eIF2a

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus sxsxcrfyexkfpeidxxvvvdvqqvaemgayvklleydnlegmiilseisrrrlrsirklirvgkneix ==================================================================================================== HUMAN p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Bombyx_mandarina ------plscRFyQekypeVeDVvmVnvrsiaemgayvhlLEynnIegmIllseLsrrRirsinklirVg Danio_rerio p-----glscRFyQhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Gallus_gallus p-----alscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Oncorhynchus_mykiss p-----nlscRFyQhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Pongo_pygmaeus p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Rattus_norvegicus p-----glscRFyQhkfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Strongylocentrotus_purpuratus ------piscRFyEqhfpeVeDVvmVkvrsiaemgayvhlLEynkIegmIllseLsrrRirsinkl---- Tetraodon_nigroviridis p-----glscRFyEhrfpeVeDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Tribolium_castaneum ------plscRFyrekypeVeDVvmVnvraiaemgayvhlLEyknIegmIllseLsrrRirsinklirVg Xenopus_laevis p-----glncRFyQhkfpeVdDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg Xenopus_tropicalis p-----alscRFyQhkfpeVdDVvmVnvrsiaemgayvslLEynnIegmIllseLsrrRirsinklirIg ==================================================================================================== YEAST StShCRFYEnKYPEIDdiVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVa Aspergillus_flavus SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVv Aspergillus_fumigatus SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVv Candida_albicans StTnCRFYEnKYPEVDevVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVa Candida_glabrata SiNhCRFYEnKYPDVDdvVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVa Chaetomium_globosum SlSnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVv Coccidioides_immitis SlTnCRFYEeKYPEIDsfVMVNVKQIAEMGAYVnLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVv Cryptococcus_neoformans ----pRFYEnKYPEVDqlVMVqVQsIeDMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVv Debaryomyces_hansenii SsShCRFYEnKYPEVDevVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVa Emericella_nidulans SlTnCRFYEeKYPEVDsyVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVv Eremothecium_gossypii StSnCRFYEnKYPEVDdvVMVNVQQIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIhKLIRVGKNEVv Gibberella_zeae SlTnCRFYEeKYPEIDsfVMVNVKQIAEMGAYVKLLEYDDIDGMILLSELSRRRIRSIQKLIRVGRNEVv Kluyveromyces_lactis StSnCRFYEnKFPEVDdvVMVNVQQIAEMGAYVRLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVv Magnaporthe_grisea SlTnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDgIDGMILLSELSRRRIRSIQKLIRVGRNEVv Neurospora_crassa SlSnCRFYEeKYPEIDsfVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVv Schizosaccharomyces_pombe StTsCRmYEnRFPEVDelVVVNVRQIqEMGAYVKLLEYDNIEGMVLLSELSRRRIRSVQKhIRVGRNEVv Ustilago_maydis -----RFYKkElPDVDevVMcqVQQIAEMGAYVKLLEYDgaEGMILLSELSRRRIRSIQKLIRVGRNEVv Yarrowia_lipolytica NtTtCRFYanKYPEVDdlVMVNVKEIADMGAYVKLLEYDDIEGMILLSELSRRRIRSIQKhIKVGKNEIv ==================================================================================================== Consensus sxsxcrfyexkfpeidxxvvvdvqqvaemgayvklleydnlegmiilseisrrrlrsirklirvgkneix 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus vvlrvdkerxxxxxxxgxxyidlskrrvsxkdiikcekkyxknkilhsvlxxlaexxexxlesLFEkiAW ==================================================================================================== HUMAN rnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeqLESLFQRtAW Bombyx_mandarina ktepVvviRvdkekgyidlskrrvsaediyKcteRyaKakavNsILrhVaelLhyetseqsEeLYKKtAW Danio_rerio rnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeqLESLFQRtAW Gallus_gallus rnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeqLESLFQRtAW Oncorhynchus_mykiss rnecVvviRvdkekgyidlskrrvspedaiKcedKftKsktvysILrhVaevLeytkDeqLESLFtRtAW Pongo_pygmaeus rneRVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeqLESLFQRtAW Rattus_norvegicus rnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeytkDeqLESLFQRtAW Strongylocentrotus_purpuratus -----vviRvdkdkgyidlskrrvsaeeikKceeKyaKakavNsILrhVgeiLgyssnsqLEeLY----- Tetraodon_nigroviridis rnecVvviRvdkekgyidlskrrvspeeaiKcedKftKsktvysILrhVaevLeyskDeqLErLYQRtAW Tribolium_castaneum ktepVvviRvdkdkgyidlskrrvsaedveKcteRfaKakavNsILrhVaelLkyesDeqLEeLYQKtAW Xenopus_laevis rnecVvviRvdkdkgyidlskrrvspeealKcedKftKsktvysILrhVaevLdytkDeqLDSLFQRtAW Xenopus_tropicalis rnecVvviRvdkdkgyidlskrrvspeealKcedKftKsktvysILrhVaevLeytkDeqLESLYQRtAW ==================================================================================================== YEAST VVLRVDKEK-------G--YIDLSKRRVSsEDIIKCEEKYqKSKtVHSILrycAEkfQipLEeLYKtIAW Aspergillus_flavus IVLRVDKEKgnilllvG--YIDLSKRRVSpEDVIKCEERYnKSKaVHSIMrhVAEatQtpLETLYQnIAW Aspergillus_fumigatus IVLRVDKEK-------GkcYIDLSKRRVSpEDVVKCEERYnKSKaVHSIMrhVAEatQtpLEeLYQKIgW Candida_albicans VVLRVDKEK-------G--YIDLSKKvVSaEDIVKCDERYnKSKaVHSILrhcAEkfnipLErLYEtIgW Candida_glabrata VVLRVDKEK-------G--YIDLSKRRVSsEDIIKCEEKYqKSKtVHSILrycAEkfQipLEdLYKtIAW Chaetomium_globosum VVLRVDKEK-------G--YIDLSKRRVSpEDIVRCEERYnKSKIVHSIMrhVAEktQtpIETLYEtIgW Coccidioides_immitis VVLRVDKEK-------G--YIDLSKRRVSaEDVVKCEERYnKSKsVHSIMrhVAEktrtpIETLYQQIgW Cryptococcus_neoformans VVMRVDpDK-------G--YIDLSKRRVSaEEVVKCEEQYeKgKaVdSIItqVAKkrgvtpESLYEKIAW Debaryomyces_hansenii VVLRVDKEK-------G--YIDLSKRRVSaEDIVKCDERYnKSKaVHSILrhcAEkftisLETLYQsIgW Emericella_nidulans IVLRVDKEK-------G--YIDLSKRRVSpEDVIKCEERYnKSKaVHSILrhVAEatQtpLETLYQQIAW Eremothecium_gossypii VVLRVDKEK-------G--YIDLSKRRVSsEDMIKCEERYqKSKaVHSILrqcAEkfQfpLEdLYKtIAW Gibberella_zeae VVLRVDKEK-------G--YIDLSKRRVSpEDIVKCEERYnKSKMVHSVMihLAKatEipLETLYQaIAW Kluyveromyces_lactis VVLRVDKEK-------G--YIDLSKRRVSaEDVIKCEERYqKSKaVHSILrqcAEkyQvsLEdLYKayAW Magnaporthe_grisea VVLRVDKEK-------G--YIDLSKRRVSqEDIVKCEERYnKSKMVHSIMrhVAEktlvpIESLYEaIAW Neurospora_crassa VVLRVDKEK-------G--YIDLSKRRVSpEDIVRCEERYnKSKIVHSIMrhVAEktlvpIEqLYEtIgW Schizosaccharomyces_pombe VVLRVDKEK-------G--YIDLSKRRVSpEDVVKCEERFnKSKaVHSIMrhIAEkhnvpLETMYttIgW Ustilago_maydis VVLRVDKEK-------G--YIDLSKRRVSpEDVIKCEEQFtKSKaVHSIIahVAgklsreVEeLYDtIvF Yarrowia_lipolytica VVLRVDKDK-------G--YIDLSKRRVSaEDVeKCEEKYtKSKtVHSILrhVAEkhKysLEkLYEQVgW ==================================================================================================== Consensus vvlrvdkerxxxxxxxgxxyidlskrrvsxkdiikcekkyxknkilhsvlxxlaexxexxlesLFEkiAW 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus plNKKYgxxxxhAFDAFKlsVSDxPnIfDxLExxxNEExrEeLxxxISRRltpxxxkiradvevscfxye ==================================================================================================== HUMAN vfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpqavkiradievacygy Bombyx_mandarina yfeEKYkkka-sAYDfFKqaavD-PSVlDecg--lDEEtKDvLlanIkRK-ltsqavkiradiecacygy Danio_rerio vfDEKYkkpgygAYDvFKqaVSD-PaIlDgLD--ltEEeRnvLidnINRR-ltpqavkiradievacygy Gallus_gallus vfDdKYkrpgygAYDAFKhaVSD-PaIlDsLD--ltEEeRrvLidnINRR-ltpqavkiradievacygy Oncorhynchus_mykiss vfDEKYkrpgygAYDvFKqaVSD-PaMlDgLD--ltEEeRavLidnINRR-ltpqavkiradievacygy Pongo_pygmaeus vfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpqavkiradievacygy Rattus_norvegicus vfDdKYkrpgygAYDAFKhaVSD-PSIlDsLD--lNEDeREvLinnINRR-ltpqavkiradievacygy Strongylocentrotus_purpuratus -----YksvgygAYEAFKtcVNE-PeLlaecn--lDEEthKvLlenIeRK-ltpqavkiradievacyg- Tetraodon_nigroviridis vfDEKYkrpgygAYDAFKqaVSD-PSIlDgLD--ltEEeRgvLidnINRR-ltpqavkiradievacygy Tribolium_castaneum yfeEKYkknkasAYDfFKqaVSD-PSIlaecQ--lDDrtKEvLlsnIkRK-ltsqavkiradiecacygy