Glutathione-S-Transferase Class Pi

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ================================================================================================= ONCHOCERCA_VOLVULUS --------------------------------------------------------------------------- ================================================================================================= HUMAN --------------------------------------------------------------------------- MOUSE --------------------------------------------------------------------------- PIG --------------------------------------------------------------------------- 1EOGA_Human --------------------------------------------------------------------------- 1EOHA_Human --------------------------------------------------------------------------- 1KBNA_Human --------------------------------------------------------------------------- 1PGTA_Human --------------------------------------------------------------------------- 22GSA_Human --------------------------------------------------------------------------- 4GSSA_Human --------------------------------------------------------------------------- Bos_taurus --------------------------------------------------------------------------- Canis_lupus qevdkgfvplrsdnqagleaaigkpqgprklrqlvpspspspspaspqrqaedphvlpeggwrpgrglssaaaaa Capra_hircus --------------------------------------------------------------------------- Cricetulus_griseus --------------------------------------------------------------------------- Macaca_mulatta --------------------------------------------------------------------------- Mesocricetus_auratus --------------------------------------------------------------------------- Pan_troglodytes skankrsi-yringd--lqinr-kdptpfslrgvaftpgllpvprls-rhacsp---pqccvnlrrnlfpcslpa Pongo_pygmaeus --------------------------------------------------------------------------- Rattus_norvegicus --------------------------------------------------------------------------- ================================================================================================= PLASMODIUM_FALCIPARUM --------------------------------------------------------------------------- ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 80 90 100 110 120 130 140 150 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxppytVvYFpVxRGRCeALRMLLADQgQSWKEEVIxxxxxsiesWxegslkxscLYgQ ================================================================================================= ONCHOCERCA_VOLVULUS -------------------sYkLtYFsI-RGlaEpIRLfLvDQdikFiDDrI-----akDdF--sSIKsqfqFGQ ================================================================================================= HUMAN ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqZGSLKaSCLYGQ MOUSE ------------------PPYTIVYFPV-RGRCEAMRMLLADQGQSWKEEVV-----TIDTWmQGlLKpTCLYGQ PIG ------------------PPYTItYFPV-RGRCEAMRMLLADQdQSWKEEVV-----TMETW--ppLKpSCLFrQ 1EOGA_Human -------------------PYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ 1EOHA_Human ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ 1KBNA_Human ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ 1PGTA_Human ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ 22GSA_Human -------------------PYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLFGQ 4GSSA_Human -------------------PYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ Bos_taurus ------------------PPYTIVYFPV-QGRCEAMRMLLADQGQSWKEEVV-----aMQSWlQGpLKaSCLYGQ Canis_lupus aaaaaaaaaatatraatmPPYTItYFPV-RGRCEAMRMLLADQGQSWKEEVV-----TMETWmKGSLKaSCLYGQ Capra_hircus ------------------asYTIVYFPV-QGRCEAMRMLLADQdQSWKEEVV-----aMQSWlQGpLKaSCLYGQ Cricetulus_griseus ------------------PPYTIVYFPV-RGRCEAMRILLADQGQSWKEEVV-----TVETWrKGSLKsTCLYGQ Macaca_mulatta ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----TMETWqEGSLKaSCLYGQ Mesocricetus_auratus ------------------PPYTIVYFPV-RGRCEAMRLLLADQGQSWKEEVV-----TgDSWvKGSLKsTCLYGQ Pan_troglodytes lltpprvaarrsr-----PgphIsYFsLpaGRCaALRMLLADQGQSWKEEVV-----TVETWqEGSLKaSCLYGQ Pongo_pygmaeus ------------------PPYTVVYFPV-RGRCaALRMLLADQGQSWKEEVV-----SMETWqEGSLKaSCLYGQ Rattus_norvegicus ------------------PPYTIVYFPV-RGRCEAtRMLLADQGQSWKEEVV-----TIDvWlQGSLKsTCLYGQ ================================================================================================= PLASMODIUM_FALCIPARUM -----------------gdnivLyYFda-RGKaElIRLIfAylGieYtDKrfgvngdafveFknfkkEkdtpFeQ ================================================================================================= Consensus xxxxxxxxxxxxxxxxxxppytVvYFpVxRGRCeALRMLLADQgQSWKEEVIxxxxxsiesWxegslkxscLYgQ 160 170 180 190 200 210 220 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus LPKFQDGDLtLYQSNaILRHLGRslxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGLYGKNQQEAAlVDMiN ================================================================================================= ONCHOCERCA_VOLVULUS LPclyDGDqqIvQSgAILRHLaRky---------------------------------nLnGENEmEttyIDMfc ================================================================================================= HUMAN LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN MOUSE LPKFEDGDLTLYQSNAILRHLGRSL---------------------------------GLYGKNQREAAqMDMVN PIG LPKFQDGDLTLYQSNAILRHLGRSf---------------------------------GLYGKDQKEAALVDMVN 1EOGA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN 1EOHA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN 1KBNA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN 1PGTA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN 22GSA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN 4GSSA_Human LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN Bos_taurus LPKFQDGDLTLYQSNAILRHLGRTL---------------------------------GLYGKDQQEAALVDMVN Canis_lupus LPKFQDGDLTLYQSNAILRHLGRSL---------------------------------GLYGKDQQEAALLDVVN Capra_hircus LPKFQDGDLTLYQSNAILRHLGRTL---------------------------------GLYGKDQREAALVDMVN Cricetulus_griseus LPKFEDGDLTLYQSNAILRHLGRSL---------------------------------GLYGKDQREAALVDMVN Macaca_mulatta LPKFQDGDLTLYQSNtfLRHLGRTL---------------------------------GLYGKDQREAALVDMVN Mesocricetus_auratus LPKFEDGDLiLYQSNAILRHLGRSL---------------------------------GLYGKDQKEAALVDMaN Pan_troglodytes LPKFQDGDLTLYQSNtILRHLGRTLgwgsqtapwlahpsdcvlirrpvtrpapphptpGLYGKDQQEAALVDMVN Pongo_pygmaeus LPKFQDGDLTLYQSNtILRHLGRTL---------------------------------GLYGKDQREAALVDMVN Rattus_norvegicus LPKFEDGDLTLYQSNAILRHLGRSL---------------------------------GLYGKDQKEAALVDMVN ================================================================================================= PLASMODIUM_FALCIPARUM VPilQiGDLiLaQSqAIVRyLsKky---------------------------------nIcGESElnefyaDMIf ================================================================================================= Consensus LPKFQDGDLtLYQSNaILRHLGRslxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGLYGKNQQEAAlVDMiN 230 240 250 260 270 280 290 300 ----|----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus DGVQDLRcKYiSLIYTnyeagxKDeYVKaxLPgxLKPFETLLSQNQggxxxxKaFIVGNQISFADYNLLDLLlIH ================================================================================================= ONCHOCERCA_VOLVULUS EGVRDLhvKYtrMIYmaYEte-KDpYIKsiLPGeLakFEkLLatrgnG----RnlILGDKISYADYaLfEeLdVH ================================================================================================= HUMAN DGVEDLRCKYISLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH MOUSE DGVEDLRgKYVTLIYTNYEnG-KNDYVKA-LPGhLKPFETLLSQNQGG----KAFIVGDQISFADYNLLDLLLIH PIG DGVEDLRCKYaTLIYTNYEAG-KEKYVKe-LPehLKPFETLLSQNQGG----QAFVVGSQISFADYNLLDLLrIH 1EOGA_Human DGVEDLRCKYISLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQIaFADYNLLDLLLIH 1EOHA_Human DGVEDLRCKYISLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFAaYNLLDLLLIH 1KBNA_Human DGVEDLRCKYISLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQaSFADaNLLDLLLIH 1PGTA_Human DGVEDLRCKYVSLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH 22GSA_Human DGVEDLRCKYISLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH 4GSSA_Human DGVEDLRCKYISLIFTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH Bos_taurus DGVEDLRCKYVSLIYTNYEAG-KEDYVKA-LPqhLKPFETLLSQNKGG----QAFIVGDQISFADYNLLDLLrIH Canis_lupus DGVEDLRCKYalLIYTNYEAG-KEEYVKA-LPGyLKPFETLLSQNEGG----QAFIVGNQISFADYNLLDLLLIH Capra_hircus DGVEDLRCKYVSLIYTNYQAG-KEDYVKA-LPqhLKPFETLLSQNKGG----QAFIVGDQISFADYNLLDLLrIH Cricetulus_griseus DGVEDLRCKYITLIYTkYEeG-KDDYVKA-LPGhLKPFETLLSQNQGG----KAFIVGDQISFvDYNLLDLLLIH Macaca_mulatta DGVEDLRCKYLSLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH Mesocricetus_auratus DGVEDLRCKYVTLIYTkYEeG-KDDYVKA-LPGhLKPFETLLSQNQGG----KAFIVGDQISFADYNLLDLLLIH Pan_troglodytes DGVEDLRCKYVSLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH Pongo_pygmaeus DGVEDLRCKYLSLIYTNYEAG-KDDYVKA-LPGqLKPFETLLSQNQGG----KtFIVGDQISFADYNLLDLLLIH Rattus_norvegicus DGVEDLRCKYgTLIYTNYEnG-KDDYVKA-LPGhLKPFETLLSQNQGG----KAFIVGNQISFADYNLLDLLLVH ================================================================================================= PLASMODIUM_FALCIPARUM cGVQDIhyKFnNt---NlfkqnEttFLnedLPkwsgyFEkLLkKNhtnnnndKyYfVGNnLTYADlaVfNLyddi ================================================================================================= Consensus DGVQDLRcKYiSLIYTnyeagxKDeYVKaxLPgxLKPFETLLSQNQggxxxxKaFIVGNQISFADYNLLDLLlIH 310 320 330 340 350 360 370 ----:----|----:----|----:----|----:----|----:----|----:----|----:----|----: Consensus EVLaPgCLDsFPLLSAYVaRLSaRPKLKAFLxSpehvnrpinGNGKQ ===================================================================== ONCHOCERCA_VOLVULUS QILdPhCLDkFPLLkvFhqRMkdRPKLKeYcekrDaakvPVNGNGKQ ===================================================================== HUMAN EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ MOUSE QVLAPGCLDNFPLLSAYVARLSARPKIKAFLsSPEHVNRPINGNGKQ PIG QVLnPsCLDaFPLLSAYVARLSARPKIKAFLaSPEHVNRPINGNGKQ 1EOGA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ 1EOHA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ 1KBNA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ 1PGTA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ 22GSA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ 4GSSA_Human EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ Bos_taurus QVLAPsCLDSFPLLSAYVARLNsRPKLKAFLaSPEHMNRPINGNGKQ Canis_lupus QVLAPsCLDSFPLLSAYVARLSARPKLKAFLsSPEHVNRPINGNGKQ Capra_hircus QVLAPsCLDSFPLLSAYVARLNsRPKLKAFLaSPEHVNRPINGNGKQ Cricetulus_griseus QVLAPGCLDNFPLLSAYVARLSARPKIKAFLsSPDHVNRPINGNGKQ Macaca_mulatta EVLAPGCLDaFPLLSAYVARLSARPKLKAFLaSPEHVNlPINGNGKQ Mesocricetus_auratus QVLAPGCLDNFPLLSAYVARLSARPKIKAFLsSPDHVNRPINGNGKQ Pan_troglodytes EVLAPGCLDaFPLLSAYVgRLSARPKLKAFLaSPEyVNlPINGNGKQ Pongo_pygmaeus EVLAPGCLDaFPLLSAYVARLSARPKLKAFLaSPEHVNlPINGNGKQ Rattus_norvegicus QVLAPGCLDNFPLLSAYVARLSARPKIKAFLsSPDHLNRPINGNGKQ ===================================================================== PLASMODIUM_FALCIPARUM EtkyPssLkNFPLLkAhnefISnlPnIKnYItNrKesvy-------- ===================================================================== Consensus EVLaPgCLDsFPLLSAYVaRLSaRPKLKAFLxSpehvnrpinGNGKQ