eIF6

10 20 30 40 50 60 70 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus aiRxqFennneIgvfsklTnsycLlaiggsknfyNvfeaeLxexipilhxSIagsrlVGrlsvxxgnknG ==================================================================================================== METHANOCOCCUS_JANNASCHII iIRkyFsgiptIGVlaltTeeitLLpIfldKDdvNevsevL--etkcLqtNIgGSsLVGsLSV--aNKyG ==================================================================================================== YEAST AtRtQFENSNEIGVFSKLTNTYCLVAVGGSENFYSaFEAELgDaIPIVHtTIAGTRIIGRMTa--GNRrG Apis_mellifera AVRvQFENNNEVGVFSKLTNSYCLVAIGGSENFYSVFEAELaEtIPVIHaSVAGcRIIGRLcV--GNKNG Aspergillus_flavus AVRaQFENSNEVGVFaRLTNSYaVVAIGaSENFYSVFEAELqDvIPIcHaTIAGTRIVGRLTa--GNRkG Aspergillus_fumigatus AVRaQFENSNEVGVFaRLTNSYaIVAIGaSENFYSVFEAELqDvIPIcHaTIAGTRIVGRLTa--GNRkG Bos_taurus AVRasFENNcEIGcFaKLTNSYCLVAIGGSENFYSVFEgELagtIPVVHaSIAGcRIIGRMcV--GNRHG Caenorhabditis_briggsae ALRvdYEgSNDVGVFctLTNSYCLVgIGGTQNFYStlEAELsDlIPVVHtSInsTRIVGRLTV--GNRHG Caenorhabditis_elegans ALRvdYEgSNDVGVFctLTNSYCLVgVGGTQNFYSIlEAELsDlIPVVHtSIAsTRIVGRLTV--GNRHG Candida_albicans AtRtQFENSNEVGVFSnLTNSYCLVAVGGSENFYSaFEAELgDvIPIVHtTIAGTRIVGRMTs--GNRrG Candida_glabrata AtRtQFENSNEVGVFSKLTNTYCLVAVGGSENFYSaFEAELgDsIPIaHtTIAGTRIVGRMTa--GNRrG Canis_lupus AVRasFENNcEIGcFaKLTNTYCLVAIGGSENFYSVFEgELaDtIPVVHaSIAGcRIIGRMcV--GNRHG Cryptococcus_neoformans AVRtQFENStDIGVFSKLTNSYCLtALasStNFYSVFEAELaDvVPIVHtTIgGTRIIGRLTa--GNRHG Danio_rerio AVRasFEkNNEIGcFaKLTNTYCLVAIGGSENFYSVFEgELsEtMPVIHaSIAGcRIIGRMcV--GNRHG Debaryomyces_hansenii AsRtQFENSNEVGVFSKLTNSYCLVAVGGSENFYSaFEAELgDvIPIVHtTIAGTRIVGRMTa--GNRrG Drosophila_melanogaster ALRvQFENNDDIGVFTKLTNTYCLVAIGGSEtFYSaFEAELgDtIPVVHaNVgGcRIIGRLTV--GNRNG Drosophila_pseudoobscura ALRvQFENNDDIGVFTKLTNTYCLVAIGGSEtFYSaFEAELaEtIPVVHaNVgGcRIIGRLTV--GNRNG Emericella_nidulans AVRaQFENSNEVGVFSRLTNSYaLVAIGaSENFYSVFEAELqDvIPIcHaTIAGTRIIGRLTa--GNRkG Eremothecium_gossypii AtRtQFENSNEVGVFSKLTNTYCLVtIGGSENFYSaFEAELgDaIPIVHtTIAGTRIVGRMTa--GNRrG Gallus_gallus AVRasFENNNELGcFaKLTNaYCLVAIGGSEDFYSVFEgELfgtIPVVHaSIAGcRIIGRMcV--GNRHG Gibberella_zeae AVRaQFENSNEVGVFatLTNSYaLVALGaSENFYSVFEAELqDiVPtVrtTIAGTRIIGRLTa--GNRkG Homo_sapiens AVRasFENNcEIGcFaKLTNTYCLVAIGGSENFYSVFEgELsDtIPVVHaSIAGcRIIGRMcV--GNRHG Kluyveromyces_lactis AtRtQFENSNEIGVFSKLTNSYCLVALGGSENFYSaFEAELgDaIPIaHtTIAGTRIVGRMTa--GNRrG Mus_musculus AVRasFENNcEVGcFaKLTNaYCLVAIGGSENFYSVFEgELsDaIPVVHaSIAGcRIIGRMcV--GNRHG Neurospora_crassa AVRaQFENSNEVGVFStLTNSYaLVAVGaSENFYSVFEAELqDvIPIcrtTIAGTRIIGRLTa--GNRkG Rattus_norvegicus vVRasFENNcEVscFaRLTNTYsLVAIGGSENFYSVFEgELsDtIPVVHaSIAscRIIGRgTsvwGtgmG Schistosoma_japonicum ALRtQFEgHNDIGVFSKLTNkYCLVsVGGSENFYSVFEAELsEnIPVVHtTIAGiRtVGRLTV--GNsHG Schizosaccharomyces_pombe ALRaQFENSNEIGVFSnLTNSYaLVALGGSENFYSVFEAELgDvVPVVHtTIgGTRIIGRLTc--GNRkG Strongylocentrotus_purpuratus ALRtQFESNNDIGVFcKLTNaYCLVAIGGSENFYSLFEgELgDaIPVVHsSInGcRILGsLaa--GNRHG Ustilago_maydis AVRcQFENSSEIGVFaRLTNaYCLVAIGGSaNFYStFEAELaDvIPVVHcSIAGTRLVGRLTV--GNRHG Xenopus_laevis AVRasFENNNEIGcFaKLTNTYCLVAIGGSENFYSVFEgELsEtIPVVHaSIAGcRIIGRMcV--GNRHG Xenopus_tropicalis AVRasFENNNEIGcFaKLTNTYCLVAIGGSENFYSVFEgELsEtIPVVHaSIAGcRIIGRMcV--GNRHG Yarrowia_lipolytica AtRaQFENSDEIGVFSKLTNSYCLVAVGGSENFYSsFEAELqDtIPIVysTIgGTRLVGRLTa--GNRrG Bigelowiella_natans AtRasFENSNEIGVFaKLTNSYCLVgtGGSQNFYStFQsELgDhIPVIHaSIgGmRIVGRMvV--GNKNG Dictyostelium_discoideum AtRlQYENScDVGVFlKLTNkYCLVgqcGSKqFlHtvEnrLaDhIPVVetSIAGTRIVGRLSa--GNKNG Plasmodium_berghei AIRvQFENSNEVGVFSRLTNSYgLIALGGSENFsSVFEAELsQhIPIVyaTIgGTRVIGRVcV--GNRkG Plasmodium_chabaudi AIRvQFENSNEVGVFSRLTNSYgLIALGGSENFsSVFEAELsQhIPIVyaTIgGTRVIGRVcV--GNRkG Plasmodium_falciparum AIRvQFENSNEVGVFSRLTNSYaLVALGGSENFsSVFEsELsQhIPLVytTIgGTRVIGRVcV--GNRkG Plasmodium_yoelii AIRvQFENSNEVGVFSRLTNSYgLIALGGSENFsSVFEAELsQhIPIIyaTIgGTRVIGRVcV--GNRkG Arabidopsis_thaliana AtRlQFENNcEVGVFSKLTNaYCLVAIGGSENFYSaFEsELaDvIPIVktSIgGTRIIGRLca--GNKNG Oryza_sativa AtRiQFENNcEVGVFSKLTNaYCLVAIGGSENFYSaFEsELaDvIPVVktSIgGTRIIGRLcV--GNKNG ==================================================================================================== Consensus aiRxqFennneIgvfsklTnsycLlaiggsknfyNvfeaeLxexipilhxSIagsrlVGrlsvxxgnknG 80 90 100 110 120 130 140 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus lllpsstsDeELqhIrNsLpexxxsLkVqrIEeklTALgNlixcNDyvaLihpELerdtkKlxxxxxxxx ==================================================================================================== METHANOCOCCUS_JANNASCHII LLLPkiveDEELdrIKNfLkEnnldLnVEiIKsKnTALGNLIltNDkgALIsPELK-DfKKd-------- ==================================================================================================== YEAST LLVPTqTTDQELQHLRNSLPD---SVKIQRVEERLSALGNVIcCNDYVALVHPDIDRETEEL-------- Apis_mellifera LLVPNTTTDtELQHIRNSLPD---kVKVQRVEERLSALGNVIaCNDYVALVHPDLDRETEEI-------- Aspergillus_flavus LLVPTTTTDQELQHLRNTLPD---SVKIQRIEERLSALGNVIcCNDhVALIHPDLERETEEMyyphhhhc Aspergillus_fumigatus LLVPTTTTDQELQHLRNTLPD---dVKIQRIEERLSALGNVIcCNDhVALVHPDLERETEEI-------- Bos_taurus LLVPNNTTDQELQHIRNcLPD---SVQIRRVEERLSALGNVttCNDYVALVHPDLDRETEEI-------- Caenorhabditis_briggsae LLVPNaTTDQELQHLRNSLPD---eVaIRRVDERLSALGNVIaCNDhVAIVHaEIsaETEQa-------- Caenorhabditis_elegans LLVPNaTTDQELQHLRNSLPD---eVaIRRVDERLSALGNVIaCNDhVAIVHaEIsaETEQa-------- Candida_albicans LLVPTqTTDQELmHLRNSLPD---SIKIQRVEERLSALGNVIcCNDYVALVHPDIERETEEL-------- Candida_glabrata LLVPTqTTDQELQHLRNSLPD---SVKIQRVEERLSALGNVIcCNDYVALVHPDIDRETEEL-------- Canis_lupus LLVPNNTTDQELQHIRNcLPD---SVQIRRVEERLSALGNVttCNDYVALVHPDLDRETEEI-------- Cryptococcus_neoformans LLVPSSTTDQELQHLRNSLPp---TVaIQRVEERLSALGNVIaCNDYVALVHPDIDRETEEI-------- Danio_rerio LLVPNNTTDQELQHIRNcLPD---SVRIQRVEERLSALGNVIaCNDYVALVHPDLDRETEEI-------- Debaryomyces_hansenii LLVPTqTTDQELmHLRNSLPD---TVKIQRVEERLSALGNVIcCNDYVALVHPDIERETEEL-------- Drosophila_melanogaster LLVPNSTTDEELQHLRNSLPD---aVKIyRVEERLSALGNVIaCNDYVALVHPDLDKETEEI-------- Drosophila_pseudoobscura LLVPNSTTDEELQHLRNSLPD---aVKIQRVEERLSALGNVVaCNDYVALVHPDLDKETEEI-------- Emericella_nidulans LLVPTTTTDQELQHLRNTLPD---dVKIQRIEERLSALGNVIcCNDhVALIHPDLERETEEI-------- Eremothecium_gossypii LLVPTqTTDQELQHLRNSLPD---SVKIQRIEERLSALGNVIcCNDYVALVHPDIDnETEEL-------- Gallus_gallus LLVPSSTTDQELQHIRNSLPD---SVRIQRVEERLSALGNVttCNDYVALVHPDLDRETEEI-------- Gibberella_zeae LLVPTTTTDQELQHLRNSLPD---SVRIQRIEERLSALGNVIvtNDhIALVHPDLERETEEI-------- Homo_sapiens LLVPNNTTDQELQHIRNSLPD---TVQIRRVEERLSALGNVttCNDYVALVHPDLDRETEEI-------- Kluyveromyces_lactis LLVPTqTTDQELQHLRNcLPD---aVKVQRVEERLSALGNVIcCNDYVALVHPDIDRETEEL-------- Mus_musculus LLVPNNTTDQELQHIRNSLPD---SVQIRRVEERLSALGNVttCNDYVALVHPDLDRETEEI-------- Neurospora_crassa LLVPTTTSDQELQHLRNSLPD---dVRIQRIEERLSALGNVIvCNDhtALIHPDLERETEEI-------- Rattus_norvegicus ywyPTTTTDQELQHIhDSLlD---SVQIRRVEEgLSALdNVttCNDYVALVHPDLDRETEEI-------- Schistosoma_japonicum LLVPhTTTDQELlHLtNSLPD---NIRVmRIEERLSALGNtMaCNDYVALVHPDLDKETaEL-------- Schizosaccharomyces_pombe LLVPSSTTDnELQHLRNSLPD---pVKIQRVDERLSALGNIVaCNDYVALVHPDIERETEEI-------- Strongylocentrotus_purpuratus LLVPNSTTDQELQHIRNSLPD---SVKIQRIEEKLSALGNVIsCNDYVALVHPDLEKETEEI-------- Ustilago_maydis LLVPSTTTDQELQHLRNSLPE---SVaIQRVEERLSALGNVIaCNDYVALVHPDLDRETEEI-------- Xenopus_laevis LMVPNNTTDQELQHMRNSLPD---SVRIQRVEERLSALGNVIaCNDYVALVHPDLDRETEEI-------- Xenopus_tropicalis LMVPNNTTDQELQHIRNSLPD---SVRIQRVEERLSALGNVIaCNDYVALVHPDLDRETEEI-------- Yarrowia_lipolytica LLVPSTTSDvELQHLRNSLPD---eVKIQRVEERLSALGNVIctNDYaALVHPDIERETEEL-------- Bigelowiella_natans LLVPSTTrEnELKHLRNSLPD---kVKVQRIEEKLSALGNcVvaNDhVALVHPDIDQNTEEL-------- Dictyostelium_discoideum LLLPNTcTDQELQqIRNSLPD---dVvVQRIEEKfSALGNcIatNDYVALVHPDIDRETEEI-------- Plasmodium_berghei LLVsSicTDQELlHLRNSLPD---NVKIKRIEERLSALGNcItCNDYVgLIHtDIDRETEEI-------- Plasmodium_chabaudi LLVsSicTDQELlHLRNSLPD---dVKIKRVEERLSALGNcItCNDYVgLIHtDIDRETEEI-------- Plasmodium_falciparum LLVsSicTDQELlHLRNcLPE---NVKIKRIEERLSALGNcIttNDYVgLIHtDIDKETEEI-------- Plasmodium_yoelii LLVsSicTDQELlHLRNSLPD---NVKIKRVEERLSALGNcItCNDYVgLIHtDIDRETEEI-------- Arabidopsis_thaliana LLVPhTTTDQELQHLRNSLPD---qVvVQRIDERLSALGNcIaCNDYVALaHtDLDKETEEI-------- Oryza_sativa LLLPhTTTDQELQHLRNcLPD---qVvVQRIDERLSALGNcVaCNDhVALtHPDLDKaTEEL-------- ==================================================================================================== Consensus lllpsstsDeELqhIrNsLpexxxsLkVqrIEeklTALgNlixcNDyvaLihpELerdtkKlxxxxxxxx 150 160 170 180 190 200 210 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus xxxxxxxxxxxxxxxxxIadvLxVEVfrqsIaxnilvGSycxlTNkGgLvhpqtsvqeqeeLssllKVxp ==================================================================================================== METHANOCOCCUS_JANNASCHII -----------------IeDsLnVEVeigTIAelptVGSnavVTNKGcLtHPlveddElEfLkSLfKVey ==================================================================================================== YEAST -----------------IsDVLgVEVFRQTIsgNILVGSYCsLSNQGGLVHPQTSVQDQEELSSLLQV-P Apis_mellifera -----------------LADtLnVEVFRQTVAsNVLVGSYsvLSNQGGLVHPKTSIQDQDELSSLLQV-P Aspergillus_flavus flitiwhgmkvltiftsIADVLgVEVFRQTIAdNVLtGSYmaLSNQGGIVHPKTSIRDQDELSSLLQV-P Aspergillus_fumigatus -----------------IADVLgVEVFRQTIAdNVLtGSYmaLSNQGGIVHPKTSIRDQDELSSLLQV-P Bos_taurus -----------------LADVLkVEVFRQkVAdqVLVGSYCvfSNQGGLVHPKTSIEDQDELSSLLQV-P Caenorhabditis_briggsae -----------------LvEVLkVEVFRvSLAqNsLVGSYCaLSSnGcLVaaRTppEtQrELaaLLQI-P Caenorhabditis_elegans -----------------LvEVLkVEVFRvSLAqNsLVGSYCiLSSnGcLVaaRTppEtQrEIaaLLQI-P Candida_albicans -----------------IADVLgVEVFRQTIAgNVLVGSYCsLSNQGGLVHPQTSIQDQEELSSLLQV-P Candida_glabrata -----------------IsDVLgVEVFRQTIsgNILVGSYCaLSNQGGLVHPQTTIQDQEELSSLLQV-P Canis_lupus -----------------LADVLkVEVFRQTVAdqVLVGSYsvfSNQGGLVHPKTSIEDQDELSSLLQV-P Cryptococcus_neoformans -----------------IADtLkVEVFRQTIAgNVLVGSYCaLSNQGGLVHPKTSrsElDELSSLLQV-P Danio_rerio -----------------LADtLkVEVFRQTVAeqVLVGSYCafSNQGGLVHaKTSIEDQDELSSLLQV-P Debaryomyces_hansenii -----------------IADVLgVEVFRQTIAgNVLVGSYCsLSNQGGLVHPQTSIQDQEELSSLLQV-P Drosophila_melanogaster -----------------IADVLkVEVFRQTIAdNsLVGSYavLSNQGGMVHPKTSIQDQDELSSLLQV-P Drosophila_pseudoobscura -----------------IgDVLnVEVFRQTIAdNtLVGSYtvLSNQGGMVHPKTSIQDQDELSSLLQV-P Emericella_nidulans -----------------IADVLgVEVFRQTIAdNVLtGSYmaLSNQGGIVHPKTSIRDQDELSSLLQV-P Eremothecium_gossypii -----------------IADVLgVEVFRQTIsgNVLVGSYCaLSNQGGLVHPQTTIQDQEELSSLLQV-P Gallus_gallus -----------------LADVLkVEVFRQTVAdqVLVGSYCvfSNQGGIVHPKTSIEDQDELSSLLQV-P Gibberella_zeae -----------------IADVLgVEVFRQTVAdNVLVGSYmsLSNQGGLVHPKTpIQDQDELSSLLQV-P Homo_sapiens -----------------LADVLkVEVFRQTVAdqVLVGSYCvfSNQGGLVHPKTSIEDQDELSSLLQV-P Kluyveromyces_lactis -----------------IADVLgVEVFRQTIsgNVLVGSYCaLSNQGGLVHPQTTVQDQEELSSLLQV-P Mus_musculus -----------------LADVLkVEVFRQTVAdqVLVGSYCvfSNQGGLVHPKTSIEDQDELSSLLQV-P Neurospora_crassa -----------------IADVLgVEVFRQTIAdNVLVGSYmaLSNQGGLVHPKTSIQDQDELSSLLQV-P Rattus_norvegicus -----------------LAgVLkVEVl--TVAdqVLVGSYCvfSNQGGLVyPKTSIEDQDELSSpLQV-P Schistosoma_japonicum -----------------VsDVLnVDVFRgvVAnqsLVGTYCvLTNQGGLVHPRvTVdElDQLSSLLQL-P Schizosaccharomyces_pombe -----------------IADVLdVEVFRQTVAgNVLtGSYCaLSNQGaLVHPRTSIQEQDELSSLLQV-P Strongylocentrotus_purpuratus -----------------IADVLkVEVFRQTVAdNVLVGTYsvISNQGGLVHPKTSVQEQnELSSLLQV-P Ustilago_maydis -----------------IADVLkVEVFRQTVgdNVLVGSYsaISNQGaLtHPRTSLQDQDELSSLLQV-P Xenopus_laevis -----------------LADVLkVEVFRQTIAeqVLVGSYCafSNQGGLLHPKTSIEDQDELSSLLQV-P Xenopus_tropicalis -----------------LADVLkVEVFRQTIAdqVLVGSYCafSNQGGLLHPKTSIEDQDELSSLLQV-P Yarrowia_lipolytica -----------------IADVLgVEVFRQTVAgNVLVGSYCaLSNQGGIVHPQTSIEDQDELSSLLQV-P Bigelowiella_natans -----------------IADVLgVEVFRQaIAkNtLVGSYCaLSNQGcLVHPKTTVpEQKEISSLLQV-P Dictyostelium_discoideum -----------------IADVLgVEVFRQTVsgNVLVGTYCaLTNQGaLVHPmTSIaDQDELSSLLQV-P Plasmodium_berghei -----------------VqDVLdIEVFRtSIAgNLLVGTYsyfTNnGGLLHamTTsQEiEELSeLLQI-P Plasmodium_chabaudi -----------------VqDVLdIEVFRtSIAgNLLVGTYsyfTNnGGLLHamTTsQEiEELSeLLQI-P Plasmodium_falciparum -----------------IqDVLdIEVFRtSIAgNLLVGTYsyfTNnGGLLHamTSsQEiEELSeLLQI-P Plasmodium_yoelii -----------------VqDVLdIEVFRtSIAgNLLVGTYsyfTNnGGLLHamTTsQEiEELSeLLQI-P Arabidopsis_thaliana -----------------IADVLgVEVFRQTIAgNILVGSYCaLSNKGGMVHPhTSVEDlEELSTLLQV-P Oryza_sativa -----------------IADVLgVEVFRQTIAgNILVGSYCaITNRGGLVHPhTSIEDlDELSTLLQV-P ==================================================================================================== Consensus xxxxxxxxxxxxxxxxxIadvLxVEVfrqsIaxnilvGSycxlTNkGgLvhpqtsvqeqeeLssllKVxp 220 230 240 250 260 270 280 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus IvaGTvNKGSdvVgagiivNdyxaxcGldsTatELsIiesifrlxxdaqxpsxixxxsxlxxrnsliesx ==================================================================================================== METHANOCOCCUS_JANNASCHII IgkGTaNKGTtsVGAcIIaNskgAvvGgDTTgpELlIIEdalgLi------------------------- ==================================================================================================== YEAST LVAGTVNRGSsVVGAGMVVNDYlAvtGLDTTApELSVIESIFRL-qDAQ-PesIs-gN-L--RDTLIETy Apis_mellifera LaAGTVNRGSDVIaAGMVVNDWvsfCGMDTTsTELSVIESVFKL-nEAa-PaaIt-sT-M--RaSLIESm Aspergillus_flavus LVAGSVNRGSaVVGAGMVVNDWlAvtGLDTTATELSVIESVFRL-gEmg-PrgVgmgS-t-nKeSIVESf Aspergillus_fumigatus LVAGSVNRGSpVVGAGMVVNDWlAvtGLDTTATELSVVESVFRL-gEmg-PrgLgvgN-a-nKeSIVESf Bos_taurus LVAGTVNRGSEVIaAGMaVNDWcAfCGLDaTsTELSVVESVsKp-nEAQ-PStIa-tS-M--RDSLtDSl