TBP (TATA-binding protein, TF2D)

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== PYRFU ---------------------------------------------------------------------- Pyrococcus_abyssi ---------------------------------------------------------------------- ==================================================================================================== HUMAN -----------------------------------------------------------qqqqq----qq YEAST ---------------------------------------------------------------------- ARABIDOPSIS_THALIANA ---------------------------------------------------------------------- 1JFIC_Human ---------------------------------------------------------------------- 1TBPA_Yeast ---------------------------------------------------------------------- Anopheles_gambiae -------------------------dqmlpspgfs-----------ipsigt-------plhqp----ee Apis_mellifera ---dqmlp-----spgfsipsigtp--lhqpeedqqil----pnal-------------qqqqq----qq Aspergillus_fumigatus -esltth--------pstaqqaraftspasl-sfpg-gagdltppssekegnitigaqgangtvnghqqg Bombyx_mandarina dhmlpspy-----nipgigtplhqpeedqqilpnam-------qqqqlqq-------qqsqaqpslaalg Bos_taurus --------------------------drndslspfdqylaspqgamspgipvfspvmhygtglt----pq Caenorhabditis_briggsae nmnspasrsmmggetpahggpssvlggpssiltg--hgpnsvmgpnsilg-pgs--mvnpqsiqpmqsh- Caenorhabditis_elegans nlnspavs-----mlggdtpahggpnsvlggqgpssiltghgpnsvmgpnsilgpgsvlnpqsi----qp Candida_albicans ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Canis_lupus ---------------------------------------------------------------------- Cryptococcus_neoformans ---------------------------------------------------------------------- Danio_rerio ----eqnn-----slppfaqglaspqgamt-pglpif-spmmpygtgltpqp----vqnsn--------- Debaryomyces_hansenii ---------------------------------------------------------------------- Drosophila_melanogaster dqmlspnf-----sipsigtplhqmeadqqivanpvyhppavsqpdslmpapgsssvqhqqqqqqsdasg Drosophila_pseudoobscura dqmlspnf-----sipsigtpmhqmeadqqiianpvyhppaipqpepaisapvpvagqqqqpdasnattg Emericella_nidulans ------------------------------------------------------------dslt----th Encephalitozoon_cuniculi ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Gallus_gallus ------------------dqnnslppyaqglaspqgamtpgip--ifsp--mm-p----ygtgl----tp Gibberella_zeae ----egiq-----thpsnaaqakaftapgslsfpgatneltpp--pvgngda-tqqpphngqqaa----- Kluyveromyces_lactis ---------------------------------------------------------------------- Magnaporthe_grisea ---------------------------------------------------------------------- Mesocricetus_auratus ----dqnn-----slppyaqglaspqgam-tpgipif-spmmpygtgltpqpiqntnslsilee----qq Mus_musculus ---dqnns-------l--ppyaqglaspqgamtpg--ipifspmmpygtg--ltpqpi-qntnslsilee Neurospora_crassa ---------------------------------------------------------------------- Petromyzon_marinus ----dssg-----smpgfspnlgsqqgg--mtpgm-----------plf----------spmmpygtglt Pneumocystis_carinii ---------------------------------------------------------------------- Rattus_norvegicus ----dqnn-----slppyaqglaspqgam-tpgipif-spmmpygtgltpqpvqntnslsilee----qq Schizosaccharomyces_pombe ---------------------------------------------------------------------- Strongylocentrotus_purpuratus -----------------------------------------------------------ynpsq----av Tetraodon_nigroviridis -----------------------desaleryfedsiandsgf-lleeelsigsptlsstylpgkaglsrg Ustilago_maydis ---------------------------------------------------------------------- Xenopus_laevis ----------------------dqnnsippfqglas-----pqgsltpginifsp----lityg----tg Xenopus_tropicalis ----------------------dqnnsippfqglas-----pqgsltpginifsp----lmpyg----tg Yarrowia_lipolytica ---------------------------------------------------------------------- Dictyostelium_discoideum -----------------------------------------------------------st--------- Tetrahymena_thermophila ---------------------ssdktsqqtfk-la----------------------------------- Glycine_max ---------------------------------------------------------------------- Oryza_sativa ---------------------------------------------------------------------- Zea_mays ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== PYRFU ---------------------------------------------------------------------- Pyrococcus_abyssi ---------------------------------------------------------------------- ==================================================================================================== HUMAN qqqq------------------------------------------------------------------ YEAST ---------------------------------------------------------------------- ARABIDOPSIS_THALIANA ---------------------------------------------------------------------- 1JFIC_Human ---------------------------------------------------------------------- 