10        20        30        40        50        60        70
                         ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----:
  Consensus              xxxxxxaxsanxnxxxxxxxxxxxxxxxxxxxxvxxxxxxxxxxxxxxxprvyksivzdvvnevreiflndgide
====================================================================================================
* S_CEREVISIAE           -----------------------------snaea---------------sRVYEiIVZsVVNEVREdFeNaGIDE
* S_cerevisiae-TOA1      -----------------------------snaea---------------sRVYEiIVEsVVNEVREdFeNaGIDE
====================================================================================================
* HUMAN                  ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE
* Canis_lupus            rycwafkeNdNrN-------------------tasyinselqvfifplkPKLYRSVIEDVINDVRDIFLDDGVDE
* Danio_rerio            ------AsSANsN-------------------qV---------------PKLYRSVMEDVIaEVRELFLDEGVDE
* Chicken                ---------------------------------------------------------------------------
* Mouse                  ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE
* Pan_troglodytes        pivsstsrStktNkkslqwskcprfrleiylllp---------------PKLYRSVIEDVINDVRDIFLDDGVDE
* Pongo_pygmaeus         ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE
* Rat                    ------AnSANtN-------------------tV---------------PKLYRSVIEDVINDVRDIFLDDGVDE
* Tetraodon_nigroviridis -------------------------------------------------PKVYKSVIDDVINEVRELFLDEGVDE
* X_laevis               ---as-AaSANaN-------------------pV---------------PKLYRSVIgDVINDVREIFLDEGVgE
* X_tropicalis           ------AaSANaN-------------------pV---------------PKLYRSVIEDVINDVRELFLDEGVDE
====================================================================================================
  Consensus              xxxxxxaxsanxnxxxxxxxxxxxxxxxxxxxxvxxxxxxxxxxxxxxxprvyksivzdvvnevreiflndgide

                            80        90       100       110       120       130       140       150
                         ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----|
  Consensus              qvlmDLKtIxxxxxxxxxxxxxxWQnxxxxxkLmexxxtravdgxxxxxxxxxfhsexeqqlllqvxqqqxxxxx
====================================================================================================
* S_CEREVISIAE           QtLqDLKnI--------------WQk-----KLtEtkvTtfswdnqfnegningvqndlnfnLatpgvnssefni
* S_cerevisiae-TOA1      QtLqDLKnI--------------WQk-----KLtEtkvTtfswdnqfnegningvqndlnfnLatpgvnssefni
====================================================================================================
* HUMAN                  QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Canis_lupus            QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Danio_rerio            QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHTE-EQQVL------------
* Chicken                ----ELKTL--------------WEN-----KLMQ---SKAVDG---------FHSE-EQQLLLQVqQQQq----
* Mouse                  QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Pan_troglodytes        QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Pongo_pygmaeus         QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Rat                    QVLMELKTL--------------WEN-----KLMQ---SRAVDG---------FHSE-EQQLLLQV-QQQh----
* Tetraodon_nigroviridis QVLLELKTVhnstvsfsvnihytWENlhrhtpLfsqegSKpLNkhfpvcsnflFyvKysppfLfQL-wEnkllqs
* X_laevis               QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHTE-EQQLLLQa-QQQq----
* X_tropicalis           QVLMELKTL--------------WES-----KLMQ---SKAVDG---------FHSE-EQQLLLQa-QQQq----
====================================================================================================
  Consensus              qvlmDLKtIxxxxxxxxxxxxxxWQnxxxxxkLmexxxtravdgxxxxxxxxxfhsexeqqlllqvxqqqxxxxx

                                160       170       180       190       200       210       220
                         ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----:
  Consensus              xxxxxxxxqpqqqqhnhnnnxhqqxepqqtvxqqxqtqqvlipasqqaxapxxqvvvpeskiiqhmsasxmxnaa
====================================================================================================
* S_CEREVISIAE           keentgneglilpniNsNNNiphsgEtnintntveaTnnsgatlNtntsgntnadVtsQpKIevkpeieltiNnA
* S_cerevisiae-TOA1      keentgneglilpniNsNNNiphsgEtnintntveaTnnsgatlNtntsgntnadVtsQpKIevkpeieltiNnA
====================================================================================================
* HUMAN                  --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA
* Canis_lupus            --------QPQQQQHHHHHH-HQQtQPQQTVpQQaQTQQVLIPASQQAaAP--QVIVPDSKLIQHMNASnM-SAA
* Danio_rerio            -----------------Haq-qQQaQaQQT-qQQtQpQQVLLPpaQttpqq--QVIVqDaKIMQHMSATgM-SAA
* Chicken                --------QqQQQQHHHHHH-HtQpQPQQTVqQQtQpQQVLIPASQQApqq--QVIVPDSKLIpHMNASgM-SAA
* Mouse                  --------QPQQQQHHHHHHqHQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLLQHMNASsItSAA
* Pan_troglodytes        --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA
* Pongo_pygmaeus         --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASnM-SAA
* Rat                    --------QPQQQQHHHHHH-HQQaQPQQTVpQQaQTQQVLIPASQQAtAP--QVIVPDSKLIQHMNASsItSAA
* Tetraodon_nigroviridis kavegfytEeQtalqaaqqq-qhQvQPvQqVaQptQaQQVILPpqpQqqAPqqQVIVqDSKILQHMSATgM-SAA
* X_laevis               --------QqQQQhsqHHrv---QqhPQQqqaashQTQQVLIPAThQAqqq--QVLVqESKMIhHMTpqgM-SA-
* X_tropicalis           --------hPQ-----HHHv-sQhpQqQQaashQtQTQQVLIPAThQApqq--QVLVqDSKLIQHMTtqgM-SAA
====================================================================================================
  Consensus              xxxxxxxxqpqqqqhnhnnnxhqqxepqqtvxqqxqtqqvlipasqqaxapxxqvvvpeskiiqhmsasxmxnaa

                           230       240       250       260       270       280       290       300
                         ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----|
  Consensus              ataatlaipagvtpvqqiltnsgqllqvvraangaqyilxqpkesvvlqqqvipqmqpggvqapviqqvlaplpg
====================================================================================================
* S_CEREVISIAE           nittvenIddesekkddeekeedvektrkekeqieQvkLqakKEkrsalldtdevgselddsdddylisegeedG
* S_cerevisiae-TOA1      nittvenIddesekkddeekeedvektrkekeqieQvkLqakKEkrsalldtdevgselddsdddylisegeedG
====================================================================================================
* HUMAN                  ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Canis_lupus            ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Danio_rerio            ATAATLALPtGVaPfQQLITpqGQILQVVRAANGAQYII-QPQQqMLLQQQVLPQMQPGGVQAPVIQQVLtPLqG
* Chicken                ATvATLALPAGVTPVQQILTNSGQILQVVRtANGAQYII-QPQQpVVLQQQVIPQMQPGGVQAPVIQQVLAPIPG
* Mouse                  ATAATLALPAGVTPVQQLLTNSGQLLQVVRAANGAQYIL-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Pan_troglodytes        ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Pongo_pygmaeus         ATAATLALPAGVTPVQQILTNSGQLLQVVRvANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Rat                    ATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIf-QPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPG
* Tetraodon_nigroviridis ATAATLALPAGVTPyQQLLTSqGQLLQVVRAANGtQYLIqQPQQqILLQQ----QMQPaGVQAPVIQQVLtPLPG
* X_laevis               --AtTLALPAGVTPVQQLITNSGQLLQVVRAANGAQYLI-QPQQSMVLQQQVIPQMQqGGVQAPVIQQVLtPMPG
* X_tropicalis           ATAATLALPAGVTPVQQLITNSGQLLQVVRAANGAQYLI-QPQQSMVLQQQVIPQMQPGGVQAPVIQQVLAPIPG
====================================================================================================
  Consensus              ataatlaipagvtpvqqiltnsgqllqvvraangaqyilxqpkesvvlqqqvipqmqpggvqapviqqvlaplpg

                                310       320       330       340       350       360       370
                         ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----:
  Consensus              gisxqtgviiqpqqilxftgnkxxxxtqvipttvaaxxxxpxxpaqaqixxxaxgqqqpqxqpaqxqaplvlqvd
====================================================================================================
* S_CEREVISIAE           pd-------------------------------------------------------------------------
* S_cerevisiae-TOA1      pd-------------------------------------------------------------------------
====================================================================================================
* HUMAN                  GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGQQQPQaQPAQtQAPLVLQVD
* Canis_lupus            GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGQQQPQtQPAQpQAPLVLQVD
* Danio_rerio            GLpqQTGVIIQPQQIV-lTGNKvpqnTQVMqaaamAvqsgP-gdAQvQtqpqAqqQQQqQqQqAsqQpPMMLQVD
* Chicken                GIpqQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--pAaGQQQPQqQqAQpQAPLVLQVD
* Mouse                  GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-aPAQApM--pAaGQQQPQaQPAQqQAPLVLQVD
* Pan_troglodytes        GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tttGQQQPQaQPAQtQAPLVLQVD
* Pongo_pygmaeus         GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--tAtGhQQPQaQPAQtQAPLVLQVD
* Rat                    GISpQTGVIIQPQQIL-FTGNK----TQVIPTTVAA----P-tPAQAQI--pAaGQQQPQaQPAQqQAPLVLQVD
* Tetraodon_nigroviridis aLpqQTGVIIQPQQIVlaSGNK----vQg-nTqVgt----PlcPsyApp--rAasvpKaQpQPqvqQpPLMLQVD
* X_laevis               GLSqQTGVIIQPQQIL-FTGNK----TQVIPnTMsA----PqaPiQgQL--tvtsQQQqQ-g--QqQAPLVLQVD
* X_tropicalis           GLSqQTGVIIQPQQIL-FTGNK----TQVIPTTMsA----PqaPtQgQL--tvtsQQQqQgQ----QqqVVLQVD
====================================================================================================
  Consensus              gisxqtgviiqpqqilxftgnkxxxxtqvipttvaaxxxxpxxpaqaqixxxaxgqqqpqxqpaqxqaplvlqvd

                           380       390       400       410       420       430       440       450
                         ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----|
  Consensus              gxgdtsseededeeedydddeeedkekdgxedgqveeeplnseddvsdeegqelfdtENLMLCqYDKVhRTKnRW
====================================================================================================
* S_CEREVISIAE           ---------------------------------------------------------ENLMLClYDKVtRTKaRW
* S_cerevisiae-TOA1      ---------------------------------------------------------ENLMLClYDKVtRTKaRW
====================================================================================================
* HUMAN                  GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Canis_lupus            GtGDTSSEEDEDEEEDYDDEEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Danio_rerio            GaGDTSSEEDEEEEDEYDEDEDEDKEKDGgEDGQVEEEPLNSgDDVSDEEdQELFDTENVVVCQYDKIHRSKNKW
* Chicken                GaGDTSSEEEEDEEEDYDDDEEEDKEKDGgEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Mouse                  GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Pan_troglodytes        GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Pongo_pygmaeus         GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Rat                    GtGDTSSEEDEDEEEDYDDDEEEDKEKDGaEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* Tetraodon_nigroviridis GaGETSSEEEEDEEEEYDEDEDEEKEKEagEDwQVEEEPLNSgDDVSDEEdQELFDTENVVVCQYDKIHRSKNKW
* X_laevis               GaGDTSSEEDEDEDEDYDDEEEEDKEKDG-EDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
* X_tropicalis           GaGDTSSEEDEDEDEDYDDEEEEDKEKDG-EDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKW
====================================================================================================
  Consensus              gxgdtsseededeeedydddeeedkekdgxedgqveeeplnseddvsdeegqelfdtENLMLCqYDKVhRTKnRW

                                460       470       480       490       500       510       520
                         ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----:
  Consensus              KfhLKDGVVnINgrDYiFsKAigEAEWx
=====================================================
* S_CEREVISIAE           KcsLKDGVVtINrnDYtFqKAqvEAEWv
* S_cerevisiae-TOA1      KcsLKDGVVtINrnDYtFqKAqvEAEWv
=====================================================
* HUMAN                  KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Canis_lupus            KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Danio_rerio            KFHLKDGIMNLNGRDFVFSKAIGDAEW-
* Chicken                KFHLKDGIMNLNGRDYVFSKAIGDAEW-
* Mouse                  KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Pan_troglodytes        KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Pongo_pygmaeus         KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Rat                    KFHLKDGIMNLNGRDYIFSKAIGDAEW-
* Tetraodon_nigroviridis KFHLKDGIMNLNGKDYVFSKAIGDAEW-
* X_laevis               KFHLKDGIMNLNGRDFVFSKAIGDAEW-
* X_tropicalis           KFHLKDGIMNLNGRDFVFSKAIGDAEW-
=====================================================
  Consensus              KfhLKDGVVnINgrDYiFsKAigEAEWx