Triosephosphate Isomerase

10 20 30 40 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ============================================================================= YEAST --------------------------------------------- Candida_albicans --------------------------------------------- Candida_glabrata --------------------------------------------- Debaryomyces_hansenii --------------------------------------------- Eremothecium_gossypii --------------------------------------------- Kluyveromyces_lactis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Zygosaccharomyces_bailii --------------------------------------------- ============================================================================= CHICKEN --------------------------------------------- C_ELEGANS --------------------------------------------- HUMAN --------------------------------------------- RABBIT --------------------------------------------- 1SPQA_Chicken --------------------------------------------- 1SPQB_Chicken --------------------------------------------- 1SQ7A_Chicken --------------------------------------------- 1SSDA_Chicken --------------------------------------------- 1SU5A_Chicken --------------------------------------------- 1SW3A_Chicken --------------------------------------------- 1SW7A_Chicken --------------------------------------------- 1TPB1_Chicken --------------------------------------------- 1TPC1_Chicken --------------------------------------------- 1TPUA_Chicken --------------------------------------------- 1TPVA_Chicken --------------------------------------------- 1TPWA_Chicken --------------------------------------------- Acipenser_brevirostrum --------------------------------------------- Anopheles_gambiae --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_briggsae --------------------------------------------- Canis_lupus --------------------------------------------- Danio_rerio --------------------------------------------- Drosophila_melanogaster ndlnrigiqciasvtllqrfpyhrnhhtiptmdqnrptvggvtae Drosophila_pseudoobscura iqivratrgrgrsv----whthqsgplsr-aimdnnps-adisvd Latimeria_chalumnae --------------------------------------------- Macaca_mulatta --------------------------------------------- Mus_musculus --------------------------------------------- Oryzias_latipes --------------------------------------------- Pongo_pygmaeus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schistosoma_mansoni --------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------------- Sus_scrofa --------------------------------------------- Xenopus_laevis --------------------------------------------- ============================================================================= ENTAMOEBA_HISTOLYTICA --------------------------------------------- ============================================================================= LEISHMANIA_MEXICANA --------------------------------------------- TRYPANOSOMA_BRUCEI --------------------------------------------- TRYPANOSOMA_CRUZI --------------------------------------------- 1KV5A_Trypanosoma_brucei --------------------------------------------- 1MSSA_Trypanosoma_brucei --------------------------------------------- 1TRI0_Trypanosoma_brucei --------------------------------------------- 1TTI0_Trypanosoma_brucei --------------------------------------------- 1TTJ0_Trypanosoma_brucei --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- ============================================================================= PLASMODIUM_FALCIPARUM --------------------------------------------- 1VGAB_Plasmodium_falciparum --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_chabaudi --------------------------------------------- Plasmodium_yoelii --------------------------------------------- ============================================================================= ECOLI --------------------------------------------- VIBRIO_MARINUS --------------------------------------------- Actinobacillus_pleuropneumoniae --------------------------------------------- Actinobacillus_succinogenes --------------------------------------------- Erwinia_carotovora --------------------------------------------- Haemophilus_ducreyi --------------------------------------------- Haemophilus_influenzae --------------------------------------------- Histophilus_somni --------------------------------------------- Mannheimia_succiniciproducens --------------------------------------------- Pasteurella_multocida --------------------------------------------- Photobacterium_profundum --------------------------------------------- Photorhabdus_luminescens --------------------------------------------- Salmonella_typhi --------------------------------------------- Vibrio_cholerae --------------------------------------------- Vibrio_fischeri --------------------------------------------- Vibrio_vulnificus --------------------------------------------- Yersinia_pestis --------------------------------------------- ============================================================================= THERMUS_AQUATICUS --------------------------------------------- ============================================================================= BACILLUS_STEAROTHERMOPHILUS --------------------------------------------- Bacillus_subtilis --------------------------------------------- Geobacillus_kaustophilus --------------------------------------------- ============================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 50 60 70 80 90 ----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ============================================================================= YEAST --------------------------------------------- Candida_albicans --------------------------------------------- Candida_glabrata --------------------------------------------- Debaryomyces_hansenii --------------------------------------------- Eremothecium_gossypii --------------------------------------------- Kluyveromyces_lactis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- Zygosaccharomyces_bailii --------------------------------------------- ============================================================================= CHICKEN --------------------------------------------- C_ELEGANS --------------------------------------------- HUMAN --------------------------------------------- RABBIT --------------------------------------------- 