Xenopus_laevis vfDEKYkkpgygAYDAFKnaVSD-PDIlDgLD--lSEDeRrvLidnINRR-ltpqavkiradievacygy Xenopus_tropicalis vfDEKYkkpgygAYDAFKhaVSD-PDVlDgLD--lNEDeRrvLidnINRR-ltpqavkiradievacygy ==================================================================================================== YEAST PLSRKFG----HAYEAFKLSIiD-etVWEgIE-ppSKDvlDELknyISKRLTPqavKIRADVEVSCFsYE Aspergillus_flavus PLNRKYG----HshDAFKISITN-tDVWNdVE-fpSEavKKELtqyISKRLTPhptKVRADIEVTCFgYE Aspergillus_fumigatus PLNRKYG----HAhDAFKISITN-PDVWqdVE-fpSEavKKELtqyISKKLTPsptKVRADIEVTCFgYE Candida_albicans PLSRKYG----HAYDAFKISITD-PSVFDsVD-vpSKDvlEELklyISRRLTPqainIRADVDVSCFsYE Candida_glabrata PLSRKFG----HAYEAFKLSIiD-etVWEgIE-ppSQDilnELktyISKRLTPqavKIRADVEVSCFsYE Chaetomium_globosum PLNKKYG----HAlDAFKLSITN-PDIWtdIK-fptDadaEELksyIgKKLTPqptKVRADIEVTCFgYE Coccidioides_immitis PLNKKYG----HAnDAFKLSITN-PSIWDdVt-fpSQavKDELllhISKRLTPqptKVRADIEVTCFsYE Cryptococcus_neoformans PLHRQYG----HAYEAFKLSISEpeaVFgsLE--lDEEtlaDLrsgIaRRLTPkpvKVRADIEVkCFsYa Debaryomyces_hansenii PLSRRYG----HAYDAlKLSITD-PtIFDdIE-apSpDvlEELklyISRRLTPqaiKIRADVEVSCFsYE Emericella_nidulans PLNRKYG----HshDAFKISITN-PDVWadVE-fpNEavKKELtqyIgKRLTPhptKVRADIEVTCFgYD Eremothecium_gossypii PLSRKYG----HAYDAFKLSIvD-etVWEgIE-ppSaEifEELkqyISRRLTPqaiKIRADVEVSCFsYE Gibberella_zeae PLNKKFG----HAlDAFKLSITN-PeVWNdIt-fpDEvtaQELktyIgKRLTPqptKVRADVEVTCFgYD Kluyveromyces_lactis PLSRKYG----HAYDAYKMSIvD-PNVWDgIE-siSDEifQELkgqITRRLTPqavKIRADVEVSCFsYE Magnaporthe_grisea PLNRKYG----HAiDAFKLSITN-PeVWEdtt-fsSEavaEELksyISKRLTPqptKVRADVEVTCFaYD Neurospora_crassa PLNKKYG----HslDAFKLSITN-PDVWNdIQ-fptEavaEELktyISKRLTPqptKVRADVEVTCFgYE Schizosaccharomyces_pombe PLyRKYG----HAYDAFKLaISNpdHVFEgLE-ppksgvinDLlaqISRRLTPqpiKIRADVEVTCFgYE Ustilago_maydis PLHEKYG----HAFDAFKLaIlDmdktFEgIQ--mDDDvRKELyanIaRRMTPqpvKIRADVEVTCFgYE Yarrowia_lipolytica PLStKYG----HAYDgFKLSITNpdqVFgdLEdpaSpaimEDLkaqIgRRLTPnpvKVRADIDITCFaYE ==================================================================================================== Consensus plNKKYgxxxxhAFDAFKlsVSDxPnIfDxLExxxNEExrEeLxxxISRRltpxxxkiradvevscfxye 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus gidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxeaixxvxkxixexxgxvxixm ==================================================================================================== HUMAN egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlsqamaViKekiEekrgVfnvq Bombyx_mandarina egidavRAalkAglalStvdmpikinLiAPplyVmTTstpEktdglkalQdaidkiQeniteaGgVfniq Danio_rerio egidavKealrAglncStEampikinLiAPpryVmTTttlErteglsVlnqamaaiKeriEekrgVfnvq Gallus_gallus egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlnqamaViKekiEekrgVfnvq Oncorhynchus_mykiss egidavKdalrAglscStEampikinLiAPpryVmTTttlErteglsVlnqamaaiKeriEekrgVfniq Pongo_pygmaeus egidavKealrAglncStEnmpikinLiAPpryVmTTttlErteglsVlsqamaViKekiEekrgVfnvq Rattus_norvegicus egidavKealrAglncStEtmpikinLiAPpryVmTTttlErteglsVlnqamaViKekiEekrgVfnvq Strongylocentrotus_purpuratus ---------ltkgldmSsEempikinLiAPpqyVvTTqtlErvegveklKeaieaiKesilksagVfkv- Tetraodon_nigroviridis dgidavKdalrAglscStDvmpikinLiAPpryVmTTttlErteglsVlnqamaaiKekiEekrgVfniq Tribolium_castaneum egidavKtalksglslStDelpikinLiAPplyVmTTstpEkqdglkIlndaiekiKatiselGgVfnvq Xenopus_laevis egidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVlnqamsViKeriEekrgVfnvq Xenopus_tropicalis egidavKdalrAglscStEnmpikinLiAPpryVmTTttlErteglsVlnqamsViKeriEekrgVfnvq ==================================================================================================== YEAST GIDAIKdALksAEdmSTeQmqVKvKLVaAPLYVLTTqaLDKqkGIeqLesAIekItEvItKygGvcnItM Aspergillus_flavus GIDAVKaALrtAEeaNTpDsqVKvKLVapPLYVLTSqcLDKaiGIkqLeEAIqrIeakIkEagGgcsVkM Aspergillus_fumigatus GIDAVKnALrtAEanNTpEnqIKvKLVapPLYVLTSqcLDKnlGIklLeEAIerIdseIkKagGgcvVkM Candida_albicans GIDAIKEALkaAEsvSTsQmqVKaKLVaAPLYfITvqaLDKneGVklLeKAIekItEsIeasgGnckVsM Candida_glabrata GIDAIKEALksAEdmSTeQmqIKvKLVaAPLYVLTTqaLDKqiGIdlLgKAIdkInEvIsKygGvcnItM Chaetomium_globosum GIDAIKtALrtAEarNTdEaqVKcRLVspPLYVLTNTcLDKnaGIarLeEAIvdVrtsIesagGnLvVkM Coccidioides_immitis GIDAVKEALrtAEanNTtDnqVKvKLVspPLYVLTShcLDKnlGIktLeDAIkgItEkIrasgGscvVqM Cryptococcus_neoformans GIDAIKRALtagEavSTpDvpIKvRLVapPLYVMSTTstDKnaaIelMeKAVevIgEtVrKdkGdItIkM Debaryomyces_hansenii GIDAIKKALtaAEeiSTeQmaVKaKLVaAPLYVISvqaLDKnqGIalLeKAIekVsEsIensgGickVtM Emericella_nidulans GIDAVKnALrtAEaeNTpEnqIKvKLVapPLYVLTSqcLDKthGIkmLeEAIerIettIkasgGgctVkM Eremothecium_gossypii GIEAIKEALkaAEatSTeQmqVKvKLVaAPLYVITTqaLDKnqGIeaLnhAIskIeEyIaKyqGvcnVtM Gibberella_zeae GIDAIKtALhtAEakNTeEtqVKvRLVspPLYVLNSTcLDKslGItrLqEAIvdIrasIeaagGhLtVkM Kluyveromyces_lactis GIDAIKEALksAEelSTeQmqIKvKLVaAPLYVITTqsLDKdqGVqlLetAIakIeEvIlKynGvcnVtM Magnaporthe_grisea GIDAIKtALrtAEsrNTqDnqVKvKLVspPLYVLTSTcLDKslGIarLeEAIvdIrtsIesagGkLiVkM Neurospora_crassa GIDAIKtALrtAEarNTeEtqVKcRLVspPLYVLTNTcLDKnaGIarLqEAIqdMrtsIeaagGhLvVkM Schizosaccharomyces_pombe GINAIKaALkaAEdvHTeEvpIKvKLVapPLYVLlTnaLDKslGLkkLeEAIgaIeKsItasnGtctVkM Ustilago_maydis GIDAVKKALragEavSTeaipIKiKLVapPLYVLiTnstDKvgGIalMeQALekItEsIrangGdVdIkM Yarrowia_lipolytica GIEAIKKALaagEtlNSelvpVKvKLVaAPLFVLTSTcLDKqkaIdtLgEAIekIrEsIeasgGsLtVkM ==================================================================================================== Consensus gidaikkalxxaexxnsxexxvkxkllxaplfvvsstxldexxgixxvxeaixxvxkxixexxgxvxixm 290 300 310 320 330 340 350 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xpkavtxnedaelqalleqreqqdxaEvxgDdexxxxexxxxxxxxxExxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== HUMAN mepkVvtDtDetelArqmERlEREnAEVdGDDDae--E--------mEakaed----------------- Bombyx_mandarina mapkVvtatDeaelArqmERaEaEnAEVaGDsaee--D--------eDqgmgdanmdgepqqngasdeed Danio_rerio mepkVvtDtDetelqrqlERlEREnAEVdGDDDae--E--------mEakted----------------- Gallus_gallus mepkVvtDtDetelAr------------------------------------------------------ Oncorhynchus_mykiss meakVvtDtDetelArqlERlEREnAEVdGDDEdg--E--------mEakaed----------------- Pongo_pygmaeus mepkVvtDtDetelArqmERlEREnAEVdGDDDae--E--------mEakaed----------------- Rattus_norvegicus mepkVvtDtDetelArqlERlEREnAEVdGDDDae--E--------mEakaed----------------- Strongylocentrotus_purpuratus ---------EeQelArhlEnlEKanAEVdGDDDge--E--------i-gneed----------------- Tetraodon_nigroviridis mepkVvtDtDetelArqlERlEREnAEVdGDDDae--E--------mEakaed----------------- Tribolium_castaneum mapkVvtatDeaelqrqmERaElEntEVaGDDDde--EdgdegqvynEndnesepeed------------ Xenopus_laevis mepkVvtDtDetelArqlERlEKEnAEVdGDDDad--E--------mEakted----------------- Xenopus_tropicalis mepkVvtDtDetelArqlERlEKEnAEVdGDDDae--E--------mEakted----------------- ==================================================================================================== YEAST pPKAVTatEDAELQALLEsKEldN-rsdseDDE--des--------dDe--------------------- Aspergillus_flavus aPKAVTeHDDAaLQeLMEKRERENmevsgdEsQ--ses--------dDg-vpe----------------- Aspergillus_fumigatus aPKAVTeHDDAaLQeLMDKREREN-mEVsGDEs--msE--------sDe--------------------- Candida_albicans pPKAVSaNEDAELErMLQRREaED-k-dssDEE--dda-------------------------------- Candida_glabrata pPKAVTatEDAELQALLEsKEQdN-rsdse-DE--dns--------dye--------------------- Chaetomium_globosum aPKAVTeSDDAELQALMEKREREN-AEVsGDEs-vses--------dDn--------------------- Coccidioides_immitis aPKAVTeeDEADLQALMEKKEREN-qEVsGDEs-vses--------dDa---------------mve--- Cryptococcus_neoformans kPKvVSetEDAELKALMEQfEaaN-mDqaGDDE--ssE--------eDe--------------------- Debaryomyces_hansenii sPKAVTatEDAELQALLERKEaED-kEssdEEE--ed--------------------------------- Emericella_nidulans aPKAVTeHDDAaLQeLMEKREREN-mEVsGDEs--qsE--------sDe--------------------- Eremothecium_gossypii pPKAVTatEDAELQALLEsKElEN-rsdseEED--sdy--------e----------------------- Gibberella_zeae ePKAVTeSDDAELQALMEKREREN-AEVsGDEs--msD--------sDenipetm--------------- Kluyveromyces_lactis aPKAVTatEDAELQALLEsKElEg-rsdseDED--sdy--------e----------------------- Magnaporthe_grisea ePKAVTeSDDAELQALMEKREREN-AEVsGDEs-vsds--------dDn-mpetmgscggglaaiieaeg Neurospora_crassa ePKAVTeSDDAELQALMEKREREN-AEVsGDEs-vses--------dDn-ipetv--------------- Schizosaccharomyces_pombe kPKAVSetDElELadLMKKfEKEN-AEIsGDEE--ddQ--------sgs--------------------- Ustilago_maydis kPKtVSevEDqELEqLMahfEKQN-AEVeGDED--seg--------dD---------------------- Yarrowia_lipolytica ePKAVTetDDAELakLMEKtEQQN-klVdGDDDdadeE--------agd--------------------- ==================================================================================================== Consensus xpkavtxnedaelqalleqreqqdxaEvxgDdexxxxexxxxxxxxxExxxxxxxxxxxxxxxxxxxxxx 360 370 380 390 400 410 420 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== HUMAN ---------------------------------------------------------------------- Bombyx_mandarina dn-------------------------------------------------------------------- Danio_rerio ---------------------------------------------------------------------- Gallus_gallus ---------------------------------------------------------------------- Oncorhynchus_mykiss ---------------------------------------------------------------------- Pongo_pygmaeus ---------------------------------------------------------------------- Rattus_norvegicus ---------------------------------------------------------------------- Strongylocentrotus_purpuratus ---------------------------------------------------------------------- Tetraodon_nigroviridis ---------------------------------------------------------------------- Tribolium_castaneum ---------------------------------------------------------------------- Xenopus_laevis ---------------------------------------------------------------------- Xenopus_tropicalis ---------------------------------------------------------------------- ==================================================================================================== YEAST ---------------------------------------------------------------------- Aspergillus_flavus ---------------------------------------------------------------------- Aspergillus_fumigatus ---------------------------------------------------------------------- Candida_albicans ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Chaetomium_globosum ---------------------------------------------------------------------- Coccidioides_immitis ---------------------------------------------------------------------- Cryptococcus_neoformans ---------------------------------------------------------------------- Debaryomyces_hansenii ---------------------------------------------------------------------- Emericella_nidulans ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Gibberella_zeae ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- Magnaporthe_grisea digfqrksvedevdlditvafagkkyisrktiniaavteivgdiyvsdclsshvnplkptlmapgfawar Neurospora_crassa ---------------------------------------------------------------------- Schizosaccharomyces_pombe ---------------------------------------------------------------------- Ustilago_maydis ---------------------------------------------------------------------- Yarrowia_lipolytica ---fe----------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 430 440 450 460 470 480 490 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== HUMAN ---------------------------------------------------------------------- Bombyx_mandarina ---------------------------------------------------------------------- Danio_rerio ---------------------------------------------------------------------- Gallus_gallus ---------------------------------------------------------------------- Oncorhynchus_mykiss ---------------------------------------------------------------------- Pongo_pygmaeus ---------------------------------------------------------------------- Rattus_norvegicus ---------------------------------------------------------------------- Strongylocentrotus_purpuratus ---------------------------------------------------------------------- Tetraodon_nigroviridis ---------------------------------------------------------------------- Tribolium_castaneum ---------------------------------------------------------------------- Xenopus_laevis ---------------------------------------------------------------------- Xenopus_tropicalis ---------------------------------------------------------------------- ==================================================================================================== YEAST ---------------------------------------------------------------------- Aspergillus_flavus ---------------------------------------------------------------------- Aspergillus_fumigatus ---------------------------------------------------------------------- Candida_albicans ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Chaetomium_globosum ----------------------------ipaav------------------------------------- Coccidioides_immitis ---------------------------------------------------------------------- Cryptococcus_neoformans ---------------------------------------------------------------------- Debaryomyces_hansenii ---------------------------------------------------------------------- Emericella_nidulans ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Gibberella_zeae ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- Magnaporthe_grisea ararawaarpgftfaqnfstsllryltwlpvaivftsnvaepykiagpsmypffnkernetrlqdwcmnw Neurospora_crassa ---------------------------------------------------------------------- Schizosaccharomyces_pombe ---------------------------------------------------------------------- Ustilago_maydis ---------------------------------------------------------------------- Yarrowia_lipolytica ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 500 510 520 530 540 550 560 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ==================================================================================================== HUMAN ---------------------------------------------------------------------- Bombyx_mandarina ---------------------------------------------------------------------- Danio_rerio ---------------------------------------------------------------------- Gallus_gallus ---------------------------------------------------------------------- Oncorhynchus_mykiss ---------------------------------------------------------------------- Pongo_pygmaeus ---------------------------------------------------------------------- Rattus_norvegicus ---------------------------------------------------------------------- Strongylocentrotus_purpuratus ---------------------------------------------------------------------- Tetraodon_nigroviridis ---------------------------------------------------------------------- Tribolium_castaneum ---------------------------------------------------------------------- Xenopus_laevis ---------------------------------------------------------------------- Xenopus_tropicalis ---------------------------------------------------------------------- ==================================================================================================== YEAST ---------------------------------------------------------------------- Aspergillus_flavus ---------------------------------------------------------------------- Aspergillus_fumigatus ---------------------------------------------------------------------- Candida_albicans ---------------------------------------------------------------------- Candida_glabrata ---------------------------------------------------------------------- Chaetomium_globosum ---------------------------------------------------------------------- Coccidioides_immitis ---------------------------------------------------------------------- Cryptococcus_neoformans ---------------------------------------------------------------------- Debaryomyces_hansenii ---------------------------------------------------------------------- Emericella_nidulans ---------------------------------------------------------------------- Eremothecium_gossypii ---------------------------------------------------------------------- Gibberella_zeae ---------------------------------------------------------------------- Kluyveromyces_lactis ---------------------------------------------------------------------- Magnaporthe_grisea klnaqddlrrgmivvfwnplkpesrsvkrivglegdivrnrdsdvwvrvpvghiwvegdagsrdsrdsny Neurospora_crassa ---------------------------------------------------------------------- Schizosaccharomyces_pombe ---------------------------------------------------------------------- Ustilago_maydis ---------------------------------------------------------------------- Yarrowia_lipolytica ---------------------------------------------------------------------- ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx 570 580 590 600 610 620 630 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx =========================================================================== HUMAN --------------------------------------------- Bombyx_mandarina --------------------------------------------- Danio_rerio --------------------------------------------- Gallus_gallus --------------------------------------------- Oncorhynchus_mykiss --------------------------------------------- Pongo_pygmaeus --------------------------------------------- Rattus_norvegicus --------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------------- Tetraodon_nigroviridis --------------------------------------------- Tribolium_castaneum --------------------------------------------- Xenopus_laevis --------------------------------------------- Xenopus_tropicalis --------------------------------------------- =========================================================================== YEAST --------------------------------------------- Aspergillus_flavus --------------------------------------------- Aspergillus_fumigatus ------------------------------------------gvp Candida_albicans --------------------------------------------- Candida_glabrata --------------------------------------------- Chaetomium_globosum --------------------------------------------- Coccidioides_immitis --------------------------------------------- Cryptococcus_neoformans --------------------------------------------- Debaryomyces_hansenii --------------------------------------------- Emericella_nidulans ------------------------------------------gvp Eremothecium_gossypii --------------------------------------------- Gibberella_zeae --------------------------------------------- Kluyveromyces_lactis --------------------------------------------- Magnaporthe_grisea ygpisarliigrltrilfpfhrsgsinwrdhpenprviktqdmvp Neurospora_crassa --------------------------------------------- Schizosaccharomyces_pombe --------------------------------e------------ Ustilago_maydis --------------------------------------------- Yarrowia_lipolytica --------------------------------------------- =========================================================================== Consensus xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx