Poly(A) polymerase

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== YEAST ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- ==================================================================================================== BOVINE ---------------------------------------------------------------------- Apis_mellifera -wssq----------------------------------------------------------------- Canis_lupus sgrkaqaeageehrg-----yptldntvaemrvvaeemekg-vtsdgfwrcnsqela-mgwlqlvsdcr- Danio_rerio ---------------------------------------------------------------------- Drosophila_melanogaster ----wn---------------------------------------------------------------- Gallus_gallus agfsqntgsggikrercaclypaakreas-----lsfrnagevsptaperaifpryagvgdsggvspavp Homo_sapiens -gtsnspghssfsa-------pstkkikt-----trkqnia----------------------------- Mus_musculus ---------------------------------------------------------------------- Rattus_norvegicus ---------------------------------------------------------------------- Strongylocentrotus_purpuratus ---------------------------------------------------------------------- Xenopus_laevis ---------------------------------------------------------------------- Xenopus_tropicalis ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxpxstqxxxxxxsxxsxxxxqqxygittpislaxpkexdxxxtqelleslkpygvfe ==================================================================================================== YEAST --------------------------------ssQkvfgiTgpvstvgataaenklnDsLiqelkkegsf Candida_glabrata --------------------------------nyQkvygiTgpvsiagptaaenklnDeLiqelkkensf Eremothecium_gossypii --------------------------------sQQkvygvTgpiskegptaaenklnDeLiqelkkegtf Kluyveromyces_lactis --------------------------------sQKkifgvTgpistegptaaenalnDsLiqqlkkegsf ==================================================================================================== BOVINE ------------pfPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcllTQKLVETLKPFGVFE Apis_mellifera ------------gnnsNSn-----nSske-eknlRtlGMTSaISVAePKpsDftrTnELkEaLKPYnVFE Canis_lupus n-plavilsnfvcsPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE Danio_rerio ------------pfPiTSQ------vqta-qptpKhYGITSPISLApPKEaDlvlTRKLtETLRPFGVFE Drosophila_melanogaster ------------sePthrQhhqhngNstSggppaKqlGMTSaISLAePRpeDlqrTdELrgSLEPYnVFE Gallus_gallus aqplslrnspg-plPvTTQ-----gS-qT-qqlQKhYGITSPISLAaPKEfDcmlTQKLIETLKPYGVFE Homo_sapiens ------------pfPvTTQ-----gSqqT-qppQKhYGITSPISLAaPKEtDcvlTQKLIETLKPFGVFE Mus_musculus ------------pfPvTTQ-----gSqqT-qppQRhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE Rattus_norvegicus ------------pfPvTTQ-----gSqqT-qppQRhYGITSPISLAaPKEtDcllTQKLIETLKPFGVFE Strongylocentrotus_purpuratus ----------------STa-----sSesS---tKKtYGITSaISLvgPRpeDnrqTKELVEaLKPhGVFE Xenopus_laevis ------------pfPlaSQ-----gSqqS----QKtYGITSPISLAtPKDtDctlTQKLIETLKPYGVFE Xenopus_tropicalis --------------reTlg-----sSvla-gqppKhYGITSPISLAgPKDtDhiyTQKLtEaMRPFGVFE ==================================================================================================== Consensus xxxxxxxxxxxxxxpxstqxxxxxxsxxsxxxxqqxygittpislaxpkexdxxxtqelleslkpygvfe 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus deeqlxxkivivgkinxllkewireisexknlpxnvmexvggkiftfgsyrlgvhtkgadidalcvaprn ==================================================================================================== YEAST EtEQetanrVqVlKIlqeLaQrfvyevskKknmsDgMardaGgkiftygsyrlgvhgpgsdidtlVvvpk Candida_glabrata EsEQetanrVkVlKtlqeLtEkfvyevskKknmsDgMardaGgkiftygsyrlgvhgpgsdidtlVvvpk Eremothecium_gossypii EsEEetaKrIkVlEelqaLaQefvfkvsrKrnmsegMardaGgkiftfgsyrlgvhgpgsdidtlVvvpk Kluyveromyces_lactis EtEEetgKrVaVlEIfqkLtQefvyqvskKknmsDgMardaGgkvftfgsyrlgvhgpgsdidtlIvvpk ==================================================================================================== BOVINE EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Apis_mellifera sEEELnhRMeILsKLNaLVKQWIRDtSvaRNMPpNVaEqVGGKIYTFGSYRLGVHhKGADIDALCVvPRH Canis_lupus EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Danio_rerio EElELqrRILVLGKLNtLVKfWIREVSEaKNIPaSVIDsVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Drosophila_melanogaster sQDELnhRMeILaKLNtLVKQWVKEISvsKNMPeSaaEkLGGKIYTFGSYRLGVHhKGADIDALCVAPRN Gallus_gallus EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Homo_sapiens EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Mus_musculus EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Rattus_norvegicus EEEELqrRILILGKLNnLVKEWIREISEsKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Strongylocentrotus_purpuratus NEEELnhRLVVLGKLDqIVKDWIRlVaEeKNIPpNIaDtVGGKIYTFGSYRLGVHTKGADIDtLCVAPlH Xenopus_laevis EEDELqhRILILGKLNnLVKEWIREISElKNLPqSVIEnVGGKIFTFGSYRLGVHTKGADIDALCVAPRH Xenopus_tropicalis DDaELshRMVVLGKLNnLVKEWIgELgEqKSLPpSIIsaVGGKIFTFGSYRLGVHTKGADIDsLCVAPRH ==================================================================================================== Consensus deeqlxxkivivgkinxllkewireisexknlpxnvmexvggkiftfgsyrlgvhtkgadidalcvaprn 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus vdrseffstffdelkkeekvkdlraveeafvpviklxfdgieidilfarlalqxipenldlrddsllknl ==================================================================================================== YEAST hvtrEdFfTvFDsLlRErKelDeiApvpdafvpIikikfsgisidLicarldQpqvplsltlsDknLlrn Candida_glabrata hvtrEdFfTvFDaLlRErEelDeiApvpdafvpIiklkfsgisidLicakldiaqvKpsltlDDkaLlrn Eremothecium_gossypii hvtrDdFfTvFDELlRarpelDeiApvpeafvpIikikysgisidLicarldipqvplnltlsDknLlrn Kluyveromyces_lactis hvsrEdFfTvFDaLlRErpelEeiAsvpdafvpIikikfngisidLifakldlpqvpisltlsDknLlrn ==================================================================================================== BOVINE VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Apis_mellifera IyRSDYFTSFFElLKmQEEVtDLRAVEEAFVPVIKMnFDGIEIDMLFAKLALKeIPDSMDLRDDmLLKNL Canis_lupus VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Danio_rerio VERTDFFSSFYEKLKEQEEVKDLRAVEEAFVPVIKLaFDGIEIDILFARLALQtIPENLDLRDDgLLKNL Drosophila_melanogaster IERTDYFqSFFEvLKKQpEVtEcRsVEEAFVPVIKMnFDGIEIDLLFARLsLKeIPDDfDLRDDNLLRNL Gallus_gallus VERSDFFTSFYEKLKQQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Homo_sapiens VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Mus_musculus VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Rattus_norvegicus VDRSDFFTSFYDKLKlQEEVKDLRAVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Strongylocentrotus_purpuratus VERSDFFkSFYDiVKalpEtKDcRAVEEAFVPVIKLvFDGIEMDILFARLALRvVPENLDLtDDSLLKNL Xenopus_laevis VDRSDFFSSFYEKLKQQEEVKDLRsVEEAFVPVIKLcFDGIEIDILFARLALQtIPEDLDLRDDSLLKNL Xenopus_tropicalis VERSDFFqSFsEKLKQQDgIKNLRAVEDAFVPVIKfeFmntEIDLVFARLpLQcIPDNLDLRDDSrLRNL ==================================================================================================== Consensus vdrseffstffdelkkeekvkdlraveeafvpviklxfdgieidilfarlalqxipenldlrddsllknl 290 300 310 320 330 340 350 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus dikcirslngcrvtddiihllpniesfrltlraiklwakqhxiysniigflggvswammlartcqlypna ==================================================================================================== YEAST ldEkdlralngtrvtDeIleLvpkpNvfrialraiklwaQrravyanIfgfpGgvawaMLvaricqlypn Candida_glabrata ldEkdlralngtrvtDeIleLvpkpSvfrialraikiwaQrraiyanVfgfpGgvawaMLvaricqlypn Eremothecium_gossypii ldEkdlralngtrvtDeIleLvpkpTafkialraiklwaQrravyanVfgfpGgvawaMLvaricqlypn Kluyveromyces_lactis vdEkdlralngtrvtDeIleLvpnKTsfkialraikiwaKrravyanVfgfpGgvawaMfvvricqlypn ==================================================================================================== BOVINE DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Apis_mellifera DqKCVRSLNGCRVTDEILrLVPNIENFRLaLRAIKLWAKRHgIYSNVLGYLGGVSWAMLVARTCQLYPNA Canis_lupus DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Danio_rerio DIRCIRSLNGCRVTDEILHLVPNIENFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Drosophila_melanogaster DhRsVRSLNGCRVTDEILaLVPNIENFRLaLRtIKLWAKKHgIYSNsLGYfGGVTWAMLVARTCQLYPNA Gallus_gallus DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Homo_sapiens DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Mus_musculus DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Rattus_norvegicus DIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Strongylocentrotus_purpuratus DpKCVRSLNGCRVTDEILNVVPSkENFRLTLRtIKLWAKKkgVYSNaLGFLGGVSWAMLVARTCQLYPNA Xenopus_laevis DIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKRHnIYSNILGFLGGVSWAMLVARTCQLYPNA Xenopus_tropicalis DIRCIRSLNGCRVTDEILHLVPNkENFRLTLRAIKLWAKRrgIYSNMLGFLGGVSWAMLVARTCQLYPNA ==================================================================================================== Consensus dikcirslngcrvtddiihllpniesfrltlraiklwakqhxiysniigflggvswammlartcqlypna 360 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs ==================================================================================================== YEAST acSaVIlnrFfIilsewnwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS Candida_glabrata acSaVIlnrFfkilsewkwpqpVIlKPiEdgpLqVrVWNPKIyaqDRsHrMPVITPAYPsmcaThNITeS Eremothecium_gossypii acSaVIvarFfhiltrwswpqpVLlKPiEdgpLqVrVWNPKIyaNDRlHkMPVITPAYPsmcSThNIceS Kluyveromyces_lactis acSaVIiskFfqilsrwkwpqpVLlKPiEdgpLqVrVWNPKIyaqDRsHkMPVITPAYPsmcaThNISeS ==================================================================================================== BOVINE IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Apis_mellifera VAaTLIeKFFLVFSQWKWPqPVLLKQPDNv-NLgfPVWDPRVNiSDRYHLMPIITPAYPQQNSTFNVSVS Canis_lupus IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Danio_rerio VAaTLVHKFFLVFSKWEWPNPVLLKQPEDc-NLNLPVWDPRVtPSDRYHLMPIITPAYPQQNSTYNVSaS Drosophila_melanogaster aAaTLVHKFFLVFSRWKWPNPVLLKhPDNv-NLrfqVWDPRVNaSDRYHLMPIITPAYPQQNSTFNVSeS Gallus_gallus IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Homo_sapiens IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Mus_musculus IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Rattus_norvegicus IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Strongylocentrotus_purpuratus aASTLVNKFFLVFTKWaWPqPVLLKpPNtsteLgfaeWDPRVNvSDRFHLMPIITPAYPQQNSTYNVSqS Xenopus_laevis IASTLVHKFFLVFSKWEWPNPVLLKQPEEc-NLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVS Xenopus_tropicalis IASTLVHKFFLVFSKWEWPNPVLLKQPEDs-NLNLPVWDPRVNPaDRcHLMPIITPAYPQQNSTYNVSIS ==================================================================================================== Consensus iastvihkfflifskwewpnpvvikqpddxxnlnlpvwnpkinpsdrfhlmpvitpaypqqnstynitvs 