Rad51/RadA/RecA

10 20 30 40 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS -------------------------------age----evke--- Pyrococcus_abyssi ------------------------mimgkkssdp----avve--- =============================================================================== METHANOCOCCUS_VOLTAE -------------------------------sdn----------- Methanococcus_jannaschii itfiyffgniiyylpiysyinnykfmlmviimdd----------- =============================================================================== SULFOLOBUS_SOLFATARICUS ----------------------------------sne----veqk Aeropyrum_pernix -----------------------------------------gedk Desulfurococcus_amylolyticus ----------------------------------seeketikers Sulfolobus_tokodaii ----------------------------------ndm----ssdg =============================================================================== HUMAN --------------------------------------------- YEAST ----------------------------------sqv-------- Apis_mellifera --------------------------------------------- Aspergillus_fumigatus --------------------------------------------- Bombyx_mandarina --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans -------------saqasrqkk--sdqeqra-------------- Candida_albicans ----------------------tqteie-qv---dlh-eeg---- Candida_glabrata ----------------------------------tev-------- Canis_lupus --------------------------------------------- Coprinus_cinereus --------------------------------------------- Cricetulus_griseus --------------------------------------------- Cryptococcus_neoformans --------------------------------------------- Danio_rerio --------------------------------------------- Debaryomyces_hansenii ---------------tet--------------------------- Drosophila_melanogaster --------------------------------------------- Drosophila_pseudoobscura --------------------------------------------- Emericella_nidulans --------------------------------------------- Encephalitozoon_cuniculi --------------------------------------------- Eremothecium_gossypii -sqvqehiiqdphssqynihatgaserqgss---eht-dgd---- Gallus_gallus --------------------------------------------- Gibberella_zeae --------------------------------------------- Kluyveromyces_lactis --------------------------------------------- Mus_musculus --------------------------------------------- Neurospora_crassa --------------sn----------------------------- Nosema_bombycis --------------------------------------------- Oikopleura_dioica ----------------------------------s---------- Oryctolagus_cuniculus --------------------------------------------- Pichia_angusta ---------------tqvaevnhitsneqqg---s---------- Pleurotus_ostreatus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schizosaccharomyces_pombe ------------adtevemqvsaadtnnnen---gqa-------- Strongylocentrotus_purpuratus --------------------------------------------- Tetraodon_nigroviridis --------------------------------------------- Ustilago_maydis --------------------------------------------- Xenopus_laevis --------------------------------------------- Xenopus_tropicalis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Cryptosporidium_spp --------------stin--------------------------- Dictyostelium_discoideum -------------asrqrqe------------------------- Entamoeba_histolytica ---------sakqiqrgseeelleseenlke---ke--------- Leishmania_donovani qtrskakgrrgrpsarpsdevevvesqpqea---lqn-eeq---- Leishmania_tropica qtrskakgrrgrpsarpseevevvesqpqev---lqn-eeq---- Plasmodium_berghei --------------ksan--------------------------- Plasmodium_falciparum --------------------------------------------- Plasmodium_yoelii ---------pamksanaked------------------------- Tetrahymena_thermophila --------------------------------------------- Theileria_annulata -------------------------ssd----------------- Theileria_parva -------------------------ssd----------------- Trypanosoma_brucei ------------ntrtknkkrtkeviedevh---did-dta---- Trypanosoma_cruzi -------ntrskrgkrkgveevevheiants---pdp-vaa---- Arabidopsis_thaliana --------------------------------------------- Oryza_sativa --------------------------------------------- Zea_mays --------------------------------------------- =============================================================================== ECOLI ----------------------------------ai--------- MYCOBACTERIUM_SMEGMATIS ----------------------------------aqq-------- MYCOBACTERIUM_TUBERCULOSIS ----------------------------------tq--------- Acetobacter_polyoxogenes -----------------aq---------------ap--------- Acinetobacter_calcoaceticus --------------------------------------------- Actinobacillus_pleuropneumoniae -----------------asdnkkaqkntvtk---qi--------- Actinobacillus_succinogenes -----------------atpndktk---------ps--------- Bacillus_licheniformis --------------------------------------------- Bacillus_subtilis --------------------------------------------- Burkholderia_fungorum -----------------eeskkgsa---------gl--------- Carboxydothermus_hydrogenoformans --------------------------------------------- Chromobacterium_violaceum -----------------------------------a--------- Clostridium_thermocellum --------------------------------------------- Colwellia_psychrerythraea --------------------------------------------- Desulfotalea_psychrophila -----------------v----------------gat-------- Enterococcus_faecalis --------------------------------------------- Erwinia_carotovora -----------------------------------ai-------- Haemophilus_ducreyi -----------------aadkkaqkntatk----qi--------- Haemophilus_influenzae ----------------------------------at--------- Histophilus_somni ----------------------------------at--------- Kineococcus_radiotolerans ----------------------------------pa--------- Leifsonia_xyli -----------------------------------ps-------- Listeria_monocytogenes --------------------------------------------- Mannheimia_succiniciproducens ----------------------------------at--------- Neisseria_gonorrhoeae --------------------------------------------- Nitrosomonas_europaea --------------------------------------------- Nitrosomonas_eutropha --------------------------------------------- Oceanobacillus_iheyensis --------------------------------------------- Pasteurella_multocida --------------------------------------------- Photobacterium_profundum --------------------------------------------- Photorhabdus_luminescens ----------------------------------ai--------- Proteus_mirabilis ----------------------------------ai--------- Pseudomonas_aeruginosa --------------------------------------------- Pseudomonas_cepacia --------------------------------------------- Salmonella_typhi ----------------------------------ai--------- Shewanella_putrefaciens -----------------------------------kv-------- Streptomyces_avermitilis -----------------------------------a--------- Streptomyces_coelicolor -----------------------------------a--------- Streptomyces_lividans -----------------------------------a--------- Vibrio_cholerae --------------------------------------------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus --------------------------------------------- Xanthomonas_vasicola --------------------------------------------- Xylella_fastidiosa --------------------------------------------- Yersinia_pestis ----------------------------------ai--------- =============================================================================== DEINOCOCCUS_RADIODURANS ----------------------------------gsh-------- Deinococcus_geothermalis --------------------------------------------- Thermus_aquaticus --------------------------------------------- =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 50 60 70 80 90 ----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS idefeelgfe---------------------------pateetpk Pyrococcus_abyssi indvdelele---------------------------vgeevtsk =============================================================================== METHANOCOCCUS_VOLTAE --------------------------------------------- Methanococcus_jannaschii --------------------------------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS ----------k---------------------------------- Aeropyrum_pernix ----------r---------------------------------- Desulfurococcus_amylolyticus ----------s---------------------------------- Sulfolobus_tokodaii ----------k---------------------------------- =============================================================================== HUMAN --------------------------------------------- YEAST --qeqh-----isesqlqygngslmstvpadlsqsvvdgngngss Apis_mellifera --------------------------------------------- Aspergillus_fumigatus --------------------------------------------- Bombyx_mandarina --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans --------------------------------------------- Candida_albicans --------------------------------------------- Candida_glabrata --hedhg----vpdsqv-n--vspistapaettqs---------- Canis_lupus --------------------------------------------- Coprinus_cinereus --------------------------------------------- Cricetulus_griseus --------------------------------------------- Cryptococcus_neoformans --------------------------------------------- Danio_rerio --------------------------------------------- Debaryomyces_hansenii --------------------------------------------- Drosophila_melanogaster --------------------------------------------- Drosophila_pseudoobscura --------------------------------------------- Emericella_nidulans --------------------------------------------- Encephalitozoon_cuniculi --------------------------------------------- Eremothecium_gossypii --------------------------------------------- Gallus_gallus --------------------------------------------- Gibberella_zeae --------------------------------------------- Kluyveromyces_lactis ----sq-----veevqttqghsqlmvsr---------------te Mus_musculus --------------------------------------------- Neurospora_crassa --------------------------------------------- Nosema_bombycis --------------------------------------------- Oikopleura_dioica --------------------------------------------- Oryctolagus_cuniculus --------------------------------------------- Pichia_angusta --------------------------------------------- Pleurotus_ostreatus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schizosaccharomyces_pombe --------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------------- Tetraodon_nigroviridis --------------------------------------------- Ustilago_maydis --------------------------------------------- Xenopus_laevis --------------------------------------------- Xenopus_tropicalis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Cryptosporidium_spp --------------------------------------------- Dictyostelium_discoideum --------------------------------------------- Entamoeba_histolytica --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_falciparum --------------------------------------------- Plasmodium_yoelii --------------------------------------------- Tetrahymena_thermophila --------------------------------------------- Theileria_annulata --------------------------------------------- Theileria_parva --------------------------------------------- Trypanosoma_brucei --------------------------------------------- Trypanosoma_cruzi --------------------------------------------- Arabidopsis_thaliana --------------------------------------------- Oryza_sativa --------------------------------------------- Zea_mays --------------------------------------------- =============================================================================== ECOLI --------------------------------------------- MYCOBACTERIUM_SMEGMATIS --------------------------------------------- MYCOBACTERIUM_TUBERCULOSIS --------------------------------------------- Acetobacter_polyoxogenes --------------------------------------------- Acinetobacter_calcoaceticus --------------------------------------------- Actinobacillus_pleuropneumoniae --------------------------------------------- Actinobacillus_succinogenes --------------------------------------------- Bacillus_licheniformis --------------------------------------------- Bacillus_subtilis --------------------------------------------- Burkholderia_fungorum --------------------------------------------- Carboxydothermus_hydrogenoformans --------------------------------------------- Chromobacterium_violaceum --------------------------------------------- Clostridium_thermocellum --------------------------------------------- Colwellia_psychrerythraea --------------------------------------------- Desulfotalea_psychrophila --------------------------------------------- Enterococcus_faecalis --------------------------------------------- Erwinia_carotovora --------------------------------------------- Haemophilus_ducreyi --------------------------------------------- Haemophilus_influenzae --------------------------------------------- Histophilus_somni --------------------------------------------- Kineococcus_radiotolerans --------------------------------------------- Leifsonia_xyli --------------------------------------------- Listeria_monocytogenes --------------------------------------------- Mannheimia_succiniciproducens --------------------------------------------- Neisseria_gonorrhoeae --------------------------------------------- Nitrosomonas_europaea --------------------------------------------- Nitrosomonas_eutropha --------------------------------------------- Oceanobacillus_iheyensis --------------------------------------------- Pasteurella_multocida --------------------------------------------- Photobacterium_profundum --------------------------------------------- Photorhabdus_luminescens --------------------------------------------- Proteus_mirabilis --------------------------------------------- Pseudomonas_aeruginosa --------------------------------------------- Pseudomonas_cepacia --------------------------------------------- Salmonella_typhi --------------------------------------------- Shewanella_putrefaciens --------------------------------------------- Streptomyces_avermitilis --------------------------------------------- Streptomyces_coelicolor --------------------------------------------- Streptomyces_lividans --------------------------------------------- Vibrio_cholerae --------------------------------------------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus --------------------------------------------- Xanthomonas_vasicola --------------------------------------------- Xylella_fastidiosa --------------------------------------------- Yersinia_pestis --------------------------------------------- =============================================================================== DEINOCOCCUS_RADIODURANS --mskd-----atkeisaptd------------------------ Deinococcus_geothermalis ---skd-----npkdfgtpsd------------------------ Thermus_aquaticus --------------------------------------------- =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 100 110 120 130 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS kkkkekiir--siedlpgv--------g-pat--------a--ek Pyrococcus_abyssi kkkkekeir--tiedlpgv--------g-pat--------a--ek =============================================================================== METHANOCOCCUS_VOLTAE -------------l--tdlpgvgp-----s----tae-----k-- Methanococcus_jannaschii -------------l--tqlpgvgp-----t----tae-----k-- =============================================================================== SULFOLOBUS_SOLFATARICUS -----------n--iktindlp------g---isq------t--- Aeropyrum_pernix -----------e--ikditdlp------g---vgp------t--- Desulfurococcus_amylolyticus -----------g--fisvrdip------g---vgs------s--- Sulfolobus_tokodaii -----------k--vkslsdlp------g---vgq------s--- =============================================================================== HUMAN --------------------a------------------------ YEAST edieatngsgdgg-------g------------------------ Apis_mellifera ------------s-------a------------------------ Aspergillus_fumigatus --------------------t------------------------ Bombyx_mandarina --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans --------------------a------------------------ Candida_albicans --------------------s------------------------ Candida_glabrata ----stnrsmdynsge----q------------------------ Canis_lupus --------------------a------------------------ Coprinus_cinereus --------------------s------------------------ Cricetulus_griseus --------------------a------------------------ Cryptococcus_neoformans -----sreqeqdp-------f------------------------ Danio_rerio --------------------------------------------- Debaryomyces_hansenii --------------------e------------------------ Drosophila_melanogaster --------------------------------------------- Drosophila_pseudoobscura --------------------------------------------- Emericella_nidulans --------------------t------------------------ Encephalitozoon_cuniculi --------------------s------------------------ Eremothecium_gossypii --------------------v------------------------ Gallus_gallus --------------------a------------------------ Gibberella_zeae --------------------s------------------------ Kluyveromyces_lactis eqme----------------d------------------------ Mus_musculus --------------------a------------------------ Neurospora_crassa --------------------n------------------------ Nosema_bombycis --------------------------------------------- Oikopleura_dioica --------------------a------------------------ Oryctolagus_cuniculus --------------------a------------------------ Pichia_angusta --------------------v------------------------ Pleurotus_ostreatus --------------------------------------------- Rattus_norvegicus --------------------a------------------------ Schizosaccharomyces_pombe --------------------q------------------------ Strongylocentrotus_purpuratus --------------------a------------------------ Tetraodon_nigroviridis --------------------a------------------------ Ustilago_maydis --------------------s------------------------ Xenopus_laevis --------------------a------------------------ Xenopus_tropicalis --------------------a------------------------ Yarrowia_lipolytica --------------------------------------------- Cryptosporidium_spp --------------------p------------------------ Dictyostelium_discoideum --------------------e------------------------ Entamoeba_histolytica --------------------k------------------------ Leishmania_donovani --------------------e------------------------ Leishmania_tropica --------------------e------------------------ Plasmodium_berghei --------------------a------------------------ Plasmodium_falciparum ---kqantkedks-------q------------------------ Plasmodium_yoelii --------------------t------------------------ Tetrahymena_thermophila --------------------------------------------- Theileria_annulata --------------------e------------------------ Theileria_parva --------------------e------------------------ Trypanosoma_brucei --------------------f------------------------ Trypanosoma_cruzi --------------------p------------------------ Arabidopsis_thaliana --------------------t------------------------ Oryza_sativa --------------------s------------------------ Zea_mays ------------s-------s------------------------ =============================================================================== ECOLI --------------------d------------------------ MYCOBACTERIUM_SMEGMATIS --------------------a------------------------ MYCOBACTERIUM_TUBERCULOSIS --------------------a------------------------ Acetobacter_polyoxogenes --------------------g------------------------ Acinetobacter_calcoaceticus --------------------d------------------------ Actinobacillus_pleuropneumoniae --------------------dp----------------------- Actinobacillus_succinogenes --------------------a------------------------ Bacillus_licheniformis --------------------------------------------- Bacillus_subtilis --------------------------------------------- Burkholderia_fungorum --------------------t------------------------ Carboxydothermus_hydrogenoformans --------------------------------------------- Chromobacterium_violaceum --------------------s------------------------ Clostridium_thermocellum --------------------------------------------- Colwellia_psychrerythraea --------------------k------------------------ Desulfotalea_psychrophila --------------------a------------------------ Enterococcus_faecalis --------------------a------------------------ Erwinia_carotovora --------------------d------------------------ Haemophilus_ducreyi --------------------dp----------------------- Haemophilus_influenzae --------------------q------------------------ Histophilus_somni --------------------p------------------------ Kineococcus_radiotolerans --------------------p------------------------ Leifsonia_xyli --------------------p------------------------ Listeria_monocytogenes --------------------------------------------- Mannheimia_succiniciproducens --------------------n------------------------ Neisseria_gonorrhoeae --------------------s------------------------ Nitrosomonas_europaea --------------------d------------------------ Nitrosomonas_eutropha --------------------d------------------------ Oceanobacillus_iheyensis --------------------------------------------- Pasteurella_multocida --------------------d------------------------ Photobacterium_profundum --------------------d------------------------ Photorhabdus_luminescens --------------------d------------------------ Proteus_mirabilis --------------------d------------------------ Pseudomonas_aeruginosa --------------------d------------------------ Pseudomonas_cepacia --------------------t------------------------ Salmonella_typhi --------------------d------------------------ Shewanella_putrefaciens --------------------d------------------------ Streptomyces_avermitilis --------------------g------------------------ Streptomyces_coelicolor --------------------g------------------------ Streptomyces_lividans --------------------g------------------------ Vibrio_cholerae --------------------d------------------------ Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus --------------------d------------------------ Xanthomonas_vasicola --------------------d------------------------ Xylella_fastidiosa --------------------d------------------------ Yersinia_pestis --------------------d------------------------ =============================================================================== DEINOCOCCUS_RADIODURANS ----------------a--kerskaie-----t----ams----q Deinococcus_geothermalis ----------------s--kerlkaie-----t----amt----q Thermus_aquaticus ----------------e--enkrksle-----n----alk----t =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 140 150 160 170 180 ----|----:----|----:----|----:----|----:----| Consensus xdqexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS l--------r--e---ag---y-----------------dtleai Pyrococcus_abyssi l--------r--e---ag---f-----------------dtleai =============================================================================== METHANOCOCCUS_VOLTAE ---lve------a----g--yi--d-------------------- Methanococcus_jannaschii ---lke------a----g--yt--d-------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS -vin------k----l--ie---a-----------------gyss Aeropyrum_pernix -taQ------k----l--me---a-----------------gytt Desulfurococcus_amylolyticus -iaD------k----l--ea---a-----------------gyls Sulfolobus_tokodaii -iln------k----l--ie---a-----------------gyss =============================================================================== HUMAN mqmQlean---a------------dts------v----------- YEAST lqEQaeaq---geme---------dea------y----------- Apis_mellifera mastaslq---gdee---------fee------y----------- Aspergillus_fumigatus aDlEtqne---y------------des------g----------- Bombyx_mandarina nttasatt---t------------svd------e----------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans dqallnaa---i------------edn------a----------- Candida_albicans hpQninad---a------------eve------a----------- Candida_glabrata lfhQeqye---egme------------------------------ Canis_lupus mqmQlean---a------------dts------v----------- Coprinus_cinereus qgyDgsqi---p------------egd------e----------- Cricetulus_griseus mqmQlean---a------------dts------v----------- Cryptococcus_neoformans vNQhge------eae---------eed------f----------- Danio_rerio -amrnasr---veve---------aev------e----------- Debaryomyces_hansenii gaQtnehe---a------------smg------d----------- Drosophila_melanogaster -EKltnvq---aqqe---------eee------------------ Drosophila_pseudoobscura ------da---l------------tns------v----------- Emericella_nidulans aDmEtqne---f------------dds------g----------- Encephalitozoon_cuniculi eEyQyq------------------dte------y----------- Eremothecium_gossypii iEvhaesg---r------------gqg------y----------- Gallus_gallus mqvQfeas---t------------dts------a----------- Gibberella_zeae qEhDesqm---g------------eeg------g----------- Kluyveromyces_lactis vqQriqet---dfma---------ee------------------- Mus_musculus mqmQleas---a------------dts------v----------- Neurospora_crassa eEyDesanm--e------------dds------g----------- Nosema_bombycis -----------s------------kqa------f----------- Oikopleura_dioica saEhneag---t------------sen------t----------- Oryctolagus_cuniculus mqmQlean---a------------dts------v----------- Pichia_angusta gEQElsag---y------------hes------mvaedd------ Pleurotus_ostreatus --sQasqd---ldeg---------des------y----------- Rattus_norvegicus mqmQlean---a------------dts------v----------- Schizosaccharomyces_pombe sNyEydvn---v------------qde------e----------- Strongylocentrotus_purpuratus mqmh---n---a------------eqe------v----------- Tetraodon_nigroviridis maaEvrgq---a------------eve------------------ Ustilago_maydis qNaQdpaq---i------------ged------d----------- Xenopus_laevis mqahyeae---a---------------------t----------- Xenopus_tropicalis mqahyeae---a---------------------t----------- Yarrowia_lipolytica --------------------------a------d----------- Cryptosporidium_spp nEivnenn---e------------nqn------n----------- Dictyostelium_discoideum eEvDiene---q------------qqe------e----------- Entamoeba_histolytica vNEEehee---e------------eee------e----------- Leishmania_donovani pqQpqqqq---s------------tdm------a----------- Leishmania_tropica pqQQqqqq---s------------tdm------a----------- Plasmodium_berghei kEdtisqt---c------------dns------t----------- Plasmodium_falciparum kisnssti---deie---------eeq------l----------- Plasmodium_yoelii isQtcdns---t------------ted------v----------- Tetrahymena_thermophila ------ae---y------------aed------v----------- Theileria_annulata lslvkeen---s------------mgv------s----------- Theileria_parva lslvkeen---s------------mgv------s----------- Trypanosoma_brucei dDaavdav---n------------dntqemqqqv----------- Trypanosoma_cruzi eqQQqqqe---d------------qqn------v----------- Arabidopsis_thaliana tmEQrrnq---navq---------qqd------d----------- Oryza_sativa tsaaaaaa---a------------eqq------q----------- Zea_mays asaQqzaa---aaie---------ze------------------- =============================================================================== ECOLI eNKQkala---a------------alg------q----------- MYCOBACTERIUM_SMEGMATIS pDREkale---l------------ama------q----------- MYCOBACTERIUM_TUBERCULOSIS pDREkale---l------------ama------q----------- Acetobacter_polyoxogenes iDKskale---g------------als------q----------- Acinetobacter_calcoaceticus dNKskalq---a------------als------q----------- Actinobacillus_pleuropneumoniae eqKEkala---a------------ala------q----------- Actinobacillus_succinogenes eEKskala---a------------alg------q----------- Bacillus_licheniformis sDRQaald---m------------alk------q----------- Bacillus_subtilis sDRQaald---m------------alk------q----------- Burkholderia_fungorum aEKskala---a------------ala------q----------- Carboxydothermus_hydrogenoformans nDKlkale---l------------tis------q----------- Chromobacterium_violaceum eDKskala---a------------ala------q----------- Clostridium_thermocellum iEKKkale---m------------vlg------q----------- Colwellia_psychrerythraea dDKEkals---a------------ala------q----------- Desulfotalea_psychrophila kDKagsve---n------------ais------q----------- Enterococcus_faecalis dDRKvald---a------------alk------k----------- Erwinia_carotovora eNKQkala---a------------alg------q----------- Haemophilus_ducreyi eqKEkala---a------------ala------q----------- Haemophilus_influenzae eEKQkala---a------------alg------q----------- Histophilus_somni eEKakale---a------------alg------q----------- Kineococcus_radiotolerans aDREkald---a------------ala------a----------- Leifsonia_xyli aDREkalv---t------------ala------q----------- Listeria_monocytogenes nDRQaald---q------------alk------q----------- Mannheimia_succiniciproducens dEKskala---a------------alg------q----------- Neisseria_gonorrhoeae dDKskala---a------------ala------q----------- Nitrosomonas_europaea eNKnkals---a------------ala------q----------- Nitrosomonas_eutropha eNKnkalt---a------------ala------q----------- Oceanobacillus_iheyensis sDRKqald---m------------alr------q----------- Pasteurella_multocida eNKQkala---a------------alg------q----------- Photobacterium_profundum dNKQkala---a------------alg------q----------- Photorhabdus_luminescens eNKQkala---a------------alg------q----------- Proteus_mirabilis eNKQkala---a------------alg------q----------- Pseudomonas_aeruginosa qaKskale---a------------als------q----------- Pseudomonas_cepacia aEKskala---a------------ala------q----------- Salmonella_typhi eNKQkala---a------------alg------q----------- Shewanella_putrefaciens pNKEkala---a------------vli------q----------- Streptomyces_avermitilis tDREkald---a------------ala------q----------- Streptomyces_coelicolor tDREkald---a------------ala------q----------- Streptomyces_lividans tDREkald---a------------ala------q----------- Vibrio_cholerae eNKQkala---a------------alg------q----------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus eNKQkala---a------------alg------q----------- Xanthomonas_vasicola eNKKrala---a------------als------q----------- Xylella_fastidiosa eNKKrals---v------------als------q----------- Yersinia_pestis eNKQkala---a------------alg------q----------- =============================================================================== DEINOCOCCUS_RADIODURANS ------iek------a---f--gk---g----------------- Deinococcus_geothermalis ------iek------a---f--gk---g----------------- Thermus_aquaticus ------iek------e---f--gk---g----------------- =============================================================================== Consensus xdqexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 190 200 210 220 ----:----|----:----|----:----|----:----|----: Consensus xxeqxxxxxxxxxxxxxxxxxfxxxxxxxxxxgxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS avaspielkevagisegtalkiiqaarkaanlGtfmradeylkkr Pyrococcus_abyssi avaspielkevagisegaalkiiqaarkaanlGtfmradeylkkr =============================================================================== METHANOCOCCUS_VOLTAE --fmkiatatvgeltdiegisekaaakmimgardlcdlgfksgid Methanococcus_jannaschii --fmkiatasigelteidgisekaaariieaarelcnlgfksgte =============================================================================== SULFOLOBUS_SOLFATARICUS letlavaspqdlsvaagiplstaqkiikeardaldirfktalevk Aeropyrum_pernix leaiaaatpqevsqatgipiltaqkivdaarealnidfktaydlk Desulfurococcus_amylolyticus awsivvaraeelaertglpvltvqkiienarkmlgitfktarevk Sulfolobus_tokodaii leavavaspqdlsvaagiplttaqriikearealdirfktalevk =============================================================================== HUMAN -eEE---------s-------F----------Gp------q---p YEAST -dEa---------a-------l----------Gsf-----v---p Apis_mellifera -npQ---------a--------------------------k---l Aspergillus_fumigatus -lpg---------p-------g----------ap------t---p Bombyx_mandarina -dad---------e-------c----------Gp------q---l Bos_taurus --------------------------------------------- Caenorhabditis_elegans -mEQ---------d-------e----------nf------t---v Candida_albicans -eEd---------edvl----n----------Gp------l---l Candida_glabrata -eDa---------a-------l----------asf-----v---p Canis_lupus -eEE---------s-------F----------Gp------q---p Coprinus_cinereus -eDy---------q-------F-s--------Gp------l---l Cricetulus_griseus -eEE---------s-------F----------Gp------q---p Cryptococcus_neoformans -e-----------s-------l----------apm-----l---- Danio_rerio -eEE---------n-------F----------Gp------q---p Debaryomyces_hansenii -eEd---------g-------ls---------Gp------l---l Drosophila_melanogaster -eEg---------p-------l----------------------s Drosophila_pseudoobscura -eEE---------e-------n----------Gp------l---n Emericella_nidulans -lpg---------p-------g----------ap------t---p Encephalitozoon_cuniculi -hsE---------s-------i----------------------s Eremothecium_gossypii -eEd---------v-------a----------la------af-vp Gallus_gallus -eEE---------s-------F----------Gp------e---p Gibberella_zeae -mpg---------p-------g----------ap------t---p Kluyveromyces_lactis -dDv---------a-------l----------aaf-----v---p Mus_musculus -eEE---------s-------F----------Gp------q---p Neurospora_crassa -ipn---------p-------g----------ap------t---p Nosema_bombycis -eEE---------e-------F----------ks------ett-s Oikopleura_dioica -mvg---------a-------i----------hn------d---l Oryctolagus_cuniculus -eEE---------s-------F----------Gp------q---p Pichia_angusta -eDy---------s-------a----------Gp------v---p Pleurotus_ostreatus -q-----------a-------t----------Gpl-----l---- Rattus_norvegicus -eEE---------s-------F----------Gp------q---p Schizosaccharomyces_pombe -dEa---------a-------a----------Gp------m---p Strongylocentrotus_purpuratus -sEE-----------------F----------Gp------l---g Tetraodon_nigroviridis -eEE---------n-------F----------Gp------q---p Ustilago_maydis -mgE---------a-------F----------Gp------l---p Xenopus_laevis -eEE---------n-------F----------Gp------q---a Xenopus_tropicalis -eEE---------n-------F----------Gp------q---a Yarrowia_lipolytica -eEi---------e-------r----------aga-----i---p Cryptosporidium_spp -lnE---------t-------vyn--------Gp------l---k Dictyostelium_discoideum -eEE---------e-------e----------ee------esyls Entamoeba_histolytica -eEE---------e-------n----------aa------v---p Leishmania_donovani -epn---------a-------s----------Gf------r---v Leishmania_tropica -epn---------a-------s----------Gf------r---v Plasmodium_berghei -tEEvdehl----y-------a----------Gp------l---k Plasmodium_falciparum -ytg---------p-------l----------------------k Plasmodium_yoelii -dEh---------l-------Y-t--------Gp------l---k Tetrahymena_thermophila -eQs---------d------------------Gp------m---l Theileria_annulata -esg---------s-------q----------np------q---r Theileria_parva -etg---------s-------q----------np------q---r Trypanosoma_brucei -gDa---------a-------g----------Gpsf----r---v Trypanosoma_cruzi -dga---------n-------n----------Gg-f----r---v Arabidopsis_thaliana -eEt---------q-------h----------Gpf---------p Oryza_sativa -eEg---------e-------h----------Gp------f---p Zea_mays --Ev---------e-------h----------Gpf---------p =============================================================================== ECOLI -iEK---------q-------F----------Gk------g---- MYCOBACTERIUM_SMEGMATIS -iDK---------n-------F----------Gk------g---- MYCOBACTERIUM_TUBERCULOSIS -iEK---------s-------Y----------Gk------g---- Acetobacter_polyoxogenes -iER---------a-------F----------Gk------g---- Acinetobacter_calcoaceticus -iEK---------q-------F----------Gk------n---- Actinobacillus_pleuropneumoniae -iEK---------q-------F----------Gk------g---- Actinobacillus_succinogenes -iEK---------q-------F----------Gk------g---- Bacillus_licheniformis -iEK---------q-------F----------Gk------g---- Bacillus_subtilis -iEK---------q-------F----------Gk------g---- Burkholderia_fungorum -iEK---------q-------F----------Gk------g---- Carboxydothermus_hydrogenoformans -iEK---------q-------F----------Gk------g---- Chromobacterium_violaceum -iEK---------q-------F----------Gk------g---- Clostridium_thermocellum -iEK---------q-------F----------Gk------g---- Colwellia_psychrerythraea -iER---------q-------F----------Gk------g---- Desulfotalea_psychrophila -iQK---------q-------F----------Gk------g---- Enterococcus_faecalis -iEK---------n-------F----------Gk------g---- Erwinia_carotovora -iEK---------q-------F----------Gk------g---- Haemophilus_ducreyi -iEK---------q-------F----------Gk------g---- Haemophilus_influenzae -iEK---------q-------F----------Gk------g---- Histophilus_somni -iEK---------q-------F----------Gk------g---- Kineococcus_radiotolerans -iDK---------n-------F----------Gk------g---- Leifsonia_xyli -iDR---------q-------F----------Gk------g---- Listeria_monocytogenes -iEK---------q-------F----------Gk------g---- Mannheimia_succiniciproducens -iEK---------q-------F----------Gk------g---- Neisseria_gonorrhoeae -iEK---------s-------F----------Gk------g---- Nitrosomonas_europaea -iEK---------q-------Y----------Gk------g---- Nitrosomonas_eutropha -iEK---------q-------Y----------Gk------g---- Oceanobacillus_iheyensis -iEK---------q-------F----------Gk------g---- Pasteurella_multocida -iEK---------q-------F----------Gk------g---- Photobacterium_profundum -iEK---------q-------F----------Gk------g---- Photorhabdus_luminescens -iEK---------q-------F----------Gk------g---- Proteus_mirabilis -iEK---------q-------F----------Gk------g---- Pseudomonas_aeruginosa -iEK---------q-------F----------Gk------g---- Pseudomonas_cepacia -iEK---------q-------F----------Gk------g---- Salmonella_typhi -iEK---------q-------F----------Gk------g---- Shewanella_putrefaciens -iEK---------q-------F----------Gk------g---- Streptomyces_avermitilis -iER---------q-------F----------Gk------g---- Streptomyces_coelicolor -iER---------q-------F----------Gk------g---- Streptomyces_lividans -iER---------q-------F----------Gk------g---- Vibrio_cholerae -iEK---------q-------F----------Gk------g---- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus -iEK---------q-------F----------Gk------g---- Xanthomonas_vasicola -iEK---------q-------F----------Gk------g---- Xylella_fastidiosa -iEK---------q-------F----------Gk------g---- Yersinia_pestis -iEK---------q-------F----------Gk------g---- =============================================================================== DEINOCOCCUS_RADIODURANS -------------------------------------------si Deinococcus_geothermalis -------------------------------------------si Thermus_aquaticus -------------------------------------------av =============================================================================== Consensus xxeqxxxxxxxxxxxxxxxxxfxxxxxxxxxxgxxxxxxxxxxxx 230 240 250 260 270 ----|----:----|----:----|----:----|----:----| Consensus lxxmxxxxxxxxxxnlxxlxxxxxxxxqxvxxxxxxxlxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS atigristgsksldkLl-gggietqaiteVf-------------- Pyrococcus_abyssi esigristgsksldkLl-gggietqaiteVf-------------- =============================================================================== METHANOCOCCUS_VOLTAE LlkqrstvwklstsSseldsvl-ggglEsqsvtefa--------- Methanococcus_jannaschii VlsqrkniwklstgSknldeil-ggglEsqsvtefa--------- =============================================================================== SULFOLOBUS_SOLFATARICUS kerMnvkkistgsqaLdgLl-aggietRtMteff----------- Aeropyrum_pernix IesMnikkittgsrNLdeLl-gggietKtItelf----------- Desulfurococcus_amylolyticus qersnigkittgskSLdeLl-gggvetKtIteff----------- Sulfolobus_tokodaii kerIntkkittgsqaLdgLl-gggietRtMtelf----------- =============================================================================== HUMAN IsrL-e-qcginanDVkkLeeagfhtvEaVayapkkeLinikgis YEAST IekL-q-vngitmaDVkkLresglhtaEaVayaprkdLleikgis Apis_mellifera IktL-e-gngitagDVkkLeeagyytvEaVayapkkcLiaikgis Aspergillus_fumigatus LsaL-egvagltsrDIklfvdagyhtvEsIaytpkrlLeqikgis Bombyx_mandarina IskL-e-gngitsgDIkkLeeagyhtvEsVayapkkwLitikgis Bos_taurus --------------------------------------------- Caenorhabditis_elegans IdkL-e-ssgissgDIskLkeagyytyEsLafttrreLrnvkgis Candida_albicans IeqL-e-gnginasDIkkLkaegfhtiEsIaytpkrhLmtvkgis Candida_glabrata LekL-q-vngitstDIkkLresglhtvEaVayapkkdLleikgis Canis_lupus IsrL-e-qcginanDVkkLeeagfhtvEaVayapkkeLisikgis Coprinus_cinereus VnkL-q-eagihanDIkkLadaglntvEaVaftpkknLlairgis Cricetulus_griseus IsrL-e-qcgisanDVkkLeeagfhtvEaVayapkkeLinikgis Cryptococcus_neoformans VakL-q-eagisaqDtkkLadagfhtvEaVaftpkktLctikgis Danio_rerio VsrL-e-qsgisssDIkkLedggfhtvEaVayapkkeLlnikgis Debaryomyces_hansenii IeqL-e-gngitsgDIrkLkaegyhtiEsIaytpkkaLllvkgis Drosophila_melanogaster VtkL-i-ggsitakDIklLqqaslhtvEsVanatkkqLmaipglg Drosophila_pseudoobscura VtkL-i-ggsitakDIklLqqaslhtvdaVanatrkhLlaipglg Emericella_nidulans LssL-egmagltsrDIklfvdagyhtvEsIaytpkrlLeqikgis Encephalitozoon_cuniculi IseL-k-nggilavDIakLieagfttvEsLafapkrqLlsikgfs Eremothecium_gossypii LerL-q-vngitnnDLkkLrenglhtvEaVayaprkdLleikgis Gallus_gallus IsrL-e-qcginanDVkkLeeagyhtvEsVahapkkeLlnikgis Gibberella_zeae LfaL-egvagltkrDIqlVvdggyntvEsVaytprrvLeqikgis Kluyveromyces_lactis IekL-q-vngitsgDIkkLresglhtaEaVayaprkdLmeikgis Mus_musculus IsrL-e-qcginanDVkkLeeagyhtvEaVayapkkeLinikgis Neurospora_crassa LsaL-egvagltkrDIqlIvdggfntvEsVaytprrvLeqikgis Nosema_bombycis LevL-k-nqgigpaDInkLieagynsvEaLayapkkqLltikgfs Oikopleura_dioica dklL-c-q-giiksDLnkLktaglhtaEqVsmctkkdLcaikgfs Oryctolagus_cuniculus VsrL-e-qcginanDVkkLeeagfhteEaVayapkkeLinikgis Pichia_angusta IqqL-v-gngitpqDIkkLkeagfhtvEsIaytpkrhIvtvkgis Pleurotus_ostreatus IskL-q-eagihanDIkkLsdaglntxEsVaftpkkaLiaikgis Rattus_norvegicus IsrL-e-qcginanDVkkLeeagyhtvEaVayapkkeLinikgis Schizosaccharomyces_pombe LqmL-e-gngitasDIkkIheagyytvEsIaytpkrqLllikgis Strongylocentrotus_purpuratus IsrL-e-asgissnDVkkLeeagmhtvEsVaystkkeLcavkgis Tetraodon_nigroviridis LcrL-e-qcgisasDIkkLedagfhtiEaVayapkkeLlnikgis Ustilago_maydis VskL-e-efgisssDckkLaesgyntvEsIaftpkkqLllvkgvs Xenopus_laevis IsrL-e-qcginanDVkkLeeagfhtvEaVayapkkeLlnikgis Xenopus_tropicalis IsrL-e-qcginanDVkkLeeagfhtvEaVayapkkeLinikgis Yarrowia_lipolytica IerL-a-vngitqtDInrLgefglytvEsVaytpkkhLltikgis Cryptosporidium_spp LehL-l-psgltkrDLeiLrengyhtiEcLayapkkaLlsvkgis Dictyostelium_discoideum InkL-e-gnginaaDLkkLqeqglntvQaVafttkktLtgikgis Entamoeba_histolytica IrkLig-lagitegDckkLeeagfftvQsIaftpkkqLitikgis Leishmania_donovani IqiL-e-nygvassDIkkLmecgfytvEsaayapkkaIlavkgis Leishmania_tropica IqiL-e-nygvassDIkkLmecgfytvEsaayapkkaIlavkgis Plasmodium_berghei IeqL-l-akgfvkrDLelLkegglqtvEcVayapmrtLcsikgis Plasmodium_falciparum IeqL-l-akgfvkrDLelLkegglqtvEcVayapmrtLcaikgis Plasmodium_yoelii IeqL-l-akgfvkrDLelLkegglqtvEcVayapmrtLcsikgis Tetrahymena_thermophila IakL-e-ehginnaDVkkLidagfqtvEsIsytakknLlqikgmt Theileria_annulata LecL-l-skgllqrDLdlLreagystlEcVayapqknLlvikgls Theileria_parva LecL-l-skgllqrDLdlLreagystlEcVayapqknLlvikgls Trypanosoma_brucei LqiM-e-nygvasaDIkkLmecgfltvEsVayapkksIlavkgis Trypanosoma_cruzi IqvL-e-sygiasaDIkkLmesgfytvEsVayapkknIlavkgis Arabidopsis_thaliana VeqL-q-aagiasvDVkkLrdaglctvEgVaytprkdLlqikgis Oryza_sativa IeqL-q-asgiaalDVkkLkdsglytvEsVaytprkdLlqikgis Zea_mays IeqL-q-asgiaalDVkkLkdsglhtvEaVaysprkdLlqikgis =============================================================================== ECOLI --------------------------------------------- MYCOBACTERIUM_SMEGMATIS --------------------------------------------- MYCOBACTERIUM_TUBERCULOSIS --------------------------------------------- Acetobacter_polyoxogenes --------------------------------------------- Acinetobacter_calcoaceticus --------------------------------------------- Actinobacillus_pleuropneumoniae --------------------------------------------- Actinobacillus_succinogenes --------------------------------------------- Bacillus_licheniformis --------------------------------------------- Bacillus_subtilis --------------------------------------------- Burkholderia_fungorum --------------------------------------------- Carboxydothermus_hydrogenoformans --------------------------------------------- Chromobacterium_violaceum --------------------------------------------- Clostridium_thermocellum --------------------------------------------- Colwellia_psychrerythraea --------------------------------------------- Desulfotalea_psychrophila --------------------------------------------- Enterococcus_faecalis --------------------------------------------- Erwinia_carotovora --------------------------------------------- Haemophilus_ducreyi --------------------------------------------- Haemophilus_influenzae --------------------------------------------- Histophilus_somni --------------------------------------------- Kineococcus_radiotolerans --------------------------------------------- Leifsonia_xyli --------------------------------------------- Listeria_monocytogenes --------------------------------------------- Mannheimia_succiniciproducens --------------------------------------------- Neisseria_gonorrhoeae --------------------------------------------- Nitrosomonas_europaea --------------------------------------------- Nitrosomonas_eutropha --------------------------------------------- Oceanobacillus_iheyensis --------------------------------------------- Pasteurella_multocida --------------------------------------------- Photobacterium_profundum --------------------------------------------- Photorhabdus_luminescens --------------------------------------------- Proteus_mirabilis --------------------------------------------- Pseudomonas_aeruginosa --------------------------------------------- Pseudomonas_cepacia --------------------------------------------- Salmonella_typhi --------------------------------------------- Shewanella_putrefaciens --------------------------------------------- Streptomyces_avermitilis --------------------------------------------- Streptomyces_coelicolor --------------------------------------------- Streptomyces_lividans --------------------------------------------- Vibrio_cholerae --------------------------------------------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus --------------------------------------------- Xanthomonas_vasicola --------------------------------------------- Xylella_fastidiosa --------------------------------------------- Yersinia_pestis --------------------------------------------- =============================================================================== DEINOCOCCUS_RADIODURANS MklgaeskldvqvvStgsLsldlalgvggIprgriteIy------ Deinococcus_geothermalis MrlgaeskldvqavStgsLsldlalgvggIprgriteIy------ Thermus_aquaticus MrlgempklqvdviptgsLgldlalgiggIprgrvteIf------ =============================================================================== Consensus lxxmxxxxxxxxxxnlxxlxxxxxxxxqxvxxxxxxxlxxxxxxx 280 290 300 310 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxkxxxixxlsxxxxxxxqxeixxissgsxxlnxi =============================================================================== PYROCOCCUS_FURIOSUS ---gefgsgktqlahtLavMvqlppeegg------------LNgs Pyrococcus_abyssi ---gefgsgktqlahtLavMvqlppeegg------------LNgs =============================================================================== METHANOCOCCUS_VOLTAE --------gvfgsgktqimhqscvnlqnp--eflfydeeavskge Methanococcus_jannaschii --------gmfgsgktqiahqacvnlqcp--eriVad-daikDeI =============================================================================== SULFOLOBUS_SOLFATARICUS ------gefgsgKtqlchqLSvnvqlppEkgg------------L Aeropyrum_pernix ------gefgsgKtqichqLSvnvqlpedkgg------------L Desulfurococcus_amylolyticus ------geygsgKtqichqLSvnvqltpEkgg------------L Sulfolobus_tokodaii ------gefgsgKtqlchqLSvnvqlplEkgg------------L =============================================================================== HUMAN eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL YEAST eakadkllneaaRlvpMgfVTaadfhmrRsELicLTTGSknLDtL Apis_mellifera eakadkilqeasKlvvMgfkSateihqtRsnIvfVTTGSseLDrL Aspergillus_fumigatus eqkatkilveaaKlvpMgftTatemharRsELisITTGSkqLDtL Bombyx_mandarina eakadkilaeasKlvpMgftTatefhqkRaEIiqLTTGSkeLDrL Bos_taurus --kpdw-shnlsRtvdLrctpgc--------LapdyvlNyyImpL Caenorhabditis_elegans dqkaekimkeamKfvqMgftTgaevhvkRsQLvqIrTGSasLDrL Candida_albicans enkaekisaeaaKlvpLgftTasefhsrRsELicLTTGSkqLDtL Candida_glabrata etkadrllneaaRlvpMgfVTaadfhmrRsEMicLTTGSknLDtL Canis_lupus eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Coprinus_cinereus eqkadkilaeaqKivpLgfqSatevharRsELvhITTGSkqLDaL Cricetulus_griseus eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Cryptococcus_neoformans eqkadkilaeacKmvpMgftTateihsrRsELvhITTGStgLDtI Danio_rerio eakadkilteaaKmvpMgftTatefhqrRaEIiqISTGSkeLDkL Debaryomyces_hansenii eakadkisleaaKvvpLgftTasefhsrRsELicITTGSkqLDtL Drosophila_melanogaster ggkveqiiteanKlvpLgfLSartfyqmRaDVvqLSTGSkeLDkL Drosophila_pseudoobscura gskvdqiiseasKmvpLgfLSartfhqmRaDVvmLTTGSkeLDkL Emericella_nidulans eqkatkilveaaKlvpMgftTatemharRsELisITTGSkqLDtL Encephalitozoon_cuniculi dikvdklikeaaKlvpMgftTasayhqrRsELvyLTTGSseVDkL Eremothecium_gossypii eakadkllaeaaRlvpMgfVTaadfhlrRaEMicLTTGSknLDtL Gallus_gallus eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Gibberella_zeae eqkatkilaeasKlvpMgftTatemhqrRsELisITTGSknLDtL Kluyveromyces_lactis eakadkllaeasRlvpMgfVTaadfhlrRnEMicLTTGSknLDtL Mus_musculus eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Neurospora_crassa eqkagkilaeasKlvpMgftTatemhqrRsELisITTGSknLDtL Nosema_bombycis dvkvdrlikeaaKlvpMgftTasayhqkRqEVvyLSTGSseLDkL Oikopleura_dioica enkamailrqalKivpMgfrTatdyhkaRsEMvrITTGSkefDrM Oryctolagus_cuniculus eakadkilteaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Pichia_angusta eqkadkllmeasKlvpLgftTatefhqrRsELicLTTGSkqLDtL Pleurotus_ostreatus eqkadkilaeaqKivpLgfqSgtevharRsELvhITTGxkqLDaL Rattus_norvegicus eakadkilaeaaKlvpMgftTatefhqrRsEIiqITTGSkeLDkL Schizosaccharomyces_pombe eakadkllgeasKlvpMgftTateyhirRsELitITTGSkqLDtL Strongylocentrotus_purpuratus eakadkilteaqKlvpMgftTatqfhqqRsEIiqVTTGSkeLDkL Tetraodon_nigroviridis eakadkilteaaKlvpMgftTatefhqrRaEIiqISTGSkeLDkL Ustilago_maydis eakadkilaeaaRlvpMgftTatefharRnELisITTGSknLDaI Xenopus_laevis eakaekilaeaaKlvpMgftTatefhqrRsEIiqISTGSkeLDkL Xenopus_tropicalis eakaekilaeaaKlvpMgftTatefhqrRsEIiqISTGSkeLDkL Yarrowia_lipolytica eakadkllseasKlvpLgftTasdvhqtRsgLitLTTGSsqLDtL Cryptosporidium_spp eqkcdkiksackElvaMgfcSgteyleaRtnLikfTTGSsqLDrL Dictyostelium_discoideum eqkadkllaeakKlvfMgfrTatdinkaRaEIiqITTGSkefDsL Entamoeba_histolytica dakadkllaessKivpLaftNaaelnnlRkEtirITTGSreLDkL Leishmania_donovani enkaekimaecaKlvpMgftSavayheaRkEIimVTTGSreVDkL Leishmania_tropica enkaekimaecaKlvpMgftSavayheaRkEIimVTTGSreVDkL Plasmodium_berghei eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL Plasmodium_falciparum eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL Plasmodium_yoelii eqkaeklkkackElcnsgfcNaidyhdaRqnLikfTTGSkqLDaL Tetrahymena_thermophila eakidkildvaaKlvpndfqTaaeyyvkRqsVinLTTGSteLDkL Theileria_annulata eqkvlkikaacrElchLgfcSgqdyleaRgnLikfTTGSsqLDkL Theileria_parva eqkvlkikaacrElchLgfcSgqdyleaRgnLikfTTGSaqLDkL Trypanosoma_brucei eakaekimaeccKltpMgftratvfqeqRkEtimVTTGSreVDkL Trypanosoma_cruzi etkadkimaecaKlvpMgftSavvyheaRkEIimVTTGSreVDkL Arabidopsis_thaliana dakvdkiveaasKlvpLgftSasqlhaqRqEIiqITSGSreLDkV Oryza_sativa eakvdkiveaasKlvpLgftSasqlhaqRlEIiqVTTGSreLDkI Zea_mays eakadkiieaasKlvpLgftSasqlhaqRlEIiqLTTGSreLDkI =============================================================================== ECOLI ---------------sImrL-ge-drs-m-DVetISTGSlsLDia MYCOBACTERIUM_SMEGMATIS ---------------sVmrL-ge-evr-Q-pIsvIpTGSisLDva MYCOBACTERIUM_TUBERCULOSIS ---------------sVmrL-gd-emr-Q-pIsvIpTGSiaLDva Acetobacter_polyoxogenes ---------------sImrM-ge-rpt-E-QVdvISTGSlgLDia Acinetobacter_calcoaceticus ---------------tVmrL-gd-ntv-Q-aVeaVSTGSltLDia Actinobacillus_pleuropneumoniae ---------------sImrL-gd-tqa-l-DIeaVSTGSigLDaa Actinobacillus_succinogenes ---------------aImkL-gd-rpd-m-DVesVSTGSigLDva Bacillus_licheniformis ---------------sImkL-ge-qte-t-rIstVpSGSlaLDaa Bacillus_subtilis ---------------sImkL-ge-ktd-t-rIstVpSGSlaLDta Burkholderia_fungorum ---------------sVmrL-ga-gev-ieDIqvVSTGSlgLDia Carboxydothermus_hydrogenoformans ---------------sImrL-ge-ntgkf-QVevIpTGSlaLDla Chromobacterium_violaceum ---------------sImrM-sdnqit-E-nLqvISTGSltLDla Clostridium_thermocellum ---------------aVmkL-ge-nth-m-nIetIpTGalgLDia Colwellia_psychrerythraea ---------------sImkL-gd-ntt-m-DVetISTGSlgLDia Desulfotalea_psychrophila ---------------sImrL-ge-qal-E-aIpvISTGalsLDia Enterococcus_faecalis ---------------sImkL-ge-kad-Q-KIstIpSGSlaLDva Erwinia_carotovora ---------------sImrL-ge-drs-m-DVetISTGSlsLDia Haemophilus_ducreyi ---------------sImrL-gd-tqa-l-DIeaVSTGSigLDaa Haemophilus_influenzae ---------------sImkL-gd-tkt-l-DVesISTGSlgLDva Histophilus_somni ---------------aImkL-ge-tqk-l-DIeaISTGSlsLDva Kineococcus_radiotolerans ---------------sVmrL-gd-evr-p-pIevIpTGSisLDva Leifsonia_xyli ---------------sVmrL-gs-der-a-pVevVpTGSiaLDva Listeria_monocytogenes ---------------sImkL-ge-hsd-Q-nIstISSGSlaLDia Mannheimia_succiniciproducens ---------------aImkL-gd-tqa-l-DVesISTGSigLDva Neisseria_gonorrhoeae ---------------aImkMdgs-qqe-E-nLevISTGSlgLDla Nitrosomonas_europaea ---------------sImrL-gdsdva-K-DIqvVSTGSlgLDia Nitrosomonas_eutropha ---------------sImrL-gdsdva-K-DIqvVSTGSlsLDia Oceanobacillus_iheyensis ---------------sImkM-ge-nei-p-KIatIpSGSlaLDva Pasteurella_multocida ---------------sImrL-gd-nra-m-DVetISTGSlsLDia