1SPQA_Chicken --------------------------------------------- 1SPQB_Chicken --------------------------------------------- 1SQ7A_Chicken --------------------------------------------- 1SSDA_Chicken --------------------------------------------- 1SU5A_Chicken --------------------------------------------- 1SW3A_Chicken --------------------------------------------- 1SW7A_Chicken --------------------------------------------- 1TPB1_Chicken --------------------------------------------- 1TPC1_Chicken --------------------------------------------- 1TPUA_Chicken --------------------------------------------- 1TPVA_Chicken --------------------------------------------- 1TPWA_Chicken --------------------------------------------- Acipenser_brevirostrum --------------------------------------------- Anopheles_gambiae --------------------------------------------- Bos_taurus --------------------------------------------- Caenorhabditis_briggsae --------------------------------------------- Canis_lupus --------------------------------------------- Danio_rerio --------------------------------------------- Drosophila_melanogaster vlkavvseallgkftavfpklfkcqwktyegqkkfyanfstdctd Drosophila_pseudoobscura lrlsvsska--hkptavfpklskrpsegqkkvskllseilyanfs Latimeria_chalumnae --------------------------------------------- Macaca_mulatta --------------------------------------------- Mus_musculus --------------------------------------------- Oryzias_latipes --------------------------------------------- Pongo_pygmaeus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Schistosoma_mansoni --------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------------- Sus_scrofa --------------------------------------------- Xenopus_laevis --------------------------------------------- ============================================================================= ENTAMOEBA_HISTOLYTICA --------------------------------------------- ============================================================================= LEISHMANIA_MEXICANA --------------------------------------------- TRYPANOSOMA_BRUCEI --------------------------------------------- TRYPANOSOMA_CRUZI --------------------------------------------- 1KV5A_Trypanosoma_brucei --------------------------------------------- 1MSSA_Trypanosoma_brucei --------------------------------------------- 1TRI0_Trypanosoma_brucei --------------------------------------------- 1TTI0_Trypanosoma_brucei --------------------------------------------- 1TTJ0_Trypanosoma_brucei --------------------------------------------- Leishmania_donovani --------------------------------------------- Leishmania_tropica --------------------------------------------- ============================================================================= PLASMODIUM_FALCIPARUM --------------------------------------------- 1VGAB_Plasmodium_falciparum --------------------------------------------- Plasmodium_berghei --------------------------------------------- Plasmodium_chabaudi --------------------------------------------- Plasmodium_yoelii --------------------------------------------- ============================================================================= ECOLI --------------------------------------------- VIBRIO_MARINUS --------------------------------------------- Actinobacillus_pleuropneumoniae --------------------------------------------- Actinobacillus_succinogenes --------------------------------------------- Erwinia_carotovora --------------------------------------------- Haemophilus_ducreyi --------------------------------------------- Haemophilus_influenzae --------------------------------------------- Histophilus_somni --------------------------------------------- Mannheimia_succiniciproducens --------------------------------------------- Pasteurella_multocida --------------------------------------------- Photobacterium_profundum --------------------------------------------i Photorhabdus_luminescens --------------------------------------------- Salmonella_typhi --------------------------------------------- Vibrio_cholerae --------------------------------------------- Vibrio_fischeri --------------------------------------------- Vibrio_vulnificus --------------------------------------------- Yersinia_pestis --------------------------------------------- ============================================================================= THERMUS_AQUATICUS --------------------------------------------- ============================================================================= BACILLUS_STEAROTHERMOPHILUS --------------------------------------------- Bacillus_subtilis --------------------------------------------- Geobacillus_kaustophilus --------------------------------------------- ============================================================================= Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 100 110 120 130 ----:----|----:----|----:----|----:----|----: Consensus xxxxxxxxxRQfxVxGNWKMNgnKxnLxELIxxLNxxxxxxxxxx ============================================================================= YEAST --------aRtFfVgGNFKLNGSKqSIkEIVerLNt-asip--en Candida_albicans --------aRQFfVgGNFKaNGtKqqItsIIdnLNk-adlp--kd Candida_glabrata --------aRtFfVgGNFKLNGtKkSIkEIVdrLNt-aslp--en Debaryomyces_hansenii --------aRQFfVgGNFKMNGtReSVsKIVdgLNk-aelp--sn Eremothecium_gossypii --------aRtFfVgGNFKLNGSKqSIkEIVerLNt-adla--dn Kluyveromyces_lactis --------aRtFfIgGNFKMNGtKaSIkEIVerLNs-asip--sn Yarrowia_lipolytica --------sRtFfVgGNFKMNGSleSIkaIVerLNa-seld--pk Zygosaccharomyces_bailii --------aRtFfVgGNFKLNGtKsSIkEIVerLNn-akld--pk ============================================================================= CHICKEN -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad C_ELEGANS -----t---RKFfVgGNWKMNGDyaSVdgIVtfLNa-sadn--ss HUMAN --gsap-s-RKFfVgGNWKMNGrKqSLgELIgtLNa-akvp--ad RABBIT -----a-psRKFfVgGNWKMNGrKkNLgELIttLNa-akvp--ad 1SPQA_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SPQB_Chicken -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SQ7A_Chicken -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SSDA_Chicken -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SU5A_Chicken -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SW3A_Chicken -----a-p-RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1SW7A_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1TPB1_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1TPC1_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1TPUA_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1TPVA_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad 1TPWA_Chicken ---------RKFfVgGNWKMNGDKkSLgELIhtLNg-akls--ad Acipenser_brevirostrum -----a-ptRKFfVgGNWKLNGDKkSLgELIhtLNs-gkin--ad Anopheles_gambiae -------g-RKFcVgGNWKMNGDKaSItELcktLSa-gpld--pn Bos_taurus -----a-psRKFfVgGNWKMNGrKnNLgELIntLNa-akvp--ad Caenorhabditis_briggsae -------a-RKFfVgGNWKMNGDfaSVdgIVafLNq-sadn--sn Canis_lupus -----a-psRKFfVgGNWKMNGrKkNLgELIttLNa-akvp--ad Danio_rerio -----s-g-RKFfVgGNWKMNGDKkSIeELantLNs-akln--pd Drosophila_melanogaster snsnnm-s-RKFcVgGNWKMNGDQkSIaEIaktLSs-aald--pn Drosophila_pseudoobscura tnskms-a-RKFcVgGNWKMNGDQkSIaEIcktLSg-aald--pn Latimeria_chalumnae -----a-p-RKFfVgGNWKMNGDKkSLgELIqtLNa-akvp--ft Macaca_mulatta -----a-psRKFfVgGNWKMNGrKqNLgELIgtLNa-akvp--ad Mus_musculus -----a-ptRKFfVgGNWKMNGrKkcLgELIctLNa-anvp--ag Oryzias_latipes -----a-q-RRFfVgGNWKMNGNKeSLeELMstLNt-aslh--ed Pongo_pygmaeus -----a-psRKFfVgGNWKMNGrKqSLgELIgtLNa-akvp--ad Rattus_norvegicus -----a-psRKFfVgGNWKMNGrKkcLgELIctLNa-aklp--ad Schistosoma_mansoni ----sg-s-RKFfVgGNWKMNGSRdDndKLLklLSe-ahfd--dn Strongylocentrotus_purpuratus ----as-g-RRFwVgGNYKMNGSKaSIdgLLkmLee-sqip--gn Sus_scrofa -----a-paRKFfVgGNWKMNGrKnNLgELIntLNa-aklp--ad Xenopus_laevis -----s-p-RKFfVgGNWKMNGDKkSLgELIntLNs-gkmn--ad ============================================================================= ENTAMOEBA_HISTOLYTICA ------g-agKFvVgGNWKcNGtlaSIetLtkgVaasvdaelakk ============================================================================= LEISHMANIA_MEXICANA -----sa-kpQpiaaaNWKcNGttaSIeKLVqvfNe-htis--hd TRYPANOSOMA_BRUCEI ------s-kpQpiaaaNWKcNGSQqSLsELIdlfNs-tsin--hd TRYPANOSOMA_CRUZI -----as-kpQpiaaaNWKcNGSEslLvpLIetLNa-atfd--hd 1KV5A_Trypanosoma_brucei ------s-kpQpiaaaNWKcNGSQqSLsELIdlfNs-tsin--hd 1MSSA_Trypanosoma_brucei ------s-kpQpiaaaNWKcNGSQqSLsELIdlfNs-tsin--hd 1TRI0_Trypanosoma_brucei ------s-kpQpiaaaNW---GSQqSLsELIdlfNs-tsin--hd 1TTI0_Trypanosoma_brucei ------s-kpQpiaaaNWK------SLsELIdlfNs-tsin--hd 1TTJ0_Trypanosoma_brucei ------s-kpQpiaaaNW-------SLsELIdlfNs-tsin--hd Leishmania_donovani -----ss-kpQpiaaaNWKcNGttaSIeKLVqvLNe-hnis--hd Leishmania_tropica -----sa-kpQpiaaaNWKcNGttaSIeKLVqvLNe-hnis--hd ============================================================================= PLASMODIUM_FALCIPARUM -----a---RKYfVaaNWKcNGtleSIksLtnsfNn-ldfd-psk 1VGAB_Plasmodium_falciparum ---------RKYfVaaNWKcNGtleSIksLtnsfNn-ldfd-psk Plasmodium_berghei -----a---RKYfVsaNWKcNGtEySIksLadsfNt-vdfd-psk Plasmodium_chabaudi -----a---RKYfVsaNWKcNGtKdSIktLadsfNt-vdfd-psk Plasmodium_yoelii --------------------------------------------- ============================================================================= ECOLI ---------RhplVmGNWKLNGSRhmVhELVsnLrk-elag-vag VIBRIO_MARINUS ---------RhpvVmGNWKLNGSKemVvDLLngLNa-eleg-vtg Actinobacillus_pleuropneumoniae ---a-----RRplVmGNWKLNGSKaftkELIagLka-elad-vkg Actinobacillus_succinogenes --as-----RKplVmGNWKLNGSKaftrELIegLkt-elag-veg Erwinia_carotovora ---------RhplVmGNWKLNGStnlVnELIagLrk-elst-vdg Haemophilus_ducreyi ---a-----RRplVmGNWKLNGSKaftqQLIaeLkt-elae-itg Haemophilus_influenzae ---a-----RRplVmGNWKLNGSKaftkELIegLka-elhd-vtg Histophilus_somni ---a-----RRplVmGNWKLNGSKaftkELItgLkd-elna-vsg Mannheimia_succiniciproducens ---a-----RRplVmGNWKLNGSKaftkELIegLka-elag-veg Pasteurella_multocida ---------RRpvVmGNWKLNGSKamVtELLtgLNa-eleg-veg Photobacterium_profundum wrktm----RhpvVmGNWKLNGSKemVvnLLngLNa-eleg-vtg Photorhabdus_luminescens ---------RhplVmGNWKLNGSthmVnELItgLrq-elss-vtg Salmonella_typhi ---------RhplVmGNWKLNGSRhmVnELVanLrk-eltg-vag Vibrio_cholerae ---------RRpvVmGNWKLNGSKamVtDLLngLNa-eleg-veg Vibrio_fischeri ---------RhpvVmGNWKLNGSKemVvELLngLNa-eleg-vtg Vibrio_vulnificus ---------RRpvVmGNWKLNGSKtmVaELLtgLNa-eleg-veg Yersinia_pestis ---------RhplVmGNWKLNGSthmVnELIagLrk-elst-vdg ============================================================================= THERMUS_AQUATICUS ---------RRvlVaGNWKMHktpsearvwfaeLkr-llpp--lq ============================================================================= BACILLUS_STEAROTHERMOPHILUS ---------RKpiIaGNWKMHktlaeavQfVedVkg-hvpp-ade Bacillus_subtilis ---------RKpiIaGNWKMNktlgeavsfVeeVks-sipa-adk Geobacillus_kaustophilus ---------RKriIaGNWKMHktlaeavQfVenVkg-hvpp-ade ============================================================================= Consensus xxxxxxxxxRQfxVxGNWKMNgnKxnLxELIxxLNxxxxxxxxxx 140 150 160 170 180 ----|----:----|----:----|----:----|----:----| Consensus xEVVVaPPxIYLNxAKxxxxLxxxxxxxxxxxxxxxxxexIxVxA ============================================================================= YEAST vEVVIcPPatYLDysvs--lV----kk-----------pqVtVgA Candida_albicans vEVVIcPPaLYLglAve--qn----kq-----------ptVaIgA Candida_glabrata vEVVIcPPatYLDytvs--lV----sk-----------KqVtVgg Debaryomyces_hansenii vEVVIAPPapYIalAvn--en----kq-----------KtIeVsA Eremothecium_gossypii vEVVIcPPatYLDhAvs--lV----sh-----------pqVtVgA Kluyveromyces_lactis vEVVIAPPaaYLDhAvs--ln----kk-----------aqVsVaA Yarrowia_lipolytica tEVVIsPPfpYLllAKe--sL----kk-----------ptVsVag Zygosaccharomyces_bailii vEVVLcPPapYLDytvs--lV----kk-----------sqVsVgA ============================================================================= CHICKEN tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA C_ELEGANS vDVVVAPPapYLayAKs--kL----ka-----------g-VlVaA HUMAN tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA RABBIT tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA 1SPQA_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SPQB_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SQ7A_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SSDA_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SU5A_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SW3A_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1SW7A_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1TPB1_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1TPC1_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1TPUA_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1TPVA_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA 1TPWA_Chicken tEVVcgaPsIYLDfARq--kL----da-----------K-IgVaA Acipenser_brevirostrum tDVVcgaPtIYLDfvRs--kL----ds-----------K-MgVaA Anopheles_gambiae tEVVVgcPapYLSlARs--lL----pe-----------t-IgVaA Bos_taurus tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Caenorhabditis_briggsae vDVVVAPPapYLayAKa--nL----ka-----------g-VlVaA Canis_lupus tEVVcAPPtaYIDfARq--kL----da-----------K-IaVaA Danio_rerio tEVVcgaPtIYLDyARs--kL----np-----------n-IdVaA Drosophila_melanogaster tEVVIgcPaIYLmyARn--lL----pc-----------E-LgLag Drosophila_pseudoobscura tEVVIgcPaIYLmyARn--lL----pc-----------t-VgVag Latimeria_chalumnae gEIVcAPPeaYLDfARl--kV----dp-----------K-fgVaA Macaca_mulatta tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Mus_musculus tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Oryzias_latipes tEVVcAaPsIYLDfARs--gL----ds-----------r-IsVaA Pongo_pygmaeus tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Rattus_norvegicus tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Schistosoma_mansoni tEVLIAPPsVFLHeiRk--sL----kk-----------E-IhVaA Strongylocentrotus_purpuratus tDVVVAPPtVYLDymns--kI----pa-----------g-VfVaA Sus_scrofa tEVVcAPPtaYIDfARq--kL----dp-----------K-IaVaA Xenopus_laevis tEVVcgaPaIYLDfARq--kL----da-----------K-IaLsA ============================================================================= ENTAMOEBA_HISTOLYTICA vEVIVgvPfIYIpkvQq--iLageang----------an-IlVsA ============================================================================= LEISHMANIA_MEXICANA vQcVVAPtfVhIplvQa--kL----rn----------pK-yvIsA TRYPANOSOMA_BRUCEI vQcVVAstfVhLamtKe--rL----sh----------pK-fvIaA TRYPANOSOMA_CRUZI vQcVVAPtfLhIpmtKa--rL----tn----------pK-fqIaA 1KV5A_Trypanosoma_brucei vQcVVAstfVhLamtKe--rL----sh----------pK-fvIaA 1MSSA_Trypanosoma_brucei vQcVVAstsshLamtKe--rL----sh----------pK-fvIaA 1TRI0_Trypanosoma_brucei vQcVVAstfVhLamtKe--rL----sh----------pK-fvIaA 1TTI0_Trypanosoma_brucei vQcVVAstfVhLamtKe--rL----sh----------pK-fvIaA 1TTJ0_Trypanosoma_brucei vQcVVAstsshLamtKe--rL----sh----------pK-fvIaA Leishmania_donovani vQcVVAPtfVhIplvQa--kL----rn----------pK-yaVsA Leishmania_tropica vQcVVAPtfVhIplvQa--kL----rn----------pK-yvVsA ============================================================================= PLASMODIUM_FALCIPARUM lDVVVfPvsVhyDhtRk--lL----q------------skfstgi 1VGAB_Plasmodium_falciparum lDVVVfPvsVhyDhtRk--lL----q------------skfstgi Plasmodium_berghei lDVVVfPvsVhyDltRk--lL----n------------KkIgtgi Plasmodium_chabaudi lDVVVfPvsVhyDlARn--lL----n------------KkIgtgi Plasmodium_yoelii --VVVfPvsVhyDltRk--lL----n------------KkIgtgi ============================================================================= ECOLI caVaIAPPeMYIDmAKr--ea----e--g--------sh-ImLgA VIBRIO_MARINUS vDVaVAPPaLFVDlAEr--tL----teag--------sa-IiLgA Actinobacillus_pleuropneumoniae cDVaIAPPvMYLaeAEa--aL----a--g-------qsv-IaLgA Actinobacillus_succinogenes cDVaIAPPvMYLaeAEt--aL----a--d--------sK-IaLgs Erwinia_carotovora cgVaIAPPaIYLDqAnh--qL----a--g--------sr-IaLgA Haemophilus_ducreyi cDVaIAPPvMYLSeAEi--aL----a--g-------qst-IrLgA Haemophilus_influenzae cDVaIAPPvMYLgtAEa--aL----s--gcgcscggksv-IqLgA Histophilus_somni cDVaIAPPvMYLaeAEt--aL----v--s--------sD-IaLgt Mannheimia_succiniciproducens cDVaIAPPvMYLaeAEa--aL----a--g--------sK-IvLgs Pasteurella_multocida vDVaVAPPaLYIDlAErliae----g--g--------nK-IiLgA Photobacterium_profundum vDVaVAPPaLFIDlAEhtlte----a--g--------sa-IiLgA Photorhabdus_luminescens cDVaIAPPaLYLSqAKq--aL----a--g--------sr-IaLgA Salmonella_typhi cDVaIAPPeMYIDlAKr--aa----a--g--------sh-ImLgA Vibrio_cholerae vDVVVAPPaMYLDlAErlike----g--g--------nK-LiLgA Vibrio_fischeri vDVaVAPPaLFVDlAErtlte----a--g--------sa-IiLgA Vibrio_vulnificus vDVaVAPPaLYIDlAErliae----g--g--------nK-IiLgA Yersinia_pestis cgVaIAPPaIYLNqAKh--eL----a--g--------sr-IaLgA ============================================================================= THERMUS_AQUATICUS sEaaVlPafpiLpvAKe--vL----ae----------tQ-VgygA ============================================================================= BACILLUS_STEAROTHERMOPHILUS visVVcaPfLFLDrlvq--aa----dg----------tD-LkIgA Bacillus_subtilis aEaVVcaPaLFLeklas--aV----kg----------tD-LkVgA Geobacillus_kaustophilus vDsVVcaPfLFLDrlvq--aa----dg----------tD-LkIgA ============================================================================= Consensus xEVVVaPPxIYLNxAKxxxxLxxxxxxxxxxxxxxxxxexIxVxA 190 200 210 220 ----:----|----:----|----:----|----:----|----: Consensus QNxxxxxnGAFTGEISpxMIKDiGaxYVILGHSERRxyYxESNEl ============================================================================= YEAST QNaylkaSGAFTGEnSvdqIKDVGAkWVILGHSERRsYFhEdDKf Candida_albicans QNvfdkscGAFTGEtcasqIlDVGAsWtLtGHSERRtiikESDEf Candida_glabrata QNtytkaSGAYTGEnSvdqLKDVGAkWVILGHSERRtYFhEdDKI Debaryomyces_hansenii QNcfdkaSGAYTGEISPeqIKDLGAtWtLtGHSERRtiikESDDf Eremothecium_gossypii QNaytkaSGAYTGEnSvdqIKDVGAkWVILGHSERRtYFnEdDEq Kluyveromyces_lactis QNaylkaSGAFTGEnSveqIKDVGAeWVILGHSERRtYFhETDEf Yarrowia_lipolytica QNsfdkgDGAFTGEVSvaqLKDVGAkWVILGHSERRtinkESSEw Zygosaccharomyces_bailii QNaylkaSGAFTGEnSvdqIKDVGAkWVILGHSERRqYFrEdDQL ============================================================================= CHICKEN QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL C_ELEGANS QNcykvpkGAFTGEISPaMIKDLGleWVILGHSERRhvFgESDaL HUMAN QNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFgESDEL RABBIT QNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFgESDEL 1SPQA_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SPQB_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SQ7A_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SSDA_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SU5A_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SW3A_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1SW7A_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1TPB1_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHSERRhvFgESDEL 1TPC1_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHpERRhvFgESDEL 1TPUA_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGNSERRhvFgESDEL 1TPVA_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGNpERRhvFgESDEL 1TPWA_Chicken QNcykvpkGAFTGEISPaMIKDIGAaWVILGHpERRhvFgESDEL Acipenser_brevirostrum QNcykvakGAFTGEVSPaMIKDcGvsWVILGHSERRhvFgESDEL Anopheles_gambiae QNcykvakGAFTGEISPaMLKDLGlgWVILGHSERRaiFgETDEL Bos_taurus QNcykvaNGAFTGEISPgMIKDLGAtWVVLGHSERRhvFgESDEL Caenorhabditis_briggsae QNcyktakGAFTGEISPaMIKDLGleWVILGHSERRhvFgESDaL Canis_lupus QNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFgESDEL Danio_rerio QNcykvakGAFTGEISPaMIKDcGvkWVILGHSERRhvFgESDEL Drosophila_melanogaster QNaykvakGAFTGEISPaMLKDIGAdWVILGHSERRaiFgESDaL Drosophila_pseudoobscura QNaykvakGAFTGEISPsMLKDIGAdWVILGHSERRaiFnESDEL Latimeria_chalumnae QNcykvskGAFTGEISPaMIKDcGvtWVILGHSERRhvFgESDEL Macaca_mulatta QNcykvtNGAFTGEISPgMIKDcGAtWVVLGHSERRhvFgESDEL Mus_musculus QNcykvtNGAFTGEISPgMIKDLGAtWVVLGHSERRhvFgESDEL Oryzias_latipes QNcykvakGAFTGEISPaMIKDcGAdWVILGHSERRhvFgENDEL Pongo_pygmaeus QNcykvtNGAFTGEISPgMIKDyGAtWVVLGHSERRhvFgESDEL Rattus_norvegicus QNcykvtNGAFTGEISPgMIKDLGAtWVVLGHSERRhiFgESDEL Schistosoma_mansoni QNcykvskGAFTGEISPaMIRDIGcdWVILGHSERRniFgESDEL Strongylocentrotus_purpuratus QNcykvpkGAFTaEtSPaMLQDLGvgWVILGHSERRhvFgESDEL Sus_scrofa QNcykvaNGAFTGEIgPgMIKDLGAtWVVLGHSERRhvFgESDEL Xenopus_laevis QNcykvakGAFTGEISPaMIKDcGAtWVILGHSERRhvFgEcDEL ============================================================================= ENTAMOEBA_HISTOLYTICA ENawtk-SGAYTGEVhvgMLvDcqvpYVILGHSERRqiFhESNEq ============================================================================= LEISHMANIA_MEXICANA ENaiak-SGAFTGEVSmpILKDIGvhWVILGHSERRtYYgETDEI TRYPANOSOMA_BRUCEI QNaiak-SGAFTGEVSlpILKDfGvnWIVLGHSERRaYYgETNEI TRYPANOSOMA_CRUZI QNaitr-SGAFTGEVSlqILKDyGisWVVLGHSERRlYYgETNEI 1KV5A_Trypanosoma_brucei QNaiak-SGAFTGEVSlpILKDfGvnWIVLGHSERRaYYgETNEI 1MSSA_Trypanosoma_brucei QNagna-D-------alasLKDfGvnWIVLGHSERRaYYgETNEI 1TRI0_Trypanosoma_brucei QNagna-D-------alasLKDfGvnWIVLGHSERRaYYgETNEI 1TTI0_Trypanosoma_brucei QNagna-D-------glasLKDfGvnWIVLGHSERRwYYgETNEI 1TTJ0_Trypanosoma_brucei QNagna-D-------alasLKDfGvnWIVLGHSERRaYYgETNEI Leishmania_donovani ENaiak-SGAFTGEVSmpILKDLGinWVILGHSERRtYYgETDEI Leishmania_tropica ENaiak-SGAFTGEVSmpILKDLGinWVILGHSERRtYYgETDEt ============================================================================= PLASMODIUM_FALCIPARUM QNvskfgNGsYTGEVSaeIaKDLnieYVIIGHfERRkYFhETDEd 1VGAB_Plasmodium_falciparum QNvskfgNGsYTGEVSaeIaKDLnieYVIIGHfERRkYFhETDEd Plasmodium_berghei QNvskfgNGsYTGEVSaeIaKNLnieYVLIGHfERRkYFhETDEd Plasmodium_chabaudi QNvskfgNGsYTGEVSaeIaKNLdieYVLIGHfERRkYFhETDEd Plasmodium_yoelii QNvskfgNGsYTGEVSaeIaKNLnieYVLIGHfERRkYFnETDEd ============================================================================= ECOLI QNvdlnlSGAFTGEtSaaMLKDIGAqYIIIGHSERRtYhkESDEL VIBRIO_MARINUS QNtdlnnSGAFTGDMSPaMLKEfGAthIIIGHSERReYhaESDEf Actinobacillus_pleuropneumoniae QNvdvnvqGAFTGDISteMLKDfGAkYIIIGHSERRtYhkEcDtf Actinobacillus_succinogenes QNvdvnvkGAFTGDISteMLKDfGAkYIIIGHSERRtYhkESDEf Erwinia_carotovora QNvdvnlSGAFTGEtSaeMLKDIGAkYIIIGHSERRtYhkESDEf Haemophilus_ducreyi QNvdintqGAFTGDIStaMLQEfcAkYIIIGHSERRtYhaESDQf Haemophilus_influenzae QNvdinvkGAFTGDISteMLKDfGAkYIIIGHSERRtYhkESDEf Histophilus_somni QNvdlnkqGAFTGDISteMLKDfGvkYVIIGHSERRqYhhESDEf Mannheimia_succiniciproducens QNvdvnvkGAFTGDISteMLKDfGAkYIIIGHSERRtYhkESDEf Pasteurella_multocida QNtdlnnSGAFTGDMSPeMLKDfGAthIIIGHSERReYhnESDEf Photobacterium_profundum QNsdlnnSGAFTGDMSPaMLKEfGAshIIIGHSERReYhnESDEf Photorhabdus_luminescens QDvdvnlSGAFTGEtSatMLKDIGAeYIIIGHSERRtYhqESDEf Salmonella_typhi QNvdlnlSGAFTGEtSaeMLKDIGAqYIIIGHSERRtYhkESDEL Vibrio_cholerae QNtdthnSGAYTGDMSPaMLKDfGAshIIIGHSERRdYhkESDEf Vibrio_fischeri QNtdlnnSGAFTGDMSPaMLKEfGAthIIIGHSERReYhnESDEf Vibrio_vulnificus QNtdinnSGAFTGDMSPaMLKDfGAthIIIGHSERReYhnESDEf Yersinia_pestis QNvdvnlSGAFTGEtSaeMLKDIGAqYIIIGHSERRtYhqESDEL ============================================================================= THERMUS_AQUATICUS QDvsahkeGAYTGEVSarMLsDLGcrYaIVGHSERRrYhgETDaL ============================================================================= BACILLUS_STEAROTHERMOPHILUS QtmhfadqGAYTGEVSPvMLKDLGvtYVILGHSERRqmFaETDEt Bacillus_subtilis QNmhfeeSGAFTGEISPvaLKDLGvdYcVIGHSERRemFaETDEt Geobacillus_kaustophilus QtmhfadqGAYTGEVSPvMLKDLGvtYVILGHSERRqmFaETDEt ============================================================================= Consensus QNxxxxxnGAFTGEISpxMIKDiGaxYVILGHSERRxyYxESNEl 230 240 250 260 270 ----|----:----|----:----|----:----|----:----| Consensus IaEKxxxAlexGLxvIxCIGESLEEREAGqTeEVvxKQIEAIvNx ============================================================================= YEAST IADKtkfALgqGVgVIlCIGETLEEKKAGKTlDVVeRQLnAVLee Candida_albicans IAEKtkfALDtGVkVIlCIGETLEERKgGvTlDVcaRQLDAVski Candida_glabrata VAEKtkfALDqGLgVIlCIGETLEEKKAGvTlKVVeRQLDAVIae Debaryomyces_hansenii IAsKtkfALDqGLsVIlCIGETLEERKAnvTlDVcaRQLDAVarv Eremothecium_gossypii VAEKtafALErGVsVIlCIGETLDEKKAGvTlDVVkRQLtpVLek Kluyveromyces_lactis IADKtkfALDsGVkVIlCIGETLEEKQkGiTlEVVqRQLQAVLDk Yarrowia_lipolytica IADKtkyALDnGLdVIlCIGETIDEKKAGKTlDVVrsQLDpVIak Zygosaccharomyces_bailii IAEKtafALsqGVgVIlCIGETLDQKKAGtTlQVVeRQLQAVIDk ============================================================================= CHICKEN IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn C_ELEGANS IAEKtvhALEaGIkVVfCIGEkLEEREAGhTKDVnfRQLQAIVDk HUMAN IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn RABBIT IgQKvahALseGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn 1SPQA_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SPQB_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SQ7A_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SSDA_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SU5A_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SW3A_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1SW7A_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1TPB1_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1TPC1_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1TPUA_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1TPVA_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn 1TPWA_Chicken IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn Acipenser_brevirostrum IgQKvahALQeGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn Anopheles_gambiae IAEKvahALaeGLkVIaCIGETLQEREAGQTEaVcfRQtKAIaaq Bos_taurus IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Caenorhabditis_briggsae IAEKtvhALEsGIkVIfCIGEkLEEREAGhTKDVnfRQLQAIVDk Canis_lupus IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Danio_rerio IgQKvahALEnGLgVIaCIGEkLDEREAGiTEKVVfaQtKfIaDn Drosophila_melanogaster IAEKaehALaeGLkVIaCIGETLEEREAGKTnEVVaRQMcAyaqk Drosophila_pseudoobscura IAEKaehALaeGLkVIaCIGETLDEREAGKTnEVVaRQMcAyakk Latimeria_chalumnae IgQKvshALseGLgVVaCIGEkLDEREAGiTEgVVfEvtEvIaDd Macaca_mulatta IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Mus_musculus IgQKvshALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Oryzias_latipes IgQKvahALEsdLsVIaCIGEkLEEREAGtTEDVIfaQtQvIaen Pongo_pygmaeus IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Rattus_norvegicus IgQKvnhALseGLgVIaCIGEkLDEREAGiTEKVVfEQtKAIaDn Schistosoma_mansoni IAEKvqhALaeGLsVIaCIGETLsEREsnKTEEVcvRQLKAIaNk Strongylocentrotus_purpuratus IAQKvahALsckLkVVaCIGEkLDEREkGQTnEVVyRQMrALaDv Sus_scrofa IgQKvahALaeGLgVIaCIGEkLDEREAGiTEKVVfEQtKvIaDn Xenopus_laevis IgQKvahALseGIgVIaCIGEkLDQREAGiTEKVVfEQtKAIaDn ============================================================================= ENTAMOEBA_HISTOLYTICA VAEKvkvAIDaGLkVIaCIGETeaQRiAnQTEEVVaaQLKAInNa ============================================================================= LEISHMANIA_MEXICANA VAQKvseAcKqGfmVIaCIGETLQQREAnQTaKVVlsQtsAIaak TRYPANOSOMA_BRUCEI VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk TRYPANOSOMA_CRUZI VAEKvaqAcaaGfhVIvCVGETnEEREAGRTaaVVltQLaAVaqk 1KV5A_Trypanosoma_brucei VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk 1MSSA_Trypanosoma_brucei VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk 1TRI0_Trypanosoma_brucei VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk 1TTI0_Trypanosoma_brucei VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk 1TTJ0_Trypanosoma_brucei VADKvaaAVasGfmVIaCIGETLQEREsGRTavVVltQIaAIakk Leishmania_donovani VAQKvadAcKqGfmVIaCIGETLQQREAnQTaKVVlsQtsAIatk Leishmania_tropica VAQKvadAcKqGfmVIaCIGETLQQREAnQTaKVVlsQtsAIatk ============================================================================= PLASMODIUM_FALCIPARUM VrEKlqasLKnnLkaVvCfGESLEQREqnKTiEVItKQVKAfVDl 1VGAB_Plasmodium_falciparum VrEKlqasLKnnLkaVvCfGESLEQREqnKTiEVItKQVKAfVDl Plasmodium_berghei VrQKlqqAIKnnLkaVvCfGESLEQREsnKTiDVItKQVKAfVDl Plasmodium_chabaudi VrEKlqqAIKhnLkaVvCfGESLEQREsnKTiEVItKQVKAfVDl Plasmodium_yoelii VrQKlqqAIKnnLkaVvCfGESLEQREsnKTiDVItKQVKAfVDl ============================================================================= ECOLI IAKKfavlkEqGLtpVlCIGETeaEnEAGKTEEVcaRQIDAVLkt VIBRIO_MARINUS VAKKfaflkEnGLtpVlCIGESdaQnEAGETmaVcaRQLDAVINt Actinobacillus_pleuropneumoniae IAKKfaalkaaGLvpVlCIGETeaEnEAGQTEaVcaKQIDAVIDa Actinobacillus_succinogenes IAKKfsalkEaGLtpVlCIGETeEEnEAGKTEEVVsRQIDAVINa Erwinia_carotovora IAKKfgvlkDaGLipVlCIGETeaEnEAGQTEaVcaRQLDAVLNt Haemophilus_ducreyi IAKKfaalktaGLtpVlCIGETeaEnEAGQTQQVcaRQIDAIINs Haemophilus_influenzae VAKKfgalkEaGLvpVlCIGESeaEnEAGKTEEVcaRQIDAVINa Histophilus_somni IAKKfgvlkDaGLvpVlCIGESeaEnEAGKTEEVcaRQIDAVMNt Mannheimia_succiniciproducens VAQKfgalkEaGLtpVlCIGESeaEnEAGKTEEVcaRQIDAVINa Pasteurella_multocida IAKKfnflkEnGLtpVfCIGESeaQnEAGETEaVcaRQInAVIDt Photobacterium_profundum VAKKfaflkEnGLtpVlCIGESdaQnEAGETmaVcaRQLDAVINt Photorhabdus_luminescens IAKKfailkQqGLipVlCIGETeQEnEAGQTEsVcaRQIDAVLNt Salmonella_typhi IAKKfavlkEqGLtpVlCIGETeaEnEAGKTEEVcaRQIDAVLkt Vibrio_cholerae VAKKfaflkEnGLtpVfCIGETeaQnEAGETEaVcaRQInAVIDa Vibrio_fischeri VAKKfaflkEnGLtpVlCIGESeaQnEAGETvaVcaRQIDAVINt Vibrio_vulnificus VAKKfaflkEnGLkpVfCIGETeaQnEAGETEaVcaRQInAVIDa Yersinia_pestis IAKKfgvlkEiGLipVlCIGESeaEnEAGQTEaVcaKQLDAVLNt ============================================================================= THERMUS_AQUATICUS VAEKakrlLEeGItpIlCVGEpLEvREkGEavpytlRQLrgsLeg ============================================================================= BACILLUS_STEAROTHERMOPHILUS VnKKvlaAftrGLipIiCcGESLEEREAGQTnaVVasQVEkaLag Bacillus_subtilis VnKKahaAfKhGIvpIiCVGETLEEREAGKTnDLVadQVKkgLag Geobacillus_kaustophilus VnKKvlaAftrGLipIiCcGESLEEREAGQTnaVVasQVEkaLag ============================================================================= Consensus IaEKxxxAlexGLxvIxCIGESLEEREAGqTeEVvxKQIEAIvNx 280 290 300 310 ----:----|----:----|----:----|----:----|----: Consensus vxxxxxFsxVVLAYEPVWaigtgksaTPEQAQQVHexLRxyLxex ============================================================================= YEAST Vkd---WTnVVVAYEPVWAIGTGlaATPEdAQdIHasIRkFLask Candida_albicans Vsd---WSnIVVAYEPVWAIGTGlaATPEdAEEtHKgIRahLaKs Candida_glabrata Vkd---WTnVVIAYEPVWAIGTGlaATaEdAQdIHhsIRsYLaEk Debaryomyces_hansenii Vsd---WSkIVVAYEPVWAIGTGlaATPEdAQEtHKaIRehLsKs Eremothecium_gossypii Vkd---WTnVVIAYEPVWAIGTGlaATaEdAQdIHaaIRdFLaEr Kluyveromyces_lactis Vqd---WTnVVVAYEPVWAIGTGlaATsDdAQaIHhsIReFLaKk Yarrowia_lipolytica Ikd---WSnVVIAYEPVWAIGTGlaATaEdAQQIHheIRaYLkDk Zygosaccharomyces_bailii Vkd---WSnVVIAYEPVWAIGTGlaATPEdAQEIHhsIReFLaKk ============================================================================= CHICKEN Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth C_ELEGANS gv---sWenIVIAYEPVWAIGTGKTASgEQAQEVHEwIRaFLkEk HUMAN Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn RABBIT Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn 1SPQA_Chicken Vk---dWSkVVLAYEPVWAIxxGKTkTPQQAQEVHEkLRgWLksh 1SPQB_Chicken Vk---dWSkVVLAYEPVWxxxxxxxxTPQQAQEVHEkLRgWLksh 1SQ7A_Chicken Vk---dWSkVVLAYEPVWAIGTGlwATPQQAQEVHEkLRgWLksh 1SSDA_Chicken Vk---dWSkVVLAYEPVWAIGTGySlTPQQAQEVHEkLRgWLksh 1SU5A_Chicken Vk---dWSkVVLAYEPVWAIGTGnpnTPQQAQEVHEkLRgWLksh 1SW3A_Chicken Vk---dWSkVVLAYEPVWAIGTGKvATPQQAQEVHEkLRgWLksh 1SW7A_Chicken Vk---dWSkVVLAYEPVWAIGTGnSsTPQQAQEVHEkLRgWLksh 1TPB1_Chicken Vk---dWSkVVLAYDPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPC1_Chicken Vk---dWSkVVLAYDPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPUA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPVA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth 1TPWA_Chicken Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth Acipenser_brevirostrum Vk---dWSkVVLAYEPVWAIGTGKTASPQQAQEVHEkLRqWLkth Anopheles_gambiae Vk---dWSnVVIAYEPVWAIGTGKTATPEQAQEVHaaLRkWftEn Bos_taurus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Caenorhabditis_briggsae gv---sWenIVIAYEPVWAIGTGKTASPEQAQEVHEwIRaFLkEk Canis_lupus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Danio_rerio Vk---dWSkVVLAYEPVWAIGTGKTASPQQAQEVHDkLRqWLktn Drosophila_melanogaster Ik---dWknVVVAYEPVWAIGTGKTATPDQAQEVHasLRqWLsDn Drosophila_pseudoobscura Vr---dWTnVVVAYEPVWAIGTGKTATPEQAQEVHafLRqWLtDn Latimeria_chalumnae Vk---dWSkVVLAYEPVWAIGTGKTASPQQsQELHgkLRkWLkEn Macaca_mulatta Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Mus_musculus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Oryzias_latipes Vm---dWekVVLAYEPVWAIGTGKTATPEQAQEVHEkLRaWfran Pongo_pygmaeus Vk---dWSkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLksn Rattus_norvegicus Vk---dWckVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkcn Schistosoma_mansoni IksadeWkrVVVAYEPVWAIGTGKvATPQQAQEVHnfLRkWfktn Strongylocentrotus_purpuratus It---dWgnVVIAYEPVWAIGTGKTATPQQAQEVHQnLRsWLtEh Sus_scrofa Vk---dWNkVVLAYEPVWAIGTGKTATPQQAQEVHEkLRgWLkth Xenopus_laevis Vk---dWSkVVLAYEPVWAIGTGKTATPEQAQEVHKkLReWVktn ============================================================================= ENTAMOEBA_HISTOLYTICA Iskea-WknIILAYEPVWAIGTGKTATPDQAQEVHQyIRkWMtEn ============================================================================= LEISHMANIA_MEXICANA Ltkda-WNqVVLAYEPVWAIGTGKvATPEQAQEVHllLRkWVsEn TRYPANOSOMA_BRUCEI Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk TRYPANOSOMA_CRUZI Lskea-WSrVVIAYEPVWAIGTGKvATPQQAQEVHElLRrWVrsk 1KV5A_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIssWVssk 1MSSA_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TRI0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TTI0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk 1TTJ0_Trypanosoma_brucei Lkkad-WakVVIAYEPVWAIGTGKvATPQQAQEaHalIRsWVssk Leishmania_donovani Lptea-WdqIVLAYEPVWAIGTGKvATPEQAQEVHalLRkWVsEk Leishmania_tropica Lpkea-WdqIVLAYEPVWAIGTGKvATPEQAQEVHalLRkWVsEk ============================================================================= PLASMODIUM_FALCIPARUM Idn---FdnVILvYEPLWAIGTGKTATPEQAQlVHKeIRkiVkDt 1VGAB_Plasmodium_falciparum Idn---FdnVILvYEPLFAIGTGKTATPEQAQlVHKeIRkiVkDt Plasmodium_berghei Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEi Plasmodium_chabaudi Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEi Plasmodium_yoelii Ien---FdnVILAYEPIWAIGTGKTATPEQAQEVHKeIRkiVkEm ============================================================================= ECOLI qgaaa-FegaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKv VIBRIO_MARINUS qgvea-legaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Actinobacillus_pleuropneumoniae Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Actinobacillus_succinogenes Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRahIaak Erwinia_carotovora Lgaka-FentVVAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKq Haemophilus_ducreyi Lgvea-FNqaVIAYEPIWAIGTGKSATPaQAQaVHafIRqhIaEk Haemophilus_influenzae Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Histophilus_somni Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaKq Mannheimia_succiniciproducens Lgvea-FNgaVIAYEPIWAIGTGKSATPaQAQaVHafIRghIaak Pasteurella_multocida ygvea-lNgaIIAYEPIWAIGTGKaATaEdAQRIHasIRalIaak Photobacterium_profundum qgvea-legaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Photorhabdus_luminescens Lgvaa-FqgaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaQk Salmonella_typhi qgaaa-FegaVIAYEPVWAIGTGKSATPaQAQaVHKfIRdhIaKa Vibrio_cholerae ygvea-lNgaIIAYEPIWAIGTGKaATaDdAQRIHasIRalIaak Vibrio_fischeri qgvda-lNgaIIAYEPIWAIGTGKaATaEdAQRIHaqIRahIaEk Vibrio_vulnificus ygvea-lNgaIIAYEPIWAIGTGKaATaEdAQRIHasIRamIaak Yersinia_pestis Lgvka-FegaVIAYEPIWAIGTGKSATPaQAQaVHKfIRdhIaKq ============================================================================= THERMUS_AQUATICUS Veppg-peaLVIAYEPVWAIGTGKNATPEdAEaMHQaIRkaLsEr ============================================================================= BACILLUS_STEAROTHERMOPHILUS Ltpeq-vkqaVIAYEPIWAIGTGKSsTPEdAnsVcghIRsvVsrl Bacillus_subtilis Lseeq-vaasVIAYEPIWAIGTGKSsTaKdAndVcahIRktVaEs Geobacillus_kaustophilus Ltpeq-vkqaVIAYEPIWAIGTGKSsTPEdAnsVcghIRsvVsrl ============================================================================= Consensus vxxxxxFsxVVLAYEPVWaigtgksaTPEQAQQVHexLRxyLxex 320 330 340 350 360 ----|----:----|----:----|----:----|----:----| Consensus iNexIAEqLRIiYGGSVSxxNaxELxxQPDVDGfLVGGASLExpe ============================================================================= YEAST LgDkaAsELRILYGGSaNgsNAvtfkdKaDVDGFLVGGASLK-PE Candida_albicans IgaeqAEKtRILYGGSVNgkNAkDfkdKaNVDGFLVGGASLK-PE Candida_glabrata LgKdtAEKtRILYGGSaNgaNAgtfkdKaDVDGFLVGGASLK-PE Debaryomyces_hansenii IgadaAEKtRILYGGSVNgkNApEfkdKaDVDGFLVGGASLK-PE Eremothecium_gossypii tSrdVADaVRILFGGSaNgaNAasfrdKaDVDGFLVGGASLK-PE Kluyveromyces_lactis LSKdtAEKIRILYGGSaNgkNAvtfkdKaDVDGFLVGGASLK-PE Yarrowia_lipolytica Igaq-ADKVRIIYGGSVNgkNsgtfkdKsDVDGFLVGGASLK-PE Zygosaccharomyces_bailii LgEktAQEtRILYGGSaNgkNAvtfkdKPDVDGFLVGGASLK-PE ============================================================================= CHICKEN VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE C_ELEGANS VSpaVADatRIIYGGSVTadNAaELgkKPDIDGFLVGGASLK-PD HUMAN VSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE RABBIT VSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE 1SPQA_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SPQB_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SQ7A_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SSDA_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SU5A_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SW3A_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1SW7A_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1TPB1_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1TPC1_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1TPUA_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1TPVA_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE 1TPWA_Chicken VSDaVAQstRIIYGGSVTggNckELasQhDVDGFLVGGASLK-PE Acipenser_brevirostrum VSEeVggaVRIIYGGSVTaatckELasKPDVDGFLVGGASLK-PE Anopheles_gambiae VSadVsnaIRIqYGGSVTaaNcrELaaKPDIDGFLVGGASLK-PE Bos_taurus VSDaVAQsaRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Caenorhabditis_briggsae VSpaVADatRIIYGGSVTadNAaELgkKPDIDGFLVGGASLK-PD Canis_lupus VSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Danio_rerio VSEaVAnsVRIIYGGSVTggtckELasQkDLDGFLVGGASLK-PE Drosophila_melanogaster ISKeVsasLRIqYGGSVTaaNAkELakKPDIDGFLVGGASLK-PE Drosophila_pseudoobscura ISKeVsaaLRIqYGGSVTaaNAkELakKPDIDGFLVGGASLK-PE Latimeria_chalumnae VSEtVADsVRIIYGGSVTgatckELasEPDVDGFLVGGASLK-PE Macaca_mulatta VSEaVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Mus_musculus VNDgVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Oryzias_latipes ISEeVsDsLRIIYGGSVTaaNcrELasQtDVDGFLVGGASLK-PE Pongo_pygmaeus VSDaVAQstRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Rattus_norvegicus VSEgVAQctRIIYGGSVTgatckELasQPDVDGFLVGGASLK-PE Schistosoma_mansoni apngVdEKIRIIYGGSVTaaNckELaqQhDVDGFLVGGASLK-PE Strongylocentrotus_purpuratus VNaaVAantRIVYGGSVNggNccDIgqQPDVDGFLVGGASLK-PE Sus_scrofa VpEaVAhstRIIYGGSVTgatckELasQPDVDGFrVsGASLK-PE Xenopus_laevis VSEgVAQsVRIIYGGSVTggtcrELagQPDIDGFLVGGASLK-PE ============================================================================= ENTAMOEBA_HISTOLYTICA ISKeVAEatRIqYGGSVNpaNcnELakKaDIDGFLVGGASLDaaK ============================================================================= LEISHMANIA_MEXICANA IgtdVAaKLRILYGGSVNaaNAatLyaKPDINGFLVGGASLK-PE TRYPANOSOMA_BRUCEI IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE TRYPANOSOMA_CRUZI LgtdIAaQLRILYGGSVTakNArtLyqmrDINGFLVGGASLK-PE 1KV5A_Trypanosoma_brucei IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE 1MSSA_Trypanosoma_brucei IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE 1TRI0_Trypanosoma_brucei IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE 1TTI0_Trypanosoma_brucei IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE 1TTJ0_Trypanosoma_brucei IgadVAgELRILYGGSVNgkNArtLyqQrDVNGFLVGGASLK-PE Leishmania_donovani IgadVAaRLRILYGGSVSagNAktLymKPDINGFLVGGASLK-PE Leishmania_tropica IgtdVAaKLRILYGGSVSagNAktLymKPDINGFLVGGASLK-PE ============================================================================= PLASMODIUM_FALCIPARUM cgEkqAnQIRILYGGSVNteNcssLiqQeDIDGFLVGnASLK-es 1VGAB_Plasmodium_falciparum cgEkqAnQIRILYGGSVNteNcssLiqQeDIDGFLVGnASLK-es Plasmodium_berghei cgEaqAnKIRILYGGSVSveNctsLikQeDIDGFLVGtsSLK-ts Plasmodium_chabaudi cgEaqAnKIRILYGGSVSveNctsLikQeDIDGFLVGtsSLK-ts Plasmodium_yoelii cgEaqAnKIRILYGGSVSveNctsLikQeDIDGFLVGtsSLK-ts ============================================================================= ECOLI -DanIAEQViIqYGGSVNasNAaELfaQPDIDGaLVGGASLKada VIBRIO_MARINUS -SEaVAKnVvIqYGGSVkpeNAaayfaQPDIDGaLVGGAaLDaks Actinobacillus_pleuropneumoniae -SQaVADQViIqYGGSVNdaNAaELftQPDIDGaLVGGASLKaPa Actinobacillus_succinogenes -SQaVADQViIqYGGSVNdaNAaELftQPDIDGaLVGGASLKaPa Erwinia_carotovora -DaaVAEQViIqYGGSVNaaNAaELftQPDIDGaLVGGASLKada Haemophilus_ducreyi -SQaVADQLiIqYGGSVNdtNAaELfsQPDIDGaLVGGASLKata Haemophilus_influenzae -SQaVAEQViIqYGGSVNdaNAaELftQPDIDGaLVGGASLKaPa Histophilus_somni -SQaVAERViIqYGGSVNdaNAaELftQPDIDGaLVGGASLKasa Mannheimia_succiniciproducens -SQaVADQViIqYGGSVNdaNAaELftQPDIDGaLVGGASLKaPa Pasteurella_multocida -DEaVAaQViIqYGGSVkpeNAeayfsQPDIDGaLVGGASLDaks Photobacterium_profundum -SEeVAKnLvIqYGGSVkpeNAaayfaQPDIDGaLVGGAaLDaks Photorhabdus_luminescens -DaaIAQQIiIqYGGSVNadNAaELfsQPDIDGaLVGGASLKana Salmonella_typhi -DakIAEQViIqYGGSVNasNAaELfaQPDIDGaLVGGASLKada Vibrio_cholerae -DaaVAEQViIqYGGSVkpeNAasyfaQPDIDGaLVGGASLDakg Vibrio_fischeri -SEeVAKnVvIqYGGSVkpeNAaayfaQPDIDGaLVGGAaLDaks Vibrio_vulnificus -DaaVAEQViIqYGGSVkpeNAeayfaQPDIDGaLVGGASLDaks Yersinia_pestis -DaaVAaQViIqYGGSVNdkNAaELftQPDIDGaLVGGASLKada ============================================================================= THERMUS_AQUATICUS ygEafAsRVRILYGGSVNpkNfaDLlsmPNVDGgLVGGASLEles ============================================================================= BACILLUS_STEAROTHERMOPHILUS fgpeaAEaIRIqYGGSVkpdNirDflaQqqIDGpLVGGASLEpas Bacillus_subtilis fSQeaADKLRIqYGGSVkpaNikEymaEsDIDGaLVGGASLEpqs Geobacillus_kaustophilus fgpeaAEaIRIqYGGSVkpdNirDflaQeqIDGaLVGGASLEpas ============================================================================= Consensus iNexIAEqLRIiYGGSVSxxNaxELxxQPDVDGfLVGGASLExpe 370 380 390 400 ----:----|----:----|----:----|----:----|----: Consensus FvEIIeAxxxxxxx ============================================== YEAST FVDIInsrn----- Candida_albicans FVDIIKsrl----- Candida_glabrata FVDIInsrn----- Debaryomyces_hansenii FVDIIKsrl----- Eremothecium_gossypii FVDIInsrr----- Kluyveromyces_lactis FVDIInsrv----- Yarrowia_lipolytica FVDIInsrl----- Zygosaccharomyces_bailii FVDIInsrs----- ============================================== CHICKEN FVDIInAkh----- C_ELEGANS FVKIInArs----- HUMAN FVDIInAkq----- RABBIT FVDIInAkq----- 1SPQA_Chicken FVDIInAkh----- 1SPQB_Chicken FVDIInAkh----- 1SQ7A_Chicken FVDIInAkh----- 1SSDA_Chicken FVDIInAkh----- 1SU5A_Chicken FVDIInAkh----- 1SW3A_Chicken FVDIInAkh----- 1SW7A_Chicken FVDIInAkh----- 1TPB1_Chicken FVDIInAkh----- 1TPC1_Chicken FVDIInAkh----- 1TPUA_Chicken FVDIInAkh----- 1TPVA_Chicken FVDIInAkh----- 1TPWA_Chicken FVDIInAkh----- Acipenser_brevirostrum FIDIInAfq----- Anopheles_gambiae FIQIVnArq----- Bos_taurus FVDIInAkq----- Caenorhabditis_briggsae FVKIInArs----- Canis_lupus FVDIInAkq----- Danio_rerio FIDIInAka----- Drosophila_melanogaster FLDIInArq----- Drosophila_pseudoobscura FVDIInArq----- Latimeria_chalumnae FVEykDvrq----- Macaca_mulatta FVDIInAkq----- Mus_musculus FVDIInAkq----- Oryzias_latipes FIDIInAra----- Pongo_pygmaeus FVDIInAkq----- Rattus_norvegicus FVDIInAkq----- Schistosoma_mansoni FtEIcKArqr---- Strongylocentrotus_purpuratus FkQIIaAgsa---- Sus_scrofa FVDIInAk------ Xenopus_laevis FIEIInAkh----- ============================================== ENTAMOEBA_HISTOLYTICA FktIInsvsekl-- ============================================== LEISHMANIA_MEXICANA FrDIIDAtr----- TRYPANOSOMA_BRUCEI FVDIIKAtq----- TRYPANOSOMA_CRUZI FVEIIEAtk----- 1KV5A_Trypanosoma_brucei FVDIIKAtq----- 1MSSA_Trypanosoma_brucei FVDIIKAtq----- 1TRI0_Trypanosoma_brucei FVDIIKAtq----- 1TTI0_Trypanosoma_brucei FVDIIKAtq----- 1TTJ0_Trypanosoma_brucei FVDIIKAtq----- Leishmania_donovani FrDIIDAtr----- Leishmania_tropica FrDIIDAtr----- ============================================== PLASMODIUM_FALCIPARUM FVDIIKsam----- 1VGAB_Plasmodium_falciparum FVDIIKsam----- Plasmodium_berghei FtEIIKsam----- Plasmodium_chabaudi FtEIIKsam----- Plasmodium_yoelii FtEIIKsam----- ============================================== ECOLI FavIVKAaeaakqa VIBRIO_MARINUS FaaIaKAaaeak-a Actinobacillus_pleuropneumoniae FavIVKAaekaka- Actinobacillus_succinogenes FavIVKAaaaaka- Erwinia_carotovora FavIVKAaadakrg Haemophilus_ducreyi FaEIVKAaekaka- Haemophilus_influenzae FavIVKAaaaakn- Histophilus_somni FavIVKAaakakn- Mannheimia_succiniciproducens FavIVKAaakaka- Pasteurella_multocida FaaIaKAaaaaka- Photobacterium_profundum FaaIaKAaaeaka- Photorhabdus_luminescens FavIVKAaaaakka Salmonella_typhi FavIVKAaeaakqa Vibrio_cholerae FaaIaKAaaeakka Vibrio_fischeri FaaIaKAaaeaka- Vibrio_vulnificus FaaIaKAaakmka- Yersinia_pestis FavIVKAaakakka ============================================== THERMUS_AQUATICUS FLaLLriag----- ============================================== BACILLUS_STEAROTHERMOPHILUS FLQLVEAgrhe--- Bacillus_subtilis FVQLLEegqye--- Geobacillus_kaustophilus FLQLVEAgrhe--- ============================================== Consensus FvEIIeAxxxxxxx