280       290       300       310
                                  ----:----|----:----|----:----|----:----|----:
Consensus                         xxxxxxxxxxxxkxxxixxlsxxxxxxxqxeixxissgsxxlnxi
===============================================================================
PYROCOCCUS_FURIOSUS               ---gefgsgktqlahtLavMvqlppeegg------------LNgs
Pyrococcus_abyssi                 ---gefgsgktqlahtLavMvqlppeegg------------LNgs
===============================================================================
METHANOCOCCUS_VOLTAE              --------gvfgsgktqimhqscvnlqnp--eflfydeeavskge
Methanococcus_jannaschii          --------gmfgsgktqiahqacvnlqcp--eriVad-daikDeI
===============================================================================
SULFOLOBUS_SOLFATARICUS           ------gefgsgKtqlchqLSvnvqlppEkgg------------L
Aeropyrum_pernix                  ------gefgsgKtqichqLSvnvqlpedkgg------------L
Desulfurococcus_amylolyticus      ------geygsgKtqichqLSvnvqltpEkgg------------L
Sulfolobus_tokodaii               ------gefgsgKtqlchqLSvnvqlplEkgg------------L
===============================================================================
HUMAN                             eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
YEAST                             eakadkllneaaRlvpMgfVTaadfhmrRsELicLTTGSknLDtL
Apis_mellifera                    eakadkilqeasKlvvMgfkSateihqtRsnIvfVTTGSseLDrL
Aspergillus_fumigatus             eqkatkilveaaKlvpMgftTatemharRsELisITTGSkqLDtL
Bombyx_mandarina                  eakadkilaeasKlvpMgftTatefhqkRaEIiqLTTGSkeLDrL
Bos_taurus                        --kpdw-shnlsRtvdLrctpgc--------LapdyvlNyyImpL
Caenorhabditis_elegans            dqkaekimkeamKfvqMgftTgaevhvkRsQLvqIrTGSasLDrL
Candida_albicans                  enkaekisaeaaKlvpLgftTasefhsrRsELicLTTGSkqLDtL
Candida_glabrata                  etkadrllneaaRlvpMgfVTaadfhmrRsEMicLTTGSknLDtL
Canis_lupus                       eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Coprinus_cinereus                 eqkadkilaeaqKivpLgfqSatevharRsELvhITTGSkqLDaL
Cricetulus_griseus                eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Cryptococcus_neoformans           eqkadkilaeacKmvpMgftTateihsrRsELvhITTGStgLDtI
Danio_rerio                       eakadkilteaaKmvpMgftTatefhqrRaEIiqISTGSkeLDkL
Debaryomyces_hansenii             eakadkisleaaKvvpLgftTasefhsrRsELicITTGSkqLDtL
Drosophila_melanogaster           ggkveqiiteanKlvpLgfLSartfyqmRaDVvqLSTGSkeLDkL
Drosophila_pseudoobscura          gskvdqiiseasKmvpLgfLSartfhqmRaDVvmLTTGSkeLDkL
Emericella_nidulans               eqkatkilveaaKlvpMgftTatemharRsELisITTGSkqLDtL
Encephalitozoon_cuniculi          dikvdklikeaaKlvpMgftTasayhqrRsELvyLTTGSseVDkL
Eremothecium_gossypii             eakadkllaeaaRlvpMgfVTaadfhlrRaEMicLTTGSknLDtL
Gallus_gallus                     eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Gibberella_zeae                   eqkatkilaeasKlvpMgftTatemhqrRsELisITTGSknLDtL
Kluyveromyces_lactis              eakadkllaeasRlvpMgfVTaadfhlrRnEMicLTTGSknLDtL
Mus_musculus                      eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Neurospora_crassa                 eqkagkilaeasKlvpMgftTatemhqrRsELisITTGSknLDtL
Nosema_bombycis                   dvkvdrlikeaaKlvpMgftTasayhqkRqEVvyLSTGSseLDkL
Oikopleura_dioica                 enkamailrqalKivpMgfrTatdyhkaRsEMvrITTGSkefDrM
Oryctolagus_cuniculus             eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Pichia_angusta                    eqkadkllmeasKlvpLgftTatefhqrRsELicLTTGSkqLDtL
Pleurotus_ostreatus               eqkadkilaeaqKivpLgfqSgtevharRsELvhITTGxkqLDaL
Rattus_norvegicus                 eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL
Schizosaccharomyces_pombe         eakadkllgeasKlvpMgftTateyhirRsELitITTGSkqLDtL
Strongylocentrotus_purpuratus     eakadkilteaqKlvpMgftTatqfhqqRsEIiqVTTGSkeLDkL
Tetraodon_nigroviridis            eakadkilteaaKlvpMgftTatefhqrRaEIiqISTGSkeLDkL
Ustilago_maydis                   eakadkilaeaaRlvpMgftTatefharRnELisITTGSknLDaI
Xenopus_laevis                    eakaekilaeaaKlvpMgftTatefhqrRsEIiqISTGSkeLDkL
Xenopus_tropicalis                eakaekilaeaaKlvpMgftTatefhqrRsEIiqISTGSkeLDkL
Yarrowia_lipolytica               eakadkllseasKlvpLgftTasdvhqtRsgLitLTTGSsqLDtL
Cryptosporidium_spp               eqkcdkiksackElvaMgfcSgteyleaRtnLikfTTGSsqLDrL
Dictyostelium_discoideum          eqkadkllaeakKlvfMgfrTatdinkaRaEIiqITTGSkefDsL
Entamoeba_histolytica             dakadkllaessKivpLaftNaaelnnlRkEtirITTGSreLDkL
Leishmania_donovani               enkaekimaecaKlvpMgftSavayheaRkEIimVTTGSreVDkL
Leishmania_tropica                enkaekimaecaKlvpMgftSavayheaRkEIimVTTGSreVDkL
Plasmodium_berghei                eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL
Plasmodium_falciparum             eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL
Plasmodium_yoelii                 eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL
Tetrahymena_thermophila           eakidkildvaaKlvpndfqTaaeyyvkRqsVinLTTGSteLDkL
Theileria_annulata                eqkvlkikaacrElchLgfcSgqdyleaRgnLikfTTGSsqLDkL
Theileria_parva                   eqkvlkikaacrElchLgfcSgqdyleaRgnLikfTTGSaqLDkL
Trypanosoma_brucei                eakaekimaeccKltpMgftratvfqeqRkEtimVTTGSreVDkL
Trypanosoma_cruzi                 etkadkimaecaKlvpMgftSavvyheaRkEIimVTTGSreVDkL
Arabidopsis_thaliana              dakvdkiveaasKlvpLgftSasqlhaqRqEIiqITSGSreLDkV
Oryza_sativa                      eakvdkiveaasKlvpLgftSasqlhaqRlEIiqVTTGSreLDkI
Zea_mays                          eakadkiieaasKlvpLgftSasqlhaqRlEIiqLTTGSreLDkI
===============================================================================
ECOLI                             ---------------sImrL-ge-drs-m-DVetISTGSlsLDia
MYCOBACTERIUM_SMEGMATIS           ---------------sVmrL-ge-evr-Q-pIsvIpTGSisLDva
MYCOBACTERIUM_TUBERCULOSIS        ---------------sVmrL-gd-emr-Q-pIsvIpTGSiaLDva
Acetobacter_polyoxogenes          ---------------sImrM-ge-rpt-E-QVdvISTGSlgLDia
Acinetobacter_calcoaceticus       ---------------tVmrL-gd-ntv-Q-aVeaVSTGSltLDia
Actinobacillus_pleuropneumoniae   ---------------sImrL-gd-tqa-l-DIeaVSTGSigLDaa
Actinobacillus_succinogenes       ---------------aImkL-gd-rpd-m-DVesVSTGSigLDva
Bacillus_licheniformis            ---------------sImkL-ge-qte-t-rIstVpSGSlaLDaa
Bacillus_subtilis                 ---------------sImkL-ge-ktd-t-rIstVpSGSlaLDta
Burkholderia_fungorum             ---------------sVmrL-ga-gev-ieDIqvVSTGSlgLDia
Carboxydothermus_hydrogenoformans ---------------sImrL-ge-ntgkf-QVevIpTGSlaLDla
Chromobacterium_violaceum         ---------------sImrM-sdnqit-E-nLqvISTGSltLDla
Clostridium_thermocellum          ---------------aVmkL-ge-nth-m-nIetIpTGalgLDia
Colwellia_psychrerythraea         ---------------sImkL-gd-ntt-m-DVetISTGSlgLDia
Desulfotalea_psychrophila         ---------------sImrL-ge-qal-E-aIpvISTGalsLDia
Enterococcus_faecalis             ---------------sImkL-ge-kad-Q-KIstIpSGSlaLDva
Erwinia_carotovora                ---------------sImrL-ge-drs-m-DVetISTGSlsLDia
Haemophilus_ducreyi               ---------------sImrL-gd-tqa-l-DIeaVSTGSigLDaa
Haemophilus_influenzae            ---------------sImkL-gd-tkt-l-DVesISTGSlgLDva
Histophilus_somni                 ---------------aImkL-ge-tqk-l-DIeaISTGSlsLDva
Kineococcus_radiotolerans         ---------------sVmrL-gd-evr-p-pIevIpTGSisLDva
Leifsonia_xyli                    ---------------sVmrL-gs-der-a-pVevVpTGSiaLDva
Listeria_monocytogenes            ---------------sImkL-ge-hsd-Q-nIstISSGSlaLDia
Mannheimia_succiniciproducens     ---------------aImkL-gd-tqa-l-DVesISTGSigLDva
Neisseria_gonorrhoeae             ---------------aImkMdgs-qqe-E-nLevISTGSlgLDla
Nitrosomonas_europaea             ---------------sImrL-gdsdva-K-DIqvVSTGSlgLDia
Nitrosomonas_eutropha             ---------------sImrL-gdsdva-K-DIqvVSTGSlsLDia
Oceanobacillus_iheyensis          ---------------sImkM-ge-nei-p-KIatIpSGSlaLDva
Pasteurella_multocida             ---------------sImrL-gd-nra-m-DVetISTGSlsLDia
Photobacterium_profundum          ---------------sImrL-gd-nkt-m-DIetVSTGSlaLDia
Photorhabdus_luminescens          ---------------sImrL-ge-drs-m-DVetISTGSlsLDia
Proteus_mirabilis                 ---------------sImrL-ge-drs-m-nVetISTGSlsLDva
Pseudomonas_aeruginosa            ---------------sImrL-gs-drt-m-DIdvISTGSlgLDia
Pseudomonas_cepacia               ---------------sImrM-gdgeaa-E-DIqvVSTGSlgLDia
Salmonella_typhi                  ---------------sImrL-ge-drs-m-DVetISTGSlsLDia
Shewanella_putrefaciens           ---------------sImkL-ge-drs-m-DVetISTGSlsLDva
Streptomyces_avermitilis          ---------------aVmrL-ge-rpn-E-pIevIpTGStaLDva
Streptomyces_coelicolor           ---------------aVmrM-gd-rtn-E-pIevIpTGStaLDva
Streptomyces_lividans             ---------------aVmrM-gd-rtn-E-pIevIpTGStaLDva
Vibrio_cholerae                   ---------------sImrL-gd-nra-m-DVetISTGSlsLDia
Vibrio_splendidus                 ---------------sImrL-gd-nrt-m-DVetISTGSlsLDia
Vibrio_vulnificus                 ---------------sImrL-gd-nra-m-DVetISTGSlsLDia
Xanthomonas_vasicola              ---------------sVmrM-gd-rvi-E-aVevIpTGSlmLDia
Xylella_fastidiosa                ---------------sVmrM-gd-rvi-E-aVeaIpTGSlmLDla
Yersinia_pestis                   ---------------sImrL-ge-drs-m-DVetISTGSlsLDia
===============================================================================
DEINOCOCCUS_RADIODURANS           -----------gpesggkttlalaivaqaqKa-------------
Deinococcus_geothermalis          -----------gpesggkttlalsviaqaqra-------------
Thermus_aquaticus                 -----------gpesggkttlaltiiaqaqKg-------------
===============================================================================
Consensus                         xxxxxxxxxxxxkxxxixxlsxxxxxxxqxeixxissgsxxlnxi