430 440 450 460 470 480 490 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus tkxvilqefqrgvaitneillnkaxwsklfeapNFFxRYKhYLvIMASaxxSDEExLKWvGLVESKVRLL ==================================================================================================== YEAST TKkVILQEFvRGVqITNDIfsNKksWanLFEknDFFfRYKfYLeItAytrgSDEQhLKWsGLVESKVRLL Candida_glabrata TKaVILKElnRGIqVTNDIfayKktWadLFtkhDFFfQYKyYLtItAatrgdDEEhLKWsGLVESKLRLL Eremothecium_gossypii TKkVILnElQRGVeVTtDIftNKktWgdLFQkhDFFyKYKfYLtVMAStkgSDEQhLKWsGLVESKLRLL Kluyveromyces_lactis TKkVILsElQRGVeVTqKIfsNElsWedLFKkhDFFfKYKfYLtVMvStkgSDEQhLKWsGfVESKLRLL ==================================================================================================== BOVINE TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Apis_mellifera TRtIMqEaFEnGLsITeEIIMgKAtWdKLFEpPNFFgKYKHYIVLLArsl-TaEDqLEWcGLVESKIRhL Canis_lupus TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Danio_rerio TRaIMVEEFKRGLAITDEILqNKAdWSKLFEAPNFFqKYKHYIVLLASAq-TEKQhLEWVGLVESKIRIL Drosophila_melanogaster TKkVILtEFnRGMnITDEIMLgRipWeRLFEAPSFFyRYRHFIVLLvNsq-TaDDhLEWcGLVESKVRLL Gallus_gallus TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Homo_sapiens TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Mus_musculus TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Rattus_norvegicus TRmVMVEEFKQGLAITDEILLSKAeWSKLFEAPNFFqKYKHYIVLLASAp-TEKQrLEWVGLVESKIRIL Strongylocentrotus_purpuratus TKtVIeQElQgGLAITqEIMqgKAtWeKLFEssNFFgKYKHYIVLIASAg-NEDDhLKWVGLVESKIRVL Xenopus_laevis TRaVMVEEFKQGLAITDEILLlKAeWSKLFDAPNFFqKYKHYILLLASAp-TEKQrLEWVGLVESKIRIL Xenopus_tropicalis TRsVMVEEFKQGLsVTDEILLgRcdWSKLFEpPNFFhKYKHYIVLtASAs-TEEhhLEWVGLVESKIRVL ==================================================================================================== Consensus tkxvilqefqrgvaitneillnkaxwsklfeapNFFxRYKhYLvIMASaxxSDEExLKWvGLVESKVRLL 500 510 520 530 540 550 560 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus VgsLEknxfItIAHvnpKsFxpxxxxxxxxxxpkdnxekxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== YEAST VmkLEvlagIkIAHpftKpF-e--------s-------syccpteddyemiqdkygshktetalnalklv Candida_glabrata tlkLEtipgIkLAHpffKpF-e--------a-------aycytddqdaktilnnhgshitekalekftkv Eremothecium_gossypii VlkLEvlsgInLAHpytKpF-e--------s-------tyaykteeqykeifdnygthktedvlkkytev Kluyveromyces_lactis VqkLEvlpgInLAHpfiEpY-e--------s-------syiynnedeykeimnnygthktegvlkkftki ==================================================================================================== BOVINE VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK------------------------------- Apis_mellifera IGTLERNphITLAHVNPEaF-P----------PlE-pEp------------------------------- Canis_lupus VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK------------------------------- Danio_rerio VGNLEKNeFITLAHVNPQSF-P--------g-PKEgnDK------------------------------- Drosophila_melanogaster IGNLERNphIaLAHVNPKcF-efkkgzsann-sQNNsgn------------------------------- Gallus_gallus VGNLEKNeFITLAHVNPQSF-P--------a-PKENpDK------------------------------- Homo_sapiens VGSLEKNeFITLAHVNPQSF-P--------a-PKENpDK------------------------------- Mus_musculus VGSLEKNeFITLAHVNPQSF-P--------a-PKESpDR------------------------------- Rattus_norvegicus VGSLEKNeFITLAHVNPQSF-P--------a-PKESpDR------------------------------- Strongylocentrotus_purpuratus VGNLERNphIkLAHVyPKSisP--------stPlDgsEE------------------------------- Xenopus_laevis