Hemoglobin V/Alpha

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxvlsxaDKsnVKaaWxKVgxNageYGaEaLeRmFlsFPstKtYFphFxxnxlxxxshgSaEV ================================================================================================= CAUDINA_ARENICOLA atqsfqsvgdLTpAEKdlIRstWdQLmtHrtgFvADvfiRIFhNdPTaQrkFPqmagl-spaelrtSrQM ================================================================================================= BOVINE ---------VLSaADKgNVKAAWgKVGgHAaEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV HORSE ---------VLSaADKTNVKAAWsKVGgHAGEYGAEALERMFLgFPTTKTYFPHF--D-L---SHGSAQV HUMAN ---------VLSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV PIG ---------VLSaADKaNVKAAWgKVGgqAGahGAEALERMFLgFPTTKTYFPHF--N-L---SHGSdQV ANSER_ANSER ---------VLSaADKTNVKgvFsKIGgHAeEYGAEtLERMFtaYPqTKTYFPHF--D-L---qHGSAQI ANSER_INDICUS ---------VLSaADKTNVKgvFsKIsgHAeEYGAEtLERMFtaYPqTKTYFPHF--D-L---qHGSAQI CANLA ---------VLSpADKTNIKstWdKIGgHAGDYGgEALDRtFqSFPTTKTYFPHF--D-L---SpGSAQV ODOCOILEUS_VIRGINIANUS ---------VLSaANKSNVKAAWgKVGgNApaYGAQALQRMFLSFPTTKTYFPHF--D-L---SHGSAQq 1IBEA_Horse ---------VLSaADKTNVKAAWsKVGgHAGEFGAEALERMFLgFPTTKTYFPHF--D-L---SHGSAQV 1A3OA_Human ---------VLSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKThFPHF--D-L---SHGSAQV 1AJ9A_Human ---------VLSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSsQV 1GLIA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPwTKTYFPHF--D-L---SHGSAQV 1J7SA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEAyERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1O1OA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1RVWA_Human ---------VLSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1XY0A_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTgTYFPHF--D-L---SHGSAQV 1XYEA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTaFPHF--D-L---SHGSAQV 1XZ5A_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1XZ7A_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1XZUA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1XZVA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1Y09A_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1Y0AA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1Y0CA_Human ----------LSpADKTNVKAAWgKVGaHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV 1C40A_Anser_indicus ---------VLSaADKTNVKgvFsKIsgHAeEYGAEtLERMFtaYPqTKTYFPHF--D-L---qHGSAQI Balaenoptera_acutorostrata ---------VLSptDKSNVKAtWaKIGnHgaEYGAEALERMFMNFPSTKTYFPHF--D-L---gHdSAQV Cebus_apella ---------VLSpADKTNVKtAWgKVGgHAGDYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Chelonia_mydas ---------VLSsgDKaNVKsvWsKVqgHleDYGAEtLDRMFtvFPqTKTYFsHF--D-V---hHGStQI Coturnix_coturnix ---------VLSaADKTNVKgiFaKIagHAeEYGAEALDRMFtTYPqTKTYFPHF--D-V---SHGSAQI Elephas_maximus ---------VLSdkDKTNVKAtWsKVGdHAsDYvAEALERMFfSFPTTKTYFPHF--D-L---SHGSgQV Gallus_gallus ---------VLSaADKNNVKgiFtKIagHAeEYGAEtLERMFtTYPpTKTYFPHF--D-L---SHGSAQI Hylobates_lar ---------VLSpADKTNVKAAWgKVGaHAGDYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Macaca_mulatta ---------VLSpADKTNVKAAWdKVGgHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Mesocricetus_auratus ---------VLSakDKTNIseAWgKIGgHAGEYGAEALERMFfvYPTTKTYFPHF--D-V---SHGSAQV Mus_musculus ---------VLSgeDKSNIKAAWgKIGgHgaEYGAEALERMFaSFPTTKTYFPHF--D-V---SHGSAQV Nycticebus_coucang ---------VLSpADKTNVKAAWeKVGsHAGDYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Oryctolagus_cuniculus ---------VLSpADKTNIKtAWeKIGsHgGEYGAEAVERMFLgFPTTKTYFPHF--D-f---THGSeQI Otolemur_crassicaudatus ---------VLSptDKSNVKAAWeKVGaHAGDYGAEALERMFLSFPTTKTYFPHF--D-L---SHGStQV Papio_hamadryas ---------VLSpdDKkHVKAAWgKVGeHAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSdQV Physeter_catodon ---------VLSpADKTNVKAAWaKVGnHAaDFGAEALERMFMSFPSTKTYFsHF--D-L---gHnStQV Presbytis_entellus ---------VLSpADKTNVKAAWgKVGgHgGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Rattus_norvegicus ---------VLSadDKTNIKncWgKIGgHgGEYGeEALQRMFaaFPTTKTYFsHi--D-V---SpGSAQV Rousettus_aegyptiacus ---------VLSsADKTNIKAAWdKVGgNAGEYGAEALERMFLSFPTTKTYFPHF--D-L---SHGSAQV Struthio_camelus ---------VLSgtDKTNVKgiFsKIssHAeEYGAEtLERMFITYPqTKTYFPHF--D-L---hHGSAQI Tursiops_truncatus ---------VLSpADKTNVKgtWsKIGnHsaEYGAEALERMFINFPSTKTYFsHF--D-L---gHGSAQI ================================================================================================= 1IT2B.EPTATRETUS_BURGERI piidqgplptLTdgDKkaInkiWpKIykeyeQYslniLlRflkcFPqaQasFPkFstkks--nleqdpEV ================================================================================================= LAMPETRA_FLUVIATILIS pivdsgsvapLSaAEKTkIRsAWapVysNyetsGvDiLvKfFtStPaaQeFFPkFkgmtsadqlkkSADV PETROMYZON_MARINUS pivdtgsvapLSaAEKTkIRsAWapVystyetsGvDiLvKfFtStPaaQeFFPkFkglttadqlkkSADV ================================================================================================= Consensus xxxxxxxxxvlsxaDKsnVKaaWxKVgxNageYGaEaLeRmFlsFPstKtYFphFxxnxlxxxshgSaEV 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus RgHgKKVadALsxAvxhVxxxDxxnMpxaLsxLSnlHAhklRVNPvNFKlLshclLvtLAxxxxxxxxxx ================================================================================================= CAUDINA_ARENICOLA haHaiRVsalMTtyIdeMdte---vLPelLatLTrtHdkn-hVgkkNYdLfgkvLMeaIkaelgvgftkq ================================================================================================= BOVINE KGHGaKVAaALTkAVeHL---D--DLPgALSeLSDLHAHKLRVDPVNFKLLSHsLLVTLAs--------- HORSE KaHGKKVgDALTlAVgHL---D--DLPgALSbLSBLHAHKLRVDPVNFKLLSHCLLsTLAv--------- HUMAN KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- PIG KaHGQKVADALTkAVgHL---D--DLPgALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- ANSER_ANSER KaHGKKVAaALveAVnHI---D--DIagALSkLSDLHAqKLRVDPVNFKfLgHCfLVvVAi--------- ANSER_INDICUS KaHGKKVvaALveAVnHI---D--DIagALSkLSDLHAqKLRVDPVNFKfLgHCfLVvVAi--------- CANLA KaHGKKVADALTtAVaHL---D--DLPgALSaLSDLHAyKLRVDPVNFKLLSHCLLVTLAc--------- ODOCOILEUS_VIRGINIANUS KaHGQKVANALTkAqgHL---N--DLPgtLSnLSNLHAHKLRVNPVNFKLLSHsLLVTLAs--------- 1IBEA_Horse KaHGKKVgDALTlAVgHL---D--DLPgALSdLSNLHAHKLRVDPVNFKLLSHCLLsTLAv--------- 1A3OA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1AJ9A_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1GLIA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1J7SA_Human KGqGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1O1OA_Human KGHGKKLADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1RVWA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPwNFKLLSHCLLVTLAa--------- 1XY0A_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1XYEA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1XZ5A_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKaRVDPVNFKLLSHCLLVTLAa--------- 1XZ7A_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLaVDPVNFKLLSHCLLVTLAa--------- 1XZUA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVgPVNFKLLSHCLLVTLAa--------- 1XZVA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDaVNFKLLSHCLLVTLAa--------- 1Y09A_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVaFKLLSHCLLVTLAa--------- 1Y0AA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1Y0CA_Human KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- 1C40A_Anser_indicus KaHGKKVvaALveAVnHI---D--DIagALSkLSNLHAqKLRVDPVNFKfLgHCfLVvVAi--------- Balaenoptera_acutorostrata KGHGKKVADALTkAVgHM---D--NLldALSdLSDLHAHKLRVDPaNFKLLSHCLLVTLAl--------- Cebus_apella KGHGKKVADALSnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Chelonia_mydas RsHGKKVmlALgdAVnHI---D--DIatALSaLSDkHAHiLRVDPVNFKLLSHCLLVvVAr--------- Coturnix_coturnix KGHGKKVAaALveAanHI---D--DIagtLSkLSDLHAqKLRVDPVNFKLLgqCfLVvVAi--------- Elephas_maximus KGHGKKVgEALTqAVgHL---D--DLPsALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLss--------- Gallus_gallus KGHGKKVvaALieAanHI---D--DIagtLSkLSDLHAHKLRVDPVNFKLLgqCfLVvVAi--------- Hylobates_lar KGHGKKVADALTnAVaHV---D--DMPnALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Macaca_mulatta KGHGKKVADALTlAVgHV---D--DMPhALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Mesocricetus_auratus KGHGKKVADALTnAVgHL---D--DLPgALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAn--------- Mus_musculus KGHGKKVADALasAagHL---D--DLPgALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAs--------- Nycticebus_coucang KaHGKKVADALTnAVsHV---D--DMPsALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAc--------- Oryctolagus_cuniculus KaHGKKVsEALTkAVgHL---D--DLPgALStLSDLHAHKLRVDPVNFKLLSHCLLVTLAn--------- Otolemur_crassicaudatus KGHGKKVADALTnAVlHV---D--DMPsALSaLSDLHAHKLRVDPVNFKLLrHCLLVTLAc--------- Papio_hamadryas nkHGKKVADALTlAVgHV---D--DMPqALSkLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Physeter_catodon KGHGKKVADALTkAVgHL---D--tLPdALSdLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Presbytis_entellus KGHGKKVADALTnAVaHV---D--DMPhALSaLSDLHAHKLRVDPVNFKLLSHCLLVTLAa--------- Rattus_norvegicus KaHGKKVADALakAadHV---E--DLPgALStLSDLHAHKLRVDPVNFKfLSHCLLVTLAc--------- Rousettus_aegyptiacus KGHGKKVgDALTnAVgHL---D--DLPgALSaLSDLHAyKLRVDPVNFKLLSHCLLVTLAn--------- Struthio_camelus KaHGKKVANALieAVnHI---D--DIsgALSkLSDLHAqKLRVDPVNFKLLgqCfLVvVAi--------- Tursiops_truncatus KGHGKKVADALTkAVgHI---D--NLPdALSeLSDLHAHKLRVDPVNFKLLSHCLLVTLAl--------- ================================================================================================= 1IT2B.EPTATRETUS_BURGERI KhqavvIfNkVNeiInsMd--NqeeIiksLkdLSqkHktvfKVDsIwFKeLSsifVsTIdg--------- ================================================================================================= LAMPETRA_FLUVIATILIS