CCAPD: Alignment of Triosephosphate Isomerase (TPIS)

10 20 30 40 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== * S_CEREVISIAE --------------------------------------------- * Candida_albicans --------------------------------------------- * Candida_glabrata --------------------------------------------- * Debaryomyces_hansenii --------------------------------------------- * Eremothecium_gossypii --------------------------------------------- * Yarrowia_lipolytica --------------------------------------------- * Zygosaccharomyces_bailii --------------------------------------------- * Kluyveromyces_lactis-TPIS --------------------------------------------- * Kluyveromyces_lactis-TPIS_KLUMA --------------------------------------------- =============================================================================== * C_ELEGANS --------------------------------------------- * HUMAN --------------------------------------------- * RABBIT --------------------------------------------- * CHICKEN --------------------------------------------- * 1SPQA_Chicken --------------------------------------------- * 1SPQB_Chicken --------------------------------------------- * 1SQ7A_Chicken --------------------------------------------- * 1SSDA_Chicken --------------------------------------------- * 1SU5A_Chicken --------------------------------------------- * 1SW3A_Chicken --------------------------------------------- * 1SW7A_Chicken --------------------------------------------- * 1TPB1_Chicken --------------------------------------------- * 1TPC1_Chicken --------------------------------------------- * 1TPUA_Chicken --------------------------------------------- * 1TPVA_Chicken --------------------------------------------- * 1TPWA_Chicken --------------------------------------------- * Acipenser_brevirostrum --------------------------------------------- * Anopheles_gambiae --------------------------------------------- * Bovine --------------------------------------------- * C_briggsae --------------------------------------------- * Canis_lupus --------------------------------------------- * Danio_rerio --------------------------------------------- * Gorilla_gorilla --------------------------------------------- * Latimeria_chalumnae --------------------------------------------- * Lepisosteus_osseus --------------------------------------------- * Macaca_mulatta --------------------------------------------- * Mouse --------------------------------------------- * Oryzias_latipes --------------------------------------------- * Pongo_pygmaeus --------------------------------------------- * Schistosoma_mansoni --------------------------------------------- * Strongylocentrotus_purpuratus --------------------------------------------- * Pig --------------------------------------------- * Tribolium_castaneum --------------------------------------------- * X_laevis --------------------------------------------- * D_melanogaster-TPIS ppgvlndlnrngiqciasvtllqrfpyhrnhhtiptmdqnrptvg * D_melanogaster-TPIS_VAR ppgvlndlnrngiqciasvtllqrfpyhrnhhtiptmdqnrptvg * Rat-Q6P793 --------------------------------------------- * Rat-TPIS --------------------------------------------- =============================================================================== ENTAMOEBA_HISTOLYTICA --------------------------------------------- =============================================================================== LEISHMANIA_MEXICANA --------------------------------------------- TRYPANOSOMA_CRUZI --------------------------------------------- TRYPANOSOMA_BRUCEI --------------------------------------------- 1KV5A_Trypanosoma_brucei --------------------------------------------- 1MSSA_Trypanosoma_brucei --------------------------------------------- 1TRI0_Trypanosoma_brucei --------------------------------------------- 1TTI0_Trypanosoma_brucei --------------------------------------------- 1TTJ0_Trypanosoma_brucei --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- =============================================================================== PLASMODIUM_FALCIPARUM --------------------------------------------- 1VGAB_Plasmodium_falciparum --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_chabaudi --------------------------------------------- =============================================================================== B E_COLI --------------------------------------------- B VIBRIO_MARINUS --------------------------------------------- B Actinobacillus_pleuropneumoniae --------------------------------------------- B Actinobacillus_succinogenes --------------------------------------------- B Erwinia_carotovora --------------------------------------------- B Haemophilus_ducreyi --------------------------------------------- B Haemophilus_influenzae --------------------------------------------- B Histophilus_somni --------------------------------------------- B Mannheimia_succiniciproducens --------------------------------------------- B Pasteurella_multocida --------------------------------------------- B Photobacterium_profundum --------------------------------------------- B Photorhabdus_luminescens --------------------------------------------- B Vibrio_cholerae --------------------------------------------- B Vibrio_fischeri --------------------------------------------- B Vibrio_parahaemolyticus --------------------------------------------- B Vibrio_vulnificus --------------------------------------------- B Yersinia_pestis --------------------------------------------- B Salmonella_typhi-TPIS --------------------------------------------- B Salmonella_typhi-TPIS_SALTY --------------------------------------------- =============================================================================== B THERMUS_AQUATICUS --------------------------------------------- =============================================================================== B BACILLUS_STEAROTHERMOPHILUS --------------------------------------------- B Bacillus_clausii --------------------------------------------- B Bacillus_halodurans --------------------------------------------- B Bacillus_licheniformis --------------------------------------------- B Bacillus_megaterium --------------------------------------------- B Bacillus_subtilis --------------------------------------------- B Listeria_monocytogenes-TPIS1 --------------------------------------------- B Listeria_monocytogenes-TPIS1_LI --------------------------------------------- =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 50 60 70 80 90 ----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== * S_CEREVISIAE --------------------------------------------- * Candida_albicans --------------------------------------------- * Candida_glabrata --------------------------------------------- * Debaryomyces_hansenii --------------------------------------------- * Eremothecium_gossypii --------------------------------------------- * Yarrowia_lipolytica --------------------------------------------- * Zygosaccharomyces_bailii --------------------------------------------- * Kluyveromyces_lactis-TPIS --------------------------------------------- * Kluyveromyces_lactis-TPIS_KLUMA --------------------------------------------- =============================================================================== * C_ELEGANS --------------------------------------------- * HUMAN --------------------------------------------- * RABBIT --------------------------------------------- * CHICKEN --------------------------------------------- * 1SPQA_Chicken --------------------------------------------- * 1SPQB_Chicken --------------------------------------------- * 1SQ7A_Chicken --------------------------------------------- * 1SSDA_Chicken --------------------------------------------- * 1SU5A_Chicken --------------------------------------------- * 1SW3A_Chicken --------------------------------------------- * 1SW7A_Chicken --------------------------------------------- * 1TPB1_Chicken --------------------------------------------- * 1TPC1_Chicken --------------------------------------------- * 1TPUA_Chicken --------------------------------------------- * 1TPVA_Chicken --------------------------------------------- * 1TPWA_Chicken --------------------------------------------- * Acipenser_brevirostrum --------------------------------------------- * Anopheles_gambiae --------------------------------------------- * Bovine --------------------------------------------- * C_briggsae --------------------------------------------- * Canis_lupus --------------------------------------------- * Danio_rerio --------------------------------------------- * Gorilla_gorilla --------------------------------------------- * Latimeria_chalumnae --------------------------------------------- * Lepisosteus_osseus --------------------------------------------- * Macaca_mulatta --------------------------------------------- * Mouse --------------------------------------------- * Oryzias_latipes --------------------------------------------- * Pongo_pygmaeus --------------------------------------------- * Schistosoma_mansoni --------------------------------------------- * Strongylocentrotus_purpuratus -----------------------------------------a--- * Pig --------------------------------------------- * Tribolium_castaneum -------------------aevdpactpi--kigsgpd---aklh * X_laevis --------------------------------------------- * D_melanogaster-TPIS gvtaevlkavvseallgkftavfpklfkcqwktyegqkkfyanfs * D_melanogaster-TPIS_VAR gvtaevlkavvseallgkftavfpklfkcqwktyegqkkfyanfs * Rat-Q6P793 --------------------------------------------- * Rat-TPIS --------------------------------------------- =============================================================================== ENTAMOEBA_HISTOLYTICA --------------------------------------------- =============================================================================== LEISHMANIA_MEXICANA --------------------------------------------- TRYPANOSOMA_CRUZI --------------------------------------------- TRYPANOSOMA_BRUCEI --------------------------------------------- 1KV5A_Trypanosoma_brucei --------------------------------------------- 1MSSA_Trypanosoma_brucei --------------------------------------------- 1TRI0_Trypanosoma_brucei --------------------------------------------- 1TTI0_Trypanosoma_brucei --------------------------------------------- 1TTJ0_Trypanosoma_brucei --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- =============================================================================== PLASMODIUM_FALCIPARUM --------------------------------------------- 1VGAB_Plasmodium_falciparum --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_chabaudi --------------------------------------------- =============================================================================== B E_COLI --------------------------------------------- B VIBRIO_MARINUS --------------------------------------------- B Actinobacillus_pleuropneumoniae --------------------------------------------- B Actinobacillus_succinogenes --------------------------------------------- B Erwinia_carotovora --------------------------------------------- B Haemophilus_ducreyi --------------------------------------------- B Haemophilus_influenzae --------------------------------------------- B Histophilus_somni --------------------------------------------- B Mannheimia_succiniciproducens --------------------------------------------- B Pasteurella_multocida --------------------------------------------- B Photobacterium_profundum --------------------------------------------- B Photorhabdus_luminescens --------------------------------------------- B Vibrio_cholerae --------------------------------------------- B Vibrio_fischeri --------------------------------------------- B Vibrio_parahaemolyticus --------------------------------------------- B Vibrio_vulnificus --------------------------------------------- B Yersinia_pestis --------------------------------------------- B Salmonella_typhi-TPIS --------------------------------------------- B Salmonella_typhi-TPIS_SALTY --------------------------------------------- =============================================================================== B THERMUS_AQUATICUS --------------------------------------------- =============================================================================== B BACILLUS_STEAROTHERMOPHILUS --------------------------------------------- B Bacillus_clausii --------------------------------------------- B Bacillus_halodurans --------------------------------------------- B Bacillus_licheniformis --------------------------------------------- B Bacillus_megaterium --------------------------------------------- B Bacillus_subtilis --------------------------------------------- B Listeria_monocytogenes-TPIS1 --------------------------------------------- B Listeria_monocytogenes-TPIS1_LI --------------------------------------------- =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 100 110 120 130 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxRQfxVxGNWKMNgnKxnLxELIxxLNxxxxxx =============================================================================== * S_CEREVISIAE ------------aRtFfVgGNFKLNGSKqSIkEIVerLNt---as * Candida_albicans ------------aRQFfVgGNFKaNGtKqqItsIIdnLNk---ad * Candida_glabrata ------------aRtFfVgGNFKLNGtKkSIkEIVdrLNt---as * Debaryomyces_hansenii ------------aRQFfVgGNFKMNGtReSVsKIVdgLNk---ae * Eremothecium_gossypii ------------aRtFfVgGNFKLNGSKqSIkEIVerLNt---ad * Yarrowia_lipolytica ------------sRtFfVgGNFKMNGSleSIkaIVerLNa---se * Zygosaccharomyces_bailii ------------aRtFfVgGNFKLNGtKsSIkEIVerLNn---ak * Kluyveromyces_lactis-TPIS ------------aRtFfIgGNFKMNGSKaSIkEIVdrLNg---as * Kluyveromyces_lactis-TPIS_KLUMA ------------aRtFfIgGNFKMNGtKaSIkEIVerLNs---as =============================================================================== * C_ELEGANS ------------tRKFfVgGNWKMNGDyaSVdgIVtfLNa---sa * HUMAN ----------apsRKFfVgGNWKMNGrKqSLgELIgtLNa---ak * RABBIT ----------apsRKFfVgGNWKMNGrKkNLgELIttLNa---ak * CHICKEN ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SPQA_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SPQB_Chicken ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SQ7A_Chicken ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SSDA_Chicken ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SU5A_Chicken ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SW3A_Chicken ----------ap-RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1SW7A_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1TPB1_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1TPC1_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1TPUA_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1TPVA_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * 1TPWA_Chicken -------------RKFfVgGNWKMNGDKkSLgELIhtLNg---ak * Acipenser_brevirostrum ----------aptRKFfVgGNWKLNGDKkSLgELIhtLNs---gk * Anopheles_gambiae -----------g-RKFcVgGNWKMNGDKaSItELcktLSa---gp * Bovine ----------apsRKFfVgGNWKMNGrKnNLgELIntLNa---ak * C_briggsae -----------a-RKFfVgGNWKMNGDfaSVdgIVafLNq---sa * Canis_lupus ----------apsRKFfVgGNWKMNGrKkNLgELIttLNa---ak * Danio_rerio ----------sg-RKFfVgGNWKMNGDKkSIeELantLNs---ak * Gorilla_gorilla ----------apsRKFfVgGNWKMNGrKqSLgELIgtLNa---ak * Latimeria_chalumnae ----------ap-RKFfVgGNWKMNGDKkSLgELIqtLNa---ak * Lepisosteus_osseus --------------------------DKkvLgDLIntLNt---ak * Macaca_mulatta ----------apsRKFfVgGNWKMNGrKqNLgELIgtLNa---ak * Mouse ----------aptRKFfVgGNWKMNGrKkcLgELIctLNa---an * Oryzias_latipes ----------aq-RRFfVgGNWKMNGNKeSLeELMstLNt---as * Pongo_pygmaeus ----------apsRKFfVgGNWKMNGrKqSLgELIgtLNa---ak * Schistosoma_mansoni ---s------gs-RKFfVgGNWKMNGSRdDndKLLklLSe---ah * Strongylocentrotus_purpuratus ----------sg-RRFwVgGNYKMNGSKaSIdgLLkmLee---sq * Pig ----------apaRKFfVgGNWKMNGrKnNLgELIntLNa---ak * Tribolium_castaneum cscs------mg-RKFvVgGNWKMNGDKkqIsEIIntLkt---gp * X_laevis ----------sp-RKFfVgGNWKMNGDKkSLgELIntLNs---gk * D_melanogaster-TPIS tdctdsnsnnms-RKFcVgGNWKMNGDQkSIaEIaktLSs---aa * D_melanogaster-TPIS_VAR tdctdsnsnnms-RKFcVgGNWKMNGDQkSIaEIaktLSs---aa * Rat-Q6P793 ----------apsRKFfVgGNWKMNGrKkcLgELIctLNa---ak * Rat-TPIS ----------apsRKFfVgGNWKMNGrKkcLgELIctLNa---ak =============================================================================== ENTAMOEBA_HISTOLYTICA -----------gagKFvVgGNWKcNGtlaSIetLtkgVaasvdae =============================================================================== LEISHMANIA_MEXICANA ----------sakpQpiaaaNWKcNGttaSIeKLVqvfNe---ht TRYPANOSOMA_CRUZI ----------askpQpiaaaNWKcNGSEslLvpLIetLNa---at TRYPANOSOMA_BRUCEI -----------skpQpiaaaNWKcNGSQqSLsELIdlfNs---ts 1KV5A_Trypanosoma_brucei -----------skpQpiaaaNWKcNGSQqSLsELIdlfNs---ts 1MSSA_Trypanosoma_brucei -----------skpQpiaaaNWKcNGSQqSLsELIdlfNs---ts 1TRI0_Trypanosoma_brucei -----------skpQpiaaaNW---GSQqSLsELIdlfNs---ts 1TTI0_Trypanosoma_brucei -----------skpQpiaaaNWK------SLsELIdlfNs---ts 1TTJ0_Trypanosoma_brucei -----------skpQpiaaaNW-------SLsELIdlfNs---ts Leishmania_donovani ----------sskpQpiaaaNWKcNGttaSIeKLVqvLNe---hn Leishmania_tropica ----------sakpQpiaaaNWKcNGttaSIeKLVqvLNe---hn =============================================================================== PLASMODIUM_FALCIPARUM ------------aRKYfVaaNWKcNGtleSIksLtnsfNn--ldf 1VGAB_Plasmodium_falciparum -------------RKYfVaaNWKcNGtleSIksLtnsfNn--ldf Plasmodium_berghei ------------aRKYfVsaNWKcNGtEySIksLadsfNt--vdf Plasmodium_chabaudi ------------aRKYfVsaNWKcNGtKdSIktLadsfNt--vdf =============================================================================== B E_COLI -------------RhplVmGNWKLNGSRhmVhELVsnLrk--ela B VIBRIO_MARINUS -------------RhpvVmGNWKLNGSKemVvDLLngLNa--ele B Actinobacillus_pleuropneumoniae -----------a-RRplVmGNWKLNGSKaftkELIagLka--ela B Actinobacillus_succinogenes ----------as-RKplVmGNWKLNGSKaftrELIegLkt--ela B Erwinia_carotovora -------------RhplVmGNWKLNGStnlVnELIagLrk--els B Haemophilus_ducreyi -----------a-RRplVmGNWKLNGSKaftqQLIaeLkt--ela B Haemophilus_influenzae -----------a-RRplVmGNWKLNGSKaftkELIegLka--elh B Histophilus_somni -----------a-RRplVmGNWKLNGSKaftkELItgLkd--eln B Mannheimia_succiniciproducens -----------a-RRplVmGNWKLNGSKaftkELIegLka--ela B Pasteurella_multocida -----------a-RRplVmGNWKLNGSKaftkaLIedLkt--ela B Photobacterium_profundum -------iwrktmRhpvVmGNWKLNGSKemVvnLLngLNa--ele B Photorhabdus_luminescens -------------RhplVmGNWKLNGSthmVnELItgLrq--els B Vibrio_cholerae -------------RRpvVmGNWKLNGSKamVtDLLngLNa--ele B Vibrio_fischeri -------------RhpvVmGNWKLNGSKemVvELLngLNa--ele B Vibrio_parahaemolyticus -------------RRpvVmGNWKLNGSKamVtELLtgLNa--ele B Vibrio_vulnificus -------------RRpvVmGNWKLNGSKtmVaELLtgLNa--ele B Yersinia_pestis -------------RhplVmGNWKLNGSthmVnELIagLrk--els B Salmonella_typhi-TPIS -------------RhplVmGNWKLNGSRhmVnELVanLrk--elt B Salmonella_typhi-TPIS_SALTY -------------RhplVmGNWKLNGSRhmVnELVanLrk--elt =============================================================================== B THERMUS_AQUATICUS -------------RRvlVaGNWKMHktpsearvwfaeLkr---ll =============================================================================== B BACILLUS_STEAROTHERMOPHILUS -------------RKpiIaGNWKMHktlaeavQfVedVkg--hvp B Bacillus_clausii -------------RKpiIaGNWKMNktigeavDfVeaVka--nvp B Bacillus_halodurans -------------RKpiIaGNWKMNktvgeakafVeeVkg--aip B Bacillus_licheniformis -------------RKpiIaGNWKMNkvlseavsfVeeVks--sip B Bacillus_megaterium -------------RKpiIaGNWKMNkvlseatsfVeeVkg--avp B Bacillus_subtilis -------------RKpiIaGNWKMNktlgeavsfVeeVks--sip B Listeria_monocytogenes-TPIS1 -------------RKpiIaGNWKMNktaakagQfaedVkn--nvp B Listeria_monocytogenes-TPIS1_LI -------------RKpiIaGNWKMNktaakagQfaedVkn--nvp =============================================================================== Consensus xxxxxxxxxxxxxRQfxVxGNWKMNgnKxnLxELIxxLNxxxxxx 140 150 160 170 180 ----|----:----|----:----|----:----|----:----| Consensus xxxxxEVVVaPPxIYLNxAKxxxxLxxxxxxxxxxxxxxxxxxxE =============================================================================== * S_CEREVISIAE ipenvEVVIcPPatYLDysvs--lV--k--k---p---------Q * Candida_albicans lpkdvEVVIcPPaLYLglAve--qn--k--q---p---------t * Candida_glabrata lpenvEVVIcPPatYLDytvs--lV--s--k---k---------Q * Debaryomyces_hansenii lpsnvEVVIAPPapYIalAvn--en--k--q---k---------t * Eremothecium_gossypii ladnvEVVIcPPatYLDhAvs--lV--s--h---p---------Q * Yarrowia_lipolytica ldpktEVVIsPPfpYLllAKe--sL--k--k---p---------t * Zygosaccharomyces_bailii ldpkvEVVLcPPapYLDytvs--lV--k--k---s---------Q * Kluyveromyces_lactis-TPIS ipsnvEVVIAPPaIYLDhAva--ln--k--r---k---------E * Kluyveromyces_lactis-TPIS_KLUMA ipsnvEVVIAPPaaYLDhAvs--ln--k--k---a---------Q =============================================================================== * C_ELEGANS dnssvDVVVAPPapYLayAKs--kL--k--a-------------g * HUMAN vpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * RABBIT vpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * CHICKEN lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SPQA_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SPQB_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SQ7A_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SSDA_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SU5A_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SW3A_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1SW7A_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1TPB1_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1TPC1_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1TPUA_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1TPVA_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * 1TPWA_Chicken lsadtEVVcgaPsIYLDfARq--kL--d--a-------------K * Acipenser_brevirostrum inadtDVVcgaPtIYLDfvRs--kL--d--s-------------K * Anopheles_gambiae ldpntEVVVgcPapYLSlARs--lL--p--e-------------t * Bovine vpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * C_briggsae dnsnvDVVVAPPapYLayAKa--nL--k--a-------------g * Canis_lupus vpadtEVVcAPPtaYIDfARq--kL--d--a-------------K * Danio_rerio lnpdtEVVcgaPtIYLDyARs--kL--n--p-------------n * Gorilla_gorilla vpadtKVVcAPPtaYIDfARq--kL--d--p-------------K * Latimeria_chalumnae vpftgEIVcAPPeaYLDfARl--kV--d--p-------------K * Lepisosteus_osseus lnpdtEVVcgaPsIYLDfARq--kL--d--a-------------K * Macaca_mulatta vpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * Mouse vpagtEVVcAPPtaYIDfARq--kL--d--p-------------K * Oryzias_latipes lhedtEVVcAaPsIYLDfARs--gL--d--s-------------r * Pongo_pygmaeus vpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * Schistosoma_mansoni fddntEVLIAPPsVFLHeiRk--sL--k--k-------------E * Strongylocentrotus_purpuratus ipgntDVVVAPPtVYLDymns--kI--p--a-------------g * Pig lpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * Tribolium_castaneum lspntEVIVgvPaIYLehvRt--nL--p--q-------------s * X_laevis mnadtEVVcgaPaIYLDfARq--kL--d--a-------------K * D_melanogaster-TPIS ldpntEVVIgcPaIYLmyARn--lL--p--c-------------E * D_melanogaster-TPIS_VAR ldpntEVVIgcPaIYLmyARn--lL--p--c-------------E * Rat-Q6P793 lpadtEVVcAPPtaYIDfARq--kL--d--p-------------K * Rat-TPIS lpadtEVVcAPPtaYIDfARq--kL--d--p-------------K =============================================================================== ENTAMOEBA_HISTOLYTICA lakkvEVIVgvPfIYIpkvQq--iLageang---a---------n =============================================================================== LEISHMANIA_MEXICANA ishdvQcVVAPtfVhIplvQa--kL--r--n---p---------K TRYPANOSOMA_CRUZI fdhdvQcVVAPtfLhIpmtKa--rL--t--n---p---------K TRYPANOSOMA_BRUCEI inhdvQcVVAstfVhLamtKe--rL--s--h---p---------K 1KV5A_Trypanosoma_brucei inhdvQcVVAstfVhLamtKe--rL--s--h---p---------K 1MSSA_Trypanosoma_brucei inhdvQcVVAstsshLamtKe--rL--s--h---p---------K 1TRI0_Trypanosoma_brucei inhdvQcVVAstfVhLamtKe--rL--s--h---p---------K 1TTI0_Trypanosoma_brucei inhdvQcVVAstfVhLamtKe--rL--s--h---p---------K 1TTJ0_Trypanosoma_brucei inhdvQcVVAstsshLamtKe--rL--s--h---p---------K Leishmania_donovani ishdvQcVVAPtfVhIplvQa--kL--r--n---p---------K Leishmania_tropica ishdvQcVVAPtfVhIplvQa--kL--r--n---p---------K =============================================================================== PLASMODIUM_FALCIPARUM dpsklDVVVfPvsVhyDhtRk--lL--q--s-------------K 1VGAB_Plasmodium_falciparum dpsklDVVVfPvsVhyDhtRk--lL--q--s-------------K Plasmodium_berghei dpsklDVVVfPvsVhyDltRk--lL--n--k-------------K Plasmodium_chabaudi dpsklDVVVfPvsVhyDlARn--lL--n--k-------------K =============================================================================== B E_COLI gvagcaVaIAPPeMYIDmAKr--ea--e------g--------sh B VIBRIO_MARINUS gvtgvDVaVAPPaLFVDlAEr--tL--te-a---g--------sa B Actinobacillus_pleuropneumoniae dvkgcDVaIAPPvMYLaeAEa--aL--a------g-------qsv B Actinobacillus_succinogenes gvegcDVaIAPPvMYLaeAEt--aL--a------d--------sK B Erwinia_carotovora tvdgcgVaIAPPaIYLDqAnh--qL--a------g--------sr B Haemophilus_ducreyi eitgcDVaIAPPvMYLSeAEi--aL--a------g-------qst B Haemophilus_influenzae dvtgcDVaIAPPvMYLgtAEa--aL--s------gcgcscggksv B Histophilus_somni avsgcDVaIAPPvMYLaeAEt--aL--v------s--------sD B Mannheimia_succiniciproducens gvegcDVaIAPPvMYLaeAEa--aL--a------g--------sK B Pasteurella_multocida gvegcDVaIAPPvMYLaeAEa--aL--kcscscgg--------ka B Photobacterium_profundum gvtgvDVaVAPPaLFIDlAEhtlte--a------g--------sa B Photorhabdus_luminescens svtgcDVaIAPPaLYLSqAKq--aL--a------g--------sr B Vibrio_cholerae gvegvDVVVAPPaMYLDlAErlike--g------g--------nK B Vibrio_fischeri gvtgvDVaVAPPaLFVDlAErtlte--a------g--------sa B Vibrio_parahaemolyticus gvegvDVaVAPPaLYIDlAErliae--g------g--------nK B Vibrio_vulnificus gvegvDVaVAPPaLYIDlAErliae--g------g--------nK B Yersinia_pestis tvdgcgVaIAPPaIYLNqAKh--eL--a------g--------sr B Salmonella_typhi-TPIS gvagcDVaIAPPeMYIDlAKr--aa--a------g--------sh B Salmonella_typhi-TPIS_SALTY gvagcDVaIAPPeMYIDlAKr--aa--a------g--------sh =============================================================================== B THERMUS_AQUATICUS pplqsEaaVlPafpiLpvAKe--vLa-e--t-------------Q =============================================================================== B BACILLUS_STEAROTHERMOPHILUS padevisVVcaPfLFLDrlvq--aad-g--t-------------D B Bacillus_clausii aqatvDsVVcaPaLFLDrllq--aVk-g--t-------------E B Bacillus_halodurans ssdkvDsVVcsPaLFLeglvq--kae-g--t-------------E B Bacillus_licheniformis aadkaEaVVcaPaLFLeklts--aVk-g--t-------------D B Bacillus_megaterium spesvDsVVcaPaLFLDrlve--atk-g--t-------------D B Bacillus_subtilis aadkaEaVVcaPaLFLeklas--aVk-g--t-------------D B Listeria_monocytogenes-TPIS1 ssdavEsVVAaPaLFLqelvr--lte-g--t-------------D B Listeria_monocytogenes-TPIS1_LI ssdavEsVVAaPaLFLqelvr--lte-g--t-------------n =============================================================================== Consensus xxxxxEVVVaPPxIYLNxAKxxxxLxxxxxxxxxxxxxxxxxxxE 190 200 210 220 ----:----|----:----|----:----|----:----|----: Consensus IxVxAQNxxxxxnGAFTGEISpxMIKDiGaxYVILGHSERRxxYx =============================================================================== * S_CEREVISIAE VtVgAQNaylkaSGAFTGEnSvdqIKDVGAkWVILGHSERRsyFh * Candida_albicans VaIgAQNvfdkscGAFTGEtcasqIlDVGAsWtLtGHSERRtiik * Candida_glabrata VtVggQNtytkaSGAYTGEnSvdqLKDVGAkWVILGHSERRtyFh * Debaryomyces_hansenii IeVsAQNcfdkaSGAYTGEISPeqIKDLGAtWtLtGHSERRtiik * Eremothecium_gossypii VtVgAQNaytkaSGAYTGEnSvdqIKDVGAkWVILGHSERRtyFn * Yarrowia_lipolytica VsVagQNsfdkgDGAFTGEVSvaqLKDVGAkWVILGHSERRtink * Zygosaccharomyces_bailii VsVgAQNaylkaSGAFTGEnSvdqIKDVGAkWVILGHSERRqyFr * Kluyveromyces_lactis-TPIS VkIsAQNayskaSGAYTGEnSveqIKDVGAeWVILGHSERRtyFn * Kluyveromyces_lactis-TPIS_KLUMA VsVaAQNaylkaSGAFTGEnSveqIKDVGAeWVILGHSERRtyFh =============================================================================== * C_ELEGANS VlVaAQNcykvpkGAFTGEISPaMIKDLGleWVILGHSERRhvFg * HUMAN IaVaAQNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFg * RABBIT IaVaAQNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFg * CHICKEN IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SPQA_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SPQB_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SQ7A_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SSDA_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SU5A_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SW3A_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1SW7A_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1TPB1_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFg * 1TPC1_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHpERRhvFg * 1TPUA_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGNSERRhvFg * 1TPVA_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGNpERRhvFg * 1TPWA_Chicken IgVaAQNcykvpkGAFTGEISPaMIKDIGAaWVILGHpERRhvFg * Acipenser_brevirostrum MgVaAQNcykvakGAFTGEVSPaMIKDcGvsWVILGHSERRhvFg * Anopheles_gambiae IgVaAQNcykvakGAFTGEISPaMLKDLGlgWVILGHSERRaiFg * Bovine IaVaAQNcykvaNGAFTGEISPgMIKDLGAtWVVLGHSERRhvFg * C_briggsae VlVaAQNcyktakGAFTGEISPaMIKDLGleWVILGHSERRhvFg * Canis_lupus IaVaAQNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFg * Danio_rerio IdVaAQNcykvakGAFTGEISPaMIKDcGvkWVILGHSERRhvFg * Gorilla_gorilla IaVaAQNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFg * Latimeria_chalumnae fgVaAQNcykvskGAFTGEISPaMIKDcGvtWVILGHSERRhvFg * Lepisosteus_osseus IaVaAQNcykvakGAFTGEISPaMIKDcGvsWVILGHSERRhvFg * Macaca_mulatta IaVaAQNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFg * Mouse IaVaAQNcykvtNGAFTGEISPgMIKDLGAtWVVLGHSERRhvFg * Oryzias_latipes IsVaAQNcykvakGAFTGEISPaMIKDcGAdWVILGHSERRhvFg * Pongo_pygmaeus IaVaAQNcykvtNGAFTGEISPgMIKDyGAtWVVLGHSERRhvFg * Schistosoma_mansoni IhVaAQNcykvskGAFTGEISPaMIRDIGcdWVILGHSERRniFg * Strongylocentrotus_purpuratus VfVaAQNcykvpkGAFTaEtSPaMLQDLGvgWVILGHSERRhvFg * Pig IaVaAQNcykvaNGAFTGEIgPgMIKDLGAtWVVLGHSERRhvFg * Tribolium_castaneum