VGSLEKNeFITLAHVNPQSF-P--------a-PsENsEK------------------------------- Xenopus_tropicalis VGNLERNsFITLAHVNPQSF-P--------g-nRDHcKd------------------------------- ==================================================================================================== Consensus VgsLEknxfItIAHvnpKsFxpxxxxxxxxxxpkdnxekxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 570 580 590 600 610 620 630 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxexxxexxxxxxxxxxxxxxxxfxTmwxIGLvFkkxensenvsvDItfdiQsFtDt ==================================================================================================== YEAST tdenkeeesikdapka---y----------------lsT-myIGLdFnienkkEkV--DIhipcteFvNl Candida_glabrata tdenkddedvkskkkv---h----------------itT-myVGLgvsvenkkEkI--DMhipcgeFfNl Eremothecium_gossypii tnenkddeslkgmekv---h----------------itT-myIGLniavdEkk-kI--DIhvpcQeFfNl Kluyveromyces_lactis tdankddeasknsnqv---h----------------iaT-mfIGLdinteESk-kI--DIhipcQeFfNl ==================================================================================================== BOVINE ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Apis_mellifera ---------------E---r----------------hcSMWfIGLLFaK---SENLNVDLTYDIKSFvDS Canis_lupus ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Danio_rerio ---------------E---E----------------FsTMWvIGIVFKKmEgSENLNVDLTFDIQSFTDT Drosophila_melanogaster ---------------E---DdlkqsqgnqsavtsapFcSMWfIGLeF---ErSENLNVDLTesIQNFTEh Gallus_gallus ---------------E---E----------------YrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Homo_sapiens ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Mus_musculus ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Rattus_norvegicus ---------------E---E----------------FrTMWvIGLVFKKtENSENLSVDLTYDIQSFTDT Strongylocentrotus_purpuratus ---------------EktdE----------------hsTLWfIGLeFQplgpatN--VNLTlDIQfFvNT Xenopus_laevis ---------------E---E----------------FrTMWvIGLVFKKmENSENLSVDLTYDIQSFTDT Xenopus_tropicalis ---------------n---E----------------YvSMWfLGIIFKKvENaESVNIDLThDIQSFTDT ==================================================================================================== Consensus xxxxxxxxxxxxxxxexxxexxxxxxxxxxxxxxxxfxTmwxIGLvFkkxensenvsvDItfdiQsFtDt 640 650 660 670 680 690 700 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus vyrqaisxxkmxKxxmkLxaxhVKkrELhExVpsxllqrxkkknsxkglxxxxxxxxxkxxxlnnsslnl ==================================================================================================== YEAST crsfnedygd-hKvf-nLalrfVKgyDLpDeVfdeneKRpsKKSkrKnLdarh--etvKrsksD------ Candida_glabrata crnfheSyqn-pEvy-sLviryLKsyELpDdVfgedeQRptKKlSkKrkeakydeeaaKrskae------ Eremothecium_gossypii crsfq-eyed-tEtf-sLvikyVKlyDLpDhVydegeQRpvKaSkkRknekag--kkaKrpksSSvlaad Kluyveromyces_lactis crsl-pdyed-pEty-sLiikyVKvhDLpDeVyqegetRpvKsSkkRkpeksg--eksKrpksD------ ==================================================================================================== BOVINE VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPShVLQK-KKKHStEGV---------KltpLNDSSLDL Apis_mellifera IlRQAeq-lsMlKegMwIevkHVKKRDLHtyVspsLLKR-ERK--vsG-------------tVHkNg-NI Canis_lupus VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEGV---------RltpLNDSSLDL Danio_rerio VYRQAIT-sKMfEqdMKItAmHVKRKQLHQlLPevaIhRsKRKHSsdGV---------R--aMNDSNLDL Drosophila_melanogaster VmmhgVN-iKMlKegMtIdArHVKRKQLslyLdSdfLKR-ERK-SmEsh---------n--nfNN-TL-L Gallus_gallus VYRQAIN-sKMfEmdMKIaArHVKRKQLHQlLPNhVLQK-KKKHStEGV---------RltaLNDSSLDL Homo_sapiens VYRQAIN-sKMfEvdMKIaAmHVKRKQLHQlLPNhVLQK-KKKHStEGV---------KltaLNDSSLDL Mus_musculus VYRQAIN-sKMfEldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEGV---------KltaLNDSSLDL Rattus_norvegicus VYRQAIN-sKMfEldMKIaAmHVKRKQLHQlLPShVLQK-RKKHStEGV---------KlaaLNDSSLDL Strongylocentrotus_purpuratus VhRhsVT-iKLlQegMKIeAkHVKR--yeEqaPT--------gNaaE-------------ip----TIkV Xenopus_laevis VYRQAIN-sKMfEteMKIaAmHVKRKQLHQlLPShVLpK-KKKHSvEGV---------KlvsLNDSSIDL Xenopus_tropicalis VYRQAnN-inMlKkgMRIeAtHVKRKQLHhyLhaeVLQK-RKKqSvpdInrsasallsKrtsLDgNcLDs ==================================================================================================== Consensus vyrqaisxxkmxKxxmkLxaxhVKkrELhExVpsxllqrxkkknsxkglxxxxxxxxxkxxxlnnsslnl 710 720 730 740 750 760 770 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus sinsessxsvxspsnxxkxxxxxssplxnsgxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxs ==================================================================================================== YEAST aaSgD-------niNgttaavdvN---------------------------------------------- Candida_glabrata TISks-------avSeattvssa----------------------------------------------- Eremothecium_gossypii aeDSt-------maDgstvseepqpPLsNTtapStntgaelsvaaggASt-------------------- Kluyveromyces_lactis psNgKSTtTtsgnTNssspvndaN-stpSSnvpansnTNaitedpmtATt-------------------- ==================================================================================================== BOVINE SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtniQatE-V-sLPqiNsSeS Apis_mellifera a-gNgNSgSV-SP----------rNP----G-nTtnRkrlsdqnqd-ASIkkrKvnD-g-eqPsvthhge Canis_lupus SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtnpQatE-V-sVPqvNsTeS Danio_rerio SLDSDNSmSVpSPTgp-s-----aakIarap-spQGsTgtatntSelqgkteatgeN-t-hLasvDgTsS Drosophila_melanogaster anrkrlSteLaqsqDplp-----pgqqpSSG--NRGRdS------g-AkIqrlsd-----sLteeNsNaS Gallus_gallus SMDSDNStSVpSPTSamK-----TSPLnSSG-sSQGRSSpapavTa-ASVtniQasE-V-tVPqtNsSeS Homo_sapiens SMDSDNSmSVpSPTSatK-----TSPLnSSG-sSQGRNSpapavTa-ASVtniQatE-V-sVPqvNsSeS Mus_musculus SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeS Rattus_norvegicus SMDSDNSmSVpSPTSamK-----TSPLnSSG-sSQGRNSpapavTa-ASVtsiQasE-V-sVPqaNsSeS Strongylocentrotus_purpuratus TapdEdT---qePS--iK-------PsgDda-qTfkRpSspppvSe-spskkvRtdNgV-tIP-----dT Xenopus_laevis SVDSDNSmSVpSPTNatR-----TSPLnSSG-lSQG-NSpatpvS--lSVtntQatD-V-mVPqnNsTeN Xenopus_tropicalis SrDTDTgtpcdSPTSchK-----SSrsdSpslpdaqRqSllektSt-gcsqkmadvh-VhaePaqglSip ==================================================================================================== Consensus sinsessxsvxspsnxxkxxxxxssplxnsgxxsqgrsnxxxxxsxxasvxxxqxxdxvxxlpxxnxsxs 780 790 800 810 820 830 840 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxgxxxxxixqsxxexxxsxxxxpsxxxxxxxxrlxspxxkxxxxxxxsgsxxxxxxxxixxpixxxkxx ==================================================================================================== YEAST ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- ==================================================================================================== BOVINE sgGtssesIpQTatQpaiSsppkPTvsrvvsstRLvNPppRp------SGNaa----akIpnPIvgvKrt Apis_mellifera dgsl----VvQScgEdsnSgfsldeykqtlsaaK----degp------TGast----vaqegyVct---- Canis_lupus sgGtssesIpQTatQpaiSpppkPTvsrvvsstRLvNPppRp------SGNaa----tkIpnPIvgvKrt Danio_rerio snasgkgaappqstsp-iqsekkPSe-----q----NPlpsp------clSae----paVkrPasalEne Drosophila_melanogaster s-------------DmgagtpttPT------taQLsaPsfKs------SGkng----seI--dVve-Qep Gallus_gallus sgGssnesIpQTatQpaiSpppkPTisriassthLlNPspRi------SGNva----tktpsPVtavKrt Homo_sapiens sgGtssesIpQTatQpaiSpppkPTvsrvvsstRLvNPppRssgnaatSGNaa----tkIptPIvgvKrt Mus_musculus pgGpssesIpQTatQpaiSpppkPTvsrvvsstRLvNPspRp------SGNta----tkVpnPIvgvKrt Rattus_norvegicus pgGpssesIpQTatQpaiSpppkPTvsrvvsstRLvNPspRp------SGNaa----tkVpnPIvgvKrt Strongylocentrotus_purpuratus kqGeddseVkETeeEe--------------detQtfk---Rp------Ss----------piPVl----e Xenopus_laevis sgGslnesIpETathpafSstprPlvtrvvssmRLvNqvqKp------vtNtv----tkMpsPVagvKrt Xenopus_tropicalis viGskpesaivvkgllppSgctiPTvvglnvipRLpSPpnfs------qGNttqnglinLspksaaaKra ==================================================================================================== Consensus xxgxxxxxixqsxxexxxsxxxxpsxxxxxxxxrlxspxxkxxxxxxxsgsxxxxxxxxixxpixxxkxx 850 860 870 880 890 900 910 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus sxpxxxesxxxxkxxxxexxsxxxxxxxxxxxdxxexeexxxxxxxxxxxxxxxxxxxxxxxqkxxsxdl ==================================================================================================== YEAST ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- ==================================================================================================== BOVINE SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqldtetsttqsetiqtatsllasQKtsStDL Apis_mellifera ---------------------------------------------------------------------- Canis_lupus SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqldtetsttqsetihtaasllasQKtsStDL Danio_rerio mt-kkaKvedlsapea-KssgetdghvapaivEvipsDgelktetelmvedtaekvp--l-aQKtsNaDL Drosophila_melanogaster TqPhnngN-----ass-nttTtevacs------------------------------------------- Gallus_gallus SsPhkeDSpkkmKieeqDeiSettscidvnehErmEtKElletevn-vnsqmehlqttlqapQKtpStDL Homo_sapiens SsPhkeESpkktKtee-DetSedanclalsghDktEaKEqldtetsttqsetiqtaasllasQKtsStDL Mus_musculus SsPnkeESpkktKtee-DetSedanclalsghDktEtKEqvdletsavqsetvpasasllasQKtsStDL Rattus_norvegicus SsPhkeESpkktKtee-DetSedanclalsghDktEtKEqvgmetsaapseaapasaslvasQKtsStDL Strongylocentrotus_purpuratus SpPkkmKTdngiKagg-EpvSltsdc-----nEngEsEE----dtsp------qplprlvirQRvpSgEL Xenopus_laevis SsPtneESpkktKtee-De-NdssnstevdeqNklEtEElkevhseekssspvpga--lpssQRssStDL Xenopus_tropicalis hpPcleDSpkriRdte-mllglpeptfiepsvpheEerQqsgeniipagampiptidr-srsQRlpSkEL ==================================================================================================== Consensus sxpxxxesxxxxkxxxxexxsxxxxxxxxxxxdxxexeexxxxxxxxxxxxxxxxxxxxxxxqkxxsxdl 920 930 940 950 960 970 980 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xdixxxlpxxxxxxvxknsiklxln ======================================================= YEAST ------------------------- Candida_glabrata ------------------------- Eremothecium_gossypii ------------------------- Kluyveromyces_lactis ------------------------- ======================================================= BOVINE sDIpa-LPanp-ipViKNSIKLrLN Apis_mellifera ------------------------- Canis_lupus sDIpa-LPanp-ipViKNSIKLrLN Danio_rerio sDVpv-LPsnp-ipVvKNSIKLrLS Drosophila_melanogaster ------------------------- Gallus_gallus sDIpa-LPanp-ipViKNSIKLrLN Homo_sapiens sDIp--------------------- Mus_musculus sDIpa-LPanp-ipViKNSIKLrLN Rattus_norvegicus sDIpa-LPanp-ipViKNSIKLrLN Strongylocentrotus_purpuratus pDMaspLPvapkapIaKNTIRLnLN Xenopus_laevis sDIsv-LPatp-ipViKNSIKLrLN Xenopus_tropicalis pDssspVPtnn-irViKNSIRLtLN ======================================================= Consensus xdixxxlpxxxxxxvxknsiklxln