Triosephosphate Isomerase

280 290 300 310 ----:----|----:----|----:----|----:----|----: Consensus vxxxxxFsxVVLAYEPVWaigtgksaTPEQAQQVHexLRxyLxex ============================================================================= YEAST Vkd---WTnVVVAYEPVWAIGTGlaATPEdAQdIHasIRkFLask Candida_albicans Vsd---WSnIVVAYEPVWAIGTGlaATPEdAEEtHKgIRahLaKs Candida_glabrata Vkd---WTnVVIAYEPVWAIGTGlaATaEdAQdIHhsIRsYLaEk Debaryomyces_hansenii Vsd---WSkIVVAYEPVWAIGTGlaATPEdAQEtHKaIRehLsKs Eremothecium_gossypii Vkd---WTnVVIAYEPVWAIGTGlaATaEdAQdIHaaIRdFLaEr Kluyveromyces_lactis Vqd---WTnVVVAYEPVWAIGTGlaATsDdAQaIHhsIReFLaKk Yarrowia_lipolytica Ikd---WSnVVIAYEPVWAIGTGlaATaEdAQQIHheIRaYLkDk Zygosaccharomyces_bailii Vkd---WSnVVIAYEPVWAIGTGlaATPEdAQEIHhsIReFLaKk ============================================================================= CHICKEN Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth C_ELEGANS gv---sWenIVIAYEPVWAIGTGKTASgEQAQEVHEwIRaFLkEk HUMAN Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn RABBIT Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn 1SPQA_Chicken Vk---dWSkVVLAYEPVWAIxxGKTkTPQQAQEVHEkLRgWLksh 1SPQB_Chicken Vk---dWSkVVLAYEPVWxxxxxxxxTPQQAQEVHEkLRgWLksh 1SQ7A_Chicken Vk---dWSkVVLAYEPVWAIGTGlwATPQQAQEVHEkLRgWLksh 1SSDA_Chicken Vk---dWSkVVLAYEPVWAIGTGySlTPQQAQEVHEkLRgWLksh 1SU5A_Chicken Vk---dWSkVVLAYEPVWAIGTGnpnTPQQAQEVHEkLRgWLksh 1SW3A_Chicken Vk---dWSkVVLAYEPVWAIGTGKvATPQQAQEVHEkLRgWLksh 1SW7A_Chicken Vk---dWSkVVLAYEPVWAIGTGnSsTPQQAQEVHEkLRgWLksh 1TPB1_Chicken Vk---dWSkVVLAYDPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPC1_Chicken Vk---dWSkVVLAYDPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPUA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPVA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPWA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth Acipenser_brevirostrum Vk---dWSkVVLAYEPVWAIGTGKTASPQQAQEVHEkLRqWLkth Anopheles_gambiae Vk---dWSnVVIAYEPVWAIGTGKTATPEQAQEVHaaLRkWftEn Bos_taurus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Caenorhabditis_briggsae gv---sWenIVIAYEPVWAIGTGKTASPEQAQEVHEwIRaFLkEk Canis_lupus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Danio_rerio Vk---dWSkVVLAYEPVWAIGTGKTASPQQAQEVHDkLRqWLktn Drosophila_melanogaster Ik---dWknVVVAYEPVWAIGTGKTATPDQAQEVHasLRqWLsDn Drosophila_pseudoobscura Vr---dWTnVVVAYEPVWAIGTGKTATPEQAQEVHafLRqWLtDn Latimeria_chalumnae Vk---dWSkVVLAYEPVWAIGTGKTASPQQsQELHgkLRkWLkEn Macaca_mulatta Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Mus_musculus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Oryzias_latipes Vm---dWekVVLAYEPVWAIGTGKTATPEQAQEVHEkLRaWfran Pongo_pygmaeus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Rattus_norvegicus Vk---dWckVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkcn Schistosoma_mansoni IksadeWkrVVVAYEPVWAIGTGKvATPQQAQEVHnfLRkWfktn Strongylocentrotus_purpuratus It---dWgnVVIAYEPVWAIGTGKTATPQQAQEVHQnLRsWLtEh Sus_scrofa Vk---dWNkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth Xenopus_laevis Vk---dWSkVVLAYEPVWAIGTGKTATPEQAQEVHKkLReWVktn ============================================================================= ENTAMOEBA_HISTOLYTICA Iskea-WknIILAYEPVWAIGTGKTATPDQAQEVHQyIRkWMtEn ============================================================================= LEISHMANIA_MEXICANA Ltkda-WNqVVLAYEPVWAIGTGKvATPEQAQEVHllLRkWVsEn TRYPANOSOMA_BRUCEI Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk TRYPANOSOMA_CRUZI Lskea-WSrVVIAYEPVWAIGTGKvATPQQAQEVHElLRrWVrsk 1KV5A_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIssWVssk 1MSSA_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TRI0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TTI0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TTJ0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk Leishmania_donovani Lptea-WdqIVLAYEPVWAIGTGKvATPEQAQEVHalLRkWVsEk Leishmania_tropica Lpkea-WdqIVLAYEPVWAIGTGKvATPEQAQEVHalLRkWVsEk ============================================================================= PLASMODIUM_FALCIPARUM Idn---FdnVILvYEPLWAIGTGKTATPEQAQlVHKeIRkiVkDt 1VGAB_Plasmodium_falciparum Idn---FdnVILvYEPLFAIGTGKTATPEQAQlVHKeIRkiVkDt Plasmodium_berghei Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEi Plasmodium_chabaudi Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEi Plasmodium_yoelii Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEm ============================================================================= ECOLI qgaaa-FegaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKv VIBRIO_MARINUS qgvea-legaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Actinobacillus_pleuropneumoniae Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Actinobacillus_succinogenes Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRahIaak Erwinia_carotovora Lgaka-FentVVAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKq Haemophilus_ducreyi Lgvea-FNqaVIAYEPIWAIGTGKSATPaQAQaVHafIRqhIaEk Haemophilus_influenzae Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Histophilus_somni Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaKq Mannheimia_succiniciproducens Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Pasteurella_multocida ygvea-lNgaIIAYEPIWAIGTGKaATaEdAQRIHasIRalIaak Photobacterium_profundum qgvea-legaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Photorhabdus_luminescens Lgvaa-FqgaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaQk Salmonella_typhi qgaaa-FegaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKa Vibrio_cholerae ygvea-lNgaIIAYEPIWAIGTGKaATaDdAQRIHasIRalIaak Vibrio_fischeri qgvda-lNgaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Vibrio_vulnificus ygvea-lNgaIIAYEPIWAIGTGKaATaEdAQRIHasIRamIaak Yersinia_pestis Lgvka-FegaVIAYEPIWAIGTGKSATPaQAQaVHKfIRdhIaKq ============================================================================= THERMUS_AQUATICUS Veppg-peaLVIAYEPVWAIGTGKNATPEdAEaMHQaIRkaLsEr ============================================================================= BACILLUS_STEAROTHERMOPHILUS Ltpeq-vkqaVIAYEPIWAIGTGKSsTPEdAnsVcghIRsvVsrl Bacillus_subtilis Lseeq-vaasVIAYEPIWAIGTGKSsTaKdAndVcahIRktVaEs Geobacillus_kaustophilus Ltpeq-vkqaVIAYEPIWAIGTGKSsTPEdAnsVcghIRsvVsrl ============================================================================= Consensus vxxxxxFsxVVLAYEPVWaigtgksaTPEQAQQVHexLRxyLxex

Triosephosphate Isomerase

Page 7 of 9