IeVaAQNcykvpkGAFTGEISPaMIKDIGvnWVILGHSERRqiFg * X_laevis IaLsAQNcykvakGAFTGEISPaMIKDcGAtWVILGHSERRhvFg * D_melanogaster-TPIS LgLagQNaykvakGAFTGEISPaMLKDIGAdWVILGHSERRaiFg * D_melanogaster-TPIS_VAR LgLagQNaykvakGAFTGEISPaMLKDIGAdWVILGHSERRaiFg * Rat-Q6P793 IaVaAQNcykvtNGAFTGEISPgMIKDLGAtWVVLGHSERRhiFg * Rat-TPIS IaVaAQNcykvtNGAFTGEISPgMIKDLGAtWVVLGHSERRhiFg =============================================================================== ENTAMOEBA_HISTOLYTICA IlVsAENawtk-SGAYTGEVhvgMLvDcqvpYVILGHSERRqiFh =============================================================================== LEISHMANIA_MEXICANA yvIsAENaiak-SGAFTGEVSmpILKDIGvhWVILGHSERRtyYg TRYPANOSOMA_CRUZI fqIaAQNaitr-SGAFTGEVSlqILKDyGisWVVLGHSERRlyYg TRYPANOSOMA_BRUCEI fvIaAQNaiak-SGAFTGEVSlpILKDfGvnWIVLGHSERRayYg 1KV5A_Trypanosoma_brucei fvIaAQNaiak-SGAFTGEVSlpILKDfGvnWIVLGHSERRayYg 1MSSA_Trypanosoma_brucei fvIaAQNagna-D-------alasLKDfGvnWIVLGHSERRayYg 1TRI0_Trypanosoma_brucei fvIaAQNagna-D-------alasLKDfGvnWIVLGHSERRayYg 1TTI0_Trypanosoma_brucei fvIaAQNagna-D-------glasLKDfGvnWIVLGHSERRwyYg 1TTJ0_Trypanosoma_brucei fvIaAQNagna-D-------alasLKDfGvnWIVLGHSERRayYg Leishmania_donovani yaVsAENaiak-SGAFTGEVSmpILKDLGinWVILGHSERRtyYg Leishmania_tropica yvVsAENaiak-SGAFTGEVSmpILKDLGinWVILGHSERRtyYg =============================================================================== PLASMODIUM_FALCIPARUM fstgiQNvskfgNGsYTGEVSaeIaKDLnieYVIIGHfERRkyFh 1VGAB_Plasmodium_falciparum fstgiQNvskfgNGsYTGEVSaeIaKDLnieYVIIGHfERRkyFh Plasmodium_berghei IgtgiQNvskfgNGsYTGEVSaeIaKNLnieYVLIGHfERRkyFh Plasmodium_chabaudi IgtgiQNvskfgNGsYTGEVSaeIaKNLdieYVLIGHfERRkyFh =============================================================================== B E_COLI ImLgAQNvdlnlSGAFTGEtSaaMLKDIGAqYIIIGHSERRtyhk B VIBRIO_MARINUS IiLgAQNtdlnnSGAFTGDMSPaMLKEfGAthIIIGHSERReyha B Actinobacillus_pleuropneumoniae IaLgAQNvdvnvqGAFTGDISteMLKDfGAkYIIIGHSERRtyhk B Actinobacillus_succinogenes IaLgsQNvdvnvkGAFTGDISteMLKDfGAkYIIIGHSERRtyhk B Erwinia_carotovora IaLgAQNvdvnlSGAFTGEtSaeMLKDIGAkYIIIGHSERRtyhk B Haemophilus_ducreyi IrLgAQNvdintqGAFTGDIStaMLQEfcAkYIIIGHSERRtyha B Haemophilus_influenzae IqLgAQNvdinvkGAFTGDISteMLKDfGAkYIIIGHSERRtyhk B Histophilus_somni IaLgtQNvdlnkqGAFTGDISteMLKDfGvkYVIIGHSERRqyhh B Mannheimia_succiniciproducens IvLgsQNvdvnvkGAFTGDISteMLKDfGAkYIIIGHSERRtyhk B Pasteurella_multocida IaLgAQNvdvnvqGAFTGDISteMLKDfGAkYIIIGHSERRtyhk B Photobacterium_profundum IiLgAQNsdlnnSGAFTGDMSPaMLKEfGAshIIIGHSERReyhn B Photorhabdus_luminescens IaLgAQDvdvnlSGAFTGEtSatMLKDIGAeYIIIGHSERRtyhq B Vibrio_cholerae LiLgAQNtdthnSGAYTGDMSPaMLKDfGAshIIIGHSERRdyhk B Vibrio_fischeri IiLgAQNtdlnnSGAFTGDMSPaMLKEfGAthIIIGHSERReyhn B Vibrio_parahaemolyticus IiLgAQNtdlnnSGAFTGDMSPeMLKDfGAthIIIGHSERReyhn B Vibrio_vulnificus IiLgAQNtdinnSGAFTGDMSPaMLKDfGAthIIIGHSERReyhn B Yersinia_pestis IaLgAQNvdvnlSGAFTGEtSaeMLKDIGAqYIIIGHSERRtyhq B Salmonella_typhi-TPIS ImLgAQNvdlnlSGAFTGEtSaeMLKDIGAqYIIIGHSERRtyhk B Salmonella_typhi-TPIS_SALTY ImLgAQNvdlnlSGAFTGEtSaeMLKDIGAqYIIIGHSERRtyhk =============================================================================== B THERMUS_AQUATICUS VgygAQDvsahkeGAYTGEVSarMLsDLGcrYaIVGHSERRryhg =============================================================================== B BACILLUS_STEAROTHERMOPHILUS LkIgAQtmhfadqGAYTGEVSPvMLKDLGvtYVILGHSERRqmFa B Bacillus_clausii LkIgAQtmhfedNGAFTGEISPkaLsDMGvhYVIIGHSERRemFa B Bacillus_halodurans LrIgAQNmhfeeSGAFTGEISPvaLsDMkvdYVILGHSERRdmFa B Bacillus_licheniformis LkVgAQNmhfeeSGAFTGEISPaaLKDLGveYcVIGHSERRemFa B Bacillus_megaterium LkIgAQNmhfeeNGAFTGEVSPvaLaDLGvnYVILGHSERRemFa B Bacillus_subtilis LkVgAQNmhfeeSGAFTGEISPvaLKDLGvdYcVIGHSERRemFa B Listeria_monocytogenes-TPIS1 LrVsAQNcyfedeGAFTGEISPfaLaDLGvsYVIIGHSERReyFh B Listeria_monocytogenes-TPIS1_LI LrVaAQNcyfedeGAFTGEISPfaLaDLGvsYVIIGHSERReyFh =============================================================================== Consensus IxVxAQNxxxxxnGAFTGEISpxMIKDiGaxYVILGHSERRxxYx 230 240 250 260 270 ----|----:----|----:----|----:----|----:----| Consensus ESNElIaEKxxxAlexGLxvIlCIGESLEEREAGqTeEVVxKQIE =============================================================================== * S_CEREVISIAE EdDKfIADKtkfALgqGVgVILCIGETLEEKKAGKTlDVVeRQLn * Candida_albicans ESDEfIAEKtkfALDtGVkVILCIGETLEERKgGvTlDVcaRQLD * Candida_glabrata EdDKIVAEKtkfALDqGLgVILCIGETLEEKKAGvTlKVVeRQLD * Debaryomyces_hansenii ESDDfIAsKtkfALDqGLsVILCIGETLEERKAnvTlDVcaRQLD * Eremothecium_gossypii EdDEqVAEKtafALErGVsVILCIGETLDEKKAGvTlDVVkRQLt * Yarrowia_lipolytica ESSEwIADKtkyALDnGLdVILCIGETIDEKKAGKTlDVVrsQLD * Zygosaccharomyces_bailii EdDQLIAEKtafALsqGVgVILCIGETLDQKKAGtTlQVVeRQLQ * Kluyveromyces_lactis-TPIS ETDEIVAEKtkfALDsGVkVILCIGETLEEKQqniTlQVVqRQLQ * Kluyveromyces_lactis-TPIS_KLUMA ETDEfIADKtkfALDsGVkVILCIGETLEEKQkGiTlEVVqRQLQ =============================================================================== * C_ELEGANS ESDaLIAEKtvhALEaGIkVVfCIGEkLEEREAGhTKDVnfRQLQ * HUMAN ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * RABBIT ESDELIgQKvahALseGLgVIaCIGEkLDEREAGiTEKVVfEQtK * CHICKEN ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SPQA_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SPQB_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SQ7A_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SSDA_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SU5A_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SW3A_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1SW7A_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1TPB1_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1TPC1_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1TPUA_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1TPVA_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * 1TPWA_Chicken ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Acipenser_brevirostrum ESDELIgQKvahALQeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Anopheles_gambiae ETDELIAEKvahALaeGLkVIaCIGETLQEREAGQTEaVcfRQtK * Bovine ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * C_briggsae ESDaLIAEKtvhALEsGIkVIfCIGEkLEEREAGhTKDVnfRQLQ * Canis_lupus ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Danio_rerio ESDELIgQKvahALEnGLgVIaCIGEkLDEREAGiTEKVVfaQtK * Gorilla_gorilla ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Latimeria_chalumnae ESDELIgQKvshALseGLgVVaCIGEkLDEREAGiTEgVVfEvtE * Lepisosteus_osseus ESDELIgQKvahALEgGLgVIaCIGEkLDEREAGiTDKVVfaQtK * Macaca_mulatta ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Mouse ESDELIgQKvshALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Oryzias_latipes ENDELIgQKvahALEsdLsVIaCIGEkLEEREAGtTEDVIfaQtQ * Pongo_pygmaeus ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Schistosoma_mansoni ESDELIAEKvqhALaeGLsVIaCIGETLsEREsnKTEEVcvRQLK * Strongylocentrotus_purpuratus ESDELIAQKvahALsckLkVVaCIGEkLDEREkGQTnEVVyRQMr * Pig ESDELIgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Tribolium_castaneum ETDELIAEKvahALEaGLkVIaCIGETLEEREgGKTEEVVfRQtK * X_laevis EcDELIgQKvahALseGIgVIaCIGEkLDQREAGiTEKVVfEQtK * D_melanogaster-TPIS ESDaLIAEKaehALaeGLkVIaCIGETLEEREAGKTnEVVaRQMc * D_melanogaster-TPIS_VAR ESDaLIAEKaehALaeGLkVIaCIGETLEEREAGKTnEVVaRQMc * Rat-Q6P793 ESDELIgQKvnhALseGLgVIaCIGEkLDEREAGiTEKVVfEQtK * Rat-TPIS ESDELIgQKvnhALseGLeVIaCIGEkLDEREAGiTEKVVfEQtK =============================================================================== ENTAMOEBA_HISTOLYTICA ESNEqVAEKvkvAIDaGLkVIaCIGETeaQRiAnQTEEVVaaQLK =============================================================================== LEISHMANIA_MEXICANA ETDEIVAQKvseAcKqGfmVIaCIGETLQQREAnQTaKVVlsQts TRYPANOSOMA_CRUZI ETNEIVAEKvaqAcaaGfhVIVCVGETnEEREAGRTaaVVltQLa TRYPANOSOMA_BRUCEI ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa 1KV5A_Trypanosoma_brucei ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa 1MSSA_Trypanosoma_brucei ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa 1TRI0_Trypanosoma_brucei ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa 1TTI0_Trypanosoma_brucei ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa 1TTJ0_Trypanosoma_brucei ETNEIVADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIa Leishmania_donovani ETDEIVAQKvadAcKqGfmVIaCIGETLQQREAnQTaKVVlsQts Leishmania_tropica ETDEtVAQKvadAcKqGfmVIaCIGETLQQREAnQTaKVVlsQts =============================================================================== PLASMODIUM_FALCIPARUM ETDEdVrEKlqasLKnnLkaVVCfGESLEQREqnKTiEVItKQVK 1VGAB_Plasmodium_falciparum ETDEdVrEKlqasLKnnLkaVVCfGESLEQREqnKTiEVItKQVK Plasmodium_berghei ETDEdVrQKlqqAIKnnLkaVVCfGESLEQREsnKTiDVItKQVK Plasmodium_chabaudi ETDEdVrEKlqqAIKhnLkaVVCfGESLEQREsnKTiEVItKQVK =============================================================================== B E_COLI ESDELIAKKfavlkEqGLtpVLCIGETeaEnEAGKTEEVcaRQID B VIBRIO_MARINUS ESDEfVAKKfaflkEnGLtpVLCIGESdaQnEAGETmaVcaRQLD B Actinobacillus_pleuropneumoniae EcDtfIAKKfaalkaaGLvpVLCIGETeaEnEAGQTEaVcaKQID B Actinobacillus_succinogenes ESDEfIAKKfsalkEaGLtpVLCIGETeEEnEAGKTEEVVsRQID B Erwinia_carotovora ESDEfIAKKfgvlkDaGLipVLCIGETeaEnEAGQTEaVcaRQLD B Haemophilus_ducreyi ESDQfIAKKfaalktaGLtpVLCIGETeaEnEAGQTQQVcaRQID B Haemophilus_influenzae ESDEfVAKKfgalkEaGLvpVLCIGESeaEnEAGKTEEVcaRQID B Histophilus_somni ESDEfIAKKfgvlkDaGLvpVLCIGESeaEnEAGKTEEVcaRQID B Mannheimia_succiniciproducens ESDEfVAQKfgalkEaGLtpVLCIGESeaEnEAGKTEEVcaRQID B Pasteurella_multocida ESDEfIAKKfaalkQaGLvpVLCIGESeaEnEAGKTEEVcaRQID B Photobacterium_profundum ESDEfVAKKfaflkEnGLtpVLCIGESdaQnEAGETmaVcaRQLD B Photorhabdus_luminescens ESDEfIAKKfailkQqGLipVLCIGETeQEnEAGQTEsVcaRQID B Vibrio_cholerae ESDEfVAKKfaflkEnGLtpVfCIGETeaQnEAGETEaVcaRQIn B Vibrio_fischeri ESDEfVAKKfaflkEnGLtpVLCIGESeaQnEAGETvaVcaRQID B Vibrio_parahaemolyticus ESDEfIAKKfnflkEnGLtpVfCIGESeaQnEAGETEaVcaRQIn B Vibrio_vulnificus ESDEfVAKKfaflkEnGLkpVfCIGETeaQnEAGETEaVcaRQIn B Yersinia_pestis ESDELIAKKfgvlkEiGLipVLCIGESeaEnEAGQTEaVcaKQLD B Salmonella_typhi-TPIS ESDELIAKKfavlkEqGLtpVLCIGETeaEnEAGKTEEVcaRQID B Salmonella_typhi-TPIS_SALTY ESDELIAKKfavlkEqGLtpVLCIGETeaEnEAGKTEEVcaRQID =============================================================================== B THERMUS_AQUATICUS ETDaLVAEKakrlLEeGItpILCVGEpLEvREkGEavpytlRQLr =============================================================================== B BACILLUS_STEAROTHERMOPHILUS ETDEtVnKKvlaAftrGLipIICcGESLEEREAGQTnaVVasQVE B Bacillus_clausii ETDEtVnKKvhaAfahhLvpIMCcGETaEEREAGKmEaVVkEQVE B Bacillus_halodurans ETDELVnKKthaAfahGLtpIVCVGETLEEREAnQTyDVVktQVE B Bacillus_licheniformis ETDEtVnKKahaAfKyGIvpIICVGETLEEREAnKTnELVadQVK B Bacillus_megaterium ETDEtVnQKtiaAfKhGLtpIVCcGETnEEyEqdQTKtVVanQVQ B Bacillus_subtilis ETDEtVnKKahaAfKhGIvpIICVGETLEEREAGKTnDLVadQVK B Listeria_monocytogenes-TPIS1 ETDEdInKKahaifKhGMtpIICcGETLDQREAGQTDtwVrgQIr B Listeria_monocytogenes-TPIS1_LI ETDEdInKKahaifKhGMtpIICcGETLDQREAGQTDtwVrgQIr =============================================================================== Consensus ESNElIaEKxxxAlexGLxvIlCIGESLEEREAGqTeEVVxKQIE 280 290 300 310 ----:----|----:----|----:----|----:----|----: Consensus AIlnxxxvexxxeFsxvVLAYEPVWaigtgksaTPEQAQEVHxxL =============================================================================== * S_CEREVISIAE AVLee--VK---DWTnVVVAYEPVWAIGTGlaATPEdAQDIHasI * Candida_albicans AVski--Vs---DWSnIVVAYEPVWAIGTGlaATPEdAEEtHkgI * Candida_glabrata AVIae--VK---DWTnVVIAYEPVWAIGTGlaATaEdAQDIHhsI * Debaryomyces_hansenii AVarv--Vs---DWSkIVVAYEPVWAIGTGlaATPEdAQEtHkaI * Eremothecium_gossypii pVLek--VK---DWTnVVIAYEPVWAIGTGlaATaEdAQDIHaaI * Yarrowia_lipolytica pVIak--IK---DWSnVVIAYEPVWAIGTGlaATaEdAQQIHheI * Zygosaccharomyces_bailii AVIDk--VK---DWSnVVIAYEPVWAIGTGlaATPEdAQEIHhsI * Kluyveromyces_lactis-TPIS AVLek--VQ---DWTnVVVAYEPVWAIGTGlaATaEdAQDIHhsI * Kluyveromyces_lactis-TPIS_KLUMA AVLDk--VQ---DWTnVVVAYEPVWAIGTGlaATsDdAQaIHhsI =============================================================================== * C_ELEGANS AIVDk--gv---sWenIVIAYEPVWAIGTGKTASgEQAQEVHewI * HUMAN vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * RABBIT vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * CHICKEN AIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * 1SPQA_Chicken AIaDn--VK---DWSkVVLAYEPVWAIxxGKTkTPQQAQEVHekL * 1SPQB_Chicken AIaDn--VK---DWSkVVLAYEPVWxxxxxxxxTPQQAQEVHekL * 1SQ7A_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGlwATPQQAQEVHekL * 1SSDA_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGySlTPQQAQEVHekL * 1SU5A_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGnpnTPQQAQEVHekL * 1SW3A_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGKvATPQQAQEVHekL * 1SW7A_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGnSsTPQQAQEVHekL * 1TPB1_Chicken AIaDn--VK---DWSkVVLAYDPVWAIGTGKTATPQQAQEVHekL * 1TPC1_Chicken AIaDn--VK---DWSkVVLAYDPVWAIGTGKTATPQQAQEVHekL * 1TPUA_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * 1TPVA_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * 1TPWA_Chicken AIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Acipenser_brevirostrum AIaDn--VK---DWSkVVLAYEPVWAIGTGKTASPQQAQEVHekL * Anopheles_gambiae AIaaq--VK---DWSnVVIAYEPVWAIGTGKTATPEQAQEVHaaL * Bovine vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * C_briggsae AIVDk--gv---sWenIVIAYEPVWAIGTGKTASPEQAQEVHewI * Canis_lupus vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Danio_rerio fIaDn--VK---DWSkVVLAYEPVWAIGTGKTASPQQAQEVHdkL * Gorilla_gorilla vItDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Latimeria_chalumnae vIaDd--VK---DWSkVVLAYEPVWAIGTGKTASPQQsQELHgkL * Lepisosteus_osseus vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHdkL * Macaca_mulatta vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Mouse vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Oryzias_latipes vIaen--Vm---DWekVVLAYEPVWAIGTGKTATPEQAQEVHekL * Pongo_pygmaeus vIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Schistosoma_mansoni AIaNk--IKsadEWkrVVVAYEPVWAIGTGKvATPQQAQEVHnfL * Strongylocentrotus_purpuratus ALaDv--It---DWgnVVIAYEPVWAIGTGKTATPQQAQEVHqnL * Pig vIaDn--VK---DWNkVVLAYEPVWAIGTGKTATPQQAQEVHekL * Tribolium_castaneum AIagk--IK---DWSnVVIAYEPVWAIGTGKTATPQQAQEVHkaL * X_laevis AIaDn--VK---DWSkVVLAYEPVWAIGTGKTATPEQAQEVHkkL * D_melanogaster-TPIS Ayaqk--IK---DWknVVVAYEPVWAIGTGQTATPDQAQEVHafL * D_melanogaster-TPIS_VAR Ayaqk--IK---DWknVVVAYEPVWAIGTGKTATPDQAQEVHafL * Rat-Q6P793 AIaDn--VK---DWckVVLAYEPVWAIGTGKTATPQQAQEVHekL * Rat-TPIS AIaDn--VK---DWckVVLAYEPVWAIGTGKTATPQQAQEVHekL =============================================================================== ENTAMOEBA_HISTOLYTICA AInNa--Iske-aWknIILAYEPVWAIGTGKTATPDQAQEVHqyI =============================================================================== LEISHMANIA_MEXICANA AIaak--Ltkd-aWNqVVLAYEPVWAIGTGKvATPEQAQEVHllL TRYPANOSOMA_CRUZI AVaqk--Lske-aWSrVVIAYEPVWAIGTGKvATPQQAQEVHelL TRYPANOSOMA_BRUCEI AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI 1KV5A_Trypanosoma_brucei AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI 1MSSA_Trypanosoma_brucei AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI 1TRI0_Trypanosoma_brucei AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI 1TTI0_Trypanosoma_brucei AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI 1TTJ0_Trypanosoma_brucei AIakk--LKka-DWakVVIAYEPVWAIGTGKvATPQQAQEaHalI Leishmania_donovani AIatk--Lpte-aWdqIVLAYEPVWAIGTGKvATPEQAQEVHalL Leishmania_tropica AIatk--Lpke-aWdqIVLAYEPVWAIGTGKvATPEQAQEVHalL =============================================================================== PLASMODIUM_FALCIPARUM AfVDl--ID---nFdnVILvYEPLWAIGTGKTATPEQAQlVHkeI 1VGAB_Plasmodium_falciparum AfVDl--ID---nFdnVILvYEPLFAIGTGKTATPEQAQlVHkeI Plasmodium_berghei AfVDl--IE---nFdnVILAYEPIWAIGTGKTATPEQAQEVHkeI Plasmodium_chabaudi AfVDl--IE---nFdnVILAYEPIWAIGTGKTATPEQAQEVHkeI =============================================================================== B E_COLI AVLkt--qgaa-aFegaVIAYEPVWAIGTGKSATPaQAQaVHkfI B VIBRIO_MARINUS AVINt--qgve-alegaIIAYEPIWAIGTGKaATaEdAQrIHaqI B Actinobacillus_pleuropneumoniae AVIDa--Lgve-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Actinobacillus_succinogenes AVINa--Lgve-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Erwinia_carotovora AVLNt--Lgak-aFentVVAYEPVWAIGTGKSATPaQAQaVHkfI B Haemophilus_ducreyi AIINs--Lgve-aFNqaVIAYEPIWAIGTGKSATPaQAQaVHafI B Haemophilus_influenzae AVINa--Lgve-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Histophilus_somni AVMNt--Lgve-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Mannheimia_succiniciproducens AVINa--Lgve-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Pasteurella_multocida AVLNt--Lgae-aFNgaVIAYEPIWAIGTGKSATPaQAQaVHafI B Photobacterium_profundum AVINt--qgve-alegaIIAYEPIWAIGTGKaATaEdAQrIHaqI B Photorhabdus_luminescens AVLNt--Lgva-aFqgaVIAYEPVWAIGTGKSATPaQAQaVHkfI B Vibrio_cholerae AVIDa--ygve-alNgaIIAYEPIWAIGTGKaATaDdAQrIHasI B Vibrio_fischeri AVINt--qgvd-alNgaIIAYEPIWAIGTGKaATaEdAQrIHaqI B Vibrio_parahaemolyticus AVIDt--ygve-alNgaIIAYEPIWAIGTGKaATaEdAQrIHasI B Vibrio_vulnificus AVIDa--ygve-alNgaIIAYEPIWAIGTGKaATaEdAQrIHasI B Yersinia_pestis AVLNt--Lgvk-aFegaVIAYEPIWAIGTGKSATPaQAQaVHkfI B Salmonella_typhi-TPIS tVLkt--qgaa-aFegaVIAYEPVWAIGTGKSATPaQAQaVHkfI B Salmonella_typhi-TPIS_SALTY AVLkt--qgaa-aFegaVIAYEPVWAIGTGKSATPaQAQaVHkfI =============================================================================== B THERMUS_AQUATICUS gsLegvepp---gpeaLVIAYEPVWAIGTGKNATPEdAEaMHqaI =============================================================================== B BACILLUS_STEAROTHERMOPHILUS kaLagltpE---QvkqaVIAYEPIWAIGTGKSsTPEdAnsVcghI B Bacillus_clausii ngLaglseE---QvkqtVIAYEPIWAIGTGKSATeKdAnEacayV B Bacillus_halodurans kgLegltdE---QvkvtVIAYEPVWAIGTGKSsSaEdAnDVcsyI B Bacillus_licheniformis kaLaglttE---QvaasVIAYEPIWAIGTGKSsTaQdAnEVcahI B Bacillus_megaterium kaLagltdE---QvkqtVIAYEPIWAIGTGKSsTaEgAnEVcayI B Bacillus_subtilis kgLaglseE---QvaasVIAYEPIWAIGTGKSsTaKdAnDVcahI B Listeria_monocytogenes-TPIS1 AaLaglteE---QviksVIAYEPIWAIGTGKSsTsadAnEtcavI B Listeria_monocytogenes-TPIS1_LI AaLaglteE---QviksVIAYEPIWAIGTGKSsTsadAnEtcavI =============================================================================== Consensus AIlnxxxvexxxeFsxvVLAYEPVWaigtgksaTPEQAQEVHxxL 320 330 340 350 360 ----|----:----|----:----|----:----|----:----| Consensus RxyLxexiNexIAExLRIiYGGSVSxxNxxELxxQPDVDGfLVGG =============================================================================== * S_CEREVISIAE RkFLaskLgDkaAseLRILYGGSaNgsNavtfkdKaDVDGFLVGG * Candida_albicans RahLaKsIgaeqAEktRILYGGSVNgkNakDfkdKaNVDGFLVGG * Candida_glabrata RsYLaEkLgKdtAEktRILYGGSaNgaNagtfkdKaDVDGFLVGG * Debaryomyces_hansenii RehLsKsIgadaAEktRILYGGSVNgkNapEfkdKaDVDGFLVGG * Eremothecium_gossypii RdFLaErtSrdVADaVRILFGGSaNgaNaasfrdKaDVDGFLVGG * Yarrowia_lipolytica RaYLkDkIgaq-ADkVRIIYGGSVNgkNsgtfkdKsDVDGFLVGG * Zygosaccharomyces_bailii ReFLaKkLgEktAQetRILYGGSaNgkNavtfkdKPDVDGFLVGG * Kluyveromyces_lactis-TPIS ReFLaEkLSrdVADsVRILYGGSaNgkNavtfkdKaDVDGFLVGG * Kluyveromyces_lactis-TPIS_KLUMA ReFLaKkLSKdtAEkIRILYGGSaNgkNavtfkdKaDVDGFLVGG =============================================================================== * C_ELEGANS RaFLkEkVSpaVADatRIIYGGSVTadNaaELgkKPDIDGFLVGG * HUMAN RgWLksnVSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * RABBIT RgWLksnVSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * CHICKEN RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SPQA_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SPQB_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SQ7A_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SSDA_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SU5A_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SW3A_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1SW7A_Chicken RgWLkshVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1TPB1_Chicken RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1TPC1_Chicken RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1TPUA_Chicken RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1TPVA_Chicken RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * 1TPWA_Chicken RgWLkthVSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGG * Acipenser_brevirostrum RqWLkthVSEeVggaVRIIYGGSVTaatckELasKPDVDGFLVGG * Anopheles_gambiae RkWftEnVSadVsnaIRIqYGGSVTaaNcrELaaKPDIDGFLVGG * Bovine RgWLksnVSDaVAQsaRIIYGGSVTgatckELasQPDVDGFLVGG * C_briggsae RaFLkEkVSpaVADatRIIYGGSVTadNaaELgkKPDIDGFLVGG * Canis_lupus RgWLksnVSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * Danio_rerio RqWLktnVSEaVAnsVRIIYGGSVTggtckELasQkDLDGFLVGG * Gorilla_gorilla RgWLksnVSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * Latimeria_chalumnae RkWLkEnVSEtVADsVRIIYGGSVTgatckELasEPDVDGFLVGG * Lepisosteus_osseus RqWLktnVSEaVAsscRIIYGGSVTggtckELasQaDVDGFLVGG * Macaca_mulatta RgWLksnVSEaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * Mouse RgWLksnVNDgVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * Oryzias_latipes RaWfranISEeVsDsLRIIYGGSVTaaNcrELasQtDVDGFLVGG * Pongo_pygmaeus RgWLksnVSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGG * Schistosoma_mansoni RkWfktnapngVdEkIRIIYGGSVTaaNckELaqQhDVDGFLVGG * Strongylocentrotus_purpuratus RsWLtEhVNaaVAantRIVYGGSVNggNccDIgqQPDVDGFLVGG * Pig RgWLkthVpEaVAhstRIIYGGSVTgatckELasQPDVDGFrVsG * Tribolium_castaneum RqWfcthVNadVgnsIRIqYGGSVTgaNckELaaQPDIDGFLVGG * X_laevis ReWVktnVSEgVAQsVRIIYGGSVTggtcrELagQPDIDGFLVGG * D_melanogaster-TPIS RqWLsDnISKeVsasLRIqYGGSVTaaNakELakKPDIDGFLVGG * D_melanogaster-TPIS_VAR RqWLsDnISKeVsasLRIqYGGSVTaaNakELakKPDIDGFLVGG * Rat-Q6P793 RgWLkcnVSEgVAQctRIIYGGSVTgatckELasQPDVDGFLVGG * Rat-TPIS RgWLkcnVSEgVAQctRIIYGGSVTgatckELasQPDVDGFLVGG =============================================================================== ENTAMOEBA_HISTOLYTICA RkWMtEnISKeVAEatRIqYGGSVNpaNcnELakKaDIDGFLVGG =============================================================================== LEISHMANIA_MEXICANA RkWVsEnIgtdVAakLRILYGGSVNaaNaatLyaKPDINGFLVGG TRYPANOSOMA_CRUZI RrWVrskLgtdIAaqLRILYGGSVTakNartLyqmrDINGFLVGG TRYPANOSOMA_BRUCEI RsWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG 1KV5A_Trypanosoma_brucei ssWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG 1MSSA_Trypanosoma_brucei RsWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG 1TRI0_Trypanosoma_brucei RsWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG 1TTI0_Trypanosoma_brucei RsWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG 1TTJ0_Trypanosoma_brucei RsWVsskIgadVAgeLRILYGGSVNgkNartLyqQrDVNGFLVGG Leishmania_donovani RkWVsEkIgadVAarLRILYGGSVSagNaktLymKPDINGFLVGG Leishmania_tropica RkWVsEkIgtdVAakLRILYGGSVSagNaktLymKPDINGFLVGG =============================================================================== PLASMODIUM_FALCIPARUM RkiVkDtcgEkqAnqIRILYGGSVNteNcssLiqQeDIDGFLVGn 1VGAB_Plasmodium_falciparum RkiVkDtcgEkqAnqIRILYGGSVNteNcssLiqQeDIDGFLVGn Plasmodium_berghei RkiVkEicgEaqAnkIRILYGGSVSveNctsLikQeDIDGFLVGt Plasmodium_chabaudi RkiVkEicgEaqAnkIRILYGGSVSveNctsLikQeDIDGFLVGt =============================================================================== B E_COLI RdhIaKv-DanIAEqViIqYGGSVNasNaaELfaQPDIDGaLVGG B VIBRIO_MARINUS RahIaEk-SEaVAKnVvIqYGGSVkpeNaaayfaQPDIDGaLVGG B Actinobacillus_pleuropneumoniae RghIaak-SQaVADqViIqYGGSVNdaNaaELftQPDIDGaLVGG B Actinobacillus_succinogenes RahIaak-SQaVADqViIqYGGSVNdaNaaELftQPDIDGaLVGG B Erwinia_carotovora RdhIaKq-DaaVAEqViIqYGGSVNaaNaaELftQPDIDGaLVGG B Haemophilus_ducreyi RqhIaEk-SQaVADqLiIqYGGSVNdtNaaELfsQPDIDGaLVGG B Haemophilus_influenzae RghIaak-SQaVAEqViIqYGGSVNdaNaaELftQPDIDGaLVGG B Histophilus_somni RghIaKq-SQaVAErViIqYGGSVNdaNaaELftQPDIDGaLVGG B Mannheimia_succiniciproducens RghIaak-SQaVADqViIqYGGSVNdaNaaELftQPDIDGaLVGG B Pasteurella_multocida RghIaKk-DnaVAEqViIqYGGSVNdaNaaELftQPDIDGaLVGG B Photobacterium_profundum RahIaEk-SEeVAKnLvIqYGGSVkpeNaaayfaQPDIDGaLVGG B Photorhabdus_luminescens RdhIaQk-DaaIAQqIiIqYGGSVNadNaaELfsQPDIDGaLVGG B Vibrio_cholerae RalIaak-DaaVAEqViIqYGGSVkpeNaasyfaQPDIDGaLVGG B Vibrio_fischeri RahIaEk-SEeVAKnVvIqYGGSVkpeNaaayfaQPDIDGaLVGG B Vibrio_parahaemolyticus RalIaak-DEaVAaqViIqYGGSVkpeNaeayfsQPDIDGaLVGG B Vibrio_vulnificus RamIaak-DaaVAEqViIqYGGSVkpeNaeayfaQPDIDGaLVGG B Yersinia_pestis RdhIaKq-DaaVAaqViIqYGGSVNdkNaaELftQPDIDGaLVGG B Salmonella_typhi-TPIS RdhIaKa-DakIAEqViIqYGGSVNasNaaELfaQPDIDGaLVGG B Salmonella_typhi-TPIS_SALTY RdhIaKa-DakIAEqViIqYGGSVNasNaaELfaQPDIDGaLVGG =============================================================================== B THERMUS_AQUATICUS RkaLsErygEafAsrVRILYGGSVNpkNfaDLlsmPNVDGgLVGG =============================================================================== B BACILLUS_STEAROTHERMOPHILUS RsvVsrlfgpeaAEaIRIqYGGSVkpdNirDflaQqqIDGpLVGG B Bacillus_clausii RqtVaanfSEeaAEaIRIqYGGSVkpgNikDymaQPDIDGaLVGG B Bacillus_halodurans RkvVtEkfSQeaADaVRIqYGGSVkpaNiaEymaQsDIDGaLVGG B Bacillus_licheniformis RktVasefgQtaADsVRIqYGGSVkpaNikEymaEsDIDGaLVGG B Bacillus_megaterium RsvVaEqfSQdVADaVRIqYGGSVkpaNikEymsQsDIDGaLVGG B Bacillus_subtilis RktVaEsfSQeaADkLRIqYGGSVkpaNikEymaEsDIDGaLVGG B Listeria_monocytogenes-TPIS1 RaeVaDaVSQkaADaVRIqYGGSVkpeNiaDylaEsDIDGaLVGG B Listeria_monocytogenes-TPIS1_LI RaeVaDaVSQkaADaVRIqYGGSVkpeNiaDylaEsDIDGaLVGG =============================================================================== Consensus RxyLxexiNexIAExLRIiYGGSVSxxNxxELxxQPDVDGfLVGG 370 380 390 400 ----:----|----:----|----:----|----:----|----: Consensus ASLExpxeFvEIIeAxxxxxxx ======================================================== * S_CEREVISIAE ASLK-P-EFVDIInsrn----- * Candida_albicans ASLK-P-EFVDIIKsrl----- * Candida_glabrata ASLK-P-EFVDIInsrn----- * Debaryomyces_hansenii ASLK-P-EFVDIIKsrl----- * Eremothecium_gossypii ASLK-P-EFVDIInsrr----- * Yarrowia_lipolytica ASLK-P-EFVDIInsrl----- * Zygosaccharomyces_bailii ASLK-P-EFVDIInsrs----- * Kluyveromyces_lactis-TPIS ASLK-P-EFVDIInsrv----- * Kluyveromyces_lactis-TPIS_KLUMA ASLK-P-EFVDIInsrv----- ======================================================== * C_ELEGANS ASLK-P-DFVKIInArs----- * HUMAN ASLK-P-EFVDIInAkq----- * RABBIT ASLK-P-EFVDIInAkq----- * CHICKEN ASLK-P-EFVDIInAkh----- * 1SPQA_Chicken ASLK-P-EFVDIInAkh----- * 1SPQB_Chicken ASLK-P-EFVDIInAkh----- * 1SQ7A_Chicken ASLK-P-EFVDIInAkh----- * 1SSDA_Chicken ASLK-P-EFVDIInAkh----- * 1SU5A_Chicken ASLK-P-EFVDIInAkh----- * 1SW3A_Chicken ASLK-P-EFVDIInAkh----- * 1SW7A_Chicken ASLK-P-EFVDIInAkh----- * 1TPB1_Chicken ASLK-P-EFVDIInAkh----- * 1TPC1_Chicken ASLK-P-EFVDIInAkh----- * 1TPUA_Chicken ASLK-P-EFVDIInAkh----- * 1TPVA_Chicken ASLK-P-EFVDIInAkh----- * 1TPWA_Chicken ASLK-P-EFVDIInAkh----- * Acipenser_brevirostrum ASLK-P-EFIDIInAfq----- * Anopheles_gambiae ASLK-P-EFIQIVnArq----- * Bovine ASLK-P-EFVDIInAkq----- * C_briggsae ASLK-P-DFVKIInArs----- * Canis_lupus ASLK-P-EFVDIInAkq----- * Danio_rerio ASLK-P-EFIDIInAka----- * Gorilla_gorilla ASLK-P-EFVDIInAkq----- * Latimeria_chalumnae ASLK-P-EFVEykDvrq----- * Lepisosteus_osseus ASLK-P-EFVEIInArq----- * Macaca_mulatta ASLK-P-EFVDIInAkq----- * Mouse ASLK-P-EFVDIInAkq----- * Oryzias_latipes ASLK-P-EFIDIInAra----- * Pongo_pygmaeus ASLK-P-EFVDIInAkq----- * Schistosoma_mansoni ASLK-P-EFtEIcKArqr---- * Strongylocentrotus_purpuratus ASLK-P-EFkQIIaAgsa---- * Pig ASLK-P-EFVDIInAk------ * Tribolium_castaneum ASLK-P-EFVnIVnAkq----- * X_laevis ASLK-P-EFIEIInAkh----- * D_melanogaster-TPIS ASLK-P-EFVDIInArq----- * D_melanogaster-TPIS_VAR ASLK-P-EFVDIInArq----- * Rat-Q6P793 ASLK-P-EFVDIInAkq----- * Rat-TPIS ASLK-P-EFVDIInAkq----- ======================================================== ENTAMOEBA_HISTOLYTICA ASLDaa-KFktIInsvsekl-- ======================================================== LEISHMANIA_MEXICANA ASLK-P-EFrDIIDAtr----- TRYPANOSOMA_CRUZI ASLK-P-EFVEIIEAtk----- TRYPANOSOMA_BRUCEI ASLK-P-EFVDIIKAtq----- 1KV5A_Trypanosoma_brucei ASLK-P-EFVDIIKAtq----- 1MSSA_Trypanosoma_brucei ASLK-P-EFVDIIKAtq----- 1TRI0_Trypanosoma_brucei ASLK-P-EFVDIIKAtq----- 1TTI0_Trypanosoma_brucei ASLK-P-EFVDIIKAtq----- 1TTJ0_Trypanosoma_brucei ASLK-P-EFVDIIKAtq----- Leishmania_donovani ASLK-P-EFrDIIDAtr----- Leishmania_tropica ASLK-P-EFrDIIDAtr----- ======================================================== PLASMODIUM_FALCIPARUM ASLK-e-sFVDIIKsam----- 1VGAB_Plasmodium_falciparum ASLK-e-sFVDIIKsam----- Plasmodium_berghei sSLK-t-sFtEIIKsam----- Plasmodium_chabaudi sSLK-t-sFtEIIKsam----- ======================================================== B E_COLI ASLKad-aFavIVKAaeaakqa B VIBRIO_MARINUS AaLDak-sFaaIaKAaaeak-a B Actinobacillus_pleuropneumoniae ASLKaP-aFavIVKAaekaka- B Actinobacillus_succinogenes ASLKaP-aFavIVKAaaaaka- B Erwinia_carotovora ASLKad-aFavIVKAaadakrg B Haemophilus_ducreyi ASLKat-aFaEIVKAaekaka- B Haemophilus_influenzae ASLKaP-aFavIVKAaaaakn- B Histophilus_somni ASLKas-aFavIVKAaakakn- B Mannheimia_succiniciproducens ASLKaP-aFavIVKAaakaka- B Pasteurella_multocida ASLKaP-aFavIVKAaakakn- B Photobacterium_profundum AaLDak-sFaaIaKAaaeaka- B Photorhabdus_luminescens ASLKan-aFavIVKAaaaakka B Vibrio_cholerae ASLDak-gFaaIaKAaaeakka B Vibrio_fischeri AaLDak-sFaaIaKAaaeaka- B Vibrio_parahaemolyticus ASLDak-sFaaIaKAaaaaka- B Vibrio_vulnificus ASLDak-sFaaIaKAaakmka- B Yersinia_pestis ASLKad-aFavIVKAaakakka B Salmonella_typhi-TPIS ASLKad-aFavIVKAaeaakqa B Salmonella_typhi-TPIS_SALTY ASLKad-aFavIVKAaeaakqa ======================================================== B THERMUS_AQUATICUS ASLE-lesFLaLLriag----- ======================================================== B BACILLUS_STEAROTHERMOPHILUS ASLE-PasFLQLVEAgrhe--- B Bacillus_clausii ASLD-adsFLELVgAak----- B Bacillus_halodurans ASLD-PqsFLQLLEAvk----- B Bacillus_licheniformis ASLE-PqsFVQLLEAgqye--- B Bacillus_megaterium ASLE-adsFLQLLEAgk----- B Bacillus_subtilis ASLE-PqsFVQLLEegqye--- B Listeria_monocytogenes-TPIS1 ASLE-PasFLaLLEAvk----- B Listeria_monocytogenes-TPIS1_LI ASLE-PasFLaLLEAvk----- ======================================================== Consensus ASLExpxeFvEIIeAxxxxxxx

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