Caenorhabditis_briggsae VVAGTVNRGSELIGAGMVVNDWvAfCGLDSTsTELSVVESIFKLgeqga-PTsIs-nq-L--RDTLIESm Caenorhabditis_elegans VVAGTcNRGSELIGAGMVVNDWvAfCGLDSTsTELSVVESIFKLgeqga-PTsIs-nq-L--RDTLIESm Candida_albicans LVAGTVNRGSsVVGAGMVVNDWlsvaGLDTTApELSVIESIFRL-qDAQ-PdaIg-gN-L--RDTLIETy Candida_glabrata LVAGTVNRGSaVVGAGMVVNDYlAvtGLDTTApELSVIESIFRL-qDAQ-PdaIs-gN-L--RDTLIETy Canis_lupus LVAGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVVESVFKL-nEAQ-PStIa-tS-M--RDSLIDSl Cryptococcus_neoformans LVAGTVNRGSEVIGAGLVVNDWcAftGLDTTATEVSVIEatFRL-qgqt-sTaVi-ne-M--RDSLIDhy Danio_rerio LVAGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVIESVFRL-sEtQ-PSaIa-tT-M--RDSLIDSl Debaryomyces_hansenii LVAGTVNRGSaVVGAGMVVNDWlAvtGLDTTApELSVVESIFRL-qDAQ-PdsIs-gN-L--RDTLIETy Drosophila_melanogaster LVAGTVNRGSEVLaAGMVVNDWlsfvGMNTTATEISVIESVFKL-nqAQ-PatVt-tk-L--RaaLIEdm Drosophila_pseudoobscura LVAGTVNRGSEVLaAGMVVNDWlsfvGMNTTATEISVIESVFKL-nqAQ-PaaVt-tk-L--RaaLIEdm Emericella_nidulans LVAGSVNRGSpVVGAGLVVNDWlAvtGLDTTATELSVIESVFRL-gEng-PggIg-qg-VanKDSIVESf Eremothecium_gossypii LVAGTINRGSsVVGAGMVVNDYlAvtGLDTTApELSVIESIFRL-qDAn-PdaIs-gN-L--RDTLIETy Gallus_gallus LVAGTVNRGSEVIGAGMVVNDWcAfCGLDTTsTELSVIESIFKL-nEAQ-PStIa-tN-M--RDSLIDSl Gibberella_zeae LVAGSVNRGSNVVGAGMVVNDWlAvtGLDTTATELSVIESVFRL-gEgQgPSnIn-tS-M--KDTMVESf Homo_sapiens LVAGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVVESVFKL-nEAQ-PStIa-tS-M--RDSLIDSl Kluyveromyces_lactis LVAGTVNRGSqVVGAGMVVNDYlAvtGLDTTApELSVIESIFRL-qDAQ-PeaIs-gN-L--RDTLIETy Mus_musculus LVAGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVVESVFKL-nEAK-PStIa-tS-M--RDSLIDSl Neurospora_crassa LVAGSVNRGSNVIGgGMVVNDWmAvtGLDTTApELSVIESVFRLgegAa-PgqIn-sS-L--KDTMVESf Rattus_norvegicus LVAGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVVESVFKL-nEAK-PStIa-tS-M--RDSLIDrl Schistosoma_japonicum LtAGTVNRGSpLIaAGLVVNDWagfCGLETTsTEIqVIESIFKL-dgem-nipVv-gS-a--hDaLVEr- Schizosaccharomyces_pombe LVAGTINRGSDVIGAGLVVNDWcAfaGLDTTATELaVcESIFKL-qDAQ-PSaIi-sN----RDTLVESy Strongylocentrotus_purpuratus LVAGTVNRGSDVLGgGMVVNDWcAfCGLDTTtaELSVIEkVFKL-sEgQ-PaaIa-te-M--RDSLVDSl Ustilago_maydis LVAGTVNRGSDLIGAGLVVNDFaAfCGtDaTATEISVIESVFRL-tgAa-nTgda-vNqL--RDaLVDTy Xenopus_laevis LVtGTVNRGSEVIaAGMVVNDWcAfCGLDTTsTELSVIESVFKL-sDAh-PStIa-tS-M--RDSLIDSl Xenopus_tropicalis LVtGTVNRGSEVIaAGMVVNDWsAfCGLDTTsTELSVIESVFKL-sDAh-PStIa-tS-M--RDSLIDSl Yarrowia_lipolytica LIAGSVNRGSpVVGAGcVVNDWmAvaGyaTTsfELTVMsSIFKLnnDqQ-geqwe-qT-k--wSqLyQqm Bigelowiella_natans VcAGTVNRGSNVIGAGLVVNDWtAfsGMDTTsTELSVIENIFnL-qDkE-qekMv-kd-M--QSSLIEdl Dictyostelium_discoideum LVAGTVNRGNEcVaAGcVVNDWtAivGaDTTATEISVIESIFaL-qgsK-PSnIi-nN-I--RNSIVDNv Plasmodium_berghei LItGTVNRGSDLIGsGLVaNDWsAfCGMDTTAiELNIIEkIFKL-nNiE-dTnIe-dT-fkyKSSIVQTm Plasmodium_chabaudi LItGTINRGSDLIGsGLVaNDWsAfCGMDTTAiELNIIEkIFKL-nNiE-dTnIe-dT-fkyKSSIVQTm Plasmodium_falciparum LItGTINRGSDLIGsGLVaNDWsAfCGMDTTAiELSIIEkVFKL-nNit-dNnMe-dT-fkyKSSIIQTm Plasmodium_yoelii LVtGTINRGSDLIGsGLVaNDWsAfCGMDTTAiELNIIEkIFKL-nNiE-dTnIe-dT-fkyKSSIVQTm Arabidopsis_thaliana LVAGTVNRGSEVIaAGMtVNDWtsfCGsDTTATELSVIDSIFKL-rEAQ-PSsIv-de-M--RkSLIDTy Oryza_sativa LVAGTVNRGSEVIaAGMtVNDWtAfCGsDTTATELSVIESVFKL-rEgQ-PaaIv-dd-M--RkSLIDSy ==================================================================================================== Consensus IvaGTvNKGSdvVgagiivNdyxaxcGldsTatELsIiesifrlxxdaqxpsxixxxsxlxxrnsliesx 290 300 310 320 330 340 350 ----:----|----:----|----:----|----:----|----:----|----:----|----:----| Consensus x =============================== METHANOCOCCUS_JANNASCHII - =============================== YEAST s Apis_mellifera s Aspergillus_flavus y Aspergillus_fumigatus y Bos_taurus t Caenorhabditis_briggsae l Caenorhabditis_elegans l Candida_albicans s Candida_glabrata s Canis_lupus t Cryptococcus_neoformans a Danio_rerio t Debaryomyces_hansenii s Drosophila_melanogaster s Drosophila_pseudoobscura s Emericella_nidulans y Eremothecium_gossypii s Gallus_gallus a Gibberella_zeae y Homo_sapiens t Kluyveromyces_lactis s Mus_musculus t Neurospora_crassa y Rattus_norvegicus t Schistosoma_japonicum - Schizosaccharomyces_pombe t Strongylocentrotus_purpuratus t Ustilago_maydis a Xenopus_laevis t Xenopus_tropicalis t Yarrowia_lipolytica g Bigelowiella_natans l Dictyostelium_discoideum - Plasmodium_berghei i Plasmodium_chabaudi i Plasmodium_falciparum i Plasmodium_yoelii i Arabidopsis_thaliana v Oryza_sativa v =============================== Consensus x