RwHaERIiNAVNdAVasMd--DtekMsmkLrdLSgkHAksfQVDPqyFKVLaavIadTVAa--------- PETROMYZON_MARINUS RwHaERIiNAVNdAVasMd--DtekMsmkLrdLSgkHAksfQVDPqyFKVLaavIadTVAa--------- ================================================================================================= Consensus RgHgKKVadALsxAvxhVxxxDxxnMpxaLsxLSnlHAhklRVNPvNFKlLshclLvtLAxxxxxxxxxx 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus hxpxdftpavHAslDKflasVstVLtsKY ======================================================== CAUDINA_ARENICOLA v---------HdawaKtfAiVqgVLiTKh ======================================================== BOVINE HlPsDFTPAVHASLDKFLANVSTVLTSKY HORSE HlPnDFTPAVHASLDKFLsSVSTVLTSKY HUMAN HlPaEFTPAVHASLDKFLASVSTVLTSKY PIG HhPdDFnPsVHASLDKFLANVSTVLTSKY ANSER_ANSER HhPsalTPeVHASLDKFLcaVgTVLTaKY ANSER_INDICUS HhPsalTaeVHASLDKFLcaVgTVLTaKY CANLA HhPtEFTPAVHASLDKFftaVSTVLTSKY ODOCOILEUS_VIRGINIANUS HlPtNFTPAVHANLNKFLANdSTVLTSKY 1IBEA_Horse HlPnDFTPAVHASLDKFLsSVSTVLTSKY 1A3OA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1AJ9A_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1GLIA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1J7SA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1O1OA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1RVWA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XY0A_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XYEA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XZ5A_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XZ7A_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XZUA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1XZVA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1Y09A_Human HlPaEFTPAVHASLDKFLASVSTVLTSKY 1Y0AA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKa 1Y0CA_Human HlPaEFTPAVHASLDKFLASVSTVLTSKF 1C40A_Anser_indicus HhPsalTaeVHASLDKFLcaVgTVLTaKY Balaenoptera_acutorostrata HlPaEFTPsVHASLDKFLASVSTVLTSKY Cebus_apella HhPaDFTPAVHASLDKFLASVSTVLTSKY Chelonia_mydas HhPtlFTPdVHvSLDKFMgTVSTVLTSKY Coturnix_coturnix HhPaalTPeVHASLDKFLcaVgTVLTaKY Elephas_maximus HqPtEFTPeVHASLDKFLsNVSTVLTSKY Gallus_gallus HhPaalTPeVHASLDKFLcaVgTVLTaKY Hylobates_lar HhPaEFTPAVHASLDKFLASVSTVLTSKY Macaca_mulatta HlPaEFTPAVHASLDKFLASVSTVLTSKY Mesocricetus_auratus HhPaDFTPAVHASLDKFfASVSTVLTSKY Mus_musculus HhPaDFTPAVHASLDKFLASVSTVLTSKY Nycticebus_coucang HhPaDFTPAVHASLDKFLASVSTVLTSKY Oryctolagus_cuniculus HhPsEFTPAVHASLDKFLANVSTVLTSKY Otolemur_crassicaudatus HhPaEFTPAVHASLDKFMASVSTVLTSKY Papio_hamadryas HlPaEFTPAVHASLDKFLASVSTVLTSKY Physeter_catodon HlPgDFTPsVHASLDKFLASVSTVLTSKY Presbytis_entellus HlPaEFTPAVHASLDKFLASVSTVLTSKY Rattus_norvegicus HhPgDFTPAMHASLDKFLASVSTVLTSKY Rousettus_aegyptiacus HlPsDFTPAVHASLDKFLASVSTVLTSKY Struthio_camelus HhPsalTPeVHASLDKFLcaVgaVLTaKY Tursiops_truncatus HlPaDFTPsVHASLDKFLASVSTVLTSKY ======================================================== 1IT2B.EPTATRETUS_BURGERI ----------gAefEKlfsiIciLLrSaY ======================================================== LAMPETRA_FLUVIATILIS g---------dAgfEKlMsmIciLLrSaY PETROMYZON_MARINUS g---------dAgfEKlMsmIciLLrSaY ======================================================== Consensus hxpxdftpavHAslDKflasVstVLtsKY