1TBPA_Yeast ---------------------------------------------------------------------- Anopheles_gambiae dqqi------------------------------------------------------------------ Apis_mellifera qqqq------------------------------------------------------------------ Aspergillus_fumigatus gnav------------------------------------------------------------------ Bombyx_mandarina sspivgfgaimgtpqrsmhtyaptasy------------------atpqqmmqpqtpqnmmspm-iaagn Bos_taurus piqs------------------------------------------------------------------ Caenorhabditis_briggsae ------qmhslqgssmqmhshlansalnlninp---asvgpgnpgsvlhhnmdinppsvayqnlaipmtp Caenorhabditis_elegans mqsq------------------------------------------------------------------ Candida_albicans ---d------------------------------------------------------------------ Candida_glabrata ---------------------------------------------------------------------- Canis_lupus ---------------------------------------------------------------------- Cryptococcus_neoformans ---------------------------------------------------------------------- Danio_rerio ---------slslleeqqr------qqqqqqaasqqqggmvggsgqtpq-lyhstqavs----------- Debaryomyces_hansenii ---------------------------------------------------------------------- Drosophila_melanogaster gsglfghepslplahkqmqsyqpsasyqqqqqqqqlqsqapggggstpqsmmqpqtpqsmmahm-mpmse Drosophila_pseudoobscura gsglfghepslplahkqmqsyqpsasyqqqqqqq--g---qpaggttpqslmqpqtpqsmmshm-ipmse Emericella_nidulans pata------------------------------------------------------------------ Encephalitozoon_cuniculi ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Gallus_gallus qpvq------------------------------------------------------------------ Gibberella_zeae ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- Magnaporthe_grisea -egi------------------------------------------------------------------ Mesocricetus_auratus reqq------------------------------------------------------------------ Mus_musculus qqrq------------------------------------------------------------------ Neurospora_crassa ---------------------------------------------------------------------- Petromyzon_marinus pqpvqg--ssmgmaddqqqpqagtsqq---------------etgasqmqvyqtqgsstt-tal-pgcap Pneumocystis_carinii ---------------------------------------------------------------------- Rattus_norvegicus rqqq------------------------------------------------------------------ Schizosaccharomyces_pombe ---------------------------------------------------------------------- Strongylocentrotus_purpuratus pvsl------------------------------------------------------------------ Tetraodon_nigroviridis s----geeldlsflpdelgtqeepsrhndtaqte-------aqaasqdsavcldynsqdstgas-lsggg Ustilago_maydis ---------------------------------------------------------------------- Xenopus_laevis ltpq------------------------------------------------------------------ Xenopus_tropicalis ltpq------------------------------------------------------------------ Yarrowia_lipolytica ---------------------------------------------------------------------- Dictyostelium_discoideum ---------------------------------------------------------------------- Tetrahymena_thermophila ---------------------------------------------------------------------- Glycine_max ---------------------------------------------------------------------- Oryza_sativa ---------------------------------------------------------------------- Zea_mays ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== PYRFU ---------------------------------------------------------------------- Pyrococcus_abyssi ---------------------------------------------------------------------- ==================================================================================================== HUMAN ------------------qqqqqqqqqqq---qqqavaaaavqq-----s---tsq-q-----atqgtsg YEAST ------------------adeerlkefke---ankivfdpntrq-----v---wen-q-----nrdgt-- ARABIDOPSIS_THALIANA ------------------------------------------------------td-q-----glegs-- 1JFIC_Human ---------------------------------------------------------------------- 1TBPA_Yeast ---------------------------------------------------------------------- Anopheles_gambiae ------------------lphayqqqqsm---phmtpmgglsss-----n---ytm-p-----aigstsg Apis_mellifera ------------------qsqqqqqsqqqyqlqqlhtmspniqsgmlmig---tpq-knmhayattptfa Aspergillus_fumigatus ------------------------------------------------------ng-n-----gvtpa-- Bombyx_mandarina ls----------------------------------------------------sq-q-----mlsqa-- Bos_taurus ------------------tdslstseeeq---qqqttvrtgrls-----t---tsq-e-----atqeald Caenorhabditis_briggsae laynnfer----dtlmhp------------------------------------pa-s-----niaat-- Caenorhabditis_elegans ------------------qmhslqgssmq---mhshlansnlnl-----n---inp-a-----svgpdrn Candida_albicans ------------------lklpptnptnp---qqaktfmksiee-----d---ekn-k-----a------ Candida_glabrata ------------------adeermkefqe---ankavfdpntrq-----v---wen-q-----vnkte-- Canis_lupus ---------------------qqqqqqqa---qqqav--tavqq-----q---tsq-q-----atqgasg Cryptococcus_neoformans ---------------------------------------sglal-----p---kas-n-----agpssss Danio_rerio ------------------------------------------------------tt-t-----alpgn-- Debaryomyces_hansenii -------------------dslklpttaa---qakaftapnsll-----fplgidg-q-----rtdin-- Drosophila_melanogaster rsvggsgaggggdalsn-------------------------------------ih-q-----tmgps-- Drosophila_pseudoobscura rsasgvgag---dslsn-------------------------------------ih-q-----tmgpa-- Emericella_nidulans ------------------qqaraftspss---lsfpggtafpgg-----a---dlt-p-----psdkdan Encephalitozoon_cuniculi ------------------------------------------------------da-p-----disye-- Eremothecium_gossypii ------------------sddkrlkefqe---qnkivfdhstrs-----v---wen-q-----dkdssmg Gallus_gallus ------------------stnslsileeq---qrqqqqqqaaqs-----s---tsq-q-----atqgtsg Gibberella_zeae ------------------------------------------------------ng-n-----gvapa-- Kluyveromyces_lactis ------------------seenrmkqfqe---enkivfdpstrs-----v---wet-q-----ekqe--- Magnaporthe_grisea ------------------qthpsnaaqak---aftapgslsfpg-----g---hgelt-----ppndang Mesocricetus_auratus ------------------qqqqqqqqqqq---qavataaasvqq-----s---tsq-q-----stqgasg Mus_musculus ------------------qqqqqqqqqqq---qavataaasvqq-----s---tsq-q-----ptqgasg Neurospora_crassa --------------------daiqthpsn---aaqakaftapgs-----l---sfp-g-----aageltp Petromyzon_marinus lyqs--------------------------------------------------pm-t-----pmtpm-- Pneumocystis_carinii ---------------------------------------------------------------apsslsf Rattus_norvegicus ------------------qqqqqqqqqqq---qavataaasvqq-----s---tsq-q-----ptqgasg Schizosaccharomyces_pombe -------------------------------------------------------d-f-----alpttas Strongylocentrotus_purpuratus ------------------hknqdnqdggq---qrshypqissqq-----s---qsy-l-----svpsi-g Tetraodon_nigroviridis alnspfc-----------------------------------------------pm-t-----pmtpm-- Ustilago_maydis ------------------------------------------------------dq-q-----gls---- Xenopus_laevis ------------------pvqttnslsil---eeqqrqqqqtqq-----s---tlq-q-----gnqg-sg Xenopus_tropicalis ------------------pvqttnslsil---eeqqrqqqqaqq-----s---tsq-q-----gnqg-sg Yarrowia_lipolytica ----------------------------d---alsaptnpaqaq-----q---fvt-q-----n-nls-- Dictyostelium_discoideum ------------------------------------------------------at-t-----tstpa-- Tetrahymena_thermophila ------------------------------------------------------pn-n-----svaqs-- Glycine_max ------------------------------------------------------ad-q-----glegs-- Oryza_sativa ----------------------------------aaavdpmalg-----l---gts-g-----ggggg-- Zea_mays ------------------------------------------------------ae-p-----glegs-- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== PYRFU ---------------------------------------------------------------------- Pyrococcus_abyssi ---------------------------------------------------------------------- ==================================================================================================== HUMAN -q-----ap---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- YEAST -k-----pa---ttf-------q-s----------e----e---d--ikr-aape----------sekd- ARABIDOPSIS_THALIANA -n-----pv---dls-------k-h----------p---------------------------------- 1JFIC_Human ---------------------------------------------------------------------- 1TBPA_Yeast ---------------------------------------------------------------------- Anopheles_gambiae -ksmhtyap---sfs-------t-p----------q----n---miqpqt-pvsgldlvvsclllksvli Apis_mellifera -t-----pq---slm-------q-p----------q----tpqnm--msp-lvqn----------tnhi- Aspergillus_fumigatus -t-----paatpgan-------a-p----------g---------------------------------- Bombyx_mandarina -s-----pa---pmt-------plt----------plsad------------------------------ Bos_taurus -q-----tp---qlf-------d-s----------q----p---l--tta-pllg----------ttpl- Caenorhabditis_briggsae mv-----pa---tpa-------s-q----------l---------------------------------- Caenorhabditis_elegans -p-----gs---vmh-------h-nldinppsvayq----n---l--tvp-mtpl----------aysv- Candida_albicans -e-----dl---dii-------k-k----------e----d---i--d---------------------- Candida_glabrata -d-----da---vkp-------e-a----------d----e---d--------------------eded- Canis_lupus -q-----tp---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- Cryptococcus_neoformans -s-----kp---egi-------q-t---------------------------ldg----------egsl- Danio_rerio -t-----plyttpltpmtpitpa-t----------pases------------------------------ Debaryomyces_hansenii -q-----ea---tpk-------k-e----------e----d---t--sdtivepn----------qded- Drosophila_melanogaster -t-----pm---tpa-------t-p----------g---------------------------------- Drosophila_pseudoobscura -t-----pm---tpa-------t-p----------g---------------------------------- Emericella_nidulans -m-----at---ngq-------s-a----------n----g---n--vng-qqqg----------anaa- Encephalitozoon_cuniculi -h-----qe---tsv-------p-n----------r---------------------------------- Eremothecium_gossypii -h--------------------------------------------------lmg----------gsvv- Gallus_gallus -q-----tp---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- Gibberella_zeae -t-----pvatpaat-------q-g----------p---------------------------------- Kluyveromyces_lactis ----------------------h-e--------------------------slpg----------td--- Magnaporthe_grisea -q-----rp-------------------------------a---a--nga-pl-g----------sqaa- Mesocricetus_auratus -q-----tp---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- Mus_musculus -q-----tp---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- Neurospora_crassa -p-----ts---tan-------s-d----------k----s---a--avn-gaig----------aqaa- Petromyzon_marinus -t-----pi---tpa-------s-e----------s---------------------------------- Pneumocystis_carinii -p-----ss---hil-------m-s----------g----a---m--ypg-srde----------kgme- Rattus_norvegicus -q-----tp---qlf-------h-s----------q----t---l--tta-plpg----------ttpl- Schizosaccharomyces_pombe -q-----as---afm-------n-n----------s----s---l--tfp-vlpn----------ann-- Strongylocentrotus_purpuratus -------tp---s-f-------g-s----------v----g---s--vss-lapg----------ssfi- Tetraodon_nigroviridis -t-----pm---tpv-------t-e----------r---------------------------------- Ustilago_maydis --------------s-------v-h--------------------------------------------- Xenopus_laevis -q-----tp---qlf-------h-p----------q----t---l--tta-plpg----------ntpl- Xenopus_tropicalis -q-----tp---qlf-------h-p----------q----t---l--tta-plpg----------ntpl- Yarrowia_lipolytica -f-----pq---da--------e-a----------d----t---s--lig-evkr----------eqvd- Dictyostelium_discoideum -q-----nv---dls-------k-h----------p---------------------------------- Tetrahymena_thermophila -n-----si---dqn-------k-n----------k---------------------------------- Glycine_max -q-----pv---dlq-------k-h----------p---------------------------------- Oryza_sativa -e-----sa---aal-------e-g----------s----e---p--vdl-a------------------ Zea_mays -q-----pv---dls-------k-h----------p---------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 290 300 310 320 330 340 350 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== PYRFU ---------------------------------------------------------------------- Pyrococcus_abyssi ---------------------------------------------------------------------- ==================================================================================================== HUMAN --y-p-------spmtpmt-----------------------------------p-------itpatpas YEAST --t-s-------at-------------------------------------------------------- ARABIDOPSIS_THALIANA ---------------------------------------------------------------------- 1JFIC_Human ----s-------hm-------------------------------------------------------- 1TBPA_Yeast ---------------------------------------------------------------------- Anopheles_gambiae lsf-sapqqslmspmvpmteskaaatpshpqsgsggsvrdpenigsvnihqtmgp-------atpmtpmt Apis_mellifera --a-p-------psigpst-------pg--------------------------p-------mtpmtpas Aspergillus_fumigatus ---------------------------------------------------------------------- Bombyx_mandarina ---------------------------------------------------------------------- Bos_taurus --y-p-------spmtpmi-----------------------------------p-------mtpampas Caenorhabditis_briggsae ---------------------------------------------------------------------- Caenorhabditis_elegans --ydr-------dalthqa-----------------------------------pasniaatmvpatpas Candida_albicans ---------------epkq-----------------------------------e-------dttdgngg Candida_glabrata --d-a-------at-------------------------------------------------------- Canis_lupus --y-p-------spmtpmt-----------------------------------p-------itpatpas Cryptococcus_neoformans --a-t-------rp--pqk-----------------------------------a-------iasvpeit Danio_rerio ---------------------------------------------------------------------- Debaryomyces_hansenii --d-g-------at-------------------------------------------------------- Drosophila_melanogaster ---------------------------------------------------------------------- Drosophila_pseudoobscura ---------------------------------------------------------------------- Emericella_nidulans --n-g-------ngvmpat-----------------------------------p-------aatpgasa Encephalitozoon_cuniculi ---------------------------------------------------------------------- Eremothecium_gossypii --q-s-------eskdsmd-----------------------------------------------adhg Gallus_gallus --y-p-------spmtpmt-----------------------------------p-------itpatpas Gibberella_zeae ---------------------------------------------------------------------- Kluyveromyces_lactis ------------------a-----------------------------------n-------aedadkgs Magnaporthe_grisea --n-g-------tgvtpat-----------------------------------p-------aatpaatq Mesocricetus_auratus --y-p-------spmtpmt-----------------------------------p-------itpatpas Mus_musculus --y-p-------spmtpmt-----------------------------------p-------itpatpas Neurospora_crassa --n-g-------ngvtpat-----------------------------------p-----a-atpaanqg Petromyzon_marinus ---------------------------------------------------------------------- Pneumocystis_carinii --h-g-------vvstsln-----------------------------------q-------tatstfag Rattus_norvegicus --y-p-------spmtpmt-----------------------------------p-------itpatpas Schizosaccharomyces_pombe --e-a-------tnetads-----------------------------------g-------daevskne Strongylocentrotus_purpuratus --p-p-------spmaplt-----------------------------------p-------atpas--s Tetraodon_nigroviridis ---------------------------------------------------------------------- Ustilago_maydis ---------------------------------------------------------------------- Xenopus_laevis --y-p-------spitpmt-----------------------------------p-------ispatpas Xenopus_tropicalis --y-p-------spmtpmt-----------------------------------p-------itpatpas Yarrowia_lipolytica ----s-------gv-------------------------------------------------------- Dictyostelium_discoideum ---------------------------------------------------------------------- Tetrahymena_thermophila ---------------------------------------------------------------------- Glycine_max ---------------------------------------------------------------------- Oryza_sativa ----k-------hp-------------------------------------------------------- Zea_mays ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 360 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxnxxxgivxxxxxxxxxxxxxxxpxLQNIVsTVNLxckLDLKsIalharNaEYNPKxxxxxxrFaaVI ==================================================================================================== PYRFU vdmS---kVk---------------lrIENIVaSVDLfaQLDLEkVldlcpNsKYNPE------eFpgII Pyrococcus_abyssi vdtN---nVk---------------lrIENIVaSVDLfaQLDLEkVldicpNsKYNPE------eFpgII ==================================================================================================== HUMAN es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI YEAST ---S---GIV---------------PtLQNIVaTVtLgCRLDLKTVALHARNAEYNPK------RFAAVI ARABIDOPSIS_THALIANA ---S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RFAAVI 1JFIC_Human ---S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI 1TBPA_Yeast ---m---GIV---------------PtLQNIVaTVtLgCRLDLKTVALHARNAEYNPK------RFAAVI Anopheles_gambiae psep---aIL---------------PqLQNIVSTVNLsCKLDLKkIALHARNAEYNPK------RFAAVI Apis_mellifera ad-p---GIL---------------PqLQNIVSTVNLnCKLDLKkIALHARNAEYNPK------RFAAVI Aspergillus_fumigatus ---S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Bombyx_mandarina ---p---GIL---------------PqLQNIVSTVNLdCKLDLKkIALHARNAEYNPK------RFAAVI Bos_taurus ei-a---eLV---------------PqLhNVVcTVNLgCKLDLKSIALlARNAEYNPK------RFAAVI Caenorhabditis_briggsae ---D---ipM---------------PaLQNIVSTVNLgvpLDLKkIALHARNAEYNPK------RFAAVI Caenorhabditis_elegans ql-D---ipM---------------PaLQNIVSTVNLgvQLDLKkIALHARNAEYNPK------RFAAVI Candida_albicans gg-i---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Candida_glabrata ---S---GIV---------------PtLQNIVaTVNLgCRLDLKTVALHARNAEYNPK------RFAAVI Canis_lupus es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Cryptococcus_neoformans av-D---GLV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPR------RFAAVV Danio_rerio ---S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Debaryomyces_hansenii ---S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Drosophila_melanogaster ---SadpGIV---------------PqLQNIVSTVNLcCKLDLKkIALHARNAEYNPK------RFAAVI Drosophila_pseudoobscura ---SadpGIV---------------PqLQNIVSTVNLcCKLDLKkIALHARNAEYNPK------RFAAVI Emericella_nidulans pg-S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Encephalitozoon_cuniculi ---S---GII---------------PtLQNVVaTVNLsCKLDLKNIALrARNAEYNPK------RFAAVI Eremothecium_gossypii tt-S---GIV---------------PtLQNIVaTVNLdCRLDLKTVALHARNAEYNPK------RFAAVI Gallus_gallus es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Gibberella_zeae ---S---GIt---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPKvhqtlrRFAAVI Kluyveromyces_lactis at-S---GII---------------PtLQNIVaTVNLdCRLDLKTVALHARNAEYNPK------RFAAVI Magnaporthe_grisea tg-S---GLt---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Mesocricetus_auratus es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Mus_musculus es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Neurospora_crassa pt-S---GMt---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Petromyzon_marinus ---S---GIV---------------PqLQNIVSTVNLcCKLDLKkIALHARNAEYNPK------RFAAVI Pneumocystis_carinii -v-S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Rattus_norvegicus es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Schizosaccharomyces_pombe gv-S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Strongylocentrotus_purpuratus es-S---GIV---------------PqLQNIVSTVNLnCRLDLKkIALHARNAEYNPK------RFAAVI Tetraodon_nigroviridis ---S---GII---------------PqLQNIVSTVNLgCpLDLKfIALqARNAEYNPK------RFAAVI Ustilago_maydis -------GIV---------------PtLQNIVaTVNLevRLDLKTIALHARNAEYNPK------RFAAVI Xenopus_laevis es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Xenopus_tropicalis es-S---GIV---------------PqLQNIVSTVNLgCKLDLKTIALrARNAEYNPK------RFAAVI Yarrowia_lipolytica ---S---GIV---------------PtLQNIVaTVNLdCRLDLKTIALHARNAEYNPK------RFAAVI Dictyostelium_discoideum ---S---GII---------------PtLQNIVSTVNMatELyLKaIALgARNAEYNPK------RFAAVI Tetrahymena_thermophila ---N---nILstietmdksisedlyPkLQNIVSTVNLstKLDLKqIALrARNAEYNPK------RFAAVI Glycine_max ---S---GIV---------------PtLQNIVSTVNLdCKLDLKTIALqARNAEYNPK------RFAAVI Oryza_sativa ---S---GII---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RFAAVI Zea_mays ---S---GIV---------------PtLQNIVSTVNLdCKLDLKaIALqARNAEYNPK------RFAAVI ==================================================================================================== Consensus xxxnxxxgivxxxxxxxxxxxxxxxpxLQNIVsTVNLxckLDLKsIalharNaEYNPKxxxxxxrFaaVI 430 440 450 460 470 480 490 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus mRIrEPRttaLIFxSGKMVcTGaKSeEnsKlAarKyAQvVQkLGfxaxKfxEfkIQNMVgScDVkfpirL ==================================================================================================== PYRFU chLdDPKvalLIFsSGKLVvTGAKSvQDiErAvaKlAQkLKsIGvkfkRapQidVQNMVfSgDIgrefnL Pyrococcus_abyssi cRfdDPKvalLIFsSGKLVvTGAKSihDiErAvaKliEkLKgIGvkfkRaplidIQNMVfSgDIgrefnL ==================================================================================================== HUMAN MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL YEAST MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGSCDVKFPIRL ARABIDOPSIS_THALIANA MRIREPKTTALIFaSGKMVCTGAKSEDfSKMAARKYARIVQKLGFpA-KFkDFKIQNIVGSCDVKFPIRL 1JFIC_Human MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL 1TBPA_Yeast MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGSCDVKFPIRL Anopheles_gambiae MRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFtA-KFlDFKVQNMVGSCDVRFPIRL Apis_mellifera MRIREPRTTALIFsSGKMVCTGAKSEEDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Aspergillus_fumigatus MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDIKFPIRL Bombyx_mandarina MRIREPRTTALIFsSGKMVCTGAKSEEDSRLAARKYARIIQKLGFtA-KFlDFKIQNMVGSCDVKFPIRL Bos_taurus MRIREPRTTALLFsSGKMVCTGgKSEEqSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Caenorhabditis_briggsae MRIREPRTTALIFsSGKMVCTGAKSEEaSRLAARKYARIVQKLGFqA-KFtEFmVQNMVGSCDVRFPIQL Caenorhabditis_elegans MRIREPRTTALIFsSGKMVCTGAKSEEaSRLAARKYARIVQKLGFqA-KFtEFmVQNMVGSCDVRFPIQL Candida_albicans MRIRDPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFcDFKIQNIVGStDVKFaIRL Candida_glabrata MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFaA-KFtDFKIQNIVGSCDVKFPIRL Canis_lupus MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Cryptococcus_neoformans MRIRDPRTTALIFaSGKMVvTGAKSEDDSRLAsRKYARIIQKLGFeA-KFaEFKIQNMVGSCDVKFPIRL Danio_rerio MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Debaryomyces_hansenii MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDVKFPIRL Drosophila_melanogaster MRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Drosophila_pseudoobscura MRIREPRTTALIFsSGKMVCTGAKSEDDSRLAARKYARIIQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Emericella_nidulans MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDIKFPIRL Encephalitozoon_cuniculi MRIREPKTTALIFaSGKMViTGAKSEKSSRMAAQRYAKIIhKLGFnA-tFdDFKIQNIVsSCDIKFsIRL Eremothecium_gossypii MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFsA-KFtDFKIQNIVGSCDVKFPIRL Gallus_gallus MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Gibberella_zeae MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDIKFPIRL Kluyveromyces_lactis MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKIGFsA-KFtDFKIQNIVGSCDVKFPIRL Magnaporthe_grisea MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDIKFPIRL Mesocricetus_auratus MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Mus_musculus MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Neurospora_crassa MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDIKFPIRL Petromyzon_marinus MRIREPRTTALIFsSGKMVCTGAKSEDqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Pneumocystis_carinii MRIREPKTTALIFaSGKMVvTGAKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDVKFPIRL Rattus_norvegicus MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Schizosaccharomyces_pombe MRIREPKSTALIFaSGKMVvlGgKSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDVKFPIRL Strongylocentrotus_purpuratus MRIREPRTTALIFsSGKMVCTGAKrEDNSRLAARKYARVVQKLGFaA-KFlDFKIQNMVGSCDVKFPIRL Tetraodon_nigroviridis MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-RFlDFKIQNMVaSCDVcFPIRL Ustilago_maydis MRIREPKTTALIFaSGKMVvTGAKSEDDSRLAsRKYARIIQKLGFeA-KFsEFKIQNIVGSCDVRFPIRL Xenopus_laevis MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Xenopus_tropicalis MRIREPRTTALIFsSGKMVCTGAKSEEqSRLAARKYARVVQKLGFpA-KFlDFKIQNMVGSCDVKFPIRL Yarrowia_lipolytica MRIREPKTTALIFaSGKMVvTGARSEDDSKLAsRKYARIIQKLGFnA-KFtDFKIQNIVGSCDVKFPIRL Dictyostelium_discoideum MRIREPKTTALIFkSGKMVCTGAKSEDaSRfAARKYARIIQKLdFpA-RFtDFKIQNIVGSCDVKFPIKL Tetrahymena_thermophila MRLRDPKTTALIFaSGKMVCTGAKTEEDSnrAARKYAKIIQKIGFpv-QFkDFKIQNIVGStDVKFPInL Glycine_max MRIRDPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGSCDVKFPIRL Oryza_sativa MRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGSCDVKFPIRL Zea_mays MRIREPKTTALIFaSGKMVCTGAKSEQqSKLAARKYARIIQKLGFpA-KFkDFKIQNIVGSCDVKFPIRL ==================================================================================================== Consensus mRIrEPRttaLIFxSGKMVcTGaKSeEnsKlAarKyAQvVQkLGfxaxKfxEfkIQNMVgScDVkfpirL 500 510 520 530 540 550 560 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus EgLxxshxxfssYEPElFPGLIYRMiqPRiVLLIFvSGKVVlTGAKvKeDiyeAfdxIfpiLexxxxxfr ==================================================================================================== PYRFU DvValTlp-nceYEPEqFPGVIYRVkEPKsVILLFsSGKIVcSGAKsEaDaWEAvrkLlreLDk------ Pyrococcus_abyssi DnValTlp-nceYEPEqFPGVIYRVkdPRaVILLFsSGKIVcSGAKsEaDaWEAvrkLlreLEk------ ==================================================================================================== HUMAN EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR YEAST EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFEaIYPVLse----FR ARABIDOPSIS_THALIANA EGLaySHaaFSSYEPELFPGLIYRMkvPKIVLLIFVSGKIVITGAKMRDEtYKAFEnIYPVLse----FR 1JFIC_Human EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR 1TBPA_Yeast EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFEaIYPVLse----FR Anopheles_gambiae EGLvlTHgrFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYDAFEnIYPILKs----FK Apis_mellifera EGLvlTHgqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYEAFDnIYPILKs----FK Aspergillus_fumigatus EGLasrHhnFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFElIYPVLsgtvilFf Bombyx_mandarina EGLvlTHgqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVREEIYEAFDnIYPILKs----FK Bos_taurus EpLvlSHqqFaSYEPELFPGLVYRMIKPRIVLLIFVSGKVVLTGAKVRsEIYEAFNnIYsILKg----FR Caenorhabditis_briggsae EGLciTHaqFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKtKKDIdDAFgqIYPILKg----FK Caenorhabditis_elegans EGLciTHsqFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKtKrDIdEAFgqIYPILKg----FK Candida_albicans EGLafaHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKkREEIYDAFEsIYPVLne----FR Candida_glabrata EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFEaIYPVLse----FR Canis_lupus EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Cryptococcus_neoformans EGLafSHgaFSSYEPELFPGLIYRMLKPKVVILIFVSGKIVLTGAKVREEIYmAFNqIYsVLle----FR Danio_rerio EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRgEIYEAFEnIYPILKg----FR Debaryomyces_hansenii EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYaAFEaIYPVLse----FR Drosophila_melanogaster EGLvlTHcnFSSYEPELFPGLIYRMVRPRIVLLIFVSGKVVLTGAKVRQEIYDAFDkIFPILKk----FK Drosophila_pseudoobscura EGLvlTHcnFSSYEPELFPGLIYRMVRPRIVLLIFVSGKVVLTGAKVRQEIYDAFDkIFPILKk----FK Emericella_nidulans EGLasrHhnFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFElIYPVLsd----FR Encephalitozoon_cuniculi EGLayaHsnYcSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVRDDIYQAFNnIYPVLiq----hR Eremothecium_gossypii EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFEaIYPVLse----FR Gallus_gallus EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Gibberella_zeae EGLasrHhnFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEmIYPVLQg----lR Kluyveromyces_lactis EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYQAFEaIYPVLse----FR Magnaporthe_grisea EGLasrHhnFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEmIYPVLQd----FR Mesocricetus_auratus EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Mus_musculus EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Neurospora_crassa EGLaskHhnFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEmIYPVLQd----FR Petromyzon_marinus EGLvlTHqqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRgEIYEAFEnIYPILKg----FR Pneumocystis_carinii EGLaySHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKVREEIYQAFEaIYPVLse----FR Rattus_norvegicus EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Schizosaccharomyces_pombe EGLaySHgtFSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFEaIYPVLse----FR Strongylocentrotus_purpuratus EGLvlTHgqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYDAFNnIYPILKs----FK Tetraodon_nigroviridis EGLvlTHqqFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKeRaEIYEAFEnIYPILrg----FR Ustilago_maydis EGLaySHgvYSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFNlIlPVLae----FR Xenopus_laevis EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Xenopus_tropicalis EGLvlTHqqFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRaEIYEAFEnIYPILKg----FR Yarrowia_lipolytica EGLafSHgtFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKqREEIYaAFEaIYPVLne----FR Dictyostelium_discoideum ElLhnaHtsFTNYEPEIFPGLIYKMIQPKVLLLIFVSGKIVLTGAKVREyIYEAFEnIYPVLsa----FK Tetrahymena_thermophila DhLeqdHkkFvqYEPEIFPGkIYRefntKIVLLIFVSGKIVLTGAKtRENInKAFqkIYwVLyn----YQ Glycine_max EGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVRDEtYtAFEnIYPVLte----FR Oryza_sativa EGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVRDEtYtAFEnIYPVLte----FR Zea_mays EGLaySHgaFSSYEPELFPGLIYRMkQPKIVLLIFVSGKIVLTGAKVREEtYtAFEnIYPVLse----FR ==================================================================================================== Consensus EgLxxshxxfssYEPElFPGLIYRMiqPRiVLLIFvSGKVVlTGAKvKeDiyeAfdxIfpiLexxxxxfr 570 580 590 600 610 620 630 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus kxxxxxxxxxxxxxxxxxxxxxxxxxxxx =========================================================== PYRFU -yglleeeeeel----------------- Pyrococcus_abyssi -yglieeeeeel----------------- =========================================================== HUMAN Ktt-------------------------- YEAST Km--------------------------- ARABIDOPSIS_THALIANA Kiqq------------------------- 1JFIC_Human Kt--------------------------- 1TBPA_Yeast Km--------------------------- Anopheles_gambiae Kq--------------------------- Apis_mellifera Kq--------------------------- Aspergillus_fumigatus gfks-------------nymltirsdfrk Bombyx_mandarina Kq--------------------------- Bos_taurus Kts-------------------------- Caenorhabditis_briggsae K---------------------------- Caenorhabditis_elegans K---------------------------- Candida_albicans Kn--------------------------- Candida_glabrata Km--------------------------- Canis_lupus Ktt-------------------------- Cryptococcus_neoformans Ktt-------------------------- Danio_rerio Kts-------------------------- Debaryomyces_hansenii Ks--------------------------- Drosophila_melanogaster Kqs-------------------------- Drosophila_pseudoobscura Kqs-------------------------- Emericella_nidulans Kv--------------------------- Encephalitozoon_cuniculi Ka--------------------------- Eremothecium_gossypii Kl--------------------------- Gallus_gallus Ktt-------------------------- Gibberella_zeae chhiisypthhiitilstcmirhkpsryh Kluyveromyces_lactis Kl--------------------------- Magnaporthe_grisea Kv--------------------------- Mesocricetus_auratus Ktt-------------------------- Mus_musculus Ktt-------------------------- Neurospora_crassa Kv--------------------------- Petromyzon_marinus Ktt-------------------------- Pneumocystis_carinii Kss-------------------------- Rattus_norvegicus Ktt-------------------------- Schizosaccharomyces_pombe Kh--------------------------- Strongylocentrotus_purpuratus Kts-------------------------- Tetraodon_nigroviridis Kq--------------------------- Ustilago_maydis Kp--------------------------- Xenopus_laevis Ktt-------------------------- Xenopus_tropicalis Ktt-------------------------- Yarrowia_lipolytica Kg--------------------------- Dictyostelium_discoideum Kvna------------------itq---- Tetrahymena_thermophila Kkdy-------rganlhnqnlnikpsikn Glycine_max Knqq------------------------- Oryza_sativa Kv----------------------qqrw- Zea_mays Kiqq------------------------- =========================================================== Consensus kxxxxxxxxxxxxxxxxxxxxxxxxxxxx