Photobacterium_profundum ---------------sImrL-gd-nkt-m-DIetVSTGSlaLDia Photorhabdus_luminescens ---------------sImrL-ge-drs-m-DVetISTGSlsLDia Proteus_mirabilis ---------------sImrL-ge-drs-m-nVetISTGSlsLDva Pseudomonas_aeruginosa ---------------sImrL-gs-drt-m-DIdvISTGSlgLDia Pseudomonas_cepacia ---------------sImrM-gdgeaa-E-DIqvVSTGSlgLDia Salmonella_typhi ---------------sImrL-ge-drs-m-DVetISTGSlsLDia Shewanella_putrefaciens ---------------sImkL-ge-drs-m-DVetISTGSlsLDva Streptomyces_avermitilis ---------------aVmrL-ge-rpn-E-pIevIpTGStaLDva Streptomyces_coelicolor ---------------aVmrM-gd-rtn-E-pIevIpTGStaLDva Streptomyces_lividans ---------------aVmrM-gd-rtn-E-pIevIpTGStaLDva Vibrio_cholerae ---------------sImrL-gd-nra-m-DVetISTGSlsLDia Vibrio_splendidus ---------------sImrL-gd-nrt-m-DVetISTGSlsLDia Vibrio_vulnificus ---------------sImrL-gd-nra-m-DVetISTGSlsLDia Xanthomonas_vasicola ---------------sVmrM-gd-rvi-E-aVevIpTGSlmLDia Xylella_fastidiosa ---------------sVmrM-gd-rvi-E-aVeaIpTGSlmLDla Yersinia_pestis ---------------sImrL-ge-drs-m-DVetISTGSlsLDia =============================================================================== DEINOCOCCUS_RADIODURANS -----------gpesggkttlalaivaqaqKa------------- Deinococcus_geothermalis -----------gpesggkttlalsviaqaqra------------- Thermus_aquaticus -----------gpesggkttlaltiiaqaqKg------------- =============================================================================== Consensus xxxxxxxxxxxxkxxxixxlsxxxxxxxqxeixxissgsxxlnxi 320 330 340 350 360 ----|----:----|----:----|----:----|----:----| Consensus LxxggiesgxitEvFxxxxxxxxxxxxxxxxxgdxxsgkSxVcns =============================================================================== PYROCOCCUS_FURIOSUS ViwidtENtfrpErireiaqn---------rglDpdevlkhIyva Pyrococcus_abyssi ViwidtENtfrpErireiakn---------rglDpdevlkhIyva =============================================================================== METHANOCOCCUS_VOLTAE VaqpkavyidtegtFrperimqmaeh---------agidgqtvld Methanococcus_jannaschii LnepkavyidtegtFrperivqmaea---------lgldgnevlN =============================================================================== SULFOLOBUS_SOLFATARICUS sgkavyidtegTfrWerienmaka---------lgldidNvMnNi Aeropyrum_pernix egkavyvdtegTfrWerieqmarg---------vgldpdevMkNi Desulfurococcus_amylolyticus ngravyidtegTfrWerieamara---------lgldpdkvMdNi Sulfolobus_tokodaii ggkavyidtegTfrWerieamska---------iglepdSaMnNi =============================================================================== HUMAN L-qGGIETGsITEMF-----------------GEfrTGKTqICHT YEAST L-gGGVETGsITELF-----------------GEfrTGKSqLCHT Apis_mellifera L-gGGIETGsITEIF-----------------GEfrSGKTqLCHT Aspergillus_fumigatus L-gGGIETGsITEIF-----------------GEfrTGKSqICHT Bombyx_mandarina L-gGGIETGsITEIF-----------------GEfrTGKTqLCHT Bos_taurus p-kGGIETGsITEMF-----------------GEfrTGKTqICHT Caenorhabditis_elegans L-gGGIETGsITEVY-----------------GEyrTGKTqLCHS Candida_albicans L-gGGVETGsITEVF-----------------GEfrTGKSqLCHT Candida_glabrata L-gGGIETGsITELF-----------------GEfrTGKSqLCHS Canis_lupus L-qGGIETGsITEMF-----------------GEfrTGKTqICHT Coprinus_cinereus L-gGGIETGaITELF-----------------GEfrTGKSqICHT Cricetulus_griseus L-qGGIETGsITEMF-----------------GEfrTGKTqICHT Cryptococcus_neoformans L-gGGIETGaITELYgkslrslvaspiantstGEfrTGKSqLCHT Danio_rerio L-qGGIETGsITEMF-----------------GEfrTGKTqLCHT Debaryomyces_hansenii L-gGGIETGsITEVF-----------------GEfrTGKSqLCHT Drosophila_melanogaster L-gGGIETGsITEIF-----------------GEfrcGKTqLCHT Drosophila_pseudoobscura L-gGGIETGsITEIF-----------------GEfrcGKTqICHT Emericella_nidulans L-gGGIETGsITEIF-----------------GEfrTGKSqICHT Encephalitozoon_cuniculi L-sGGfESGsITEIF-----------------GEfrTGKTqLCHT Eremothecium_gossypii L-gGGIETGsITELF-----------------GEfrTGKSqLCHT Gallus_gallus L-qGGIETGsITELF-----------------GEfrTGKTqLCHT Gibberella_zeae L-aGGIETGsVTELF-----------------GEfrTGKSqICHT Kluyveromyces_lactis L-gGGIETGsITELF-----------------GEfrTGKSqLCHT Mus_musculus L-qGGIETGsITEMF-----------------GEfrTGKTqICHT Neurospora_crassa L-aGGIETGsVTEIF-----------------GEfrTGKSqICHT Nosema_bombycis L-nGGIESGsITEIF-----------------GEfrTGKTqICHT Oikopleura_dioica L-aGGVETGsITELF-----------------GEfrTGKSqLCmT Oryctolagus_cuniculus L-qGGIETGsITEMF-----------------GEfrTGKTqICHT Pichia_angusta L-gGGIETGaITEVF-----------------GEfrTGKSqLCHT Pleurotus_ostreatus L-gGGIETGaITEMF-----------------GEfrTGKSqICHT Rattus_norvegicus L-qGGIETGsITEMF-----------------GEfrTGKTqICHT Schizosaccharomyces_pombe L-qGGVETGsITELF-----------------GEfrTGKSqICHT Strongylocentrotus_purpuratus L-qGGIETGsITEIF-----------------GEfrTGKTqLCHT Tetraodon_nigroviridis L-qGGIETGsITEMF-----------------GEfrTGKTqLCHT Ustilago_maydis L-gGGMETGsITELY-----------------GEfrTGKSqLCHT Xenopus_laevis L-qGGIETGsITEMF-----------------GEfrTGKTqLCHT Xenopus_tropicalis L-qGGIETGsITEMF-----------------GEfrTGKTqLCHT Yarrowia_lipolytica L-gGGIETGaITEMF-----------------GEfrTGKSqLCHT Cryptosporidium_spp L-qGGIETGsITEIF-----------------GEfrTGKTqLCHT Dictyostelium_discoideum L-dGGIESGsITEIF-----------------GEfrTGKTqICHT Entamoeba_histolytica L-cGGfETGsITELF-----------------GEfrTGKTqLCHq Leishmania_donovani L-gGGIETGsITELF-----------------GEfrTGKTqLCHT Leishmania_tropica L-gGGIETGsITELF-----------------GEfrTGKTqLCHT Plasmodium_berghei L-kGGIETGgITELF-----------------GEfrTGKSqLCHT Plasmodium_falciparum L-kGGIETGgITELF-----------------GEfrTGKSqLCHT Plasmodium_yoelii L-kGGIETGgITELF-----------------GEfrTGKSqLCHT Tetrahymena_thermophila L-gGGfETGsLTEIF-----------------GEfrTGKTqICHT Theileria_annulata L-qGGVETGsITEIi-----------------GEfkTGKSqLCHT Theileria_parva L-qGGVETGsITEIi-----------------GEfkTGKSqLCHT Trypanosoma_brucei L-gGGIEvGsITELF-----------------GEfrTGKTqLCHT Trypanosoma_cruzi L-gGGIETGgITELF-----------------GEfrTGKTqLCHT Arabidopsis_thaliana L-eGGIETGsITELY-----------------GEfrSGKTqLCHT Oryza_sativa L-dGGIETGsITEIY-----------------GEfrSGKTqLCHT Zea_mays L-zGGIETGsITEMY-----------------GEfrSGKTqLCHT =============================================================================== ECOLI LgaGGLpmGrIvEIY-----------------GpesSGKTtLtlq MYCOBACTERIUM_SMEGMATIS LgiGGLprGrViEIY-----------------GpesSGKTtValh MYCOBACTERIUM_TUBERCULOSIS LgiGGLprGrVvEIY-----------------GpesSGKTtValh Acetobacter_polyoxogenes LgiGGLprGrIiEIY-----------------GpesSGKTtMalh Acinetobacter_calcoaceticus LgiGGLpkGrIvEIY-----------------GpesSGKTtMtlq Actinobacillus_pleuropneumoniae LgiGGLpmGrIvEIY-----------------GpesSGKTtLtlS Actinobacillus_succinogenes LgiGGLpmGrIvEIF-----------------GpesSGKTtLtlS Bacillus_licheniformis LgvGGyprGrIiEVY-----------------GpesSGKTtValh Bacillus_subtilis LgiGGyprGrIiEVY-----------------GpesSGKTtValh Burkholderia_fungorum LgvGGLprGrVvEIY-----------------GpesSGKTtLtlq Carboxydothermus_hydrogenoformans LgvGGVprGrVvEIF-----------------GpesSGKTtValh Chromobacterium_violaceum LgvGGLprGrVvEIY-----------------GpesSGKTtLClq Clostridium_thermocellum LgvGGVprGrIvEIF-----------------GpesSGKTtValh Colwellia_psychrerythraea LgaGGLpmGrVvEIY-----------------GpesSGKTtLtle Desulfotalea_psychrophila LgvGGLpkGrMTEIY-----------------GpesSGKTtLalh Enterococcus_faecalis LgvGGyprGrIiEVY-----------------GpesSGKTtVslh Erwinia_carotovora LgaGGLpmGrIvEIY-----------------GpesSGKTtLtlq Haemophilus_ducreyi LgiGGLpmGrIvEIY-----------------GpesSGKTtLtlS Haemophilus_influenzae LgiGGLpmGrIvEIF-----------------GpesSGKTtLtlS Histophilus_somni LgiGGLpmGrIvEIF-----------------GpesSGKTtLtlS Kineococcus_radiotolerans LgiGGLprGrVvEIY-----------------GpesSGKTtValh Leifsonia_xyli LgiGGLprGrIvEIY-----------------GpesSGKTtLtlh Listeria_monocytogenes LgvGGyprGrIiEVY-----------------GpesSGKTtValh Mannheimia_succiniciproducens LgiGGLpmGrVvEIF-----------------GpesSGKTtLtlS Neisseria_gonorrhoeae LgvGGLprGrIvEIF-----------------GpesSGKTtLCle Nitrosomonas_europaea LgvGGLprGrIiEIY-----------------GpesSGKTtLtlq Nitrosomonas_eutropha LgvGGLprGrIiEIY-----------------GpesSGKTtLtlq Oceanobacillus_iheyensis LgiGGyprGrVvEIY-----------------GpesSGKTtValh Pasteurella_multocida LgaGGLpmGrIvEIY-----------------GpesSGKTtLtle Photobacterium_profundum LgaGGLpmGrIvEIY-----------------GpesSGKTtLtle Photorhabdus_luminescens LgaGGLpmGrIvEIY-----------------GpesSGKTtLtlq Proteus_mirabilis LgaGGLprGrIvEIY-----------------GpesSGKTtLtlq Pseudomonas_aeruginosa LgvGGLprGrIvEIY-----------------GpesSGKTtLtlS Pseudomonas_cepacia LgvGGLprGrVvEIY-----------------GpesSGKTtLtlq Salmonella_typhi LgaGGLpmGrIvEIY-----------------GpesSGKTtLtlq Shewanella_putrefaciens LgaGGLpmGrIvEIY-----------------GpesSGKTtLtle Streptomyces_avermitilis LgvGGLprGrVvEVY-----------------GpesSGKTtLtlh Streptomyces_coelicolor LgvGGIprGrVvEVY-----------------GpesSGKTtLtlh Streptomyces_lividans LgvGGIprGrVvEVY-----------------GpesSGKTtLtlh Vibrio_cholerae LgaGGLpmGrIvEIF-----------------GpesSGKTtLtle Vibrio_splendidus LgaGGLpmGrIvEVY-----------------GpesSGKTtLtle Vibrio_vulnificus LgaGGLpmGrIvEIF-----------------GpesSGKTtLtle Xanthomonas_vasicola LgtGGLpkGrVvEIY-----------------GpesSGKTtLtlq Xylella_fastidiosa LgiGGLpkGrVvEIY-----------------GpesSGKTtLtlq Yersinia_pestis LgaGGLpmGrIvEIY-----------------GpesSGKTtLtlq =============================================================================== DEINOCOCCUS_RADIODURANS -----ggTcafiDaehaldpvyaralg---------------v-- Deinococcus_geothermalis -----ggTcafiDaehaldpvyarslg---------------v-- Thermus_aquaticus -----ggvaafvDaehaldplyakklg---------------v-- =============================================================================== Consensus LxxggiesgxitEvFxxxxxxxxxxxxxxxxxgdxxsgkSxVcns 370 380 390 400 ----:----|----:----|----:----|----:----|----: Consensus lxiscQlxxxxxgxxxxxxxxxxxxxxgqxxfINxExxxxpxrxx =============================================================================== PYROCOCCUS_FURIOSUS rafNsnhqmllvqqaedk-ikellntdrpvklLivDsltshfRse Pyrococcus_abyssi rafNsnhqmllvqqaedk-ikellntdkpvklLivDsltshfRse =============================================================================== METHANOCOCCUS_VOLTAE ntfvaRaynsdmqmlfaekiedliqeg-----nNiKlvvidslts Methanococcus_jannaschii nifvaRaynsdmqmlyaenvenlireg-----hNiKlvivdslts =============================================================================== SULFOLOBUS_SOLFATARICUS yyIraintdhqiaivddlqel-vsk----dpsIklivvdsvtshf Aeropyrum_pernix ywIrainshhqiaivdklftm-vkn----d-nIklvvvdsvtshf Desulfurococcus_amylolyticus yyMraynsdhqiaivdelftf-vpk----n-dVrlvildsvtshf Sulfolobus_tokodaii yyMrainsdhqmaivddlqel-isk----dpaIklvivdsvtshf =============================================================================== HUMAN LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll YEAST LaVTCQIpldigG------------geGKclYIDtEgtfrPvRlv Apis_mellifera LaVNCQLpidmgG------------aeGKclYIDtEgtfrPeRli Aspergillus_fumigatus LaVTCQLpfdmgG------------geGKclYIDtEgtfrPvRll Bombyx_mandarina LaVTCQLpieqsG------------geGKcmYIDtEgtfrPeRll Bos_taurus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Caenorhabditis_elegans LaVlCQLpidmgG------------geGKcmYIDtnatfrPeRii Candida_albicans LaVTCQLpidmgG------------geGKclYIDtEgtfrPnRlv Candida_glabrata LaVTCQIpldlgG------------geGKclYIDtEgtfrPvRlv Canis_lupus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Coprinus_cinereus LaVTCQLpvsmgG------------geGKclYIDtEgtfrPvRll Cricetulus_griseus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Cryptococcus_neoformans LaVTCQLpvsmgG------------geGKclYIDtEgtfrPvRml Danio_rerio LaVTCQLpidqgG------------geGKamYIDtEgtfrPeRll Debaryomyces_hansenii LaVTCQLpidmgG------------geGKclYIDtEgtfrPvRlv Drosophila_melanogaster LaVTCQLpisqkG------------geGKcmYIDtEntfrPeRla Drosophila_pseudoobscura LaVTCQLpisqkG------------geGKclYIDtEstfrteRls Emericella_nidulans LaVTCQLpfdmgG------------geGKclYIDtEgtfrPvRll Encephalitozoon_cuniculi VaVTCQLppeqgG------------ggGKamYIDtEgtfrseRlv Eremothecium_gossypii LaVTCQIpldmgG------------geGKclYIDtEgtfrPiRlv Gallus_gallus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Gibberella_zeae LaVTCQLpfdmgG------------geGKcmYIDtEgtfrPvRll Kluyveromyces_lactis LaVTCQIpldmgG------------geGKclYIDtEgtfrPiRlv Mus_musculus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Neurospora_crassa LaVTCQLpfdmgG------------geGKclYIDtEgtfrPvRll Nosema_bombycis VaVTCQLppeqgG------------anGKalYIDtEgtfrseRff Oikopleura_dioica LaVTaQLpvdlgG------------geGKalYIDtEgtfrPeRll Oryctolagus_cuniculus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Pichia_angusta LaVTCQLpidngG------------geGKclYIDtEgtfrPiRlv Pleurotus_ostreatus LaVTCQLpvsmgG------------geGKclYIDtEgtfrPvRll Rattus_norvegicus LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Schizosaccharomyces_pombe LaVTCQLpidmgG------------geGKclYIDtEgtfrPvRll Strongylocentrotus_purpuratus MaVTCQLpidngG------------geGKclYIDtEgtfrPeRli Tetraodon_nigroviridis LaVTCQLpidqgG------------geGKamYIDtEgtfrPeRll Ustilago_maydis LaVTCQLpvdmgG------------geGKclYIDtEntfrPtRll Xenopus_laevis LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Xenopus_tropicalis LaVTCQLpidrgG------------geGKamYIDtEgtfrPeRll Yarrowia_lipolytica LaVTCQLpidqgG------------geGKclYIDtEgtfrPeRlh Cryptosporidium_spp LaVTCQLpvehkG------------geGKclWIDtEgtfrPeRiv Dictyostelium_discoideum LcVTCQLgysqgG------------geGRalYIDtEgtfrPeRll Entamoeba_histolytica LcVTCQLgiengG------------teGRaiYIDtEgtfrPeRlt Leishmania_donovani LcVTCQLpisqgG------------aeGmalYIDtEgtfrPeRlv Leishmania_tropica LcVTCQLpisqgG------------aeGmalYIDtEgtfrPeRlv Plasmodium_berghei LaITCQLpieqsG------------geGKclWIDtEgtfrPeRiv Plasmodium_falciparum LaITCQLpieqsG------------geGKclWIDtEgtfrPeRiv Plasmodium_yoelii LaITCQLpieqsG------------geGKclWIDtEgtfrPeRiv Tetrahymena_thermophila LcITCQLpkekgG------------geGKamYIDtEgtfrPeRle Theileria_annulata LaVTCQLpveqsG------------geGKclWVDsEgtfrPeRiv Theileria_parva LaVTCQLpveqsG------------geGKclWVDsEgtfrPeRiv Trypanosoma_brucei LcVTCQLplsqgG------------geGmalYIDtEgtfrPeRlv Trypanosoma_cruzi LcVTCQLpisqgG------------aeGmalYIDtEgtfrPeRlv Arabidopsis_thaliana LcVTCQLpmdqgG------------geGKamYIDaEgtfrPqRll Oryza_sativa LcVTCQLpldqgG------------geGKalYIDaEgtfrPqRll Zea_mays LcVTCQLpldqgG------------geGKalYIDaEgtfrPqRll =============================================================================== ECOLI ViaaaQre------------------gktcaFIDaEhaldPiyar MYCOBACTERIUM_SMEGMATIS avaNaQaa------------------gGiaaFIDaEhaldPeyak MYCOBACTERIUM_TUBERCULOSIS avaNaQaa------------------gGvaaFIDaEhaldPeyak Acetobacter_polyoxogenes aiaeaQrk------------------gGtcaFIDaEhaldPgyar Acinetobacter_calcoaceticus aiaqCQka------------------gGtcaFIDaEhaldPqyar Actinobacillus_pleuropneumoniae ViaqaQks------------------gktcaFIDaEhaldPvyar Actinobacillus_succinogenes ViaqaQka------------------gkvcaFIDaEhaldPiyaa Bacillus_licheniformis aiaevQqq------------------gGQaaFIDaEhaldPvyaq Bacillus_subtilis aiaevQqq-------------------rtsaFIDaEhaldPvyaq Burkholderia_fungorum ViaemQki------------------gGtaaFIDaEhaldiqyas Carboxydothermus_hydrogenoformans IiaeaQkm------------------gGiaaFIDaEhaldPvyaq Chromobacterium_violaceum avaeaQkl------------------gGtcaYIDaEnaldPvyaq Clostridium_thermocellum IiaeaQka------------------gGEaaFIDaEhaldPvyak Colwellia_psychrerythraea ViaeaQrn------------------gkvcaFIDaEhaldPvyae Desulfotalea_psychrophila VvaeaQkl------------------gGiaaFIDaEhaldtayae Enterococcus_faecalis aiaevQrn------------------gGtaaFIDaEhaldPqyae Erwinia_carotovora ViaaaQre------------------gktcaFIDaEhaldPiyak Haemophilus_ducreyi ViaqaQri------------------gktcaFIDaEhaldPvyar Haemophilus_influenzae ViaqaQka------------------gktcaFIDaEhaldPiyaa Histophilus_somni ViaqaQka------------------gktcaFIDaEhaldPiyaa Kineococcus_radiotolerans avaSaQka------------------gGiaaFIDaEhaldPdyaa Leifsonia_xyli aiaNaQra------------------gGiaaFIDaEhaldPdyar Listeria_monocytogenes aiaevQaq------------------gGtaaFIDaEhaldPayak Mannheimia_succiniciproducens ViaqaQka------------------gkvcaFIDaEhaldPiyaa Neisseria_gonorrhoeae avaqCQkn------------------gGvcaFVDaEhafdPvyar Nitrosomonas_europaea aiaemQkl------------------gGtaaFIDaEhaldPqyaq Nitrosomonas_eutropha ViaemQkl------------------gGtaaFIDaEhaldPqyaq Oceanobacillus_iheyensis aiaeaQkq------------------gGQaaFIDaEhaldPvyak Pasteurella_multocida LiaaaQre------------------gktcaFIDaEhaldPvyak Photobacterium_profundum ViaSaQka------------------gktcaFIDaEhaldPiyaq Photorhabdus_luminescens ViaaaQre------------------gktcaFIDaEhaldPiyak Proteus_mirabilis ViaSaQre------------------gkicaFIDaEhaldPiyaq Pseudomonas_aeruginosa ViaeaQrq------------------gltcaFVDaEhaldPiyaa Pseudomonas_cepacia ViaelQkl------------------gGtaaFIDaEhaldvqyaa Salmonella_typhi ViaaaQre------------------gktcaFIDaEhaldPvyar Shewanella_putrefaciens ViaaaQre------------------gktcaFIDaEhaldPiyak Streptomyces_avermitilis avaNaQka------------------gGQvaFVDaEhaldPeyak Streptomyces_coelicolor avaNaQka------------------gGQvaFVDaEhaldPeyak Streptomyces_lividans avaNaQka------------------gGQvaFVDaEhaldPeyak Vibrio_cholerae LiaaaQre------------------gktcaFIDaEhaldPvyak Vibrio_splendidus LiaaaQrv------------------gktcaFVDaEhaldPiyaq Vibrio_vulnificus LiaaaQre------------------gktcaFIDaEhaldPvyak Xanthomonas_vasicola aiaqCQkl------------------gGtaaFIDaEhaldPvyaa Xylella_fastidiosa aiaqCQkk------------------gGtaaFIDaEhaldPiyag Yersinia_pestis ViaaaQre------------------gktcaFIDaEhaldPiyak =============================================================================== DEINOCOCCUS_RADIODURANS ntdellVsqpdnGeqaleimellvr--sg------a-idvvvvds Deinococcus_geothermalis ntdellVsqpdnGeqaleimellvr--sg------a-idvvvvds Thermus_aquaticus dvqellVsqpdtGeqaleivellar--sg------a-vdvivvds =============================================================================== Consensus lxiscQlxxxxxgxxxxxxxxxxxxxxgqxxfINxExxxxpxrxx 410 420 430 440 450 ----|----:----|----:----|----:----|----:----| Consensus xLaxkxxxxxxxxxxxxxxxxxiedlxxxQxxsxExxlqIvxxxx =============================================================================== PYROCOCCUS_FURIOSUS yIgrgala----erqq--klakhladlhrlanlyDiaVfVtnqvq Pyrococcus_abyssi yIgrgala----erqq--klakhladlhrlanlyEiaVfVtnqvq =============================================================================== METHANOCOCCUS_VOLTAE tfrnEytgrgkla----erqq--KlgrhmatlNkladLfncvvlv Methanococcus_jannaschii tfrtEyigrgkla----erqq--KlgrhmatlNkladIyncvviv =============================================================================== SULFOLOBUS_SOLFATARICUS raeypgrenla----vrqq--kLnkhlhqltrlaEvydiaViitn Aeropyrum_pernix raefpgrenla----mrqq--lLnrhlhqlmrlaDifnvaVvitn Desulfurococcus_amylolyticus raeypgrehla----erqq--kLnshlhqlmrlaEaynvaVvvtn Sulfolobus_tokodaii raefpgrenla----vrqq--kLnkhlhqlvrlaEmydlaViitn =============================================================================== HUMAN aVAeR---------yglsgsdvLDNVayaRafNtDhqtQLLyqas YEAST sIAqR---------fgldpddaLnNVayaRayNaDhqLRLLdaaa Apis_mellifera aVAeR---------ykiagdsvLDNVacaRayNtDhqtQLLiqas Aspergillus_fumigatus aVAqR---------yglvgeevLDNVayaRayNsDhqLQLLnqas Bombyx_mandarina aVAqR---------ygmegaavLDNVayaRayNtDhqtQLLvqac Bos_taurus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Caenorhabditis_elegans aIAqR---------ynmdsahvLENIavaRayNsEhlMaLIirag Candida_albicans sIAqR---------yglnpndcLDNVayaRayNaEhqLnLLniaa Candida_glabrata sIAqR---------fgldpddaLnNVayaRayNaDhqMRLLdaaa Canis_lupus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Coprinus_cinereus aVAeR---------fglngeevLDNVayaRayNaDhqqaLLtsas Cricetulus_griseus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Cryptococcus_neoformans aVAeR---------ygldgeevLDNIayaRayNaDhqLQLLvqas Danio_rerio aVAeR---------yglvgsdvLDNVayaRafNtDhqtQLLyqas Debaryomyces_hansenii sIAqR---------yglnpedcLDNVayaRayNaEhqfQLLnhaa Drosophila_melanogaster aIAqR---------yklnesevLDNVaftRahNsDqqtKLIqmaa Drosophila_pseudoobscura aIAqR---------fklnesevLDNVscaRayNsDqqtKLLqmaa Emericella_nidulans aVAqR---------yglvgeevLDNVayaRayNsDhqLQLLnqas Encephalitozoon_cuniculi pIAeR---------fgldpnevMDNIsyaRayNsDhqsQLLikas Eremothecium_gossypii sIAqR---------fgldpddaLnNVayaRayNaDhqLRLLdaaa Gallus_gallus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Gibberella_zeae gVAnR---------fglsgeevLDNVayaRayNsDhqLQLLnqaa Kluyveromyces_lactis sIAqR---------fgldpddaLnNVayaRayNaDhqLKLLdaaa Mus_musculus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Neurospora_crassa aVAnR---------yglsgeevLDNVayaRayNsDhqLQLLnqaa Nosema_bombycis pIAeR---------ygldptevLDNIsyaRayNsDhqsQLLiqas Oikopleura_dioica aIseR---------yglsgkdvLDNVavaRafStDhqMtMLhtca Oryctolagus_cuniculus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Pichia_angusta aIArR---------fgldenetLDNVayaRayNaDhqLQLLhqaa Pleurotus_ostreatus aVAeR---------yglngeevLDNVayaRayNaDhqnQLLtsat Rattus_norvegicus aVAeR---------yglsgsdvLDNVayaRgfNtDhqtQLLyqas Schizosaccharomyces_pombe aVAdR---------yglngeevLDNVayaRayNaDhqLELLqqaa Strongylocentrotus_purpuratus aVAdR---------ynlsgsdvLDNVayaRahNsDhqsQLLlqas Tetraodon_nigroviridis aVAeRrvsgrslavyglvgsdvLDNVayaRafNtDhqtQLLyqas Ustilago_maydis aVAeR---------fglngeevLDNVayaRayNaDhqLQLLmqas Xenopus_laevis aVAeR---------yglsgsdvLDNVayaRafNtDhqtQLLyqas Xenopus_tropicalis aVAeR---------yglsgsdvLDNVayaRafNtDhqtQLLyqas Yarrowia_lipolytica qIArR---------yglngdevLDNVayaRahNsDhqMQLLqmaa Cryptosporidium_spp qIAdR---------fnlnasdcLDNIayaRgfNtEhqMdLLqsav Dictyostelium_discoideum aIAeR---------ynlngehvLDNVsyaRayNsDhqLELLvqas Entamoeba_histolytica qIAeK---------yglnseeaLnNVavaRahNtEhqMpLLqmas Leishmania_donovani aVAeR---------ykldpedvLaNVacaRafNtDhqqQLLlqas Leishmania_tropica aVAeR---------ykldpedvLaNVacaRafNtDhqqQLLlqas Plasmodium_berghei aIAkR---------yglhptdcLnNIayaKayNcDhqtELLidas Plasmodium_falciparum aIAkR---------yglhptdcLnNIayaKayNcDhqtELLidas Plasmodium_yoelii aIAkR---------yglhptdcLnNIayaKayNcDhqtELLidas Tetrahymena_thermophila sIAeR---------fgldpqecMENVayaRafNcDqqnKLLvqaa Theileria_annulata sIAkR---------fglspsdcLDNVayaRayNtDhqLELLveas Theileria_parva sIAkR---------fglspsdcLDNVayaRayNtDhqLELLveas Trypanosoma_brucei aVAeR---------ysldpeavLENVacaRayNtDhqqQLLlqas Trypanosoma_cruzi aVAeR---------ykldpqdvLsNVacaRafNtDhqqQLLlqas Arabidopsis_thaliana qIAdR---------fglngadvLENVayaRayNtDhqsRLLleaa Oryza_sativa qIAdR---------fglngadvLENVayaRayNtDhqsRLLleaa Zea_mays qIAdR---------fglngadvLENVayaRayNtDhqsRLLleaa =============================================================================== ECOLI kLg---------------v--dIDNLlcsQpdTgEqaLEIcdala MYCOBACTERIUM_SMEGMATIS kLg---------------v--dtDsLlvsQpdTgEqaLEIadmlv MYCOBACTERIUM_TUBERCULOSIS kLg---------------v--dtDsLlvsQpdTgEqaLEIadmli Acetobacter_polyoxogenes kLg---------------v--dVDNLlisQpdagEqaLEIadtlv Acinetobacter_calcoaceticus kLg---------------v--dIDNLlvsQpdhgEqaLEIadmlv Actinobacillus_pleuropneumoniae kLg---------------v--dtDaLlisQpdNgEqaLEIcdalv Actinobacillus_succinogenes kLg---------------v--dVKELfisQpdNgEqaLEIcdalv Bacillus_licheniformis kLg---------------v--nIDELllsQpdTgEqaLEIaealv Bacillus_subtilis kLg---------------v--nIEELllsQpdTgEqaLEIaealv Burkholderia_fungorum kLg---------------v--nVnDLlvsQpdTgEqaLEIadalv Carboxydothermus_hydrogenoformans kLg---------------v--dIENLlvsQpdTgEqaLEIaeslv Chromobacterium_violaceum kLg---------------v--nVEDLlisQpdTgEqaLEIcdmlv Clostridium_thermocellum nLg---------------v--dIENLivsQpdTgEqaLEIaealv Colwellia_psychrerythraea kLg---------------v--nIDELlisQpdTgEqaLEIVdmlt Desulfotalea_psychrophila kLg---------------v--nIDNLlvsQpdfgEqaLEIaeili Enterococcus_faecalis kLg---------------v--nIDELllsQpdTgEqgLEIadalv Erwinia_carotovora kLg---------------v--dIDNLlcsQpdTgEqaLEIcdalt Haemophilus_ducreyi kLg---------------v--dIDaLlisQpdNgEqaLEIcdalv Haemophilus_influenzae kLg---------------v--dVKELfvsQpdNgEqaLEIcdalv Histophilus_somni kLg---------------v--dVKELlisQpdNgEqaLEIcdalv Kineococcus_radiotolerans kLg---------------v--dtDaLlvsQpdTgEqaLEIadmli Leifsonia_xyli kLg---------------v--dIDaLlvsQpdTgEqaLEIadmlv Listeria_monocytogenes nLg---------------v--nIDELllsQpdTgEqaLEIaealv Mannheimia_succiniciproducens kLg---------------v--dVKELlvsQpdNgEqaLEIcdalv Neisseria_gonorrhoeae kLg---------------v--kVEELylsQpdTgEqaLEIcdtlv Nitrosomonas_europaea kIg---------------v--nVQELlisQpdNgEqaLEItdmlv Nitrosomonas_eutropha kIg---------------v--nVQELlisQpdNgEqaLEItdmlv Oceanobacillus_iheyensis aLg---------------v--nIDELllsQpdTgEqaLEIaealv Pasteurella_multocida kLg---------------v--dIDaLlvsQpdTgEqaLEIcdala Photobacterium_profundum kLg---------------v--dIDqLlcsQpdTgEqaLEIVdala Photorhabdus_luminescens kLg---------------v--dIDNLlcsQpdTgEqaLEIcdalt Proteus_mirabilis kLg---------------v--dIDNLlcsQpdTgEqaLEIcdals Pseudomonas_aeruginosa kLg---------------v--nIDELlcsQpdTgEqaLEIVdilt Pseudomonas_cepacia kLg---------------v--nVpELlisQpdTgEqaLEItdalv Salmonella_typhi kLg---------------v--dIDNLlcsQpdTgEqaLEIcdala Shewanella_putrefaciens kLg---------------v--dIDNLlcsQpdTgEqaLEIcdalt Streptomyces_avermitilis kLg---------------v--dIDNLilsQpdNgEqaLEIVdmlv Streptomyces_coelicolor kLg---------------v--dIDNLilsQpdNgEqaLEIVdmlv Streptomyces_lividans kLg---------------v--dIDNLilsQpdNgEqaLEIVdmlv Vibrio_cholerae kLg---------------v--nIDELlvsQpdTgEqaLEIcdala Vibrio_splendidus kLg---------------v--dIDaLlvsQpdTgEqaLEIcdala Vibrio_vulnificus kLg---------------v--nIDqLlvsQpdTgEqaLEIcdala Xanthomonas_vasicola kLg---------------v--nVDDLllsQpdTgEqaLEIadmlv Xylella_fastidiosa kLg---------------v--nVDDLllsQpdTgEqaLEIadmlv Yersinia_pestis kLg---------------v--dIDNLlcsQpdTgEqaLEIcdalt =============================================================================== DEINOCOCCUS_RADIODURANS vaAltpraeiegdmgdslpglqar--lmsQalrkltaIlsktgta Deinococcus_geothermalis vaAltpraeiegemgdslpglqar--lmsQalrkltaIlsktgta Thermus_aquaticus vaAlvpkaeiegemgdqhvglqar--lmsQalrkltaVlsksnta =============================================================================== Consensus xLaxkxxxxxxxxxxxxxxxxxiedlxxxQxxsxExxlqIvxxxx 460 470 480 490 ----:----|----:----|----:----|----:----|----: Consensus qvxvxexxxxxsxxniVVIdSvxalxxxxyxxxxxgexnxxxqxx =============================================================================== PYROCOCCUS_FURIOSUS arpdaffgdptrpigghILahsa---------------------- Pyrococcus_abyssi arpdaffgdptrpigghILahsa---------------------- =============================================================================== METHANOCOCCUS_VOLTAE tnqVsakpdaffgmaeqaIgghivghaa----------------- Methanococcus_jannaschii tnqVaarpdalfgpSeqaIgghivghaa----------------- =============================================================================== SULFOLOBUS_SOLFATARICUS QVmarpdmfygdptvaVgghTLyhVp------------------- Aeropyrum_pernix QVmarpdvfygdptqaVgghvLghap------------------- Desulfurococcus_amylolyticus QVmarpdvfygdpttaVgghvLahtp------------------- Sulfolobus_tokodaii QVmarpdmfygdptvaVgghTLyhVp------------------- =============================================================================== HUMAN aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm YEAST QM-MsE-----SrfSLIVVDSVmALyrtdFsgr--GElS--aRqm Apis_mellifera aM-MtE-----SryaLLIVDSatgLyrteYsgr--GEla--aRqm Aspergillus_fumigatus QM-McE-----TrfSLLVVDSatsLyrtdFngr--GElS--sRqt Bombyx_mandarina aM-MaE-----SrySLIIVDSatALyrtdYsgr--GElN--sRql Bos_taurus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Caenorhabditis_elegans aM-MsE-----SryaVVIVDcatAhfrneYtgr--GDla--eRqm Candida_albicans EM-MaE-----SrfSLLIVDSImsLyrtdYagr--GElS--aRqt Candida_glabrata QM-MsE-----SrfSLIVVDSVmALyrtdFsgr--GElS--aRqm Canis_lupus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Coprinus_cinereus aL-MsE-----SrfcLLIVDSctALyrtdFsgr--GElS--sRqt Cricetulus_griseus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Cryptococcus_neoformans aM-MaE-----SrfSLLIVDSctsLyrtdFsgr--GElS--aRqm Danio_rerio aM-MtE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqg Debaryomyces_hansenii QM-MsE-----SrfScLIVDSImsLyrtdYsgr--aElS--aRqt Drosophila_melanogaster gM-LfE-----SryaLLIVDSamALyrsdYigr--GEla--aRqn Drosophila_pseudoobscura gM-LfE-----TryaaVIVDSVmALyrsdYigr--GEla--aRqn Emericella_nidulans QM-McE-----TrfSLLVVDSatsLyrtdFngr--GElS--tRqt Encephalitozoon_cuniculi aM-MsE-----SkySVLIIDSatALyrtdFsgr--GElg--aRql Eremothecium_gossypii QM-MsE-----SrfSLIVVDSImALyrtdFsgr--GElS--aRqm Gallus_gallus aM-MaE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Gibberella_zeae aM-McE-----TrfSLLIVDSatsLyrtdFcgr--GElS--nRqt Kluyveromyces_lactis QM-MsE-----SrfSLIIVDSImALyrtdFsgr--GElS--aRqm Mus_musculus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Neurospora_crassa aM-McE-----TrfSLLIVDSatsLyrtdFlgr--GElS--sRqt Nosema_bombycis sL-MsQ-----NkyaVLIIDSatALyrtdFsgr--GElg--aRqi Oikopleura_dioica aM-MtE-----SrySIMIVDSImALyrsdYsgr--GEla--aRqm Oryctolagus_cuniculus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Pichia_angusta sM-MtE-----SrfSLLIVDSImALyrtdYsgr--GElS--aRqm Pleurotus_ostreatus RL-MsE-----SrfcLLIVDSctALyrtdFsgr--GElS--sRqn Rattus_norvegicus aM-MvE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Schizosaccharomyces_pombe nM-MsE-----SrfSLLVVDSctALyrtdFsgr--GElS--aRqm Strongylocentrotus_purpuratus aM-MaE-----SryaLLIVDSatALyrtdYsgr--GEla--sRqm Tetraodon_nigroviridis aM-MaE-----SryaLLIVDSatALyrtdYsgrvwrrcg--dnqs Ustilago_maydis aM-MaE-----SrfSLLIVDSLtsLyrtdFsgr--GElS--aRqm Xenopus_laevis aM-MaE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Xenopus_tropicalis aM-MaE-----SryaLLIVDSatALyrtdYsgr--GElS--aRqm Yarrowia_lipolytica nM-MtK-----SrfScLIVDSImALyrtdYagr--GElS--aRqt Cryptosporidium_spp aM-MtE-----SrfaLMIVDSatALyrseYngr--GEla--tRqs Dictyostelium_discoideum aM-MsE-----SryaLLIVDSatALyrtdYagr--GEla--dRqk Entamoeba_histolytica gL-MaK-----erygLLIIDSatALyrtdYsgr--GEla--sRqm Leishmania_donovani aM-MaE-----NrfaLIIVDSatALyrtdYsgr--nEla--aRqm Leishmania_tropica aM-MaE-----NrfaLIIVDSatALyrtdYsgr--nEla--aRqm Plasmodium_berghei aM-MaD-----TrfaLLIVDSatALyrseYtgr--GEla--nRqs Plasmodium_falciparum aM-MaD-----arfaLLIVDSatALyrseYigr--GEla--nRqs Plasmodium_yoelii aM-MaD-----TrfaLLIVDSatALyrseYtgr--GEla--nRqs Tetrahymena_thermophila aL-MaE-----SkyaLLIVDSatALyrtdYsgr--GElS--vRqn Theileria_annulata aM-MaQ-----TrfaLLIVDSatsLyrsdYsgr--GEla--sRqm Theileria_parva aM-MaQ-----TrfaLLIVDSatsLyrsdYsgr--GEla--sRqm Trypanosoma_brucei at-MaE-----hrvaIIVVDSatALyrtdYngr--GEla--aRqm Trypanosoma_cruzi aM-MaE-----NrfaIIIVDSatALyrtdYsgr--nEla--aRqm Arabidopsis_thaliana sM-MiE-----TrfaLLIVDSatALyrtdFsgr--GElS--aRqm Oryza_sativa sM-MiE-----TrfaLMIVDSatALyrtdFsgr--GElS--aRqm Zea_mays sM-MvE-----TrfaLMVVDSatALyrtdFsgr--GElS--aRqm =============================================================================== ECOLI R--sg------a-vDVIVVDSVaALtpkaeiegeiGDsHmglaar MYCOBACTERIUM_SMEGMATIS R--sg------a-lDIIVIDSVaALvpraeiegemGDsHvglQar MYCOBACTERIUM_TUBERCULOSIS R--sg------a-lDIVLIDSVaALvpraelegemGDsHvglQar Acetobacter_polyoxogenes R--sg------a-vDVLVVDSVaALvpraelegdmGDsHvglhar Acinetobacter_calcoaceticus R--sg------a-iDLIVVDSVaALtpkaeiegemGDsHmglQar Actinobacillus_pleuropneumoniae R--sg------a-vDVIIVDSVaALtpkaeiegdmGDsHmglQar Actinobacillus_succinogenes R--sg------a-iDVIIVDSVaALtpkaeiegdmGDaHvglQar Bacillus_licheniformis R--sg------a-vDIVVIDSVaALvpkaeiegdmGDsHvglQar Bacillus_subtilis R--sg------a-vDIVVVDSVaALvpkaeiegdmGDsHvglQar Burkholderia_fungorum R--sg------S-iDMIVIDSVaALvpkaeiegemGDslpglQar Carboxydothermus_hydrogenoformans R--sg------a-iDVIVIDSVaALvpraeiegemGDaHvglQar Chromobacterium_violaceum R--ss------g-vDVIVVDSVaALvpkaeiegemGDsHvglQar Clostridium_thermocellum R--sg------a-iDVIVIDSVaALvpkaeidgemGDsHvglQar Colwellia_psychrerythraea R--sg------a-iDVIVVDSVaALtpkaeiegdmGDsHmglQar Desulfotalea_psychrophila R--sg------g-vDIIVVDSVaALtpkaeidgnvGDvHvglQar Enterococcus_faecalis s--sg------a-iDIVVIDSVaALvpraeidgemGasHvglQar Erwinia_carotovora R--sg------a-vDVIIVDSVaALtpkaeiegeiGDsHmglaar Haemophilus_ducreyi R--sg------a-vDVIIVDSVaALtpkaeiegdmGDsymglQar Haemophilus_influenzae R--sg------a-iDVIIVDSVaALtpkaeiegdmGDsHmglQar Histophilus_somni R--sg------a-vDVVIVDSVaALtpkaeiegemGDtHvglQar Kineococcus_radiotolerans R--sg------a-lDIIVIDSVaALvpkaeiegemGDsHvglQar Leifsonia_xyli R--sg------S-iDLIVIDSVaALvpraeiegemGDaHvglQar Listeria_monocytogenes R--sg------a-vDMLVIDSVaALvpraeiegemGDaHvglQar Mannheimia_succiniciproducens R--sg------a-vDVIIVDSVaALtpkaeiegdmGDsHvglQar Neisseria_gonorrhoeae R--sg------g-iDMVVVDSVaALvpkaeiegdmGDsHvglQar Nitrosomonas_europaea R--sg------S-vDVVVVDSVaALtpraeiegemGEpqmglQar Nitrosomonas_eutropha R--sg------S-vDIVVIDSVaALtpraeiegemGEpqmglQar Oceanobacillus_iheyensis R--sg------a-vDIIVVDSVaALvpkaeiegemGDsHvglQar Pasteurella_multocida R--sg------a-iDVMVVDSVaALtpkaeiegemGDsHmglQar Photobacterium_profundum R--sg------a-vDLIVVDSVaALtpkaeiegemGDsHmglQar Photorhabdus_luminescens R--sg------a-vDVIIVDSVaALtpkaeiegeiGDsHmglaar Proteus_mirabilis R--sg------a-vDVIVVDSVaALtpkaeiegeiGDsHvglaar Pseudomonas_aeruginosa R--sg------a-vNLIVVDSVaALvpkaeiegeiGDsHvglaar Pseudomonas_cepacia R--sg------S-iDMIVIDSVaALvpkaeiegemGDslpglQar Salmonella_typhi R--sg------a-vDVIVVDSVaALtpkaeiegeiGDsHmglaar Shewanella_putrefaciens R--sg------a-vDVIVVDSVaALtpkaeiegeiGDsHmglaar Streptomyces_avermitilis R--sg------a-lDLIVIDSVaALvpraeiegemGDsHvglQar Streptomyces_coelicolor R--sg------a-lDLIVIDSVaALvpraeiegemGDsHvglQar Streptomyces_lividans R--sg------a-lDLIVIDSVaALvpraeiegemGDsHvglQar Vibrio_cholerae R--sg------a-vDVIVVDSVaALtpkaeiegemGDsHmglQar Vibrio_splendidus R--sg------a-iDVLVIDSVaALtpkaeiegemGDsHmglQar Vibrio_vulnificus R--sg------a-vDVIVVDSVaALtpkaeiegemGDsHmglQar Xanthomonas_vasicola R--ss------S-vDIVVIDSVaALtpkaeiegemGDqlpglQar Xylella_fastidiosa R--sg------S-iDIMVIDSVaALtpraeiegemGDqlpglQar Yersinia_pestis R--sg------a-vDVIIVDSVaALtpkaeiegeiGDsHmglaar =============================================================================== DEINOCOCCUS_RADIODURANS aIfInQvrekigvmygnpetTtggralkfYa-------------- Deinococcus_geothermalis aIfInQvrekigvmygnpetTtggralkfYa-------------- Thermus_aquaticus aIfInQvrekvgvmygnpetTpggralkfYs-------------- =============================================================================== Consensus qvxvxexxxxxsxxniVVIdSvxalxxxxyxxxxxgexnxxxqxx 500 510 520 530 540 ----|----:----|----:----|----:----|----:----| Consensus xxxmxqxlrxlxxlxeqxxixiIxsNqixxkvxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS -------------tlrvylrkgkg----------gkr--iarlid Pyrococcus_abyssi -------------tlrvylrkgkg----------gkr--varlid =============================================================================== METHANOCOCCUS_VOLTAE ------------------tfrffvrkgkg----------dkr--v Methanococcus_jannaschii ------------------tfrIflrkakg----------dkr--v =============================================================================== SULFOLOBUS_SOLFATARICUS ----------------girIqLkkSrg----------nrr--iar Aeropyrum_pernix ----------------gvrVyLkkSrg----------nkr--iar Desulfurococcus_amylolyticus ----------------gvrIqLrkSkg----------nkr--iar Sulfolobus_tokodaii ----------------girVqLkkSrg----------nkr--iar =============================================================================== HUMAN --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- YEAST --hLaKfMRaLqrLaDQfgVaVVvTNQVvaQVd-g--g-m----- Apis_mellifera --hLgRfLRmLlrLaDEhgVaVViTNQVvaQVd-g--a-a----- Aspergillus_fumigatus --hLaKfMRtLqrLaDEfgIaVViTNQVvaQVd-ggps-a----- Bombyx_mandarina --hLgRfMRmLlrLaDEfgVaVIiTNQVvaQVd-s--v-g----- Bos_taurus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Caenorhabditis_elegans --kLsafLKcLakLaDEygVaVIiTNQVvaQVdgg--a-s----- Candida_albicans --hVaKfMRtLqrLaDEfgIaVViTNQVvaQVd-g-ms-g----- Candida_glabrata --hLaKfMRaLqrLaDQfgVaVVvTNQVvaQVd-g--g-m----- Canis_lupus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Coprinus_cinereus --hLgKfLRtLqrLaDEfgIaVVvTNQVmstpd-a--apg----- Cricetulus_griseus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Cryptococcus_neoformans --hLaKfLRtLmrLaDEfgVaVVvTNQVvaQVd-g--g-q----- Danio_rerio --hLgRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Debaryomyces_hansenii --hVaKyMRtLqrLaDEfgIaVViTNQVvaQVd-g--asa----- Drosophila_melanogaster --hLglfLRmLqrLaDEfgVaVViTNQVtasLd-g--a-p----- Drosophila_pseudoobscura --hLglcMRqLqrLaDEfgVaVViTNQVtaQLdgg--g-g----- Emericella_nidulans --hLaKfMRtLqrLaDEfgIaVViTNQVvaQVd-ggps-a----- Encephalitozoon_cuniculi --hLaKyLRsLvnLaEtfrIaVIiTNQVvsnVd-g--avg----- Eremothecium_gossypii --hLaKfMRaLqrLaDQfgVaVVvTNQVvaQVd-g--a-a----- Gallus_gallus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Gibberella_zeae --hLaKfMRtLqrLaDEfgIaVViTNQVvaQVd-ggps-a----- Kluyveromyces_lactis --hLaKfMRsLqrLaDQfgVaaVvTNQVvaQVd-g--g-m----- Mus_musculus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Neurospora_crassa --hLaKfMRtLqrLaDEfgIaVViTNQVvaQVd-ggps-a----- Nosema_bombycis --sLaRyLRdLvnIaEtfhVaVIiTNQVvsnpd-g--ams----- Oikopleura_dioica --hLgKfLRgLlkLaDtfgVaIViTNQVtanVd-g---------- Oryctolagus_cuniculus --hLaRfLRmLlrLaDEfgVtVViTNQVvaQVd-g--a-a----- Pichia_angusta --hVaKfMRtLqrLaDEfgIaVViTNQVvaQVd-g--g-a----- Pleurotus_ostreatus --hLgKfLRtLqrLaDEfgIaVViTNQVmsnpd-a--a-a----- Rattus_norvegicus --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Schizosaccharomyces_pombe --hLaRfMRtLqrLaDEfgIaVViTNQVvaQVd-g--i-s----- Strongylocentrotus_purpuratus --hLgRfLRtLlrLaDEygVaVViTNQVvaQVd-g--a-a----- Tetraodon_nigroviridis gggtgRrgRhVfrrsQEthwrqhsgSRfyhpVs-g--v-f----- Ustilago_maydis --hLaKfLRgLmrLaDEfgVaVViTNQVvaQVd-g--a-t----- Xenopus_laevis --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Xenopus_tropicalis --hLaRfLRmLlrLaDEfgVaVViTNQVvaQVd-g--a-a----- Yarrowia_lipolytica --hVaKfMRtLqrLaDEfgIaVViTNQVvaQVd-g--a-v----- Cryptosporidium_spp --hLgQfLRaLqkIaDtfgVaVViTNQVmsKVd-a--m-a----- Dictyostelium_discoideum --hLaRfLRtLqrLaDEfgVaVViTNQVvasVd-g--agg----- Entamoeba_histolytica --hLvKfLRaLqrIaDEfsVaVVlTNQVvaQVd-g-qa-s----- Leishmania_donovani --hLgKfLRsLhnLaEEygVaVVvTNQVvanVd-g--saq----- Leishmania_tropica --hLgKfLRsLhnLaEEygVaVVvTNQVvanVd-g--s-a----- Plasmodium_berghei --hLcRfLRgLqrIaDiygVaVIiTNQVvaKVd-a--m-s----- Plasmodium_falciparum --hLcRfLRgLqrIaDiygVaVIiTNQVvaKVd-a--m-s----- Plasmodium_yoelii --hLcRfLRgLqrIaDiygVaVIiTNQVvaKVd-a--m-s----- Tetrahymena_thermophila --hLgKfLRnLqrLaDEfgIaVViTNQVmsQVd-g--a-a----- Theileria_annulata --hLcKfLRaLqrIaDtfgVaVViTNQVvaRVd-a--m-stffgi Theileria_parva --hLcKfLRaLqrIaDtfgVaVViTNQVvaKVd-a--m-s----- Trypanosoma_brucei --hLgKfLRsLrnLanEynVaVVvTNQVvanVd-g--a-ap---- Trypanosoma_cruzi --hLgKfLRsLhnLaEEygVaVVvTNQVvanVd-g--s-a----- Arabidopsis_thaliana --hLaKfLRsLqkLaDEfgVaVViTNQVvaQVd-g--s-a----- Oryza_sativa --hMaKfLRsLqkLaDEfgVaVViTNQVvaQVd-g--s-a----- Zea_mays --hLaKfLRsLqkLaDEfgVaVViTNQVvaQVd-g--a-a----- =============================================================================== ECOLI --mMsQaMRkLagnlKQsntlLIfiNQIrmKIgvmfg--npettt MYCOBACTERIUM_SMEGMATIS --lMsQaLRkMtgalnnsgttaIfiNQLreKIgvmfg--spettt MYCOBACTERIUM_TUBERCULOSIS --lMsQaLRkMtgalnnsgttaIfiNQLreKIgvmfg--spettt Acetobacter_polyoxogenes --lMsQaLRkLtgsvsRsntmLIflNQIrlKIgvmfg--spestt Acinetobacter_calcoaceticus --lMsQaLRkItgnaKRsncmVIfiNQIrmKIgvmfg--spettt Actinobacillus_pleuropneumoniae --lMsQaLRkLtaniKatnclVVfiNQIrmKIgvmfg--npettt Actinobacillus_succinogenes --lMsQaLRkLtaqiKssnclVVfiNQIrmKIgvmfg--npettt Bacillus_licheniformis --lMsQaLRkLsgainKsktiaIfiNQIreKVgvmfg--npettp Bacillus_subtilis --lMsQaLRkLsgainKsktiaIfiNQIreKVgvmfg--npettp Burkholderia_fungorum --lMsQaLRkLtgtiKRtnclVIfiNQIrmKIgvmfg--npettt Carboxydothermus_hydrogenoformans --lMsQaLRkLtgaisKsktvaIfiNQMreKVgvmfg--npettp Chromobacterium_violaceum --lMsQaLRkLtgniKRtntlVIfiNQIrmKIgvmfg--npettt Clostridium_thermocellum --lMsQaLRkLagVinKsrttaIfiNQLreKVgvmfg--npettp Colwellia_psychrerythraea --mLsQaMRkLtgnlKKsntmLIfiNQIrmKIgvmfg--spettt Desulfotalea_psychrophila --lMsQaMRkfagVlnRsntvLIfiNQIrmKIgvmfg--spettt Enterococcus_faecalis --lMsQaLRkLsgsinKtktiaIfiNQIreKVgvmfg--npettp Erwinia_carotovora --mMsQaMRkLagnlKQantlLIfiNQIrmKIgvmfg--npettt Haemophilus_ducreyi --lMsQaLRkLtaniKatnclVVfiNQIrmKIgvmfg--npettt Haemophilus_influenzae --lMsQaLRkLtgqiKnanclVVfiNQIrmKIgvmfg--npettt Histophilus_somni --lMsQaLRkLtgqiKnsnclVVfiNQIrmKIgvifg--npettt Kineococcus_radiotolerans --lMsQaLRkItgalnhsgttaIfiNQLreKIgvmfg--spettt Leifsonia_xyli --lMsQaLRkLtgalsQtnttMIfiNQLreKVgvffg--spetta Listeria_monocytogenes --lMsQaLRkLsgVinKsktiaIfiNQIreKVgvmfg--npeitp Mannheimia_succiniciproducens --lMsQaLRkLtgqiKnanclVVfiNQIrmKIgvmfg--npettt Neisseria_gonorrhoeae --lMsQaLRkLtghiKKtntlVVfiNQIrmKIgvmfg--spettt Nitrosomonas_europaea --lMsQaLRkLtaniKRtntmVIfiNQIrmKIgvifg--npettt Nitrosomonas_eutropha --lMsQaLRkLtaniKRtnttVIfiNQIrmKIgvmfg--npettt Oceanobacillus_iheyensis --lMsQaLRkLsgainKskttaIfiNQIreKVgvmfg--npettp Pasteurella_multocida --mLsQaMRkLtgnlKQsncmcIfiNQIrmKIgvmfg--npettt Photobacterium_profundum --mLsQaMRkLtgnlKnancmcIfiNQIrmKIgvmfg--npettt Photorhabdus_luminescens --mMsQaMRkLagnlKssntlLIfiNQIrmKIgvmfg--npettt Proteus_mirabilis --mMsQaMRkLagnlKnsntlLIfiNQIrmKIgvmfg--npettt Pseudomonas_aeruginosa --mMsQaMRkItgnlKnsntmcIfiNQIrmKIgvmfg--npettt Pseudomonas_cepacia --lMsQaLRkLtgtiKRtnclVIfiNQIrmKIgvmfg--npettt Salmonella_typhi --mMsQaMRkLagnlKQsntlLIfiNQIrmKIgvmfg--npettt Shewanella_putrefaciens --mMsQaMRkLagnlKQsntlLIfiNQIrmKIgvmfg--npettt Streptomyces_avermitilis --lMsQaLRkItsalnQskttaIfiNQLreKIgvmfg--spettt Streptomyces_coelicolor --lMsQaLRkItsalnQskttaIfiNQLreKIgvmfg--spettt Streptomyces_lividans --lMsQaLRkItsalnQskttaIfiNQLreKIgvmfg--spettt Vibrio_cholerae --mLsQaMRkLtgnlKQsncmcIfiNQIrmKIgvmfg--npettt Vibrio_splendidus --mLsQaMRkLtgnlKQsncmaIfiNQIrmKIgvmfg--npettt Vibrio_vulnificus --mLsQaMRkLtgnlKQsncmcIfiNQIrmKIgvmfg--npettt Xanthomonas_vasicola --lMsQaLRkLtgniKRsntlVVfiNQLrmKIgvmmpgqspevtt Xylella_fastidiosa --lMsQaLRkLtgniKRsntlVIfiNQLrmKIgimmpgqspettt Yersinia_pestis --mMsQaMRkLagnlKnantlLIfiNQIrmKIgvmfg--npettt =============================================================================== DEINOCOCCUS_RADIODURANS ---------------------sVrlDvrkigqptkvgndavantv Deinococcus_geothermalis ---------------------sVrlDvrkigqpvklgndavgntv Thermus_aquaticus ---------------------sVrlDvrksgqpikvgneavgikv =============================================================================== Consensus xxxmxqxlrxlxxlxeqxxixiIxsNqixxkvxxxxxxxxxxxxx 550 560 570 580 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxixxxxxsxr =============================================================================== PYROCOCCUS_FURIOSUS aphlp-egeavfsit-ekgied----------------------- Pyrococcus_abyssi aphlp-egeavfrit-ekgied----------------------- =============================================================================== METHANOCOCCUS_VOLTAE aklydsphlp-daeaifrit-ekgiqd------------------ Methanococcus_jannaschii aklydsphlp-daeamfrit-ekgihd------------------ =============================================================================== SULFOLOBUS_SOLFATARICUS vvdaphlp-egevvfalt-eegird--ae---------------- Aeropyrum_pernix vvdaphlp-egetvfait-ewgird--pe---------------- Desulfurococcus_amylolyticus vvdaphlp-egevvfvit-eegird--se---------------- Sulfolobus_tokodaii ivdaphlp-egevvfait-eegvrd--ae---------------- =============================================================================== HUMAN ---------------------m--faadpkkpiggnIiahasTtR YEAST ---------------------a--fnpdpkkptggnImahssTtR Apis_mellifera ---------------------s-mfggdqkkpigghIiahasTtR Aspergillus_fumigatus ---------------------m--fnpdpkkpiggnIiahasTtR Bombyx_mandarina ---------------------v--fnadtkkpigghIiahasTtR Bos_taurus ---------------------m--faadpkkpiggnIiahasTtR Caenorhabditis_elegans ---------------------m--fqadakkpigghIiahmsTtR Candida_albicans ---------------------m--fnpdpkkpiggnIiahssTtR Candida_glabrata ---------------------s--fnpdpkkpiggnImahssTtR Canis_lupus ---------------------m--faadpkkpiggnIiahasTtR Coprinus_cinereus ---------------------p--yagnekkpiggnImahasTtR Cricetulus_griseus ---------------------m--ftadpkkpiggnIiahasTtR Cryptococcus_neoformans ---------------------f--avadakkpiggnImahasTtR Danio_rerio ---------------------m--fsadpkkpiggnIlahasTtR Debaryomyces_hansenii ---------------------m--fnpdpkkpiggnIiahssTtR Drosophila_melanogaster ---------------------g--mf-dakkpigghImahssTtR Drosophila_pseudoobscura ---------------------m--fvadakkpvgghIlahasTtR Emericella_nidulans ---------------------m--fnpdpkkpiggnIiahasTtR Encephalitozoon_cuniculi ---------------------m--ftgdikkpiggnImahasTtR Eremothecium_gossypii ---------------------m--fnpdpkkpiggnImahssTtR Gallus_gallus ---------------------m--faadpkkpiggnIiahasTtR Gibberella_zeae ---------------------m--fnpdpkkpiggnIiahasTtR Kluyveromyces_lactis ---------------------m--fnpdpkkpiggnImahssTtR Mus_musculus ---------------------m--faadpkkpiggnIiahasTtR Neurospora_crassa ---------------------m--fnpdpkkpiggnIiahasTtR Nosema_bombycis ---------------------m--fagdvkkpiggnImahasTtR Oikopleura_dioica ---------------------m--mmgdnqtpvggnIlahasctR Oryctolagus_cuniculus ---------------------m--faadpkkpiggnIiahasTtR Pichia_angusta ---------------------i--fnpdpkkpiggnIvahssTtR Pleurotus_ostreatus ---------------------gp-yagnekkpiggnImahasTtR Rattus_norvegicus ---------------------m--faadpkkpiggnIiahasTtR Schizosaccharomyces_pombe ------------------------fnpdpkkpiggnIlahssTtR Strongylocentrotus_purpuratus ---------------------m--ftsdpkkpigghImahasTtR Tetraodon_nigroviridis ---------------------k--tcgygiteetsefvqlvlfav Ustilago_maydis ---------------------a--ftadakkpiggnIvahasTtR Xenopus_laevis ---------------------m--faadpkkpiggnIiahasTtR Xenopus_tropicalis ---------------------m--faadpkkpiggnIiahasTtR Yarrowia_lipolytica ------------------------fnpdpkkpiggnIvahasTtR Cryptosporidium_spp ---------------------a--mfqndkvpiggnIiahasqtR Dictyostelium_discoideum ---------------------m--fnpdpkkpigghImahssTtR Entamoeba_histolytica ---------------------m--fggdtkkpvggnIiahasTtR Leishmania_donovani ---------------------m--fqadskkpigghImahasTtR Leishmania_tropica ----------------q----m--fqadskkpigghImahasTtR Plasmodium_berghei ---------------------m--fgghekipiggnIiahasqtR Plasmodium_falciparum ---------------------m--fgghekipiggnIiahasqtR Plasmodium_yoelii ---------------------m--fgghekipiggnIiahasqtR Tetrahymena_thermophila ---------------------m--fagdmkkpiggnImahasTtR Theileria_annulata lllyiiiycyilinickfyidk--fvgndklpvgghIiahasqtR Theileria_parva ---------------------t--ffgndklpvgghIiahasqtR Trypanosoma_brucei ---------------------t--fqadskkpigghImahasTtR Trypanosoma_cruzi ----------------q----m--fqadakkpigghImahasTtR Arabidopsis_thaliana ---------------------l--fagpqfkpiggnImahatTtR Oryza_sativa ---------------------m--fagpqikpiggnImahasTtR Zea_mays ---------------------m--fagpqikpiggnImahasTtR =============================================================================== ECOLI ggnalkfya---------------------------------SvR MYCOBACTERIUM_SMEGMATIS ggkalkfya---------------------------------SvR MYCOBACTERIUM_TUBERCULOSIS ggkalkfya---------------------------------SvR Acetobacter_polyoxogenes ggnalkfya---------------------------------SvR Acinetobacter_calcoaceticus ggnalkfya---------------------------------SvR Actinobacillus_pleuropneumoniae ggnalkfya---------------------------------SvR Actinobacillus_succinogenes ggnalkfys---------------------------------SvR Bacillus_licheniformis ggralkfys---------------------------------SvR Bacillus_subtilis ggralkfys---------------------------------SvR Burkholderia_fungorum ggnalkfya---------------------------------SvR Carboxydothermus_hydrogenoformans ggralkfya---------------------------------SiR Chromobacterium_violaceum ggnalkfya---------------------------------SvR Clostridium_thermocellum ggralkfya---------------------------------SvR Colwellia_psychrerythraea ggnalkfya---------------------------------SvR Desulfotalea_psychrophila ggnalkfyc---------------------------------SeR Enterococcus_faecalis ggralkfya---------------------------------TvR Erwinia_carotovora ggnalkfya---------------------------------SvR Haemophilus_ducreyi ggnalkfya---------------------------------SvR Haemophilus_influenzae ggnalkfys---------------------------------SvR Histophilus_somni ggnalkfya---------------------------------SvR Kineococcus_radiotolerans ggkalkfya---------------------------------SvR Leifsonia_xyli ggkalkfya---------------------------------SvR Listeria_monocytogenes ggralkfys---------------------------------TvR Mannheimia_succiniciproducens ggnalkfys---------------------------------SvR Neisseria_gonorrhoeae ggnalkfys---------------------------------SvR Nitrosomonas_europaea ggnalkfya---------------------------------SvR Nitrosomonas_eutropha ggnalkfya---------------------------------SvR Oceanobacillus_iheyensis ggralkfys---------------------------------SvR Pasteurella_multocida ggnalkfya---------------------------------SvR Photobacterium_profundum ggnalkfya---------------------------------SvR Photorhabdus_luminescens ggnalkfya---------------------------------SvR Proteus_mirabilis ggnalkfya---------------------------------SvR Pseudomonas_aeruginosa ggnalkfya---------------------------------SvR Pseudomonas_cepacia ggnalkfys---------------------------------SvR Salmonella_typhi ggnalkfya---------------------------------SvR Shewanella_putrefaciens ggnalkfya---------------------------------SvR Streptomyces_avermitilis ggralkfya---------------------------------SvR Streptomyces_coelicolor ggralkfya---------------------------------SvR Streptomyces_lividans ggralkfya---------------------------------SvR Vibrio_cholerae ggnalkfya---------------------------------SvR Vibrio_splendidus ggnalkfya---------------------------------SvR Vibrio_vulnificus ggnalkfya---------------------------------SvR Xanthomonas_vasicola ggnalkfya---------------------------------SvR Xylella_fastidiosa ggnalkfya---------------------------------SvR Yersinia_pestis ggnalkfya---------------------------------SvR =============================================================================== DEINOCOCCUS_RADIODURANS --kiktvknkvaapfkevelalvygkgfdq-lsd-lVglaadmdi Deinococcus_geothermalis --kvktvknkvappfkeveltllygkgfdq-lsd-lVtlaadmdi Thermus_aquaticus --kvkvvknklappfreaeleiyfgrgldp-vmd-lVnvavaagv =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxixxxxxsxr 590 600 610 620 630 ----|----:----|----:----|----:----|----:----| Consensus Lxlrrxkxxxxxxxxxxxdqxxxxxkvxxnxxxpxxxeaxfxixx =============================================================================== PYROCOCCUS_FURIOSUS --------------------------------------------- Pyrococcus_abyssi --------------------------------------------- =============================================================================== METHANOCOCCUS_VOLTAE --------------------------------------------- Methanococcus_jannaschii --------------------------------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS ---------------e----------------------------- Aeropyrum_pernix --------------------------------------------- Desulfurococcus_amylolyticus ---------------ee---------------------------- Sulfolobus_tokodaii ---------------e----------------------------- =============================================================================== HUMAN LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- YEAST LgfKKgKg----------cQr--lcKVvdSpclP-eaEcvFaIy- Apis_mellifera LyLRKgRg----------Etr--icKIydSpclP-esEAmFaIn- Aspergillus_fumigatus LsLKKgRg----------Etr--vcKIydSpclP-esDclFaIn- Bombyx_mandarina LyLRKgRg----------Dnr--vcKIydSpclP-etEAmFaIs- Bos_taurus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Caenorhabditis_elegans LyLRKgKg----------Enr--vaKMvqSpnlP-eaEAtYsIt- Candida_albicans LsfKKgRg----------Etr--icKIydSpclP-esEciFaIy- Candida_glabrata LgfKKgKg----------cQr--ycKVvdSpclP-eaEcvFaIy- Canis_lupus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Coprinus_cinereus LqLKKgRg----------Ntr--acKIydSpclP-esEttFaIl- Cricetulus_griseus LyLRKgRg----------Etr--icKVydSpclP-eaEAmFaIn- Cryptococcus_neoformans LnLRKgRg----------tsr--vcKIvdSpclP-eaEAiFaIn- Danio_rerio LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Debaryomyces_hansenii LsfKKgRa----------EQr--icKIydSpclP-esEcvFaIy- Drosophila_melanogaster LyLRKgKg----------Etr--icKIydSpclP-esEAmFaIl- Drosophila_pseudoobscura LyLRKgKg----------Etr--icKIydSpclP-esEAmFaIl- Emericella_nidulans LsLKKgRg----------Etr--vcKIydSpclP-esDclFaIn- Encephalitozoon_cuniculi LyLRKgRg----------Etr--icKIydSpclP-esEAvFaIt- Eremothecium_gossypii LgfKKgKg----------cQr--lcKVvdSpclP-eaEcvFaIy- Gallus_gallus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Gibberella_zeae IsLKKgRa----------Etr--iaKIydSpclP-esDtlFaIg- Kluyveromyces_lactis LgfKKgKg----------pQr--ycKVvdSpclP-eaEcvFaIy- Mus_musculus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Neurospora_crassa IsLKKgRg----------Etr--iaKIydSpclP-esDclFaIn- Nosema_bombycis LsLRKgKg----------str--icKIydSpllP-esEAmFsIt- Oikopleura_dioica IkMKKgRg----------NnrfgtaRIydSpclP-deQitFaIs- Oryctolagus_cuniculus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Pichia_angusta LyfKKaKg----------anr--icKIydSpcla-esEtvFaLg- Pleurotus_ostreatus LqLKKgRg----------ttr--tcKIydSpclP-emEtqFaIl- Rattus_norvegicus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Schizosaccharomyces_pombe LsLRKgRg----------EQr--icKIydSpclP-esEAiFaIn- Strongylocentrotus_purpuratus LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Tetraodon_nigroviridis ctLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Ustilago_maydis LsLRKgRg----------NQr--icRIadSpclP-eaDAvFaIg- Xenopus_laevis LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Xenopus_tropicalis LyLRKgRg----------Etr--icKIydSpclP-eaEAmFaIn- Yarrowia_lipolytica LyfKKgRg----------vQr--icKIydSpclP-esgcvFaIh- Cryptosporidium_spp LfLKKgRg----------Etr--icKIydSpnlP-egDAtFsIt- Dictyostelium_discoideum LsLRKgKg----------Emr--icKIydSpslP-esEkpFgIy- Entamoeba_histolytica LyLRKgKg----------Ear--icKVydSpclP-esEAsFaIt- Leishmania_donovani LsLRKgRg----------EQr--iiKVydSpcla-eaEAiFgIy- Leishmania_tropica LsLRKgRg----------EQr--iiKVydSpcla-eaEAiFgIy- Plasmodium_berghei LyLRKgRg----------Esr--icKIydSpvlP-egEAvFaIt- Plasmodium_falciparum LyLRKgRg----------Esr--icKIydSpvlP-egEAvFaIt- Plasmodium_yoelii LyLRKgRg----------Esr--icKIydSpvlP-egEAvFaIt- Tetrahymena_thermophila LyLRKgRg----------Esr--icKIydSpclP-esEAiYaIg- Theileria_annulata LfLRQsKg----------Esr--icKVydSpvlP-egEAvFaIt- Theileria_parva LfLRQsKg----------Esr--icKIydSpvlP-egEAvFaIt- Trypanosoma_brucei LsLRKgRg----------EQr--iiKVydSpcla-esEAiFgIy- Trypanosoma_cruzi LsLRKgRg----------EQr--imKVydSpcla-eaEAiFgIy- Arabidopsis_thaliana LaLRKgRa----------EEr--icKVisSpclP-eaEArFqIs- Oryza_sativa LaLRKgRg----------EEr--icKVisSpcla-eaEArFqIa- Zea_mays LfLRKgRg----------EEr--icKVisSpcla-eaEArFqIa- =============================================================================== ECOLI LdIRRigavkegenvvg-sEt--rvKVvkNkiaapfkQAeFqIly MYCOBACTERIUM_SMEGMATIS LdVRRiEtlkdgtdavg-NRt--rvKVvkNkvsPpfkQAeFdIly MYCOBACTERIUM_TUBERCULOSIS MdVRRiEtlkdgtnavg-NRt--rvKIvkNkxxxpfkQAeFdIly Acetobacter_polyoxogenes MdIRRigsikdkdevtg-NQt--rvKVvkNkmaPpfrQveFdImy Acinetobacter_calcoaceticus LdIRRigqvkegdeiig-sEt--kvKVvkNkmaPpfrEAiFqIly Actinobacillus_pleuropneumoniae LdIRRsgvvkdgdevvg-sEt--kvKIvkNkvaPpfrEvqFdImy Actinobacillus_succinogenes LdIRRigsvkagdeiig-NEt--rvKVvkNklaapfrtvdFqImy Bacillus_licheniformis LeVRRaEqlkqgndvmg-NKt--kiKVvkNkvaPpfrtAevdImy Bacillus_subtilis LeVRRaEqlkqgndvmg-NKt--kiKVvkNkvaPpfrtAevdImy Burkholderia_fungorum LdIRRigsikkndevig-NEt--rvKVvkNkvsPpfrEAiFdIly Carboxydothermus_hydrogenoformans MdVRKidvikqgndiig-sRt--rvKIvkNkvaPpfkQAdFdImy Chromobacterium_violaceum LdIRRtggikkgdevig-Ndt--rvKVvkNkvsPpfrQAdFeIly Clostridium_thermocellum LdVRRlEsikqgnevig-sRt--kvKVvkNkvaPpfkEAeFdIiy Colwellia_psychrerythraea LdIRRigavkngdeivg-NEt--rvKVvkNkiaPpfkQAeFqIly Desulfotalea_psychrophila LdIRRigaikdgqeitg-NRt--rvKVvkNkvaPpfkiAeFdIiy Enterococcus_faecalis LeVRRaEqlkqgtdivg-NRt--kiKVvkNkvaPpfkvAevdImy Erwinia_carotovora LdIRRtgaikngeevvg-sEt--rvKVvkNkvaapfkQAeFqIly Haemophilus_ducreyi LdIRRsgvvkdgdevvg-sEt--kvKIvkNkvaPpfrEvqFdImy Haemophilus_influenzae LdIRRtgsvkdgeniig-NEt--rvKVvkNklaapfrQvdFqIly Histophilus_somni LdIRRvgsikngdevig-NEt--rvKVvkNkvaPpfrQvdFqIly Kineococcus_radiotolerans LdVRRiEtlkdgtnpvg-NRt--rvKVvkNkvsPpfkQAeFdIiy Leifsonia_xyli LdIRRiEtlkdgtdavg-NRt--rvKVvkNkmaPpfkQAeFdIly Listeria_monocytogenes LeVRRaEqlkqgtdvmg-NKt--kiKVvkNkvaPpfriAevdImy Mannheimia_succiniciproducens LdIRRvgavkdgdeiig-NEt--rvKVvkNklaPpfrQvdFqIly Neisseria_gonorrhoeae LdIRRtgsikkgeevlg-NEt--rvKVikNkvaPpfrQAeFdIly Nitrosomonas_europaea LdIRRtgsikrgeemvg-NEt--rvKIvkNkvaPpfkQAdFdIly Nitrosomonas_eutropha LdIRRtgsikrgeeivg-NEt--rvKVvkNkvaPpfkQAdFaIly Oceanobacillus_iheyensis LeVRRaEtlklgndavg-NKa--riKVvkNkvaPpfkQAevdImy Pasteurella_multocida LdIRRtgaikegdevvg-NEt--riKVvkNkiaapfkEAntqImy Photobacterium_profundum LdIRRtgaikdgdevvg-NEt--riKVvkNkiaapfkQAetqIly Photorhabdus_luminescens LdIRRigsvkngeevvg-sEt--rvKVvkNkvaapfkQAeFqImy Proteus_mirabilis LdIRRigsvkngdevig-sEt--rvKVvkNkvaapfkQAeFqImy Pseudomonas_aeruginosa LdIRRtgavkegeevvg-sEt--rvKVvkNkvaapfrQAeFqIvy Pseudomonas_cepacia LdIRRigsikkndevig-NEt--rvKVvkNkvsPpfrEAiFdIly Salmonella_typhi LdIRRigavkegdnvvg-sEt--rvKVvkNkiaapfkQAeFqIly Shewanella_putrefaciens LdIRRtgaikdgdevvg-NEt--rvKVvkNkvaapfkQAeFqIly Streptomyces_avermitilis LdIRRiEtlkdgtdavg-NRt--rvKVvkNkvaPpfkQAeFdIly Streptomyces_coelicolor LdIRRiEtlkdgtdavg-NRt--rvKVvkNkvaPpfkQAeFdIly Streptomyces_lividans LdIRRiEtlkdgtdavg-NRt--rvKVvkNkvaPpfkQAeFdIly Vibrio_cholerae LdIRRtgaikegeevvg-NEt--riKVvkNkiaapfkEAntqImy Vibrio_splendidus LdIRRtgaikdgdevvg-NEt--riKVvkNkiaapfkQAetqIly Vibrio_vulnificus LdIRRtgaikegdevvg-NEt--riKVvkNkiaapfkEAntqImy Xanthomonas_vasicola LdIRRigaikkgdeiig-NQt--kiKVvkNklaPpfkQvvteIly Xylella_fastidiosa LdIRRigaikkgdeiig-NQt--kiKVvkNklaPpfkQvvteIly Yersinia_pestis LdIRRigavkdgdvvvg-sEt--rvKVvkNkiaapfkQAeFqIly =============================================================================== DEINOCOCCUS_RADIODURANS Ikkagsfysygderigqgk-e-k--t--i-a-y-iaerpemeqei Deinococcus_geothermalis Ikkagsfysygeerigqgk-e-k--a--i-a-y-iaerpeleqei Thermus_aquaticus Iekagswfsygehrlgqgk-e-k--a--a-e-y-lrerpelleei =============================================================================== Consensus Lxlrrxkxxxxxxxxxxxdqxxxxxkvxxnxxxpxxxeaxfxixx 640 650 660 670 ----:----|----:----|----:----|----:----|----: Consensus xegixnxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS --------------------------------------------- Pyrococcus_abyssi --------------------------------------------- =============================================================================== METHANOCOCCUS_VOLTAE --------------------------------------------- Methanococcus_jannaschii --------------------------------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS --------------------------------------------- Aeropyrum_pernix --------------------------------------------- Desulfurococcus_amylolyticus --------------------------------------------- Sulfolobus_tokodaii --------------------------------------------- =============================================================================== HUMAN aDGVgD---ak----------------------------d----- YEAST eDGVgD---pr----------------------------e-e-d- Apis_mellifera aDGIgD---vk----------------------------e----- Aspergillus_fumigatus eDGIgDp-spk----------------------------d-l-e- Bombyx_mandarina aEGItD---ak----------------------------e----- Bos_taurus aDGVgD---ak----------------------------d----- Caenorhabditis_elegans nhGIeD---ar----------------------------e-d--- Candida_albicans eDGIgD---pk----------------------------v-e-dn Candida_glabrata eDGIgD---pr----------------------------e-e-d- Canis_lupus aDGVgD---ak----------------------------d----- Coprinus_cinereus pgGIgD---pe----------------------------e-e-s- Cricetulus_griseus aDGVgD---ak----------------------------d----- Cryptococcus_neoformans pnGIgD---pe----------------------------e-l-q- Danio_rerio aDGVgD---ak----------------------------d----- Debaryomyces_hansenii eDGIgD---pk----------------------------t-e-dd Drosophila_melanogaster pDGIgD---ar----------------------------e-s--- Drosophila_pseudoobscura pDGIgD---ak----------------------------e-g-h- Emericella_nidulans eDGIgDp-spk----------------------------d---l- Encephalitozoon_cuniculi eQGInD---pd----------------------------e----- Eremothecium_gossypii eDGIgD---pr----------------------------e-d-de Gallus_gallus aDGVgD---ak----------------------------e----- Gibberella_zeae eEGIgDp-apk----------------------------d---t- Kluyveromyces_lactis eDGIgD---pr----------------------------e-d-d- Mus_musculus aDGVgD---ak----------------------------d----- Neurospora_crassa eDGIgDp-spk----------------------------d---me Nosema_bombycis eaGInD---pe----------------------------e----- Oikopleura_dioica pgGItD---ae----------------------------e-e--- Oryctolagus_cuniculus aDGVgD---ak----------------------------d----- Pichia_angusta qgGViD---ps----------------------------d-e-te Pleurotus_ostreatus qsGIgD---pe----------------------------e-e-t- Rattus_norvegicus aDGVgD---ak----------------------------d----- Schizosaccharomyces_pombe sDGVgD---pk----------------------------e-i-ia Strongylocentrotus_purpuratus pDGVgD---ak----------------------------d----- Tetraodon_nigroviridis aDGVgD---ak----------------------------d----- Ustilago_maydis pEGIiD---pv----------------------------d----- Xenopus_laevis aDGVgD---ak----------------------------d----- Xenopus_tropicalis aDGVgD---ak----------------------------d----- Yarrowia_lipolytica eDGIgD---pk----------------------------d-e-e- Cryptosporidium_spp egGInD---pk----------------------------d-e-k- Dictyostelium_discoideum sDGIsD---yk----------------------------e-q--- Entamoeba_histolytica tnGIeD---vk----------------------------d-d--- Leishmania_donovani dDGVgD---ar----------------------------d----- Leishmania_tropica dDGVgD---ar----------------------------d----- Plasmodium_berghei egGIaD---ye----------------------------e-k--- Plasmodium_falciparum egGIaD---ye----------------------------e-k--- Plasmodium_yoelii egGIaD---ye----------------------------e-k--- Tetrahymena_thermophila kgGIeD---fn----------------------------e----- Theileria_annulata dgGInD---yh----------------------------d-r--- Theileria_parva dgGInD---yh----------------------------d-r--- Trypanosoma_brucei enGVgD---vr----------------------------d----- Trypanosoma_cruzi eDGVgD---ar----------------------------d----- Arabidopsis_thaliana tEGVtD---ck----------------------------d----- Oryza_sativa sEGVaD---vk----------------------------d----- Zea_mays sEGVtD---vk----------------------------d----- =============================================================================== ECOLI gEGInf-yge-lvdlgvkekliekagawysykgekigqg-k-a-n MYCOBACTERIUM_SMEGMATIS gQGIsr-egs-lidmgvehgfirksgswftyegeqlgqg-k-e-n MYCOBACTERIUM_TUBERCULOSIS grGIsr-egs-lidmgvdqgfirksgswftyegeqlgqg-k-e-n Acetobacter_polyoxogenes gEGIsk-vge-lidlgvkagiveksgawfscdsqrigqg-r-e-n Acinetobacter_calcoaceticus gKGVnq-lge-lvdlavqqnivqkagawysyqgnkigqg-k-n-n Actinobacillus_pleuropneumoniae gEGIsr-mne-llilaeangfiqkagawfsyegtkigqg-k-n-n Actinobacillus_succinogenes gEGIsk-nge-lielgvkqklvqksgawfayegqkigqg-k-a-n Bacillus_licheniformis gEGIsk-ege-iidlgteldivqksgawysyqeerlgqg-r-e-n Bacillus_subtilis gEGIsk-ege-iidlgteldivqksgswysyeeerlgqg-r-e-n Burkholderia_fungorum gEGIsr-qge-iidlgvqakivdkagawysysgerigqg-k-d-n Carboxydothermus_hydrogenoformans gEGIsk-egs-lldvavelkivqkvgswysynderlgqg-r-e-n Chromobacterium_violaceum gEGIsr-qge-iielgvkhgfidksgawyayngqkigqg-k-d-n Clostridium_thermocellum gQGIsk-egn-ildvavnldivnksgawfsyngqkigqg-r-e-n Colwellia_psychrerythraea gEGInN-lge-lielgvkhefvekagawyscngerigqg-k-a-n Desulfotalea_psychrophila gEGIsk-igd-mfdlavgldiidksgswysyknerigqg-r-e-n Enterococcus_faecalis gQGIsq-ege-lldmavekdlisksgawygykeerigqg-r-e-n Erwinia_carotovora gEGIni-hge-lvdlgvkhkliekagawysyngdkigqg-k-a-n Haemophilus_ducreyi gEGIar-mne-llilaeangfiqkagawfsyngtkigqg-k-n-n Haemophilus_influenzae gEGIsk-age-llelgvkhklveksgawysyngekigqg-k-a-n Histophilus_somni gEGIsr-nge-lielgvkhklvnksgawfsyegekigqg-k-t-n Kineococcus_radiotolerans gQGIsr-egg-lidlgvehgfvrksgawytyegdqlgqg-k-e-n Leifsonia_xyli gvGIsH-egs-lldfgvehalvkksgawytyegdqlgqg-k-e-n Listeria_monocytogenes gEGIsr-ege-lvdmaaevdvinksgswysykeerigqg-r-e-n Mannheimia_succiniciproducens gEGIsk-nge-lielgvkhklvdksgawyayngdkigqg-k-a-n Neisseria_gonorrhoeae gEGIsw-ege-lidigvkndiinksgawysyngakigqg-k-d-n Nitrosomonas_europaea gEGIsr-ese-iielgvlhkliekagawysyngekigqg-k-d-n Nitrosomonas_eutropha gEGIsr-ese-iielgvlhkliekagawysyngekigqg-r-d-n Oceanobacillus_iheyensis gKGIsk-ege-vldigsdldivmksgawysynndrlgqg-r-e-n Pasteurella_multocida gQGfnr-ege-lidlgvkhklvekagawysyngdkigqg-k-a-n Photobacterium_profundum gQGfnr-nge-lidlgvkhklvekagawysykgnkigqg-k-a-n Photorhabdus_luminescens gEGInt-yge-lidlgvkhklvekagawysyngdkigqg-k-a-n Proteus_mirabilis gEGInt-yge-lidlgvkhklvekagawysyngekigqg-k-a-n Pseudomonas_aeruginosa gQGIsk-age-ivdlavannfveksgawysfegnkigqg-k-a-n Pseudomonas_cepacia gEGIsr-qge-iidlgvqakivdkagawysyngekigqg-k-d-n Salmonella_typhi gEGInf-yge-lvdlgvkekliekagawysyngekigqg-k-a-n Shewanella_putrefaciens gQGInr-tge-lvdlgvahkliekagawysykgdkigqg-r-a-n Streptomyces_avermitilis gQGIsr-egg-lidmgvengfvrkagawytyegdqlgqg-k-e-n Streptomyces_coelicolor gQGIsr-egg-lidmgvengfvrkagawytyegdqlgqg-k-e-n Streptomyces_lividans gQGIsr-egg-lidmgvengfvrkagawytyegdqlgqg-k-e-n Vibrio_cholerae gQGfnr-ege-lidlgvkhkmveksgawysyngdkigqg-k-a-n Vibrio_splendidus gKGfnr-ege-lidlgvknklvekaga------------------ Vibrio_vulnificus gQGfnr-ege-lidlgvkcklieksgawysyngdkigqg-k-a-n Xanthomonas_vasicola gEGIsr-ege-lidmgveaklvekagawysygderigqg-k-d-n Xylella_fastidiosa gEGIsr-ege-liemgveaklvekagawysyggerigqg-k-d-n Yersinia_pestis gEGIni-nge-lvdlgvkhkliekagawysyngdkigqg-k-a-n =============================================================================== DEINOCOCCUS_RADIODURANS rDrVma-airag-------------------nageap-------- Deinococcus_geothermalis rDrVla-aik----------------------egrdp-------- Thermus_aquaticus rakVl--------------------------eradkv-------- =============================================================================== Consensus xegixnxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 680 690 700 710 720 ----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS --------------------------------------------- Pyrococcus_abyssi --------------------------------------------- =============================================================================== METHANOCOCCUS_VOLTAE --------------------------------------------- Methanococcus_jannaschii --------------------------------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS --------------------------------------------- Aeropyrum_pernix --------------------------------------------- Desulfurococcus_amylolyticus --------------------------------------------- Sulfolobus_tokodaii --------------------------------------------- =============================================================================== HUMAN --------------------------------------------- YEAST e-------------------------------------------- Apis_mellifera --------------------------------------------- Aspergillus_fumigatus -nd------------------------------------------ Bombyx_mandarina --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans --------------------------------------------- Candida_albicans e-------------------------------------------- Candida_glabrata e-------------------------------------------- Canis_lupus --------------------------------------------- Coprinus_cinereus --------------------------------------------- Cricetulus_griseus --------------------------------------------- Cryptococcus_neoformans e-------------------------------------------- Danio_rerio --------------------------------------------- Debaryomyces_hansenii ----d-n-------------------------------------- Drosophila_melanogaster --------------------------------------------- Drosophila_pseudoobscura --------------------------------------------- Emericella_nidulans end------------------------------------------ Encephalitozoon_cuniculi --------------------------------------------- Eremothecium_gossypii ----d---------------------------------------- Gallus_gallus --------------------------------------------- Gibberella_zeae ekd------------------------------------------ Kluyveromyces_lactis d-------------------------------------------- Mus_musculus --------------------------------------------- Neurospora_crassa kmn-q---------------------------------------- Nosema_bombycis --------------------------------------------- Oikopleura_dioica --------------------------------------------- Oryctolagus_cuniculus --------------------------------------------- Pichia_angusta aae-d-e-------------------------------------- Pleurotus_ostreatus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schizosaccharomyces_pombe -pv------------------------------------------ Strongylocentrotus_purpuratus --------------------------------------------- Tetraodon_nigroviridis --------------------------------------------- Ustilago_maydis --------------------------------------------- Xenopus_laevis --------------------------------------------- Xenopus_tropicalis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Cryptosporidium_spp --------------------------------------------- Dictyostelium_discoideum --------------------------------------------- Entamoeba_histolytica --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_falciparum --------------------------------------------- Plasmodium_yoelii --------------------------------------------- Tetrahymena_thermophila --------------------------------------------- Theileria_annulata --------------------------------------------- Theileria_parva --------------------------------------------- Trypanosoma_brucei --------------------------------------------- Trypanosoma_cruzi --------------------------------------------- Arabidopsis_thaliana --------------------------------------------- Oryza_sativa --------------------------------------------- Zea_mays --------------------------------------------- =============================================================================== ECOLI -at-a-wlkdnpetakeiekkvre-lllsn--------------- MYCOBACTERIUM_SMEGMATIS -ar-k-fllentdvaneiekkike-klg----------------- MYCOBACTERIUM_TUBERCULOSIS -ar-t-flmenddvaneiekkike-klgig--------------- Acetobacter_polyoxogenes -ak-q-flrdhpemaadierrvre---qag--------------- Acinetobacter_calcoaceticus -vi-r-yleenpqisteieavire-qlltk--------------- Actinobacillus_pleuropneumoniae -ai-k-wlkenpeiaekieqdire-qlist--------------- Actinobacillus_succinogenes -am-k-wladnpekaaeleskira-efqen--------------- Bacillus_licheniformis -ak-q-flkenkdillmiqeqire-hyg----------------- Bacillus_subtilis -ak-q-flkenkdimlmiqeqire-hygld--------------- Burkholderia_fungorum -ar-e-flrenpdiareienrire-sl--g--------------- Carboxydothermus_hydrogenoformans -ak-e-flrqnpeiyreieqkire-qvlns--------------- Chromobacterium_violaceum -tr-e-wlkanpaiadeierkire-avgvk--------------- Clostridium_thermocellum -ak-q-flkenpeiakeietkire-nynqt--------------- Colwellia_psychrerythraea -aa-k-yldehpemakdvdtklrd-mflsk--------------- Desulfotalea_psychrophila -sk-q-flmdtpaicheieekvrs-ayg----------------- Enterococcus_faecalis -ak-q-ymadhpemmaevsklvrd-ayg----------------- Erwinia_carotovora -ac-n-flkenpemynelnkklre-ml------------------ Haemophilus_ducreyi -ai-k-wlkenpevaekieqeirn-llilt--------------- Haemophilus_influenzae -sm-k-wlnenieksdelearlra-elvan--------------- Histophilus_somni -am-k-wlaehpeqaaileqklrs-ellan--------------- Kineococcus_radiotolerans -ar-a-flrdnpdlgdeiekrike-klgig--------------- Leifsonia_xyli -sr-n-flianpdiaaeienkiki-klg----------------- Listeria_monocytogenes -ak-q-ylkehtdirdeiskrvre-eye----------------- Mannheimia_succiniciproducens -am-k-wlaenptvaaelenkira-ellan--------------- Neisseria_gonorrhoeae -vr-v-wlkenpeisdeidakira-lngve--------------- Nitrosomonas_europaea -vr-d-ylkehksiaheieqkir---------------------- Nitrosomonas_eutropha -vr-d-ylkehkdlaheieqkira-av------------------ Oceanobacillus_iheyensis -ak-q-ylkeheevlteihqsirq-hyeld--------------- Pasteurella_multocida -ac-n-ylrehpeiaktidtklre-mlls---------------- Photobacterium_profundum -sc-k-hlvenpaiaeeiekllrd-mllsp--------------- Photorhabdus_luminescens -at-i-ylkehpevateldkklre-mllhn--------------- Proteus_mirabilis -at-n-ylkehpemynelntklre-mllnh--------------- Pseudomonas_aeruginosa -tm-k-wllenkptmdklegmire-klmsk--------------- Pseudomonas_cepacia -ar-e-flrenpeiareienrire-sl--g--------------- Salmonella_typhi -at-t-wlkenpatakeiekrvre-lllsn--------------- Shewanella_putrefaciens -ag-k-yltenpaiateidktlrellls----------------- Streptomyces_avermitilis -ar-n-flkdnpdlaneiekkike-klgvgvrpeeptaepgadaa Streptomyces_coelicolor -ar-n-flkdnpdlaneiekkikq-klgvg--------------- Streptomyces_lividans -ar-n-flkdnpdlaneiekkikq-klgvg--------------- Vibrio_cholerae -ac-k-ylkenpeiaktldkklre-mllnp--------------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus -ac-k-ylkenvdvakvldtklre-mlls---------------- Xanthomonas_vasicola -ar-t-ylrdnpqvavrleaelre-kf--q--------------- Xylella_fastidiosa -ar-g-ylrenphlaakleadlre-kfept--------------- Yersinia_pestis -as-n-ylkenpaiaaeldkklre-mllng--------------- =============================================================================== DEINOCOCCUS_RADIODURANS ---ala--p---apaapeaae---------------a-------- Deinococcus_geothermalis ----ia--a---vpetpalae------------------------ Thermus_aquaticus ---vla--------ageeege------------------------ =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 730 740 750 760 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =============================================================================== PYROCOCCUS_FURIOSUS --------------------------------------------- Pyrococcus_abyssi --------------------------------------------- =============================================================================== METHANOCOCCUS_VOLTAE --------------------------------------------- Methanococcus_jannaschii --------------------------------------------- =============================================================================== SULFOLOBUS_SOLFATARICUS --------------------------------------------- Aeropyrum_pernix --------------------------------------------- Desulfurococcus_amylolyticus --------------------------------------------- Sulfolobus_tokodaii --------------------------------------------- =============================================================================== HUMAN --------------------------------------------- YEAST --------------------------------------------- Apis_mellifera --------------------------------------------- Aspergillus_fumigatus --------------------------------------------- Bombyx_mandarina --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_elegans --------------------------------------------- Candida_albicans --------------------------------------------- Candida_glabrata --------------------------------------------- Canis_lupus --------------------------------------------- Coprinus_cinereus --------------------------------------------- Cricetulus_griseus --------------------------------------------- Cryptococcus_neoformans --------------------------------------------- Danio_rerio --------------------------------------------- Debaryomyces_hansenii --------------------------------------------- Drosophila_melanogaster --------------------------------------------- Drosophila_pseudoobscura --------------------------------------------- Emericella_nidulans --------------------------------------------- Encephalitozoon_cuniculi --------------------------------------------- Eremothecium_gossypii --------------------------------------------- Gallus_gallus --------------------------------------------- Gibberella_zeae --------------------------------------------- Kluyveromyces_lactis --------------------------------------------- Mus_musculus --------------------------------------------- Neurospora_crassa --------------------------------------------- Nosema_bombycis --------------------------------------------- Oikopleura_dioica --------------------------------------------- Oryctolagus_cuniculus --------------------------------------------- Pichia_angusta --------------------------------------------- Pleurotus_ostreatus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schizosaccharomyces_pombe --------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------------- Tetraodon_nigroviridis --------------------------------------------- Ustilago_maydis --------------------------------------------- Xenopus_laevis --------------------------------------------- Xenopus_tropicalis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Cryptosporidium_spp --------------------------------------------- Dictyostelium_discoideum --------------------------------------------- Entamoeba_histolytica --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_falciparum --------------------------------------------- Plasmodium_yoelii --------------------------------------------- Tetrahymena_thermophila --------------------------------------------- Theileria_annulata --------------------------------------------- Theileria_parva --------------------------------------------- Trypanosoma_brucei --------------------------------------------- Trypanosoma_cruzi --------------------------------------------- Arabidopsis_thaliana --------------------------------------------- Oryza_sativa --------------------------------------------- Zea_mays --------------------------------------------- =============================================================================== ECOLI ----p---n--s---t---p----dfsv---d---ds-------- MYCOBACTERIUM_SMEGMATIS ---------------i---g----avvt---a---ea-------- MYCOBACTERIUM_TUBERCULOSIS ----a---v--v---t---d----dxs----d---d--------- Acetobacter_polyoxogenes ----v---v--a---e---a----mlvg---p---de-------- Acinetobacter_calcoaceticus ----a---s--d---q---t----a-ah---d---et-------- Actinobacillus_pleuropneumoniae ----p---e--k---t---sag--eqnv---l---da-------- Actinobacillus_succinogenes ----p---e--k---t---l----iael---d---gs-------- Bacillus_licheniformis ---------------l-dtg----gaap---a---qe-------- Bacillus_subtilis ----n---n--g---v---v----qqqa---e---et-------- Burkholderia_fungorum ----v---n--a---m---a----eaat---v---as-------- Carboxydothermus_hydrogenoformans ----p---e--s---s----------sf---k---ns-------- Chromobacterium_violaceum ----i---e--i---n---e----nqg----d---e--------- Clostridium_thermocellum ----f---lmsi---n---a----qvd----t---d--------- Colwellia_psychrerythraea ------------------------tvva---e---dk-------- Desulfotalea_psychrophila ---------------l---p----dree---t---kr-------- Enterococcus_faecalis ---------------igedg----stit---e---ea-------- Erwinia_carotovora ---------------------------l---n---ha-------- Haemophilus_ducreyi ----p---d--q---p---asekleldv---n---de-------- Haemophilus_influenzae ----p---e--q---a---l----madi---e---qs-------- Histophilus_somni ----p---e--k---a-lla----dlea---e---se-------- Kineococcus_radiotolerans ----a---r--l---d---a----paev---d---ve-------- Leifsonia_xyli ---------------i---v----adpn---a---daeptaaags Listeria_monocytogenes ---------------i---d----gsnkepld---ek-------- Mannheimia_succiniciproducens ----p---e--q---a----------ll---a---di-------- Neisseria_gonorrhoeae ----m---h--i---t--------egtq---d---et-------- Nitrosomonas_europaea -----------a---a---v----glae---t---ds-------- Nitrosomonas_eutropha ------------------------dlae---t---nn-------- Oceanobacillus_iheyensis ----k------v---d---e----dkt----e---e--------- Pasteurella_multocida ----p------a---q---p----eapa---a---ge-------- Photobacterium_profundum ----v---g--e---e---v----ekad---v---kk-------- Photorhabdus_luminescens ----a---gefn---s---a----asdy---e---dn-------- Proteus_mirabilis ----ageft--s---a---a----dfag---e---es-------- Pseudomonas_aeruginosa ----p---q--a---e---t----sarl---a---tq-------- Pseudomonas_cepacia ----v---v--a---m---p----dgag---n---ea-------- Salmonella_typhi ----q---n--a---t---p----dfav---d---ds-------- Shewanella_putrefaciens ---------------n---p----sala---a---ka-------- Streptomyces_avermitilis vtsaa---a--a---t---d----dta----k---t--------- Streptomyces_coelicolor ----v---h--p---e---e----sat----epgad--------- Streptomyces_lividans ----v---h--p---e---e----sat----epgad--------- Vibrio_cholerae ----e---n--mqlia---e----tssa---a---dd-------- Vibrio_splendidus --------------------------------------------- Vibrio_vulnificus ----p---a--n---i---n----desa---e---lv-------- Xanthomonas_vasicola ----p---a--e---a---p----reag---d---de-------- Xylella_fastidiosa ----e---l--s---r---e----egde---d---tl-------- Yersinia_pestis ----g---n--g---e---q----pvaa---a---ta-------- =============================================================================== DEINOCOCCUS_RADIODURANS --------------------------------------------- Deinococcus_geothermalis --------------------------------------------- Thermus_aquaticus --------------------------------------------- =============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 770 780 790 800 810 ----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ============================================================================== PYROCOCCUS_FURIOSUS -------------------------------------------- Pyrococcus_abyssi -------------------------------------------- ============================================================================== METHANOCOCCUS_VOLTAE -------------------------------------------- Methanococcus_jannaschii -------------------------------------------- ============================================================================== SULFOLOBUS_SOLFATARICUS -------------------------------------------- Aeropyrum_pernix -------------------------------------------- Desulfurococcus_amylolyticus -------------------------------------------- Sulfolobus_tokodaii -------------------------------------------- ============================================================================== HUMAN -------------------------------------------- YEAST -------------------------------------------- Apis_mellifera -------------------------------------------- Aspergillus_fumigatus -------------------------------------------- Bombyx_mandarina -------------------------------------------- Bos_taurus -------------------------------------------- Caenorhabditis_elegans -------------------------------------------- Candida_albicans -------------------------------------------- Candida_glabrata -------------------------------------------- Canis_lupus -------------------------------------------- Coprinus_cinereus -------------------------------------------- Cricetulus_griseus -------------------------------------------- Cryptococcus_neoformans -------------------------------------------- Danio_rerio -------------------------------------------- Debaryomyces_hansenii -------------------------------------------- Drosophila_melanogaster -------------------------------------------- Drosophila_pseudoobscura -------------------------------------------- Emericella_nidulans -------------------------------------------- Encephalitozoon_cuniculi -------------------------------------------- Eremothecium_gossypii -------------------------------------------- Gallus_gallus -------------------------------------------- Gibberella_zeae -------------------------------------------- Kluyveromyces_lactis -------------------------------------------- Mus_musculus -------------------------------------------- Neurospora_crassa -------------------------------------------- Nosema_bombycis -------------------------------------------- Oikopleura_dioica -------------------------------------------- Oryctolagus_cuniculus -------------------------------------------- Pichia_angusta -------------------------------------------- Pleurotus_ostreatus -------------------------------------------- Rattus_norvegicus -------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------- Tetraodon_nigroviridis -------------------------------------------- Ustilago_maydis -------------------------------------------- Xenopus_laevis -------------------------------------------- Xenopus_tropicalis -------------------------------------------- Yarrowia_lipolytica -------------------------------------------- Cryptosporidium_spp -------------------------------------------- Dictyostelium_discoideum -------------------------------------------- Entamoeba_histolytica -------------------------------------------- Leishmania_donovani -------------------------------------------- Leishmania_tropica -------------------------------------------- Plasmodium_berghei -------------------------------------------- Plasmodium_falciparum -------------------------------------------- Plasmodium_yoelii -------------------------------------------- Tetrahymena_thermophila -------------------------------------------- Theileria_annulata -------------------------------------------- Theileria_parva -------------------------------------------- Trypanosoma_brucei -------------------------------------------- Trypanosoma_cruzi -------------------------------------------- Arabidopsis_thaliana -------------------------------------------- Oryza_sativa -------------------------------------------- Zea_mays -------------------------------------------- ============================================================================== ECOLI -e---gv--ae-tne-----df---------------------- MYCOBACTERIUM_SMEGMATIS -d---dv--lp-apv-----df---------------------- MYCOBACTERIUM_TUBERCULOSIS -----gv--lp-apv-----df---------------------- Acetobacter_polyoxogenes -d---ga--eh--------------------------------- Acinetobacter_calcoaceticus -e---ee--pd-lle-----s----------------------- Actinobacillus_pleuropneumoniae -d---dv--ndfede-----af-------neeel---------- Actinobacillus_succinogenes -g---kn--te-lddsedtvnf----------e----------- Bacillus_licheniformis -d---ea--qaqeel-----ef---------------------- Bacillus_subtilis -q---ee--le-fee----------------------------- Burkholderia_fungorum -a---ev--ad-eee----------------------------- Carboxydothermus_hydrogenoformans -e---ef--ee--------------------------------- Chromobacterium_violaceum -----ef--ad-daf-----da---------------------- Clostridium_thermocellum -----de--vd-led-----ee---------------------- Colwellia_psychrerythraea -s---ev--ke-kek-----a----------------------- Desulfotalea_psychrophila -e---etaqip-dte-----ktkd-----v-------------- Enterococcus_faecalis -e---gq--ee-lpl-----de---------------------- Erwinia_carotovora -n---ef--kp-ara-----gc---------------------- Haemophilus_ducreyi -s---df--de-afe-----eq----------e----------- Haemophilus_influenzae -e---nn--te-ses-----df----------e----------- Histophilus_somni -s---ni--se-ves-----df---------------------- Kineococcus_radiotolerans -e---kv-------------df---------------------- Leifsonia_xyli le---ek--lp-ark-----ga---------------------- Listeria_monocytogenes -e---et--ls-lld-----de---------------------- Mannheimia_succiniciproducens -e---tn--se-eke-----df----------e----------- Neisseria_gonorrhoeae -d---g----e-rpe-----e----------------------- Nitrosomonas_europaea -r---vv--pp-ssg-----e----------------------- Nitrosomonas_eutropha -r---tv--pp-sps-----e----------------------- Oceanobacillus_iheyensis -----ea--sq-esl-----dl----------k----------- Pasteurella_multocida -k-------pe-qee-----ef---------------------- Photobacterium_profundum -d---ak--kd-aae-----al----------k----------- Photorhabdus_luminescens -e---ne--em-nne-----ef---------------------- Proteus_mirabilis -d---sd--ad-dtk-----e----------------------- Pseudomonas_aeruginosa -e---el--ad-dy------------------------------ Pseudomonas_cepacia -e---am--de-ee------------------------------ Salmonella_typhi -e---gv--ae-tne-----df---------------------- Shewanella_putrefaciens -d---as--te-dnv-----dl-------etgev---f------ Streptomyces_avermitilis -----vs--ap-aak-----tt-------------kskaaaaks Streptomyces_coelicolor -----aa--sa-apa-----daapavpapttakatkskataaks Streptomyces_lividans -----aa--sa-apa-----daapavpapttakatkskaaaaks Vibrio_cholerae -v---ef--ga-vpe-----ef---------------------- Vibrio_splendidus -------------------------------------------- Vibrio_vulnificus -e---em--pe--qe-----ef---------------------- Xanthomonas_vasicola -e---ke------------------------------------- Xylella_fastidiosa -e---da--m---------------------------------- Yersinia_pestis -efadga--de-tne-----ef---------------------- ============================================================================== DEINOCOCCUS_RADIODURANS -------------------------------------------- Deinococcus_geothermalis -------------------------------------------- Thermus_aquaticus -------------------------------------------- ============================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx