrLN * X_tropicalis RlpSkELpDssspVPtnn-irViKNSIRLtLN ================================================================ Consensus kxxsxdlxdxxxxlpxxxxxxvxknsiklxln

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